Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #26 10:49 DIFFERENTIAL MECHANISMS OF SUSCEPTIBILITY TO OXIDANT-INDUCED LUNG DISEASE. E. M. Postlethwait. Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL. #27 11:25 TARGETING INFLAMMATION AND THE INFLAMMASOME USING ANAKINRA, A POTENTIAL THERAPEUTIC AGENT FOR MESOTHELIOMA. B. Mossman. Pathology, University of Vermont College of Medicine, Burlington, VT. Sponsor: L. Mantell. Monday Morning, March 7 9:15 AM to 12:00 NOON Room 150 Novel Approaches to Preclinical Safety Assessment: Bridging the Gap between Discovery and the Clinic through Translational Toxicology Symposium Session: High Content Imaging—Applications in Toxicology and Toxicity Testing Chairperson(s): William Mundy, U.S. EPA, Research Triangle Park, NC, and Joseph Trask, The Hamner Institutes for Health Sciences, Research Triangle Park, NC. Sponsor: In Vitro and Alternative Methods Specialty Section Endorsed by: Molecular Biology Specialty Section Neurotoxicology Specialty Section High Content Imaging (HCI) often referred as high content screening (HCS), combines state-of-the-art microscopy, robotics, and computerassisted image analysis to measure multiple cellular and sub-cellular features. The technology produces information (digital images and metadata) on cellular response or morphological changes at a high level of detail. Assays are amenable to high-throughput automation generating hundreds of measurements per cell and millions of data points from a single microtiter plate. Introduction of this technology in the pharmaceutical industry led to analysis of cell signaling and processes such as receptor internalization. The technology has expanded to include applications in angiogenesis, wound healing, cell cycle regulation, cell death, neurodegeneration, regeneration, and genotoxicity, etc. Using these approaches, measurements are made at the single cell or population level. HCI assays are generally conducted using cell lines, primary cells, and stem cells. Ex vivo tissue and whole organisms such as Drosophila, C. elegans, and zebrafish can also be imaged providing knowledge from intact specimens. Novel strategies for toxicity testing are likely to expand with HCI studies examining biologically significant cellular perturbations by linking genetic, phenotypic, or functional cellular changes with adverse outcomes from exposure to environmental chemicals or pharmaceutical compounds. HCI is likely to become a key technology for developing toxicity pathway assays as outlined by the 2007 NRC report Toxicity Testing in the 21st Century: A Vision and A Strategy. Furthermore, it is now evident toxicology programs in the pharmaceutical industry have adopted this technology in an effort to expedite the fate of compound candidate selection in preclinic and clinical trials using key measurements generated with HCI. Therefore it is important to provide an overview of this technology and its applications in toxicity testing relative to the HCI field from academia, biopharma, and government agencies with examples and case studies to gain knowledge and insight into toxicity pathways. #28 9:15 HIGH CONTENT IMAGING – APPLICATIONS IN TOXICOLOGY AND TOXICITY TESTING. W. Mundy. Integrated Systems Toxicology Division, U.S. EPA, Research Triangle Park, NC. 9:15 INTRODUCTION. William Mundy #29 9:25 AN INTRODUCTION TO HIGH CONTENT IMAGING TECHNOLOGIES AND APPLICATIONS IN TOXICOLOGY. O. Joseph Trask. The Hamner Institutes for Health Sciences, Research Triangle Park, NC. Sponsor: R. Thomas. #30 9:45 HIGH CONTENT ANALYSIS OF CYTOTOXICITY FOR PREDICTION, MECHANISTIC ELUCIDATION, AND BLOOD BIOMARKERS OF HUMAN TOXICITY. P. J. O’Brien. University College