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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #530 Poster Board Number.....................................325 IGE POSITIVITY IN B LYMPHOCYTES: A VALUABLE BIOMARKER FOR DIAGNOSIS OF CANINE ALLERGY. Q. Peng 1 , M. Ko 1 , A. Gonzales 1,2 , E. McCandless 1,2 , Q. Zong 1 , F. Sace 1 , R. Yafawi 1 , J. Wang 1 and A. John-Baptiste 1 . 1 DSRD, Pfizer, San Diego, CA and 2 Animal Health, Pfizer, Kalamazoo, MI. Sponsor: G. Stevens. #531 Poster Board Number.....................................326 INFLUENCE OF A MIXTURE OF FIVE PESTICIDES ON THE REPRODUCTIVE SYSTEM OF FEMALE SPRAGUE-DAWLEY RATS. V. M. Pacotto 1 , M. T. Guerra 2 , J. V. de Camargo 1 and C. S. Franchi 1 . 1 Pathology, Sao Paulo State University - UNESP - Medical School, Botucatu, San Paulo, Brazil and 2 Graduate Program in Cell and Structural Biology, State University of Campinas, Campinas, Sao Paulo, Brazil. Sponsor: S. Cohen. #532 Poster Board Number.....................................327 BIOLOGICAL PATHWAY ANALYSES OF HEPATOTOXICANT-INDUCED CHANGES IN HEPATIC GENE EXPRESSION IN CHIMERIC PXB-MOUSE ® WITH HIGHLY HUMANIZED LIVER. S. Nagatsuka 1 , D. Hynes 1 , S. Ninomiya 1 , M. Kakuni 2 , C. Tateno-Mukaidani 2 , T. Shimada 2 and Y. Yamazoe 3 . 1 R&D, Sekisui Medical Co., ADME & Toxicology Research Institute, Tokai-mura, Ibaraki, Japan, 2 PhoenixBio Co., Higashi-Hiroshima, Hiroshima, Japan and 3 Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan. Sponsor: T. Miyaoka. #533 Poster Board Number.....................................328 THE EFFECTS OF CILOSTAZOL ON MOUSE OOCYTE MEIOTIC MATURATION AND MORPHOLOGY. A. M. Taiyeb 1 , D. Kraemer 1 , V. Fajt 1 and C. M. Sayes 1,2 . 1 Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX and 2 Interdisciplinary Program in Toxicology, Texas A&M University, College Station, TX. #534 Poster Board Number.....................................329 3D LIVER CO-CULTURES MAINTAIN PHASE I, II, AND III METABOLISM ACTIVITY IN LONG-TERM CULTURE. J. Llamas Vidales 1 , L. New 1 , C. I. Pearson 1 , A. H. Roter 2 , B. A. Naughton 1 and D. R. Applegate 1 . 1 R&D, RegeneMed, Inc., San Diego, CA and 2 Entelos, Inc., Foster City, CA. Sponsor: R. Thomas. Monday Afternoon, March 7 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Animal Models in Toxicology Chairperson(s): Jessica Whritenour, Pfizer Global Research and Development, Groton, CT. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #535 Poster Board Number.....................................333 ATP-BINDING-CASSETTE TRANSPORTER KNOCKOUT RAT MODELS. I. D. Carbery, L. C. Little, E. J. Weinstein and X. Cui. SAGE, Sigma- Aldrich, St. Louis, MO. #536 Poster Board Number.....................................334 PATHOLOGY OF A BROWN-NORWAY RAT MODEL OF AMODIAQUINE-INDUCED LIVER INJURY. H. C. Workman 1 , J. Li 2 , P. Cai 3 , M. Odin 1 , M. David 1 and J. Uetrecht 3,4 . 1 Nonclinical Safety, Hoffmann-La Roche, Nutley, NJ, 2 Immunotoxicology, Bristol-Myers Squibb, New Brunswick, NJ, 3 Pharmacy, University of Toronto, Toronto, ON, Canada and 4 Medicine, University of Toronto, Toronto, ON, Canada. #537 Poster Board Number.....................................335 ALTERED BEHAVIOR, BODY WEIGHT, AND BRAIN CHEMISTRY IN PAK5-/-, PAK6 -/-AND PAK5-/-/PAK6-/-MICE. M. A. Furnari 1 , M. L. Jobes 1 , T. Nekrasova 2 , A. Minden 2 and G. C. Wagner 1,3 . 