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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # #1638 Poster Board Number.....................................832 POLYCYCLIC AROMATIC HYDROCARBONS EXERT STRUCTURE- DEPENDENT DIFFERENTIAL MECHANISMS OF TOXICITY IN DEVELOPING ZEBRAFISH. B. C. Goodale 1 , J. K. La Du 1 , S. C. Tilton 2 , K. M. Waters 2 and R. L. Tanguay 1 . 1 Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR and 2 Pacific Northwest National Laboratory, Richland, WA. #1639 Poster Board Number.....................................833 GENE EXPRESSION EVALUATION OF THE RELATIVE SAFETY OF PRENATAL STRESS AND/OR ANTIDEPRESSANT EXPOSURE. C. H. Bourke, C. F. Capello and M. J. Owens. Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA. #1640 Poster Board Number.....................................834 FACIAL ANOMALIES IN A RAT MODEL WITH ETHANOL: ANIMAL FRIENDLY MARKERS FOR FETAL ALCOHOL SYNDROME (FAS). R. Slieker, L. vd Horst, R. Nederlof, M. Otto and D. De Groot. TNO Quality of Life, Zeist, Netherlands. Sponsor: R. Woutersen. #1641 Poster Board Number.....................................835 DEVELOPMENTAL ARSENIC EXPOSURE INCREASES PERINATAL MORTALITY AND CAUSES LIVER INFLAMMATION IN FEMALE MICE. M. W. Carmody, A. R. King, A. E. Hill and R. J. Sommer. Biology Department, Bates College, Lewiston, ME. #1642 Poster Board Number.....................................836 MICRORNA EXPRESSION PROFILES AFTER DEVELOPMENTAL EXPOSURE OF ZEBRAFISH (DANIO RERIO) EMBRYOS TO TCDD. N. Aluru 1 , M. J. Jenny 1,2 and M. E. Hahn 1 . 1 Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA and 2 Department of Biological Sciences, University of Alabama, Tuscaloosa, AL. #1643 Poster Board Number.....................................837 MIRNAS ARE ESSENTIAL FOR BILE ACID HOMEOSTASIS DURING LIVER DEVELOPMENT. Y. J. Cui, J. Liu, Z. Fu, Y. Guo and C. D. Klaassen. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS. #1644 Poster Board Number.....................................838 AN INHALATION DEVELOPMENTAL TOXICITY STUDY OF N-ETHYL ACETAMIDE IN RATS. J. Domoradzki 1 , T. Edwards 2 and D. Kirkpatrick 2 . 1 Dow Corning Corporation, Auburn, MI and 2 WIL Research Laboratories, LLC, Ashland, OH. #1645 Poster Board Number.....................................839 EFFECTS OF THALIDOMIDE ON NORMAL FETAL GROWTH AND HEART RATE IN CYNOMOLGUS MONKEYS. C. Diabo, M. Kob, C. Cohle, K. Griffin, B. Lewis, A. Kuzmin, S. Magness and A. S. Faqi. Drug Safety Evaluation, MPI Research, Mattawan, MI. #1646 Poster Board Number.....................................840 COMPARATIVE EVALUATION OF LEARNING AND MEMORY IN RATS USING MORRIS MAZE VIDEO TRACKING SYSTEM AND PASSIVE AVOIDANCE. C. Lanphear, A. Terpstra, A. Rohr and A. S. Faqi. Drug Safety Evaluation, MPI Research, Mattawan, MI. #1647 Poster Board Number.....................................841 2, 3, 7, 8-TETRACHLORODIBENZO-P- DIOXIN (TCDD) INHIBITS EPICARDIAL DEVELOPMENT IN THE EMBRYONIC ZEBRAFISH HEART. J. S. Plavicki, W. Heideman and R. E. Peterson. School of Pharmacy, University of Wisconsin at Madison, Madison, WI. Tuesday Afternoon, March 8 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Apoptosis/Cell Death Chairperson(s): Salmaan Inayat-Hussain, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, and Sidhartha Ray, UAMS College of Pharmacy & Health Sciences, Brooklyn, NY. