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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # #1428 Poster Board Number.....................................336 EVALUATION OF A TEST METHOD FOR THE MEASUREMENT OF THE URINARY BIOMARKERS S-BENZYLMERCAPTURIC ACID AND S-PHENYLMERCAPTURIC ACID. C. B’Hymer and J. E. Snawder. BHAB, NIOSH, Cincinnati, OH. #1429 Poster Board Number.....................................337 MIR-34A EXPRESSION WAS UP-REGULATED BY SEVEN DIFFERENT GENOTOXIC AGENTS IN A DOSE- DEPENDENT MANNER IN TK6 CELLS. Z. Li, J. Yan and T. Chen. Division of Genetic and Molecular Toxicology, U.S. FDA NCTR, Jefferson, AR. #1430 Poster Board Number.....................................338 VALIDATION OF DIKI BIOMARKERS IN CYNOMOLGUS MONKEY. M. Guha 1 , A. Heier 4 , S. Price 4 , M. Balenstein 5 , R. Caccese 1 , T. Simpson 2 , D. Stong 1 , L. Kinter 1 , Y. Dragan 1 and E. Bodes 3 . 1 Safety Assessment, Astra Zeneca, Wilmington, DE, 2 Medicinal Chemistry, AstraZeneca Pharmaceuticals, Wilmington, DE, 3 Emerging Product Team, AstraZeneca Pharmaceuticals, Wilmington, DE, 4 Safety Assessment, AstraZeneca Pharmaceuticals, Alderly Park, Manchester, United Kingdom and 5 Clinical Pharmacology &DMPK, AstraZeneca Pharmaceuticals, Sodertalje, Sweden. #1431 Poster Board Number.....................................339 SHIPPING OF NONCLINICAL SPECIMENS: THE IDEAL CONDITION FOR CONSISTENCY OF SAMPLE HANDLING THROUGHOUT THE DRUG DEVELOPMENT PROCESS. J. J. Stewart, D. Efterfield, A. Powell and L. Brown. Flow Contract Site Laboratory, LLC, Kirkland, WA. Sponsor: J. Hill. #1432 Poster Board Number.....................................340 VALIDATION OF BIOMARKERS FOR ASSESSMENT OF CARDIAC EFFECTS IN RATS. J. C. Mirsalis, N. Chini, D. Vuong, K. Altera, B. Schneider and H. Ng. Preclinical Development, SRI International, Menlo Park, CA. #1433 Poster Board Number.....................................341 INSTABILITY OF QUINONE ELECTROPHILE ADDUCTS ON CYSTEINE RESIDUES: A BASIS FOR THE PREFERENTIAL DETECTION OF COVALENT MODIFICATION OF LYSINES AND ARGININES. C. L. Kuhlman 1 , M. L. Labenski 1 , A. A. Fisher 1 , B. Z. Olenyuk 2 , T. J. Monks 1 and S. S. Lau 1 . 1 Southwest Environmental Health Sciences Center, Department of Pharmacology/ Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ and 2 Department of Chemistry/ Biochemistry, College of Science, University of Arizona, Tucson, AZ. #1434 Poster Board Number.....................................342 URINARY BIOMARKER DETECTION OF MELAMINE-CYANURIC ACID-INDUCED KIDNEY DAMAGE IN RATS. Q. Zhang 1 , G. Gamboa da Costa 2 , R. Beger 2 , L. Schnackenberg 2 , J. Sun 2 , L. Pence 2 , S. Bhattacharyya 2 , C. Jacob 2 , R. P. Brown 1 and P. L. Goering 1 . 1 CDRH, U.S. FDA, Silver Spring, MD and 2 NCTR, U.S. FDA, Jefferson, AR. #1435 Poster Board Number.....................................343 VALIDATION OF BEST DETECTION METHODS FOR MEASURING OXIDATIVE STRESS. M. B. Kadiiska. NIEHS/NIH, Research Triangle Park, NC. #1436 Poster Board Number.....................................344 STEROID HORMONE PROFILING BY MASS SPECTROMETRY IN RAT BLOOD COLLECTED VIA THE CULEX® AUTOMATED IN VIVO SAMPLING SYSTEM. C. Penno 1,2 , L. Morawiec 1 , M. Schwald 1 , N. Zamurovic 1 , S. Busch 1 , A. Wolf 1 , F. Pognan 1 , S. Chibout 1 , A. Odermatt 2 and M. Dong 1 . 1 Preclinical Safety, Novartis, Basel, Switzerland and 2 Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. #1437 Poster Board Number.....................................345 SERUM CARDIAC TROPONIN I CONCENTRATION AS AN EARLY BIOMARKER OF MYOCARDIAL HYPERTROPHY IN THE ROSIGLITAZONE OR 3, 3’, 5-TRIIODO-L-THYRONINE TREATED RAT. M. Dunn 1 , D. Coluccio 1 , R. Fernandes 1 , D. Knapp 1 , R. Nicklaus 1 , G. Hirkaler 1 , W. Geng 1 , M. Sanders 1 , T. Singer 2 and I. Mikaelian 1 . 