1 Joint Graduate Program in Toxicology, Rutgers University, Piscataway, NJ, 2 Susan Lehman Cullman Laboratory for Cancer Research, Rutgers University, Piscataway, NJ and 3 Psychology, Rutgers University, Piscataway, NJ. #538 Poster Board Number.....................................336 THE TOXICITY OF METHIMAZOLE IN THE MOUSE OLFACTORY MUCOSA IS AT LEAST PARTLY MEDIATED THROUGH TARGET-TISSUE METABOLIC ACTIVATION BY CYP2A5. J. Gu 1 , F. Xie 1 , X. Zhou 1 , M. Genter 2 and X. Ding 1 . 1 Wadsworth Center, New York State Department of Health, Albany, NY and 2 Department of Environmental Health, University of Cincinnati, Cincinnati, OH. #539 Poster Board Number.....................................337 MODELS OF ACUTE LUNG INFLAMMATION IN NON HUMAN PRIMATES: LPS, MECHANICAL VENTILATION, PSEUDOMONAS AERUGINOSA, AND CIGARETTE SMOKE. R. W. Spindle, M. Doyle-Eisele, O. Denise, J. Tipper, K. Harrod, R. Jaramillo and J. McDonald. LRRI, Albuquerque, NM. #540 Poster Board Number.....................................338 EVALUATING THE CELLULAR CHANGES IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS MODELS: IT VS. INHALATION. M. Doyle-Eisele, R. W. Spindle, A. Gigliotti and J. D. McDonald. LRRI, Albuquerque, NM. #541 Poster Board Number.....................................339 THE PATHOPHYSIOLOGY OF PROGRESSIVE EXPOSURE TO TOBACCO SMOKE IN A RODENT MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). L. Wang 1 , S. Bolton 2 and K. E. Pinkerton 1 . 1 Center for Health and the Environment, University of California, Davis, Davis, CA and 2 Safety Assessment, AstraZeneca R&D, Loughborough, United Kingdom. #542 Poster Board Number.....................................340 USE OF MOUSE MODEL AS AN EARLY SCREENING TOOL FOR PDE4 INHIBITOR- INDUCED GASTROINTESTINAL TOXICITY. C. Chen, H. Sexton, K. Jarnagin, X. Fan, W. Bu, A. Wu, Y. Freund and S. Chanda. Toxicology, Anacor Pharmaceuticals, Palo Alto, CA. 162 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #543 Poster Board Number.....................................341 EFFICACY OF PHARMACEUTICAL DRUG COCKTAILS FOR TREATING CHLORINE VAPOR INDUCED CUTANEOUS LESIONS. J. Rhone 1 , J. L. Plahovinsak 1 , E. M. Benson 1 , R. C. Hamilton 1 , F. M. Reid 1 , J. F. Dillman 2 and J. S. Graham 2 . 1 Biomedical Research Center, Battelle, Columbus, OH and 2 U.S. Army Medical Research Institute of Chemical Defense, Aberdeen, MD. #544 Poster Board Number.....................................342 EFFICACY OF PHARMACEUTICAL DRUG COCKTAILS FOR AMELIORATION OF CUTANEOUS SULFUR MUSTARD INJURIES. F. M. Reid 1 , J. L. Plahovinsak 1 , M. D. Etheridge 1 , J. Rhone 1 , J. F. Dillman 2 and J. S. Graham 2 . 1 Biomedical Research Center, Battelle, Columbus, OH and 2 U.S. Army Medical Research Institute of Chemical Defense, Aberdeen, MD. #545 Poster Board Number.....................................343 BEHAVIORAL EFFECTS OF REPIN IN MICE. W. K. Rumbeiha and J. Nunez. Michigan State University, East Lansing, MI. #546 Poster Board Number.....................................344 INTRAVITREOUS INJECTION-RELATED RESPONSES AND THEIR MANAGEMENT IN NON-HUMAN PRIMATE - A CASE STUDY. T. T. Lam, J. Seeman and B. J. Christian. Covance, Madison, WI. #547 Poster Board Number.....................................345 DIURON-INDUCED DECREASE OF CD4+ LYMPHOCYTES IN THE SPLEEN OF MALE WISTAR RATS. S. M. Ihlaseh, A. Domingues, A. F. Cardoso, A. T. Spinardi-Barbisan, M. C. de Oliveira and J. V. de Camargo. Pathology, Sao Paulo State University - UNESP - Medical School, Botucatu, Brazil. #548 Poster Board Number.....................................346 INCREASED SECONDARY BILE ACIDS IN OATP1A1-NULL MICE CAN BE EXPLAINED BY AN OVERGROWTH OF INTESTINAL BACTERIA. P. B. Limaye 1 , Y. Zhang 1 , I. L. Csanaky 1 , L. Lehman-McKeeman 2 and C. D. Klaassen 1 . 