Program - Society of Toxicology

More documents

Recommendations

Info

50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #731 Poster Board Number.....................................733 APPLICATION OF A HUMAN PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL TO EVALUATE BENZENE BLOOD LEVELS FOR PUBLIC HEALTH CONCERN. D. A. Fowler 1 , R. R. Worley 1 , J. S. Wheeler 1 , C. Welsh 1 , D. Moffett 1 and J. Fisher 2 . 1 Agency for Toxic Substances and Disease Registry, CDC/ATSDR/NCEH, Atlanta, GA and 2 National Center for Toxicological Research, U.S. FDA, Jefferson, AR. #732 Poster Board Number.....................................734 CHARACTERIZATION OF STRAIN & DOSE- DEPENDENT ROUTES OF ELIMINATION FOR BENZENE & ITS METABOLITES IN 4 MOUSE STRAINS. G. A. Knudsen 1 , R. K. Kuester 1 , M. L. Cunningham 2 , J. E. French 2 and I. G. Sipes 1 . 1 Medical Pharmacology, University of Arizona, Tucson, AZ and 2 National Toxicology Program, National Institutes of Environmental Health Sciences, Research Triangle Park, NC. #733 Poster Board Number.....................................735 VIRTUAL LIVER: EVALUATING THE IMPACT OF HEPATIC MICRODOSIMETRY FOR TOXCAST CHEMICALS. J. F. Wambaugh 1 , J. Jack 1 , C. Haugh 1 , J. Zaldívar Comenges 2 and I. Shah 1 . 1 National Center for Computational Toxicology, U.S. EPA, Research Triangle Park, NC and 2 Institute for Health and Consumer Protection, European Commission, Joint Research Centre, Ispra, Italy. #734 Poster Board Number.....................................736 MOLECULAR DYNAMICS STABILITY STUDY OF THE WILD-TYPE AND MUTANTS OF THE HEPTAPEPTIDE (NNFGAIL) SEGMENT OF AMYLIN AGGREGATE. W. M. Berhanu 1,2 and A. E. Masunov 1,2 . 1 Chemistry, University of Central Florida, Orlando, FL and 2 Nanoscience Technology Center, University of Central Florida, Orlando, FL. #735 Poster Board Number.....................................846 MECHANISTIC UNDERSTANDING OF DRUG EFFECTS USING METABOLOMICS: A COMPUTATIONAL APPROACH BASED ON A RAT LIVER MODEL. O. Shaikh, S. Das, R. Kumar, S. Raghavan and K. Subramanian. Strand Life Sciences, Bangalore, India. #736 Poster Board Number.....................................847 DEVELOPMENT OF A PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR RDX (HEXAHYDRO-1, 3, 5-TRINITRO-1, 3, 5-TRIAZINE) IN FEMALE B6C3F1 MICE. M. L. Gargas 1 , C. P. Gut 1 , M. R. Okolica 1 , A. Ntamack 1 , L. M. Sweeney 1 , L. R. Williams 2 , G. Reddy 2 and M. S. Johnson 2 . 1 Naval Medical Research Unit - Dayton, Wright-Patterson AFB, OH and 2 U.S. Army Public Health Command, Aberdeen Proving Ground, MD. #737 Poster Board Number.....................................848 BIOMARKERS OF EXPOSURE VERSUS PBPK MODEL ESTIMATES OF INTERNAL DOSE: A CASE STUDY WITH ACRYLAMIDE. R. S. DeWoskin. U.S. EPA, Research Triangle Park, NC. Monday Afternoon, March 7 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Kidney Chairperson(s): Sue Ford, St. Johns University, Jamaica, NY, and Vijay Kale, Medical University of South Carolina, Charleston, SC. Displayed: 1:00 PM–4:30 PM Author Attended: 2:45 PM–4:30 PM #738 Poster Board Number.....................................801 IN VITRO 3, 5-DICHLOROANILINE NEPHROTOXICITY IN FRESHLY ISOLATED RAT RENAL CORTICAL CELLS. C. Smurthwaite, S. Baksi, T. Ferguson, C. Schuetz, D. Anestis and G. O. Rankin. Pharmacology, Physiology, and Toxicology, Marshall University, Huntington, WV. #739 Poster Board Number.....................................802 IN VITRO ANALYSIS OF CYCLOSPORINE A-INDUCED NEPHROTOXICITY BY GENE EXPRESSION AND 1H-NMR- METABONOMICS OF CELL LYSATES. K. Herrgen 1 , O. Schmal 1 , C. J. Burek 1 , M. Gruene 2 , P. Jennings 3 and W. Dekant 1 . 