Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 202A Symposium Session: Stem Cell Biology and Cell Therapy Approaches to Understanding Cellular Injury and Wound Healing in Dermal, Ocular, and Pulmonary Injury Chairperson(s): Jeffrey Yourick, Defense Threat Reduction Agency, Fort Belvoir, VA, and John Graham, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD. Sponsor: Dermal Toxicology Specialty Section Endorsed by: Ocular Toxicology Specialty Section Thermal and chemical burns as well as chemical injury to the skin, eye, and lung invoke a vast tissue and cellular response followed by the initiation of wound healing mechanisms. Stem cells may be defined as undifferentiated cells that have the capacity for self-renewal and may differentiate into many different cell types when stimulated by specific cellular signals. Injury to stem cell tissue populations has immense implications for normal repair and restoration of tissue function after chemical injury. Research on stem cells, such as epidermal stem cells, dermal stem cells, mesenchymal stem cells and embryonic stem cells all have potential to repair and restore structure and function to the skin and eye after extensive injury. An overview of recent advances in dermal, ocular, and pulmonary induced injury related to stem cells will be presented along with potential stem cell and other cellbased therapies as they relate to tissue repair and wound healing. #890 9:00 STEM CELL AND CELL THERAPY APPROACHES FOR UNDERSTANDING CELLULAR INJURY AND WOUND HEALING IN DERMAL, OCULAR, AND LUNG INJURY. J. J. Yourick. Medical Chemical Countermeasure, Defense Threat Reduction Agency, Fort Belvior, VA. 9:00 INTRODUCTION. Jeffrey Yourick #891 9:05 THE INVOLVEMENT OF EPITHELIAL STEM CELLS IN THE PATHOGENESIS OF SULFUR MUSTARD INJURIES: MECHANISM AND POTENTIAL THERAPY. T. Kadar, V. Horwitz, L. Cohen, M. Cohen, R. Sahar, H. Gutman, L. Tveria, R. Gez, S. Dachir and A. Amir. Pharmacology, Israel Institute for Biological Research, Ness Ziona, Israel. Sponsor: J. Yourick. #892 9:37 CELL-BASED THERAPEUTICS IN BURN MEDICINE. J. S. Graham. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD. Sponsor: J. Yourick. #893 10:09 STEM CELLS AND DAUGHTER CELLS IN REGENERATION OF EPITHELIAL SURFACES. M. Simon 1 , J. Tafrova 1 , L. Wan 1 , J. S. Graham 2 , J. Azeke 2 , E. Braue 2 and S. McClain 3 . 1 Stony Brook University, Stony Brook, NY, 2 U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD and 3 McClain Laboratories, LLC, Smithtown, NY. Sponsor: J. Yourick. #894 10:41 EMBRYONIC, MESENCHYMAL, AND PHARMACOLOGICAL MODULATION OF STEM CELLS FOR THE TREATMENT OF CUTANEOUS VESICANT INJURY. M. P. Nambiar. Closed Head Injury, Water Reed Army Institute of Research, Silver Spring, MD. #895 11:13 CONTROL OF STEM CELL DIFFERENTIATION IN THE LUNG. J. D. Laskin 1,3 and D. L. Laskin 2,3 . 1 Environmental & Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, 2 Pharmacology and Toxicology, Rutgers University, Piscataway, NJ and 3 Environmental and Occupational Health Sciences Institute, Piscataway, NJ. Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 147 Symposium Session: Uncovering the Role of Non-Coding RNAs in Toxicology Chairperson(s): Mark Hahn, Woods Hole Oceanographic Institute, Woods Hole, MA, and Tamara Tal, Oregon State University, Corvallis, OR. Sponsor: Molecular Biology Specialty Section Endorsed by: Carcinogenesis Specialty Section Mechanisms Specialty Section Over the past ten years non-coding RNAs (ncRNAs) have emerged as pivotal players in fundamental physiological and cellular processes and have been increasingly implicated in cancer, immune disorders, and cardiovascular, neurodegenerative, and metabolic diseases. MicroRNAs (miRNAs) represent a class of ncRNA molecules that are predicted to post-transcriptionally regulate the expression of 30–60% of all human protein-coding genes and as such, miRNAs play key roles in