Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
Wednesday
Abstract # Abstract #
#2278 Poster Board Number.....................................422
TOXICOKINETICS OF CAPTAN
BIOMARKERS IN ORALLY AND
DERMALLY EXPOSED VOLUNTEERS. ​M.
Bouchard 1 , A. Berthet 1,2 and D. Vernez 2 . 1 Department
Environmental & Occupational Health, University
of Montréal, Montréal, QC, Canada and 2 Institute for
Work and Health, Lausanne, Switzerland.
#2279 Poster Board Number.....................................423
IMPACT OF NON-LINEAR
PHARMACOKINETICS AND METABOLISM
OF CHLORPYRIFOS ON BIOLOGICAL
RESPONSE IN THE RAT. ​M. Bartels 1 , M.
S. Marty 1 , J. A. Hotchkiss 1 and D. R. Juberg 2 .
1
Toxicology, Dow Chemical, Midland, MI and
2
Toxicology, Dow AgroSciences, Indianapolis, IN.
#2280 Poster Board Number.....................................424
COMPARISON OF THE EFFECT OF ASSAY
CONDITIONS ON INTERPRETATION
OF TIME-DEPENDENT INHIBITION OF
CYTOCHROME P450 ENZYMES USING
SINGLE POINT AND IC50 SHIFT ASSAYS. ​
K. Fox 2 , R. Pearson 2 , P. Butler 2 , C. Dilworth 2 and K.
Tsaioun 1,2 . 1 Apredica, Watertown, MA and 2 Cyprotex,
Macclesfield, United Kingdom.
#2281 Poster Board Number.....................................425
REACTIVITY OF BRO3- EXPLAINS POOR
APPARENT ABSORPTION OF LOW ORAL
DOSES F344 RATS. ​R. J. Bull 1 , N. Kolisetty 2 ,
Z. Guo 3 , J. W. Fisher 4 , J. A. Cotruvo 5 and B. S.
Cummings 2 . 1 Washington State University, Richland,
WA, 2 University of Georgia, Athens, GA, 3 Center for
Water Technology Public Utility Board Singapore,
Singapore, 4 U.S. FDA, Jefferson, AR ad 5 Joseph
Cotruvo & Associates LLC, Washington, D.C.
#2282 Poster Board Number.....................................426
GENETIC VARIATION IN ISOGENIC
STRAINS OF LABORATORY MICE ALTERS
DISPOSITION IN KIDNEYS AND LIVERS
AFTER ACUTE EXPOSURE TO [14C]
BENZENE. ​R. Kuester 1 , G. A. Knudsen 1 , M.
L. Cunningham 2 and G. Sipes 1 . 1 Department of
Pharmacology, University of Arizona, Tucson, AZ
and 2 NTP NIEHS, Montréal, QC, Canada.
#2283 Poster Board Number.....................................427
PYRIDAZINE REDUCES
TRICHLOROACETIC ACID (TCA)
BIOAVAILABILITY BY ENHANCING ITS
URINARY ELIMINATION. ​J. Bruckner, S. Lee,
C. A. White, S. Muralidhara and R. Govindaarajan.
PBS, University of Georgia, Athens, GA.
#2284 Poster Board Number.....................................428
DETERMINATION OF TACROLIMUS IN
RAT WHOLE BLOOD USING DRIED BLOOD
SPOT ANALYSES BY LC-MS/MS. ​M. Kim 1 , G.
Ray 1 , Y. Liu 1 , R. Losson 2 and G. Bricker 2 . 1 KCAS,
Shawnee, KS and 2 Xenometrics, Stilwell, KS.
Sponsor: D. Dandekar.
#2285 Poster Board Number.....................................429
A SENSITIVE LC-MS/MS ASSAY FOR
DETERMINATION OF BENAZEPRIL AND
BENAZEPRILAT IN DOG PLASMA. ​C.
Chung, M. Luna, Y. Liu, G. Ray and D. Dadgar.
KCAS, Shawnee, KS. Sponsor: D. Dandekar.
Wednesday Afternoon, March 9
1:00 PM to 4:30 PM
Exhibit Hall
Poster Session: Risk Assessment: Models and Approaches for
Inhaled Agents
Chairperson(s): Annie Jarabek, U.S. EPA, Research Triangle Park, NC,
and Richard Corley, Pacific Northwest National Laboratory, Richland,
WA.
Displayed: 1:00 PM–4:30 PM
Author Attended: 2:45 PM–4:30 PM
#2286 Poster Board Number.....................................432
EVALUATION OF ADVERSE EFFECTS
ON HUMAN LUNG FUNCTION CAUSED
BY OZONE. ​R. L. Prueitt 1 and J. E. Goodman 2 .
1
Gradient, Seattle, WA and 2 Gradient, Cambridge,
MA.
#2287 Poster Board Number.....................................433
MODELING NF-κB REDOX SENSITIVITY:
APPLICATIONS TO OZONE-INDUCED
LUNG INFLAMMATION. ​D. J. Miller and P.
D. White. U.S. EPA, Washington, D.C. Sponsor: S.
Vulimiri.
#2288 Poster Board Number.....................................434
COMBINED CFD/PBPK MODELS FOR
DETERMINING SITE-SPECIFIC UPTAKE
AND TISSUE CONCENTRATIONS OF
REACTIVE GASES IN THE RESPIRATORY
TRACT OF RATS AND HUMANS. ​R. A.
Corley 1 , S. Kabilan 1 , J. E. Carson 1 , R. Jacob 1 ,
K. R. Minard 1 , R. W. Glenny 2 , S. Pipavath 2 , M.
Fanucchi 3 and D. R. Einstein 1 . 1 Pacific Northwest
National Laboratory, Richland, WA, 2 University of
Washington, Seattle, WA and 3 University of Alabama
at Birmingham, Birmingham, AL.
#2289 Poster Board Number.....................................435
MODELING VAPOR UPTAKE AND TISSUE
DISPOSITION IN HUMAN LUNGS. ​M. Singal 1 ,
B. Asgharian 2 , O. T. Price 2 , J. S. Schroeter 3 and
J. S. Kimbell 4 . 1 Research Institute for Fragrance
Materials, Inc., Woodcliff Lake, NJ, 2 Health Effects
& Medical Response, Applied Research Associates,
Raleigh, NC, 3 Division of Computational Biology,
The Hamner Institutes for Health Sciences,
Research Triangle Park, NC and 4 Department of
Otolaryngology/Head and Neck Surgery, University
of North Carolina at Chapel Hill, Chapel Hill, NC.
#2290 Poster Board Number.....................................436
DOSIMETRY OF SOLUBLE, REACTIVE
VAPORS IN THE UPPER RESPIRATORY
TRACT OF THE SPRAGUE-DAWLEY
RAT USING A COMPUTATIONAL FLUID
DYNAMICS MODEL. ​J. Schroeter 1 , J. S.
Kimbell 2 , B. Asgharian 3 and M. Singal 4 . 1 The Hamner
Institutes for Health Sciences, Research Triangle
Park, NC, 2 Otolaryngology/Head and Neck Surgery,
University of North Carolina at Chapel Hill, Chapel
Hill, NC, 3 Applied Research Associates, Inc.,
Raleigh, NC and 4 Research Institute for Fragrance
Materials, Inc., Woodcliff Lake, NJ.
318
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