Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #680 Poster Board Number.....................................630 METAL OXIDE NANOPARTICLES MODULATE EXOSOMES. B. Andersson 1 , T. Bürki-Thurnherr 2 , H. Krug 2 , B. Fadeel 3 , A. Scheynius 1 and S. Gabrielsson 1 . 1 Clinical Allergy Research Unit, Karolinska Institutet, Stockholm, Sweden, 2 Federal Laboratories for Material Science and Technology, St. Gallen, Switzerland and 3 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. #681 Poster Board Number.....................................631 ROLE OF NEUTROPHILS IN A MOUSE MODEL OF CHEMICAL-INDUCED ASTHMA. S. Smulders 1 , V. De Vooght 1 , G. Opdenakker 2 , B. Nemery 1 , P. Hoet 1 and J. Vanoirbeek 1 . 1 Research Unit for Lung Toxicology, K.U. Leuven, Leuven, Belgium and 2 Rega Institute for Medical Research, Laboratory of Immunobiology, K.U. Leuven, Leuven, Belgium. #682 Poster Board Number.....................................632 EFFECTS OF PENICILLIUM MYCOTOXINS ON BOVINE MACROPHAGES IN VITRO. H. J. Boermans 2 , S. Oh 1 , N. A. Karrow 1 , B. Sharma 1 and S. Haladi 3 . 1 Animal and Poultry Sciences, University of Guelph, Guelph, ON, Canada, 2 Biomedical Sciences, University of Guelph, Guelph, ON, Canada and 3 Alltech, Guelph, ON, Canada. #683 Poster Board Number.....................................633 EFFECT OF ASBESTOS EXPOSURE ON PRODUCTION OF CYTOKINES, APOPTOSIS, AND CELL PROLIFERATION RELATED WITH DIFFERENTIATION OF HUMAN CTL. N. Kumagai, Y. Nishimura, M. Maeda, H. Hayashi and T. Otsuki. Hygiene, Kawasaki Medical School, Kurashiki, Japan. #684 Poster Board Number.....................................634 1, 3-DIBROMOPROPANE UP-REGULATES INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION VIA NF-KB ACTIVATION IN MACROPHAGES. J. Yang 1 , E. Han 1 , J. Im 1 , K. Lee 2 , T. Jeong 3 and H. Jeong 1 . 1 Pharmacy, Chungnam National University, Daejeon, Republic of Korea, 2 Pharmacy, Chonnam National University, Gwangju, Republic of Korea and 3 Pharmacy, Yeungnam University, Kyungsan, Republic of Korea. #685 Poster Board Number.....................................635 SYNERGISM OF LEPTIN SIGNALING AND POST TRANSLATIONAL PROTEIN OXIDATION IN BROMODICHLOROMETHANE EXPOSURE IS KEY TO THE DEVELOPMENT OF STEATOHEPATITIS OF OBESITY. S. Chatterjee, J. Clark, M. Kadiiska and R. P. Mason. Laboratory of Toxicology and Pharmacology, NIEHS, Research Triangle Park, NC. #686 Poster Board Number.....................................636 EFFECT OF LEAD EXPOSURE ON THE MACROPHAGES ACTIVATION THROUGH TLR4. A. L. Luna 1,2 , N. A. Torres-Aviles 1 , L. C. Acosta-Saavedra 1 , E. K. Silbergeld 3 and E. S. Calderon-Aranda 1 . 1 Department Toxicologia, Cinvestav, Mexico, Mexico, 2 Biomedicina Molecular, ENMH-IPN, Mexico, Mexico and 3 BSPH, Johns Hopkins University, Baltimore, MD. #687 Poster Board Number.....................................637 CONTINUOUS AND LOW-DOSE EXPOSURE TO ASBESTOS ENHANCES TGF-β1 PRODUCTION IN A HUMAN ADULT T CELL LEUKEMIA VIRUS-IMMORTALIZED T CELL LINE, MT-2. T. Otsuki, M. Maeda, N. Kumagai, N. Miyahara, M. Katoh, S. Yamamoto, T. Hatayama and Y. Nishimura. Hygiene, Kawasaki Medical School, Kurashiki, Japan. #688 Poster Board Number.....................................638 EFFECT OF VIBRIO VULNIFICUS LIPOPOLYSACCHARIDE (LPS) ON RAT BRAIN MICROGLIA: CYTOKINE AND CHEMOKINE EXPRESSION PROFILING BY ANTIBODY ARRAY TECHNOLOGY. L. D. Ottenhoff 1 , N. Patel 1 , M. L. Hall 1 , K. B. Glaser 2,1 , P. B. Jacobson 2 , D. Rowley 3 , C. De Castro 4 , A. Molinaro 4 and A. M. Mayer 1 . 