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #1648 Poster Board Number.....................................901 MINOCYCLINE AND DOXYCYLINE, BUT NOT TETRACYCLINE, DECREASE LIVER AND KIDNEY INJURY AFTER HEMORRHAGIC SHOCK AND RESUSCITATION IN MICE. A. Kholmukhamedov 1 , C. Czerny 1 , J. Hu 1 , J. Schwartz 1 and J. J. Lemasters 1,2 . 1 Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC and 2 Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC. #1649 Poster Board Number.....................................902 DOXYCYCLINE AND MINOCYCLINE, BUT NOT OTHER TETRACYCLINE DERIVATIVES, INHIBIT THE MITOCHONDRIAL PERMEABILITY TRANSITION AND MITOCHONDRIAL IRON UPTAKE. J. Schwartz 1 , E. Holmuhamedov 1 and J. J. Lemasters 1,2 . 1 Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC and 2 Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC. #1650 Poster Board Number.....................................903 LYSOSOMES, COMPOUND ACCUMULATION, AND IN VITRO TOXICITY. S. Lu 1 , 1 S. Nadanaciva 2 , R. Swiss 2 , B. Jessen 1 and Y. Will 2 . 1 Drug Safety Research and Development, Pfizer Inc., San Diego, CA and 2 Compound Safety Prediction, Pfizer Inc., Groton, CT. 258 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1651 Poster Board Number.....................................904 LYSOSOMAL IRON RELEASE AND MITOCHONDRIAL IRON UPTAKE CONTRIBUTE TO ISCHEMIA- REPERFUSION INJURY TO RAT HEPATOCYTES. X. Zhang and J. J. Lemasters. Medical University of South Carolina, Charleston, SC. #1652 Poster Board Number.....................................905 THE CYTOTOXIC INTERACTION BETWEEN HYPOXIA AND NEUTROPHIL ELASTASE IN A MURINE HEPATOMA CELL LINE IS INDEPENDENT OF HIF-1α SIGNALING. E. M. Sparkenbaugh, M. A. Nothem, P. E. Ganey and R. A. Roth. Pharmacology and Toxicology, Michigan State University, Lansing, MI. #1653 Poster Board Number.....................................906 THE ROLE OF MITOCHONDRIA IN AMIODARONE-INDUCED APOPTOSIS IN RAT PLEURAL MESOTHELIAL CELLS. E. S. Taneva and J. M. Cerreta. PHS, St. Johns University, Queens, NY. Sponsor: L. Trombetta. #1654 Poster Board Number.....................................907 ACUTE SINGLE-MITOCHONDRION RESPONSES TO 1, 3-DINITROBENZENE IN ASTROCYTES. L. Maurer 1 , I. C. Speirs 1 , J. Fernandez 1 , D. Song 2 , T. Epstein 3 , A. Jureziz 1 , S. Steiner 1 and M. A. Philbert 1 . 1 Department of Environmental Health Sciences, Toxicology, University of Michigan, Ann Arbor, MI, 2 Mechanical Engineering Department, University of Michigan, Ann Arbor, MI and 3 Chemistry Department, University of Michigan, Ann Arbor, MI. #1655 Poster Board Number.....................................908 ARE REACTIVE OXYGEN SPECIES REQUIRED FOR AUTOPHAGY? J. Jiang 1 , D. A. Stoyanovsky 1 , A. Maeda 1 , J. S. Greenberger 2 and V. E. Kagan 1 . 1 Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA and 2 Radiation Oncology, University of Pittsburgh, Pittsburgh, PA. #1656 Poster Board Number.....................................909 CONNEXIN32 HEMICHANNELS FACILITATE THE APOPTOTIC-TO- NECROTIC TRANSITION DURING FAS-MEDIATED HEPATOCYTE CELL DEATH. M. Vinken 1 , E. Decrock 2 , E. De Vuyst 2 , M. De Bock 2 , V. Roosmarijn 3 , B. De Geest 4 , J. Demeester 4 , N. Sanders 5 , T. Vanhaecke 1 , L. Leybaert 2 and V. Rogiers 1 . 