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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #115 Poster Board Number.....................................141 ARSENIC INHIBITS THE NUCLEOTIDE EXCISION REPAIR PATHWAY IN HUMAN LUNG CELLS AND MOUSE KERATINOCYTES. N. Holcomb, M. Goswami, T. Scott, T. Bhattarai, J. D’Orazio, D. Orren, G. Gairola and I. Mellon. Graduate Center for Toxicology, University of Kentucky, Lexington, KY. #116 Poster Board Number.....................................142 EXPLORING THE ROLE OF NUCLEOTIDE EXCISION REPAIR (NER) AND HELICASE IN ZIDOVUDINE (AZT)-INDUCED GENOTOXICITY. D. Momot, T. A. Nostrand, K. John, M. C. Poirier and O. A. Olivero. LCBG, National Cancer Institute, Bethesda, MD. #117 Poster Board Number.....................................143 DOSE-RESPONSE EVALUATION OF P53 AND H2AX DNA DAMAGE RESPONSE BY METHYL METHANESULFONATE, ETOPOSIDE, AND QUERCETIN. B. Sun 1 , K. Daniels 1 , S. Ross 1 , Q. Zhang 1 , M. Andersen 1 , P. Carmichael 2 and R. Clewell 1 . 1 The Hamner Institute, Durham, NC and 2 Unilever SEAC, Bedfordshire, United Kingdom. #118 Poster Board Number.....................................144 TO STUDY THE SIGNAL TRANSDUCTION ON 2-ABP & 4-ABP INDUCED DNA DAMAGE IN HEP G2 CELL. J. Wong 1 , J. Wu 2 , S. Chen 1 and L. Chen 3 . 1 Department of Biotechnology, National Kaohsiung Normal University, Kaohsiung, Taiwan, 2 Department of Applied Chemistry, Fooyin University, Kaohsiung, Taiwan and 3 Department of Medical Nutrition, I-Shou University, Kaohsiung, Taiwan. #119 Poster Board Number.....................................145 GENOTOXICITY AND CHANGES IN GENE EXPRESSION PROFILES INDUCED BY AIRBORNE PARTICLES IN HUMAN CELL LINES. J. Topinka, K. Uhlirova, H. Libalova, A. Milcova, J. Schmuczerova and R. J. Sram. Genetic Ecotoxicology, Institute of Experimental Medicine AS CR, Prague 4, Czech Republic. #120 Poster Board Number.....................................146 MOLECULAR DETERMINANTS OF DNA POLYMERASE ETA FIDELITY. S. C. Suarez and S. D. McCulloch. Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC. #121 Poster Board Number.....................................147 MECHANISMS OF THE WERNER SYNDROME PROTEIN IN PROTECTING AGAINST CR(VI) INDUCED TELOMERE LOSS. F. Liu, K. E. Knickelbein, A. Barchowsky and P. L. Opresko. Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. #122 Poster Board Number.....................................148 ANALYSIS OF MOLECULAR SPLINT MUTANTS OF HUMAN DNA POL η AND THEIR EFFECT ON POLYMERASE PROPERTIES. R. A. Beardslee and S. D. McCulloch. Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall Poster Session: Bioinformatic Profiling and Computational Pathway Prediction Chairperson(s): Hao Zhu, University of North Carolina at Chapel Hill, Chapel Hill, NC, and Imran Shah, U.S. EPA, Chapel Hill, NC. Displayed: 9:30 AM–12:30 PM Author Attended: 11:00 AM–12:30 PM #123 Poster Board Number.....................................212 COMMONALITY AND STOCHASTICITY IN GENE EXPRESSION PROFILES DURING AGING PROCESS. T. Inoue 1 and Y. Hirabayashi 2 . 1 Center for Biological Safety & Research, National Institute of Health Sciences, Tokyo, Japan and 2 Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences, Tokyo, Japan. #124 Poster Board Number.....................................213 COMPARISON OF TOXICOGENOMICS PROFILES TO DISCOVER CO-REGULATED GENES. Y. Igarashi 1 , N. Nakatsu 1 , H. Yamada 1 , A. Ono 2 , Y. Ohno 2 and T. Urushidani 1,3 . 