cellular and developmental processes, human health, and disease. Recently, miRNAs have surfaced as targets of developmental, hepatic, neurological, and carcinogenic toxicological agents, and have increasingly been identified as putative regulators of phase I xenobiotic-metabolizing enzymes. We will highlight impactful research demonstrating the growing understanding of the role of miRNAs in toxicological modes of action, study the mechanisms of miRNA-mediated toxicity in a variety of emerging model systems. #896 9:00 UNCOVERING THE ROLE OF NON- CODING RNAS IN TOXICOLOGY. M. E. Hahn 1 and T. Tal 2 . 1 Biology, Woods Hole Oceanographic Institution, Woods Hole, MA and 2 Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR. 9:00 INTRODUCTION. Mark Hahn #897 9:05 EXPLORING THE ROLE OF MICRORNAS AS MEDIATORS OF DEVELOPMENTAL NEUROBEHAVIORAL TOXICITY IN ZEBRAFISH. T. L. Tal 1 , J. A. Franzosa 1 , S. Tilton 2 , K. Waters 2 and R. L. Tanguay 1 . 1 Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR and 2 Computational Biology & Bioinformatics Group, Pacific Northwest National Laboratories, Richland, WA. #898 9:35 DEFINING THE DEVELOPMENTAL ROLE OF MICRORNAS IN ORCHESTRATING TOXICOLOGICAL RESPONSES. J. A. Franzosa, T. L. Tal and R. L. Tanguay. Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR. #899 10:05 IDENTIFICATION OF NEW NON-CODING SMALL RNA IN BREAST CANCER. C. Rovira. Clinical Sciences, Department of Oncology, Lund University, Lund, Sweden. Sponsor: T. Tal. 196 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #900 10:35 ONCOGENIC MICRORNAS AS DRUG TARGETS FOR CANCER CHEMOTHERAPY. S. Safe. Veterinary Physiology, Texas A&M University, College Station, TX. #901 11:05 MICRORNA REGULATION OF DEP- INDUCED INFLAMMATION IN AIRWAY EPITHELIAL CELLS. M. J. Jardim, L. Dailey and D. Diaz-Sanchez. U.S. EPA, Chapel Hill, NC. Sponsor: T. Tal. 11:35 PANEL DISCUSSION/Q&A. Mark Hahn Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 207 Workshop Session: Identification of Chemical Respiratory Allergens: Principles and New Developments Chairperson(s): Ian Kimber, University of Manchester, Manchester, United Kingdom, and Takahiko Yoshida, Asahikawa Medical College, Asahikawa, Japan. Sponsor: Immunotoxicology Specialty Section Japanese Society of Immunotoxicology There are several new developments and opportunities in chemical respiratory allergy. This is an important occupational health problem associated with significant morbidity, and occasionally mortality. The identification and characterization of chemical respiratory allergens has presented toxicologists with some significant challenges, not least because there remains uncertainty about the immunological mechanisms that may result in allergic sensitization of the respiratory tract. Moreover, there is continuing debate about the relevant routes of exposure for the acquisition of sensitization. Previously attention focused primarily on the development of predictive test methods based upon animal, mainly guinea pig and mouse models, or through exploitation of (quantitative) structure-activity relationships. More recently, however, other strategies have been proposed and developed, included among which are modified peptide reactivity assays, and the identification of altered gene expression signatures specific for chemical respiratory allergens. Recent progress will be reviewed critically and prospects for the development of widely accepted methods for the identification and characterization of chemical respiratory allergens will be discussed. #902 9:00 IDENTIFICATION OF CHEMICAL RESPIRATORY ALLERGENS: PRINCIPLES AND NEW DEVELOPMENTS. I. Kimber 1 and T. Yoshida 2 . 1 Faculty of Life Sceinces, University of Manchester, Manchester, UK, United Kingdom and 2 Asahikawa Medical College, Asahikawa, Japan. 