Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#744 Poster Board Number.....................................807
URINARY FIBRINOGEN: A MECHANISTIC
TRANSLATIONAL BIOMARKER FOR
VASCULAR DYSFUNCTION AND
INFLAMMATION IN THE KIDNEY. ​D.
Hoffmann 1 , A. Krishnamoorthy 1 , V. Ramirez
Gonzalez 1 , Q. Zhang 2 , P. L. Goering 2 , R. B. Brown 2 ,
S. Waikar 1 and V. S. Vaidya 1 . 1 Renal Division,
Brigham and Women’s Hospital, Harvard Medical
School, Boston, MA and 2 CDRH, U.S. FDA, Silver
Spring, MD.
#745 Poster Board Number.....................................808
METABOLOMICS ANALYSIS SUGGESTS
ROLE OF 3-INDOXYL SULFATE IN
CENTRAL NERVOUS SYSTEM TOXICITY
AND AN EARLY INDICATOR OF
CHEMICALLY-INDUCED RENAL FAILURE. ​
M. V. Milburn 1 , D. Alexander 1 , J. R. Zgoda-Pols 2 ,
S. Chowdhury 2 , M. Wirth 2 and K. B. Alton 2 .
1
Metabolon, Durham, NC and 2 Department of Drug
Metabolism and Pharmacokinetics, Merck Research
Laboratories, Kenilworth, NJ. Sponsor: G. Vansant.
#746 Poster Board Number.....................................809
SHORT-TERM TOXICITY OF MELAMINE
AND ITS MIXTURE WITH CYANURIC ACID
IN F344 NEONATAL RATS AND SEARCHING
FOR NOVEL KIDNEY BIOMARKERS. ​H.
Kang 1 , Y. Park 1 , S. Jeong 2 , J. Seo 1 , Y. Jean 1 , J.
Kang 1 , H. Shin 1 and S. Son 1 . 1 Veterinary Toxicology
and Chemistry, National Veterinary Research and
Quarantine Service, Anyang, Republic of Korea
and 2 GLP Research Center, Hoseo University, Asan,
Republic of Korea.
#747 Poster Board Number.....................................810
TRANSCRIPTION LEVELS OF
BIOMARKERS OF ACUTE RENAL INJURY
IN F344 RATS CO-EXPOSED TO MELAMINE
AND CYANURIC ACID FOR SEVEN DAYS. ​
L. Camacho, K. Kelly and G. Gamboa da Costa.
Division Biochemical Toxicology, National Center
for Toxicological Research. U.S. FDA, Jefferson,
AR.
#748 Poster Board Number.....................................811
THE USE OF FLOW CYTOMETRY
TO STUDY MECHANISMS OF
MITOCHONDRIAL BIOGENESIS IN RENAL
CELLS. ​V. Kale and R. Schnellmann. Department
of Pharmaceutical and Biomedical Sciences, Medical
University of South Carolina, Charleston, SC.
#749 Poster Board Number.....................................812
OXIDANT INJURY INDUCES RAPID
DEGRADATION OF MITOCHONDRIAL
CALPAIN 10 IN RENAL PROXIMAL
TUBULE CELLS. ​M. A. Smith and R. G.
Schnellmann. Pharmaceutical Sciences, Medical
University of South Carolina, Charleston, SC.
#750 Poster Board Number.....................................813
MITOCHONDRIAL HOMEOSTASIS AFTER
ACUTE KIDNEY INJURY: SUSTAINED
ALTERATIONS IN MITOCHONDRIAL
PROTEINS, FUSION/FISSION, AND
BIOGENESIS. ​J. A. Funk, B. E. Shaner and R.
G. Schnellmann. Pharmaceutical and Biomedical
Sciences, Medical University of South Carolina,
Charleston, SC.
Abstract #
#751 Poster Board Number.....................................814
IDENTIFICATION AND
CHARACTERIZATION OF
MITOCHONDRIAL TOXICANTS. ​L. P. Wills,
G. C. Beeson, R. Trager, C. Lindsey, Y. K. Peterson,
C. C. Beeson and R. G. Schnellmann. Department of
Pharmaceutical and Biomedical Sciences, Medical
University of South Carolina, Charleston, SC.
#752 Poster Board Number.....................................815
MITOCHONDRIAL GSH STATUS IN
COMPENSATORY RENAL HYPERTROPHY
DUE TO UNINEPHRECTOMY AND
DIABETIC NEPHROPATHY. ​L. H. Lash, B.
Benipal, D. A. Putt and Q. Zhong. Pharmacology,
Wayne State University School of Medicine, Detroit,
MI.
#753 Poster Board Number.....................................816
THE CYTOPROTECTIVE EFFECT
OF N-ACETYLCYSTEINE AGAINST
ROS-INDUCED CYTOTOXICITY IS
INDEPENDENT OF ITS ABILITY TO
ENHANCE GLUTATHIONE SYNTHESIS. ​F.
Zhang, S. S. Lau and T. J. Monks. Department of
Pharmacology and Toxicology, College of Pharmacy,
University of Arizona, Tucson, AZ.
#754 Poster Board Number.....................................817
PLASMA, URINE, AND TISSUE
CONCENTRATIONS OF HEXAVALENT
CHROMIUM ASSOCIATED ACUTE KIDNEY
INJURY IN SPRAGUE-DAWLEY RATS. ​R. P.
Brown 1 , Q. Zhang 1 , D. S. Barber 2 , A. C. Komiyama 1
and P. L. Goering 1 . 1 CDRH, U.S. FDA, Silver Spring,
MD and 2 University of Florida, Gainesville, FL.
#755 Poster Board Number.....................................818
COVALENT MODIFICATIONS OF KIDNEY
PROTEINS BY S-(1, 2-DICHLOROVINYL)-L-
CYSTEINE SULFOXIDE (DCVCS): IN VITRO
CHARACTERIZATION USING N-BIOTINYL-
DCVCS (NB-DCVCS). ​R. M. Irving 1 , M. S.
Brownfield 2 and A. A. Elfarra 1,2 . 1 Molecular and
Environmental Toxicology Center, University of
Wisconsin Madison, Madison, WI and 2 Department
of Comparative Biosciences, University of Wisconsin
Madison, Madison, WI.
#756 Poster Board Number.....................................819
ZINC DEFICIENCY EXACERBATES
DIABETES-INDUCED RENAL OXIDATIVE
DAMAGE, INFLAMMATION, AND
FIBROSIS. ​B. Li 1,2 , L. Miao 2 and L. Cai 1 .
1
University of Louisville, Louisville, KY and
2
Nephrology, Jilin University, Changchun, Jilin,
China.
#757 Poster Board Number.....................................820
ROLE OF OXIDATIVE STRESS INDUCED
BY CHROMATE IN THE ACTIVATION
OF MAPK IN NRK-52E CELLS. ​L. Arreola-
Mendoza 1,2 , J. L. Reyes 3 , E. I. Sanchez 3 and L.
M. Del Razo 2 . 1 Biosciences and Engineering,
CIIEMAD-IPN, Mexico D.F., Mexico, 2 Toxicology,
Cinvestav-Ipn, Mexico D.F., Mexico and 3 Physiology
& Biophysics, Cinvestav-Ipn, Mexico D.F., Mexico.
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