1 National Institute of Biomedical Innovation, Ibaraki-City, Osaka, Japan, 2 National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan and 3 Doshisha Women’s College of Liberal Arts, Kyotanabe-City, Kyoto, Japan. #125 Poster Board Number.....................................214 USE OF PATHWAY ANALYSES TO IDENTIFY POTENTIAL TARGET SAFETY RISKS FOR ANTIBODY DRUG CONJUGATES (ADC). B. Lu 1 , L. Obert 1 , A. Hooper 2 and M. Gosink 1 . 1 Drug Safety Research & Dev, Pfizer, Groton, CT and 2 Center for Integrative Biology & Biotherapeutics, Pfizer, Pearl River, NY. #126 Poster Board Number.....................................215 COMPARISON OF NEXT GENERATION SEQUENCING AND MICROARRAY ANALYSES OF GENE EXPRESSION IN KIDNEY OF THE RATS TREATED WITH CARCINOGEN ARISTOLOCHIC ACID. T. Chen 1 , Z. Li 1 , Z. Su 2 and L. Shi 3 . 1 Division of Genetic and Molecular Toxicology, U.S. FDA NCTR, Jefferson, AR, 2 Z-Tech, U.S. FDA NCTR, Jefferson, AR and 3 Division of System Biology, U.S. FDA NCTR, Jefferson, AR. #127 Poster Board Number.....................................216 THE ARYL HYDROCARBON RECEPTOR PROTEIN INTERACTION NETWORK (AHR- PIN). J. J. LaPres 1,2 , D. M. Tappenden 1,2 , L. Yang 3 and R. S. Thomas 3 . 1 Biochemistry, Michigan State University, East Lansing, MI, 2 Center for Integrative Toxicology, Michigan State University, East Lansing, MI and 3 The Hamner Institutes for Health Sciences, Research Triangle Park, NC. 126 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #128 Poster Board Number.....................................217 SEQUENCE TAGGING REVEALS UNEXPECTED MODIFICATIONS IN TOXICOPROTEOMICS. S. Dasari 1 , M. C. Chambers 1 , D. C. Liebler 2 , F. P. Guengerich 2 and D. L. Tabb 1,2 . 1 Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, TN and 2 Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN. #129 Poster Board Number.....................................218 PROTEOMIC PROFILING OF DYNAMIC CELLULAR RESPONSES TO SILICA NANOPARTICLES USING STABLE ISOTOPE AMINO ACID LABELING. B. Thrall 1 , B. Webb- Robertson 2 , K. Burnham 3 , M. H. Littke 1 , N. J. Karin 3 , J. Jacobs 3 and K. M. Waters 2 . 1 Cell Biology & Biochemistry, PNNL, Richland, WA, 2 Computational Biology & Bioinformatics, PNNL, Richland, WA and 3 Biological Separations & Mass Spectrometry Groups, Pacific Northwest National Laboratory, Richland, WA. #130 Poster Board Number.....................................219 ENVIRONMENTAL CHEMICALS AND HUMAN HEALTH: UNCOVERING THE CONNECTIONS WITH CTD. C. Mattingly, C. G. Murphy, C. A. Saraceni-Richards, S. Mockus, M. C. Rosenstein, T. C. Wiegers, B. King and A. P. Davis. Bioinformatics, MDI Biological Laboratory, Salisbury Cove, ME. #131 Poster Board Number.....................................220 GENERATING A GENE NETWORKS ASSOCIATED WITH KOLA ACUMINATA- BIZZY NUT INDUCE APOPTOSIS. R. Ledet and W. G. Gray. Chemistry, Southern University A&M College, Baton Rouge, LA. #132 Poster Board Number.....................................221 VIRTUAL SCREENING OF DIFFERENTIAL PROTEIN TARGETS FOR TROVAFLOXACIN AND LEVOFLOXACIN. J. Olivero-Verbel, C. Ortega-Zuñiga and M. Cabarcas-Montalvo. Environmental and Computational Chemistry Group, University of Cartagena, Cartagena, Bolivar, Colombia. #133 Poster Board Number.....................................222 THE MOUSE GENOME INFORMATICS DATABASE: INTEGRATING INFORMATION TO FACILITATE DISCOVERY. S. M. Bello, C. L. Smith, H. Dene, D. L. Burkart, L. L. Washburn, M. Tomczuk, A. Anagnostopoulos, B. Richards- Smith, H. Onda, R. P. Babiuk, M. Knowlton, J. Xu, J. A. Bubier and J. T. Eppig. Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME. #134 Poster Board Number.....................................223 FINDING CLUSTERS OF CHEMICALS AFFECTING SUB-NETWORKS OF THE PROTEIN INTERACTOME. R. Thomas 1 , I. Gerlovina 1 , A. Hubbard 1 , M. North 2 and C. Vulpe 2 . 1 Biostatistics, University of California, Berkeley, Berkeley, CA and 2 Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, CA. Abstract # #135 Poster Board Number.....................................224 A BIOINFORMATICS-BASED PIPELINE FOR BIOMARKER DISCOVERY UTILIZING BOTH IN VITRO AND IN VIVO DATA. R. C. Grafström 1,2 , R. Ceder 1 , C. A. Staab 3 , J. Höög 3 , H. Jörnvall 3 , M. Nees 2 , B. Fadeel and K. Roberg 4 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2 Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland, 3 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden and 4 Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. #136 Poster Board Number.....................................225 CHARACTERIZATION OF A QSAR MODEL FOR PHOSPHOLIPIDOSIS USING A HIERARCHICAL SCAFFOLD TREE OF SIGNIFICANT MOLECULAR FEATURES. N. L. Kruhlak 1 , K. Cross 2 and A. M. Orogo 1,3 . 1 U.S. FDA/CDER/OTR/DAPR, Silver Spring, MD, 2 Leadscope Inc., Columbus, OH and 3 GlobalNet Services Inc., Rockville, MD. Sponsor: R. Benz. #137 Poster Board Number.....................................226 IN SILICO PREDICTIVE MODEL FOR DRUG-INDUCED PHOSPHOLIPIDOSIS USING BIOEPISTEME SOFTWARE. S. S. Choi, L. G. Valerio and N. Sadrieh. U.S. FDA, Silver Spring, MD. #138 Poster Board Number.....................................227 PREDICTION OF DRUG-INDUCED LIVER INJURY IN HUMANS WITH TOXICOGENOMICS. M. Zhang, Q. Shi, M. Chen and W. Tong. NCTR, U.S. FDA, Jefferson, AR. #139 Poster Board Number.....................................228 PREDICTIVE VALUE OF CHEMICAL AND TOXICOGENOMIC DESCRIPTORS FOR DRUG-INDUCED HEPATOTOXICITY. Y. Low 1,5 , T. Uehara 1,2 , Y. Minowa 2 , H. Yamada 2 , Y. Ohno 3 , T. Urushidani 2,4 , A. Sedykh 5 , D. Fourches 5 , H. Zhu 5 , I. Rusyn 1 and A. Tropsha 5 . 1 Environmental Sciences & Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2 Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, Osaka, Japan, 3 National Institute of Health Sciences, Tokyo, Japan, 4 Doshisha Women’s College of Liberal Arts, Kyoto, Japan and 5 Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC. #140 Poster Board Number.....................................229 CLASSIFICATION OF HUMAN CYTOCHROME 3A4 LIGANDS BY MEANS OF MOLECULAR DOCKING. Y. Tie 1 , B. T. McPhail 1 , H. Hong 2 , R. D. Beger 2 , B. A. Fowler 1 and E. Demchuk 1 . 1 Division Toxicology & Environmental Medicine, ATSDR/CDC, Atlanta, GA and 2 Division Systems Biology, NCTR/U.S. FDA, Jefferson, AR. #141 Poster Board Number.....................................230 BUILDING STRUCTURE FEATURE-BASED MODELS FOR PREDICTING ISOFORM- SPECIFIC HUMAN CYTOCHROME P450 (HCYP 3A4, 2D6 AND 2C9) INHIBITION ASSAY RESULTS IN TOXCAST. P. Volarath 1 , B. Bienfait 2 , J. Gasteiger 2 , K. Houck 1 and A. Richard 1 . 1 NCCT, U.S. EPA, Research Triangle Park, NC and 2 Molecular Networks GmbH, Erlangen, Germany. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 127
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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Society of Toxicology 2011 ToxExpo
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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