Dublin, Belfield, Dublin, Ireland. Sponsor: J. Trask. #31 10:15 QUANTITATIVE IN VITRO MEASUREMENT OF CELLULAR PROCESSES CRITICAL TO THE DEVELOPMENT OF NEURAL CONNECTIVITY USING HCA. J. A. Harrill. Integrated Systems Toxicology Division, U.S. EPA, Research Triangle Park, NC. #32 10:45 BEYOND DECREASING ATTRITION: HIGH CONTENT IMAGING (HCI) IN GENETIC TOXICOLOGY. E. Rubitski. Genetic Toxicology, Pfizer, Groton, CT. Sponsor: J. Aubrecht. #33 11:15 HIGH CONTENT SCREENING (HCS) IN EARLY SAFETY ASSESSMENT: FROM DATA TO PREDICTIVE MODELS. M. Kansy 1 and A. Hoffman 2 . 1 Nonclinical Safety, F. Hoffmann-La Roche Ltd., Basel, Switzerland and 2 Discovery Technologies, F. Hoffmann-La Roche Ltd., Nutely, NJ. 11:45 PANEL DISCUSSION/Q&A. Monday Morning, March 7 9:15 AM to 12:00 NOON Room 207 Symposium Session: Ribotoxic Stress: Mechanisms and Models for Human Disease Chairperson(s): James Pestka, Michigan State University, East Lansing, MI, and Yuseok Moon, Pusan National University School of Medicine, Yangsan, Japan. Sponsor: Food Safety Specialty Section Endorsed by: Immunotoxicology Specialty Section Mechanisms Specialty Section Molecular Biology Specialty Section Many xenobiotics evoke toxicity and cause disease by modifying critical mitogen-activated protein kinase (MAPK) signaling pathways that regulate growth, differentiation, and cell survival. A number of plant, fungal, bacterial, and algal toxins can aberrantly activate the P38, ERK, and JNK MAPKs by targeting the ribosome via a process termed the ribotoxic stress response. Examples of ribotoxic agents include natural toxins produced by plants (ricin), fungi (trichothecenes), bacteria (Shiga toxins), and algae (palytoxin). These agents can be encountered in food and water and are of further concern because of their potential use in chemical terrorism. Cells involved in the innate immunity appear to be particularly sensitive to ribotoxic stress. Ribotoxic stress is not completely understood but possible mechanisms activation of intracellular signaling pathways by sensors of damage-associated molecular patterns (DAMPs) or endoplasmic reticulum stress. From a translational perspective, exposure of experimental animals to ribotoxic stressors can result in downstream pathologic sequelae that remarkably mimic clinical signs associated with inflammatory human diseases such as acute respiratory distress, ulcerative colitis, IgA nephropathy, and hemolytic uremic syndrome. To address these issues, our panel of experts will explore commonalities and differences in upstream mechanisms 118 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # of ribotoxic stress by different biotoxins and relate these to downstream sequelae associated with human inflammatory diseases. #34 9:15 RIBOTOXIC STRESS: MECHANISMS AND MODELS FOR HUMAN DISEASE. J. J. Pestka 1 , V. L. Tesh 2 , B. E. Magun 3 , Y. Moon 4 and N. Tumer 5 . 1 Michigan State University, East Lansing, MI, 2 Texas A&M University Health Science Center, College Station, TX, 3 Oregon Health and Science University, Portland, OR, 4 Pusan National University School of Medicine, Yangsan, Republic of Korea and 5 Rutgers University, New Brunswick, NJ. 9:15 INTRODUCTION. James J. Pestka #35 9:20 RICIN MEDIATES ACUTE RESPIRATORY DISTRESS THROUGH IL-1BETA. B. Magun. Oregon Health and Science University, Portland, OR. Sponsor: J. Pestka. #36 9:52 MUCOSAL RIBOTOXIC STRESS AND INTESTINAL INFLAMMATORY DISEASES. Y. Moon. Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Republic of Korea. #37 10:24 SHIGA TOXINS AND THE HEMOLYTIC UREMIC SYNDROME. V. L. Tesh. Microbial and Molecular Pathogenesis, Texas A&M University Health Science Center, College Station, TX. Sponsor: J. Pestka. #38 10:56 ROLE OF RIBOTOXIC STRESS AND INNATE IMMUNE ACTIVATION IN TRICHOTHECENE-INDUCED IGA NEPHROPATHY. J. J. Pestka. Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI. #39 11:28 RICIN AND SHIGA TOXINS INTERACT DIFFERENTLY WITH THE RIBOSOMAL STALK. N. Tumer 1 , J. Chiou 1 , X. Li 1 , M. Remacha 2 and J. P. Ballesta 2 . 1 Rutgers University, New Brunswick, NJ and 2 Universidad Autonoma de Madrid, Madrid, Spain. Sponsor: J. Pestka. Monday Morning, March 7 9:15 AM to 12:00 NOON Room 144 Emerging Global Public Health Issues Workshop Session: Disease Prevention: The Next 50 Years Chairperson(s): Helmut Zarbl, University of Medicine and Dentistry New Jersey, Piscataway, NJ, and Dean P. Jones, Emory University, Atlanta, GA. Sponsor: Disease Prevention Task Force Endorsed by: Carcinogenesis Specialty Section Mixtures Specialty Section The science of toxicology has had a tremendous impact on preventing adverse effects of environmental toxicants, consumer products, and drugs on human health. The Society of Toxicology played a pivotal role in developing the practice of toxicology as a profession and a research discipline. As the Society embarks on its next fifty years, new opportunities and challenges will no doubt change the role of toxicology in the improving human health. High- throughput genomic technologies are increasingly providing mechanistic insights into how exposure to toxicants interacts with other exposures, genetic background, diet, lifestyle, co-morbid disease and Abstract # numerous other factors to modulate the disease risk. The Society thus has an opportunity to once again play a leading role in improving public health by not only preventing toxicity, but by developing approaches to predicting and preventing disease in those already exposed and, by identifying individuals or populations at increased risk from exposures. Therefore, the future of toxicology should include an increasing presence in disease prevention through biomarker based exposure and risk assessment, and individualized intervention, chemoprevention, and predictive toxicology. These emerging approaches will be reviewed to provide a roadmap for increasing the role of mechanistically based, predictive toxicology and ‘omics technologies in disease prevention. #40 9:15 DISEASE PREVENTION: THE NEXT 50 YEARS. H. Zarbl. Environmental and Occupational Health Sciences Institiute, Robert Wood Johnson Medical School, Piscataway, NJ. 9:15 INTRODUCTION. Helmut Zarbl #41 9:20 ASSESSING THE IMPACT OF INTER- INDIVDUAL GENETIC VARIABILITY ON TOXICITY THROUGH TOXICOGENOMIC DATA. I. Rusyn. Environmental Science and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC. #42 9:47 COMBINING THE GENOME WITH ITS EXPOSOME FOR MECHANISTICALLY- BASED DISEASE PREVENTION. C. P. Wild, International Agency for Cancer Research, Lyon, France. Sponsor: H. Zarbl. #43 10:14 TOP-DOWN EXPOSOMIC STRATEGIES TO CHARACTERIZE THE HUMAN EXPOSOME. M. Smyth. University of California Berkeley, CA. #44 10:41 HIGH-THROUGHPUT METABOLOMICS FOR IDENTIFICATION OF QUANTITATIVE EXPOSURE BIOMARKERS. D. Jones. Emory University, Atlanta, GA. #45 11:08 ROLE OF THE HUMAN MICROBIOME IN HUMAN ENVIRONMENTAL EXPOSURE AND DISEASE PREVENTION. E. Holmes. Imperial College, London, United Kingdom. Sponsor: H. Zarbl. #46 11:34 PUBLIC HEALTH OPPORTUNITIES AND CHALLENGES IN DISEASE PREVENTION. J. D. Groopman. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 119
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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SOT Presidents 1961-2011 1966 1967
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Society of Toxicology 2011 2010-201
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