1 Nonclinical Safety, Roche, Nutley, NJ and 2 Nonclinical Safety, Roche, Basel, Switzerland. Sponsor: K. Kolaja. #1438 Poster Board Number.....................................346 CHARACTERISATION OF THE PRODROMAL AND REVERSIBILITY VALUE OF NOVEL RENAL SAFETY BIOMARKERS IN GENTAMICIN-TREATED RATS. J. Wood 1 , A. Shoieb 1 , A. McGuinty 1 , P. Cleall 1 , D. Hardy 1 , D. Collins 1 , C. Dubray 1 , R. Williams 1 , A. Moody 1 , K. Lynch 2 , D. Ennulat 2 , T. Sellars 2 , T. Lambert 2 , S. Beushausen 3 , E. Harpur 4 , M. Guffroy 1 and D. Brees 1 . 1 Pfizer, Sandwich, United Kingdom, 2 GlaxoSmithKline, King of Prussia, PA, 3 Pfizer, St. Louis, MO and 4 Sanofi-Aventis, Alnwick, United Kingdom. Sponsor: D. Robinson Gravatt. #1439 Poster Board Number.....................................347 EVALUATION OF NOVEL BIOMARKERS OF NEPHROTOXICITY IN MICE. J. Gautier 1 , T. Gury 1 , J. Léonard 1 , O. Dorchies 1 , L. Stimmer 1 , E. Harpur 2 , S. Küsters 3 , J. Mapes 3 and M. Guffroy 1 . 1 sanofi-aventis, Paris, France, 2 sanofi-aventis, Alnwick, United Kingdom and 3 Rules-Based Medicine, Austin, TX. #1440 Poster Board Number.....................................348 IMPACT OF NUTRITION ON THE PLASMA METABOLOME IN RATS. W. Mellert 1 , M. Kapp 1 , V. Strauss 1 , J. Wiemer 2 , E. Leibold 1,2 , H. G. Kamp 1,2 , T. Walk 2 , R. Looser 2 , A. Prokoudine 2 , E. Fabian 1 , G. Krennrich 1 , M. Herold 2 and B. van Ravenzwaay 1 . 1 Experimental Toxicology and Ecology, BASF SE, Ludwigshafen am Rhein, Germany and 2 Metanomics GmbH, Berlin, Germany. Sponsor: R. Landsiedel. #1441 Poster Board Number.....................................349 UTILITY OF MICRORNAS AS POTENTIAL BIOMARKERS OF TESTICULAR TOXICITY. H. Lin 3 , J. Milano 1 , L. Barone 1 , J. Stewart 2 , S. Ramaiah 3 and Y. Dragan 1 . 1 Safety Assessment, AstraZeneca Pharmaceuticals, Wilmington, DE, 2 Reproductive Toxicology, AstraZeneca Pharmaceuticals, Alderley Park, Cheshire, United Kingdom and 3 DSRD, Pfizer Inc., Cambridge, MA. 242 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1442 Poster Board Number.....................................350 SURFACE PLASMON-BASED CELL AND PROTEIN MICROARRAYS FOR THE IDENTIFICATION OF STRESS AND DISEASE BIOSIGNATURES. J. M. Rice 1 , C. Rich 1 , P. E. Reinhold 1 , D. A. Lawrence 2 and M. A. Lynes 1 . 1 Molecular and Cell Biology, University of Connecticut, Storrs, CT and 2 New York State Department of Health, Wadsworth Center, Albany, NY. #1443 Poster Board Number.....................................351 INITIAL BIOLOGICAL QUALIFICATION OF SBDP-145 IN CEREBROSPINAL FLUID AS A BIOMARKER OF COMPOUND-INDUCED NEURODEGENERATION IN THE RAT. M. L. Pritt 1 , W. H. Jordan 2 , D. G. Hall 1 , D. W. Ballard 1 , U. W. Muller 3 , K. W. Wang 3 and D. E. Watson 1 . 1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 2 VetPath Services, Mason, OH and 3 Banyan Biomarkers, Alachua, FL. #1444 Poster Board Number.....................................352 PET IMAGING OF TRANSLOCATOR PROTEIN 18 kDa (TSPO) REVEALS DELAYED NEUROINFLAMMATION COINCIDENT WITH PERSISTENT BEHAVIORAL DEFICITS IN RATS ACUTELY INTOXICATED WITH DFP. D. A. Bruun 1 , D. Rowland 2 , Y. Li 1 , B. Ford 3 and P. Lein 1 . 1 Molecular Biosciences, University of California, Davis, CA, 2 Center for Molecular and Genomic Imaging, University of California, Davis, CA and 3 Anatomy and Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA. #1445 Poster Board Number.....................................353 MOVING BEYOND THE ORTHODOX ‘TBNK’ PANEL: NEW IMMUNOPHENOTYPING STRATEGIES FOR IMMUNE-TOXICOLOGICAL ASSESSMENTS IN PRECLINICAL AND CLINICAL PHARMACEUTICAL STUDIES. T. Warren, A. R. Mcintyre, T. Salewsky, R. Eyre and H. Tsusaki. SNBL USA, Ltd., Everett, WA. #1446 Poster Board Number.....................................354 GENOMICS AND PROTEOMICS ANALYSIS IDENTIFIED THE PROTEINS ASSOCIATED WITH ADIPOCYTE LIPOLYSIS AS A KEY REGULATOR FOR THE PATHOGENESIS OR PROGRESSION OF METABOLIC SYNDROME. J. Chang 2 , S. Oikawa 4 , C. Ando 1 , K. Kuzuya 1 , G. Ichihara 3 and S. Ichihara 2,1 . 