1 Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany, 2 Department of Organic Chemistry, University of Wuerzburg, Wuerzburg, Germany and 3 Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck, Austria. #740 Poster Board Number.....................................803 EVALUATION OF MRP2 TRANSPORTER- MEDIATED PROTECTION AGAINST CISPLATIN-INDUCED NEPHROTOXICITY USING IN VITRO AND IN VIVO APPROACHES. X. Wen 1 , M. Goedken 2 , C. D. Klaassen 3 , J. E. Manautou 4 and L. M. Aleksunes 1 . 1 Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, 2 Pathology, Merck & Co., Inc., Lafayette, NJ, 3 Pharmacology, University of Kansas Medical Center, Kansas City, KS and 4 Pharmaceutical Sciences, University of Connecticut, Storrs, CT. #741 Poster Board Number.....................................804 MODULATION OF CISPLATIN MEDIATED OXIDATIVE STRESS BIOMARKERS BY RESVERATROL. M. Valentovic, J. G. Ball and J. Brown. Pharmacology, Physiology, and Toxicology, Marshall University School of Medicine, Huntington, WV. #742 Poster Board Number.....................................805 URINARY BIOMARKERS FOR THE EARLY PREDICTION OF CISPLATIN-INDUCED CHANGES IN KIDNEY FUNCTION AND INJURY IN RATS. Y. Chen, D. Brott, P. Bentley, D. Thurman, L. Kinter and R. Bialecki. Safety Assessment, AstraZeneca Pharmaceuticals, Wilmington, DE. #743 Poster Board Number.....................................806 STATE-OF-THE-ART DETECTION OF NEPHROTOXICITY BY URINARY PROTEIN BIOMARKERS. B. Emde, P. Hewitt, S. Czasch, F. v. Landenberg and T. C. Fuchs. Toxicology, Merck Serono, Darmstadt, Germany. 178 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #744 Poster Board Number.....................................807 URINARY FIBRINOGEN: A MECHANISTIC TRANSLATIONAL BIOMARKER FOR VASCULAR DYSFUNCTION AND INFLAMMATION IN THE KIDNEY. D. Hoffmann 1 , A. Krishnamoorthy 1 , V. Ramirez Gonzalez 1 , Q. Zhang 2 , P. L. Goering 2 , R. B. Brown 2 , S. Waikar 1 and V. S. Vaidya 1 . 1 Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA and 2 CDRH, U.S. FDA, Silver Spring, MD. #745 Poster Board Number.....................................808 METABOLOMICS ANALYSIS SUGGESTS ROLE OF 3-INDOXYL SULFATE IN CENTRAL NERVOUS SYSTEM TOXICITY AND AN EARLY INDICATOR OF CHEMICALLY-INDUCED RENAL FAILURE. M. V. Milburn 1 , D. Alexander 1 , J. R. Zgoda-Pols 2 , S. Chowdhury 2 , M. Wirth 2 and K. B. Alton 2 . 1 Metabolon, Durham, NC and 2 Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Kenilworth, NJ. Sponsor: G. Vansant. #746 Poster Board Number.....................................809 SHORT-TERM TOXICITY OF MELAMINE AND ITS MIXTURE WITH CYANURIC ACID IN F344 NEONATAL RATS AND SEARCHING FOR NOVEL KIDNEY BIOMARKERS. H. Kang 1 , Y. Park 1 , S. Jeong 2 , J. Seo 1 , Y. Jean 1 , J. Kang 1 , H. Shin 1 and S. Son 1 . 1 Veterinary Toxicology and Chemistry, National Veterinary Research and Quarantine Service, Anyang, Republic of Korea and 2 GLP Research Center, Hoseo University, Asan, Republic of Korea. #747 Poster Board Number.....................................810 TRANSCRIPTION LEVELS OF BIOMARKERS OF ACUTE RENAL INJURY IN F344 RATS CO-EXPOSED TO MELAMINE AND CYANURIC ACID FOR SEVEN DAYS. L. Camacho, K. Kelly and G. Gamboa da Costa. Division Biochemical Toxicology, National Center for Toxicological Research. U.S. FDA, Jefferson, AR. #748 Poster Board Number.....................................811 THE USE OF FLOW CYTOMETRY TO STUDY MECHANISMS OF MITOCHONDRIAL BIOGENESIS IN RENAL CELLS. V. Kale and R. Schnellmann. Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC. #749 Poster Board Number.....................................812 OXIDANT INJURY INDUCES RAPID DEGRADATION OF MITOCHONDRIAL CALPAIN 10 IN RENAL PROXIMAL TUBULE CELLS. M. A. Smith and R. G. Schnellmann. Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC. #750 Poster Board Number.....................................813 MITOCHONDRIAL HOMEOSTASIS AFTER ACUTE KIDNEY INJURY: SUSTAINED ALTERATIONS IN MITOCHONDRIAL PROTEINS, FUSION/FISSION, AND BIOGENESIS. J. A. Funk, B. E. Shaner and R. G. Schnellmann. Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC. Abstract # #751 Poster Board Number.....................................814 IDENTIFICATION AND CHARACTERIZATION OF MITOCHONDRIAL TOXICANTS. L. P. Wills, G. C. Beeson, R. Trager, C. Lindsey, Y. K. Peterson, C. C. Beeson and R. G. Schnellmann. Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC. #752 Poster Board Number.....................................815 MITOCHONDRIAL GSH STATUS IN COMPENSATORY RENAL HYPERTROPHY DUE TO UNINEPHRECTOMY AND DIABETIC NEPHROPATHY. L. H. Lash, B. Benipal, D. A. Putt and Q. Zhong. Pharmacology, Wayne State University School of Medicine, Detroit, MI. #753 Poster Board Number.....................................816 THE CYTOPROTECTIVE EFFECT OF N-ACETYLCYSTEINE AGAINST ROS-INDUCED CYTOTOXICITY IS INDEPENDENT OF ITS ABILITY TO ENHANCE GLUTATHIONE SYNTHESIS. F. Zhang, S. S. Lau and T. J. Monks. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ. #754 Poster Board Number.....................................817 PLASMA, URINE, AND TISSUE CONCENTRATIONS OF HEXAVALENT CHROMIUM ASSOCIATED ACUTE KIDNEY INJURY IN SPRAGUE-DAWLEY RATS. R. P. Brown 1 , Q. Zhang 1 , D. S. Barber 2 , A. C. Komiyama 1 and P. L. Goering 1 . 1 CDRH, U.S. FDA, Silver Spring, MD and 2 University of Florida, Gainesville, FL. #755 Poster Board Number.....................................818 COVALENT MODIFICATIONS OF KIDNEY PROTEINS BY S-(1, 2-DICHLOROVINYL)-L- CYSTEINE SULFOXIDE (DCVCS): IN VITRO CHARACTERIZATION USING N-BIOTINYL- DCVCS (NB-DCVCS). R. M. Irving 1 , M. S. Brownfield 2 and A. A. Elfarra 1,2 . 1 Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, WI and 2 Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI. #756 Poster Board Number.....................................819 ZINC DEFICIENCY EXACERBATES DIABETES-INDUCED RENAL OXIDATIVE DAMAGE, INFLAMMATION, AND FIBROSIS. B. Li 1,2 , L. Miao 2 and L. Cai 1 . 1 University of Louisville, Louisville, KY and 2 Nephrology, Jilin University, Changchun, Jilin, China. #757 Poster Board Number.....................................820 ROLE OF OXIDATIVE STRESS INDUCED BY CHROMATE IN THE ACTIVATION OF MAPK IN NRK-52E CELLS. L. Arreola- Mendoza 1,2 , J. L. Reyes 3 , E. I. Sanchez 3 and L. M. Del Razo 2 . 1 Biosciences and Engineering, CIIEMAD-IPN, Mexico D.F., Mexico, 2 Toxicology, Cinvestav-Ipn, Mexico D.F., Mexico and 3 Physiology & Biophysics, Cinvestav-Ipn, Mexico D.F., Mexico. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 179
Page 1 and 2:
50 th Anniversary Annual Meeting &
Page 3 and 4:
Scientific Program Overview A page
Page 5 and 6:
9:00 AM-12:30 PM POSTER SESSionS
Page 7 and 8:
March 6-10, 2011 Walter E. Washingt
Page 9 and 10:
Celebration Activities Historical H
Page 11 and 12:
of the Society Regional Chapter Yea
Page 13 and 14:
SOT Presidents 1961-2011 1966 1967
Page 15 and 16:
The SOT Council Thanks and Recogniz
Page 17 and 18:
of the Past 50 Years 2003 Michael D
Page 19 and 20:
Thank You to the following individu
Page 21 and 22:
SOT Celebration Event Floor Plan Ba
Page 23 and 24:
50 th Anniversary Annual Meeting an
Page 25 and 26:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 27 and 28:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 29 and 30:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 31 and 32:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 33 and 34:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 35 and 36:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 37 and 38:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 39 and 40:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 41 and 42:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 43 and 44:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 45 and 46:
