Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
MONday
Abstract # Abstract #
#827 2:00 THE FATE, BEHAVIOR, AND WEATHERING
OF SPILLED OIL FROM THE DEEPWATER
HORIZON SPILL. ​J. Michel. Research Planning,
Inc., Columbia, SC. Sponsor: M. Madden.
#828 2:00 OIL SPILL CHEMICAL DISPERSANTS:
THE GOOD, THE BAD, OR THE UGLY? ​C.
L. Mitchelmore. Center for Environmental Science,
University of Maryland, Solomons, MD. Sponsor: M.
Madden.
#829 2:00 SHORT-TERM HEALTH EFFECTS FROM
OIL SPILLS. ​N. Sathiakumar. University of
Alabama Birmingham, Birmingham, AL. Sponsor:
M. Madden.
#830 2:00 RISK ASSESSMENT OF THE SPILL:
CRITICAL INFORMATION NEEDS. ​W. H.
Farland. Colorado State University, Fort Collins,
CO.
Monday Afternoon, March 7
2:00 PM to 4:45 PM
Room 147
Emerging Global Public Health Issues
Symposium Session: Translational Toxicology: Molecules to
Global Health
Chairperson(s): Thomas Kensler, Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD, and John Groopman, Johns Hopkins
Bloomberg School of Public Health, Baltimore, MD.
Sponsor:
Disease Prevention Task Force
Endorsed by:
Risk Assessment Specialty Section
The appreciation that the environment plays a universal role in human health
has evolved rapidly in recent decades, drawing largely on new analytic technologies,
advanced data acquisition, informatics and modeling, mechanistic
studies in toxicology, and the conceptual framework of risk assessment.
To adequately explore rapidly evolving issues, we will highlight four case
studies detailing exposures through the vectors of air, food and water to
agents, natural and anthropogenic that impact health across the lifespan of
millions of people across the globe. Specific attention will be given relative
to the use of toxicologic and epidemiologic data with improved techniques
for quantifying exposure of biologically effective dose produce estimates of
risks from environmental hazards to selected target populations. The global
health implications of these exposures and possible intervention strategies
to mitigate these exposures and their consequent health effects will also be
discussed. In conclusion, the panelists will discuss the current status of toxicology
and global health and a consideration of the challenges emerging in
the next 50 years.
#831 2:00 TRANSLATIONAL TOXICOLOGY:
MOLECULES TO GLOBAL HEALTH. ​T. W.
Kensler 1,2 and J. D. Groopman 2 . 1 Pharmacology
& Chemical Biology, University of Pittsburgh,
Pittsburgh, PA and 2 Environmental Health Sciences,
Johns Hopkins Bloomberg School of Public Health,
Baltimore, MD.
2:00 INTRODUCTION. ​Thomas Kensler
#832 2:05 MYCOTOXINS: IMPACTS ON CANCER AND
CHILDREN’S HEALTH. ​C. P. Wild. International
Agency for Research on Cancer, Lyon, France.
Sponsor: T. Kensler.
#833 2:40 ARSENIC: RECENT FINDINGS FROM
THE HEALTH EFFECTS OF ARSENIC
LONGITUDINAL STUDY IN BANGLADESH. ​
J. H. Graziano. Environmental Health Sciences,
Columbia University, New York, NY.
#834 3:15 SECONDHAND TOBACCO SMOKE: USING
BIOMARKERS TO INFORM PUBLIC
POLICY. ​S. S. Hecht. Masonic Cancer Center,
University of Minnesota, Minneapolis, MN. Sponsor:
T. Kensler.
#835 3:50 STRUCTURAL AND FUNCTIONAL CNS
EFFECTS OF LEAD IN ADULTS. ​B. S.
Schwartz. Environmental Health Sciences, Johns
Hopkins Bloomberg School of Public Health,
Baltimore, MD.
4:25 PANEL DISCUSSION/Q&A.
Monday Afternoon, March 7
2:00 PM to 4:45 PM
Room 206
Symposium Session: Vascular Developmental Toxicity:
Identification, Prioritization, and Application
Chairperson(s): Nicole Kleinstreuer, U.S. EPA, Research Triangle Park,
NC, and Thomas Knudsen, U.S. EPA, Research Triangle Park, NC.
Sponsor:
Reproductive and Developmental Toxicology Specialty Section
Endorsed by:
Biological Modeling Specialty Section
Cardiovascular Toxicology Specialty Section
Mechanisms Specialty Section
Advanced research approaches to vascular developmental toxicity, including
new computational modeling methods, high-throughput in vitro tests,
alternative platforms such as embryonic stem cells and zebrafish reporter
gene constructs, and potential chemical prioritization, risk-assessment, and
clinical applications to human health are important issues. The formation
of the vascular network during embryogenesis is crucial to all aspects of
development, both through maternal placental oxygen and nutrient delivery
as well as direct effects on morphogenesis. Disruption in local signal-flow
phenomena during development alters morphogenetic gradients that control
endothelial cell differentiation, proliferation, chemotaxis, and subsequent
signals. This, in turn, affects the distribution of nutrients, metabolic products
and/or chemicals, and seriously impacts organogenesis. Due to the
centralized role and complexity of the signaling networks underlying
blood vessel formation and remodeling and their centralized role across
all embryonic systems, developmental defects mediated by disruption of
the vascular network can be manifested in diverse ways and attributed to a
variety of factors. Associated severe developmental effects include embryonic
lethality and in less severe cases, phenotypes such as preeclampsia,
microphthalmia, and limb defects. Traditional prenatal animal testing is not
informative for resolving and attributing the inherent phenotypic ambiguity
that arises due to various vascular network perturbations, prompting a new
paradigm for toxicity testing (NRC 2007). There is a need to deepen current
understanding of developmental vascular biology, to identify biologically
significant perturbations in potential toxicity pathways that may lead to
vascular disruption, and to develop and implement new testing strategies
with greater specificity and predictive power to identify the many vascular
signaling pathways during developmental angiogenesis that are highly
conserved and factor heavily in pathogenesis of adult vascular disease.
#836 2:00 VASCULAR DEVELOPMENTAL TOXICITY:
IDENTIFICATION, PRIORITIZATION,
AND APPLICATION. ​T. B. Knudsen and N. C.
Kleinstreuer. ORD / NCCT, U.S. EPA, Research
Triangle Park, NC.
2:00 INTRODUCTION. ​Nicole Kleinstreuer
186
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