9:00 INTRODUCTION. Ian Kimber #903 9:05 IDENTIFICATION AND CHARACTERIZATION OF CHEMICAL RESPIRATORY ALLERGENS:CHALLENGES AND OPPORTUNITIES. I. Kimber. Faculty of Life Sceinces, University of Manchester, Manchester, UK, United Kingdom. #904 9:37 ANIMAL MODELS OF CHEMICAL RESPIRATORY ALLERGY. J. Pauluhn. Toxicology, Bayer HealthCare, Wuppertal, Germany. #905 10:09 PEPTIDE REACTIVITY OF CHEMICAL RESPIRATORY ALLERGENS. J. F. Lalko 1,2 . 1 The University of Manchester, Manchester, United Kingdom and 2 Research Institute for Fragrance Materials Inc., Woodcliff Lake, NJ. Sponsor: I. Kimber. Abstract # #906 10:41 GENE EXPRESSION CHANGES AND THE IDENTIFICATION OF CHEMICAL RESPIRATORY ALLERGENS. D. R. Boverhof. The Dow Chemical Company, Midland, MI. #907 11:13 A MODIFIED LOCAL LYMPH NODE ASSAY FOR HAZARD IDENTIFICATION OF CHEMICAL RESPIRATORY ALLERGENS. T. Yoshida. Health Science, Asahikawa Medical University, Asahikawa, Hokkaido, Japan. Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 144 Emerging Global Public Health Issues Workshop Session: Safer Products for a Sustainable World: Linking Chemical Design and Toxicology Chairperson(s): Patricia Beattie, SciVera, Inc. and Arcalis Scientific, LLC, West Bloomfield, MI, and Hal Zenick, U.S. EPA, Research Triangle Park, NC. Sponsor: Risk Assessment Specialty Section Endorsed by: Disease Prevention Task Force Occupational and Public Health Specialty Section There is no more greatly studied characteristic of molecules than their ability to exhibit biological activity and major industries, including pharmaceuticals and pesticides, are based on this science. Billions of dollars are spent to evaluate the risk of chemicals in the environment and billions more are to discover new chemicals that have beneficial biological effects. One of the goals of green chemistry first introduced by Paul Anastas and John Warner in 1998, is to reduce or eliminate the use and generation of hazardous substances throughout the design, manufacture, and use of chemical products. The principles of green chemistry and engineering are now being widely embraced beyond the traditional chemical and pharmaceutical industries, into formulators and manufacturers of consumer products. Information on the potential hazards of the substances that are incorporated into final products is needed in order to assess and design safer products and processes. Recent advances in understanding the mechanisms of toxicity, the development of in vitro high-throughput screening (HTS) assays as well as other predictive and in silico methods allow for rapid assessment and screening of many more chemicals than had been possible in the past using traditional whole animal models. With the reform of the Toxic Substances Control Act (TSCA) and other state and global regulations requiring toxicity information and assessment of safer alternatives on thousands of chemicals, it is imperative that these predictive toxicology methods be incorporated into the assessment paradigm. As new industrial chemicals are designed with green chemistry and engineering principles, these toxicology screening methods can be used to efficiently evaluate substances, minimizing potential adverse health effects both in the workplace and to the final consumer. #908 9:00 SAFER PRODUCTS FOR A SUSTAINABLE WORLD: LINKING CHEMICAL DESIGN AND TOXICOLOGY. H. Zenick 1 and P. Beattie 2 . 1 National Health Environmental Effects Research Lab., U.S. EPA, Research Triangle Park, NC and 2 SciVera, Inc. and Arcalis Scientific, LLC, West Bloomfield, MI. 9:00 INTRODUCTION. Patricia Beattie #909 9:05 GREEN CHEMISTRY DONE RIGHT: A PARTNERSHIP BETWEEN CHEMICAL DESIGN AND TOXICOLOGY. P. Anastas. Office of Research and Development, U.S. EPA, Washington, D.C. Sponsor: H. Zenick. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 197
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Program
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Society of Toxicology 2011 2010-201
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