Toxicological Sciences The Official
Page 47 and 48:
Society of Toxicology 2011 Walter E
Page 49 and 50:
Society of Toxicology 2011 Washingt
Page 51 and 52:
Society of Toxicology 2011 Map of W
Page 53 and 54:
2011 SOT 50 th Anniversary Featured
Page 55 and 56:
Society of Toxicology 2011 Washingt
Page 57 and 58:
Society of Toxicology 2011 ToxExpo
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Society of Toxicology 2011 Exhibito
Page 65 and 66:
Creating a Safer and Healthier Worl
Page 67 and 68:
Society of Toxicology 2011 General
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
SOT Job Bank YOUR RECRUITMENT AND E
Page 83 and 84:
Society of Toxicology 2011 Career R
Page 85 and 86:
Society of Toxicology 2011 SOT 2011
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Society of Toxicology 2011 2011 Awa
Page 95 and 96:
Endowment Awardees for SOT’s 50 t
Page 97 and 98:
Society of Toxicology 2011 SOT Endo
Page 99 and 100:
Society of Toxicology 2011 Recognit
Page 101 and 102:
Society of Toxicology 2011 Recognit
Page 103 and 104:
Society of Toxicology 2011 RC, SIG,
Page 105 and 106:
Society of Toxicology 2011 Student
Page 107 and 108:
Society of Toxicology 2011 Outreach
Page 109 and 110:
Society of Toxicology 2011 Satellit
Page 111 and 112:
Society of Toxicology 2011 Continui
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Society of Toxicology 2011 Scientif
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Society of Toxicology 2011 Poster S
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Society of Toxicology 2011 Program
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150: Society of Toxicology 2011 Program
Page 199: Society of Toxicology 2011 Program
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321 and 322:
Page 323 and 324:
Page 325 and 326:
Page 327 and 328:
Page 329 and 330:
Page 331 and 332:
Page 333 and 334:
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347 and 348:
Page 349 and 350:
Page 351 and 352:
Page 353 and 354:
Page 355 and 356:
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Page 363 and 364:
Page 365 and 366:
Page 367 and 368:
Page 369 and 370:
Page 371 and 372:
Page 373 and 374:
Page 375 and 376:
Page 377 and 378:
Page 379 and 380:
Page 381 and 382:
Society of Toxicology 2011 Author I
Page 383 and 384:
Page 385 and 386:
Page 387 and 388:
Page 389 and 390:
Page 391 and 392:
Page 393 and 394:
Page 395 and 396:
Page 397 and 398:
Page 399 and 400:
Page 401 and 402:
Page 403 and 404:
Page 405 and 406:
Page 407 and 408:
Page 409 and 410:
Society of Toxicology 2011 Abstract
Page 411 and 412:
Page 413 and 414:
Page 415 and 416:
Page 417 and 418:
Page 419 and 420:
Page 421 and 422:
Page 423 and 424:
Page 425 and 426:
Society of Toxicology 2011 2010-201
Page 427 and 428:
Society of Toxicology 2011 Elected
Page 429 and 430:
Society of Toxicology 2011 Elected
Page 431 and 432:
Society of Toxicology 2011 Regional
Page 433 and 434:
Society of Toxicology 2011 Specialt
Page 435 and 436:
Society of Toxicology 2011 Specialt
Page 437 and 438:
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
Page 439 and 440:
Society of Toxicology 2011 Endowmen
Page 441 and 442:
Page 443 and 444:
Page 445 and 446:
Page 447 and 448:
Society of Toxicology 2011 SOT Affi
Page 449 and 450:
Society of Toxicology 2011 Notes up
Page 451 and 452:
Society of Toxicology 2011 Notes up
Page 453 and 454:
Society of Toxicology 2011 Headquar
Page 455 and 456:
QUICK REFERENCE Visit www.mwata.com
show all

Program - Society of Toxicology

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?