1 Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS and 2 Discovery Toxicology, Bristol-Myers Squibb Co., Princeton, NJ. #549 Poster Board Number.....................................347 TREATMENT PARADIGM FOR ASSESSMENT OF ETIOLOGIES OF PAFURAMDINE-INDUCED KIDNEY AND LIVER TOXICITY. K. D. DeSmet 1 , A. Harrill 1 , J. Hall 2 , M. Paine 3 , M. Wang 3 , R. Tidwell 2 and P. Watkins 1 . 1 Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, 2 Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC and 3 Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC. Abstract # #550 Poster Board Number.....................................348 CO-EXPOSURE OF A NOVEL MOUSE MODEL TO LOW-DOSE TRICHLOROETHYLENE AND INORGANIC ARSENIC: INTERACTIONS, GENETICS, AND RENAL TOXICITY. M. C. DeSimone 1,2 , G. Glavich 2 , A. Bohn 2 and D. Threadgill 1,2 . 1 Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC and 2 Department of Genetics, North Carolina State University, Raleigh, NC. #551 Poster Board Number.....................................349 LIPIDOMIC CHANGES IN THE LIVERS OF HEPATIC ALCOHOL DEHYDROGENASE- DEFICIENT DEER MICE AFTER SUBCHRONIC EXPOSURE TO ETHANOL. H. Fernando, K. K. Bhopale, G. A. Ansari and B. S. Kaphalia. Department of Pathology, University of Texas Medical Branch, Galveston, TX. #552 Poster Board Number.....................................350 DEVELOPMENT AND EVALUATION OF A MUCOCILIARY CLEARANCE MODEL IN BEAGLE DOGS VIA PLANAR GAMMA CAMERA IMAGE ANALYSIS. P. Kuehl, R. Chand, M. Doyle-Eisele and J. McDonald. LRRI, Albuquerque, NM. #553 Poster Board Number.....................................351 REPRESSION OF MULTIPLE CYP2B MEMBERS BY RNAI IN MICE. B. Damiri, X. Yu, E. Holle and W. S. Baldwin. Biology/ Clemson University, Environmental Toxicology, Clemson, SC. #554 Poster Board Number.....................................352 ENDOTHELIAL CELL-SPECIFIC ARYL HYDROCARBON RECEPTOR KNOCKOUT MICE ARE HYPOTENSIVE AND EXHIBIT DIMINISHED RESPONSES TO ANGIOTENSIN II. L. N. Agbor, M. T. Walsh and M. K. Walker. Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM. #555 Poster Board Number.....................................353 STUDY DESIGN CONSIDERATIONS FOR ACCURATE CARDIAC TROPONIN EVALUATION IN NON-HUMAN PRIMATES AND RATS. W. J. Reagan, D. Blackwell, L. Correia, K. Alger, C. Kaplan and F. Geoly. Pfizer, Groton, CT. #556 Poster Board Number.....................................354 EFFECTS OF TRAINING ON BLOOD PRESSURE MEASUREMENT BY HDO IN CYNOMOLGUS MONKEYS. B. Niggemann, M. Niehoff, J. Luft and G. Weinbauer. Covance Laboratories GmbH, Muenster, Germany. #557 Poster Board Number.....................................355 RELIABLE DETECTION OF HYPERTENSION AND HYPOTENSION IN CONSCIOUS, FREELY MOVING CYNOMOLGUS MONKEYS (MACACA FASCICULARIS). M. Niehoff, B. Niggemann, J. Sternberg, U. Zuehlke and G. Weinbauer. Covance Laboratories GmbH, Muenster, Germany. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 163
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Endowmen
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