1 Life Science Research Center, Mie University, Tsu, Japan, 2 Graduate School of Regional Innovation Studies, Mie University, Tsu, Japan, 3 Nagoya University Graduate School of Medicine, Nagoya, Japan and 4 Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Japan. Abstract # #1447 Poster Board Number.....................................355 DEVELOPMENTAL CONTAMINANT EXPOSURE IMPACTS PHYSIOLOGICAL FUNCTION IN AMERICAN ALLIGATORS, ALLIGATOR MISSISSIPPIENSIS. M. A. Pickett 1 , J. T. Martin 1 , S. S. Smith 1 , E. J. Hulse 1 , A. Boggs 2 , L. J. Guillette 2,3 and M. P. Gunderson 1 . 1 Biology, The College of Idaho, Caldwell, ID, 2 Biology, University of Florida, Gainesville, FL and 3 Marine Biomedicine and Environmental Sciences Center Medical University South Carolina, Charleston, SC. Sponsor: S. Heggland. #1448 Poster Board Number.....................................356 DEVELOPMENT OF A METHOD FOR QUANTITATING SPHINGOID BASE 1-PHOSPHATES IN BLOOD SPOTS. R. T. Riley 1,2 , N. C. Zitomer 1 and J. Gelineau van Waes 3 . 1 Toxicology and Mycotoxin Research Unit, USDA- ARS, Athens, GA, 2 Interdisciplinary Toxicology Program, University of Georgia, Athens, GA and 3 Creighton University School of Medicine, Omaha, NE. #1449 Poster Board Number.....................................357 DEVELOPMENT OF HUMAN EPITHELIAL CELL-BASED ALTERNATIVE MONITORING OF XENOBIOTIC-INDUCED ENDOPLASMIC RETICULUM STRESS. H. Choi, H. Yang, J. Kim and Y. Moon. Department of Microbiology and Immunology, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Republic of Korea. #1450 Poster Board Number.....................................358 INTEGRATION OF TRANSCRIPTOMIC AND PROTEOMIC DATA TO IDENTIFY SUSCEPTIBILITY FACTORS FOR PULMONARY INFECTION DURING DIET- INDUCED OBESITY IN MICE EXPOSED TO LIPOPOLYSACCHARIDE. S. C. Tilton, K. M. Waters, B. Webb-Robertson, N. J. Karin, X. Zhang, J. M. Jacobs, J. G. Pounds and R. A. Corley. Pacific Northwest National Laboratory, Richland, WA. #1451 Poster Board Number.....................................359 CERIVASTATIN INDUCES THE MUSCLE ATROPHY PROGRAM IN A TIME- AND FIBER-DEPENDENT MANNER WITH AN INCREASE IN BIOMARKERS OF MYOPATHY. J. D. Vassallo 1,2 , J. A. Rathmacher 3 , E. B. Janovitz 1 , S. Stryker 1 , D. Robertson 1 , L. J. Lowe-Krentz 2 and L. D. Lehman-McKeeman 1 . 1 Discovery Toxicology, Bristol-Myers Squibb, Princeton, NJ, 2 Biological Sciences, Lehigh University, Bethlehem, PA and 3 Metabolic Technologies, Ames, IA. #1452 Poster Board Number.....................................360 USE OF A QUANTITATIVE IMMUNOHISTOCHEMICAL METHOD FOR DIAGNOSING PHOSPHOLIPIDOSIS. K. A. Haskins 1 , S. Stewart 1 , D. Mans 2 , J. Zhang 1 , D. Peters 1 , T. Colatsky 1 and K. L. Thompson 1 . 1 Division of Applied Pharmacology Research, CDER, U.S. FDA, Silver Spring, MD and 2 Division of Pharmaceutical Analysis, CDER, U.S. FDA, St. Louis, MO. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 243
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Celebration Event Floor Plan Ba
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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Society of Toxicology 2011 Washingt
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 2011 Awa
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Society of Toxicology 2011 SOT Endo
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 RC, SIG,
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Satellit
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Society of Toxicology 2011 Program
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 Abstract
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Endowmen
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Society of Toxicology 2011 SOT Affi
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