1 Toxicology, Free University Brussels, Brussels, Belgium, 2 Basic Medical Sciences/Physiology Group, Ghent University, Ghent, Belgium, 3 Molecular Biomedical Research, Ghent University, Ghent, Belgium, 4 General Biochemistry and Physical Pharmacy, Ghent University, Ghent, Belgium and 5 Gene Therapy, Ghent University, Ghent, Belgium. #1657 Poster Board Number.....................................910 DECIPHERING THE ROLE OF FASL IN REGULATING C-FLIP EXPRESSION IN GERM CELLS. Y. Lin, P. Yao and J. H. Richburg. Center for Molecular and Cellular Toxicology, College of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX. Abstract # #1658 Poster Board Number.....................................911 APOPTOSIS AND CELL PROLIFERATION IN HEPG2 CELLS TREATED WITH TROVAFLOXACIN AND TUMOR NECROSIS FACTOR. K. M. Beggs, P. E. Ganey and R. A. Roth. Pharmacology and Toxicology, Michigan State University, East Lansing, MI. #1659 Poster Board Number.....................................912 CAFFEINE PROMOTES UVB-INDUCED APOPTOSIS THROUGH INHIBITING THE AKT/COX-2 PATHWAYS. W. Han, M. Ming and Y. He. Medicine/Dermatology, University of Chicago, Chicago, IL. #1660 Poster Board Number.....................................913 NEUROTOXIC SIGNALING PATHWAY OF BISPHENOL AF IN HIPPOCAMPAL NEURONAL CELLS: ROLE OF CALCIUM- INDUCED ROS, MAPKS, AND NF-κB. S. Kim 2 and S. Lee 1 . 1 Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea and 2 Toxicology Branch, National Toxicology Program, Morrisville, NC. #1661 Poster Board Number.....................................914 QUANTITATIVE ASSESSMENT OF [18F]-DFNSH UPTAKE BY MICROPET IMAGING AS A BIOMARKER OF ANESTHETIC-INDUCED NEURONAL DEATH. X. Zhang 1 , C. Wang 1 , G. D. Newport 1 , M. G. Paule 1 , F. Liu 1 , M. S. Berridge 2 , S. M. Apana 2 , G. Kabalka 3 and W. Slikker 1 . 1 NCTR /U.S. FDA, Jefferson, AR, 2 3D Imaging, Little Rock, AR and 3 The University of Tennessee, Knoxville, TN. #1662 Poster Board Number.....................................915 INDUCTION OF APOPTOSIS- ASSOCIATED RIBOSOMAL RNA (RRNA) CLEAVAGE BY THE TRICHOTHECENE DEOXYNIVALENOL. K. He 1,2 , H. Zhou 3 and J. Pestka 1,2,3 . 1 Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, MI, 2 Center for Integrative Toxicology, Michigan State University, East Lansing, MI and 3 Food Science & Human Nutrition, Michigan State University, East Lansing, MI. #1663 Poster Board Number.....................................916 DEVELOPMENT OF NOVEL INDOLEQUINONE ANTI-TUMOR AGENTS: MECHANISM OF TOXICITY IN HUMAN PANCREATIC CANCER. C. Yan 1 , D. Siegel 1 , M. Colucci 2 , A. Chilloux 2 , J. Newsome 2 , C. J. Moody 2 and D. Ross 1 . 1 Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO and 2 Chemistry, University of Nottingham, Nottingham, United Kingdom. #1664 Poster Board Number.....................................917 SDF-1β PROTECTS CARDIAC CELLS FROM PALMITATE-INDUCED NITROSATIVE STRESS-MEDIATED ER STRESS AND CELL DEATH THROUGH ACTIVATION OF AMPK- MEDIATED IL-6 EXCRETION. Y. Zhao 2,1 , W. Li 2 and L. Cai 1,2 . 1 University of Louisville, Louisville, KY and 2 The Fist Hospital of Jilin University, Changchun, China. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 259
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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