1 Pharmacology, Midwestern University, Downers Grove, IL, 2 Abbott Laboratories, Chicago, IL, 3 Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI and 4 Chimica Organica e Biochimica, Università di Napoli Federico II, Naples, Italy. #689 Poster Board Number.....................................639 ENHANCED SUPPRESSIVE FUNCTION ON REGULATORY T CELL-LIKE CELL LINE, MT-2, BY CONTINUOUS EXPOSURE TO ASBESTOS. M. Maeda 1 , Y. Chen 1 , Y. Nishimura 1 , N. Kumagai 1 , H. Hayashi 1 , Y. Miura 2 and T. Otsuki 1 . 1 Hygiene, Kawasaki Medical School, Kurashiki, Okayama, Japan and 2 Molecular Genetics, Kyushu University, Fukuoka, Japan. #690 Poster Board Number.....................................640 HISTONE DEACETYLASES PLAY A CRITICAL ROLE IN REGULATING IFNα- MEDIATED ANTI-HCV GENE EXPRESSION. S. Mathews 1 , S. Joshi-Barve 1 , C. McClain 1,2 and S. Barve 1 . 1 Department of Medicine/GI, University of Louisville, Louisville, KY and 2 Robley Rex Veterans Administration Medical Center, Louisville, KY. #691 Poster Board Number.....................................641 ZIRAM INDUCES APOPTOSIS IN HUMAN IMMUNE CELLS. Q. Li, M. Kobayashi and T. Kawada. Nippon Medical School, Tokyo, Japan. #692 Poster Board Number.....................................642 ENHANCEMENT OF HUMORAL IMMUNITY BY THE ENDOCRINE DISRUPTER PROPANIL IS NOT ALTERED BY NEONATAL ANDROGEN TREATMENT. R. Schafer 1 , S. Hileman 2 , R. Goodman 2 and I. Holaskova 1 . 1 Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV and 2 Physiology and Pharmacology, West Virginia University, Morgantown, WV. #693 Poster Board Number.....................................643 ASBESTOS EXPOSURE CAUSES DECREASE IN PRODUCTION OF CYTOKINES RELATED TO NK CELL ACTIVATION. Y. Nishimura, N. Kumagai, M. Maeda, H. Hayashi and T. Otsuki. Hygiene, Kawasaki Medical School, Kurashiki, Japan. 174 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #694 Poster Board Number.....................................644 IFN PRODUCTION BY RESTIMULATED NRF2-NULL T CELLS IS MODULATED BY PRESENCE OF WILD-TYPE ANTIGEN- PRESENTING CELLS. C. E. Rockwell 1 , P. E. Fields 2 and C. D. Klaassen 1 . 1 Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS and 2 Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS. #695 Poster Board Number.....................................645 TBTO INHIBITS MTOR SIGNALING IN HUMAN T CELLS, A NOVEL PUTATIVE IMMUNOTOXIC MECHANISM OF TBTO. O. L. Volger 1 , J. Shao 1 , A. A. Peijnenburg 1 and H. van Loveren 2 . 1 Toxicology and Effect Monitoring, RIKILT Institute of Food Safety, Wageningen, Netherlands and 2 Laboratory for Health Protection Research, National Institute of Public Health and the Environment, Bilthoven, Netherlands. #696 Poster Board Number.....................................646 CHARACTERIZATION OF ACUTE EFFECTS OF METHYLISOTHIOCYANATE (MITC) IN AN IN VITRO AND AN IN VIVO MODEL. W. Tan, B. Jan, X. Deng and S. Pruett. Department of Basic Sciences, Mississippi State University, Mississippi State, MS. #697 Poster Board Number.....................................647 SODIUM METHYLDITHIOCARBAMATE- INDUCED OXIDATIVE STRESS ON NF-KAPPAB REPORTER MICE. M. Gadson, W. Tan, X. Deng and S. Pruett. Department of Basic Sciences, Mississippi State University, Mississippi State, MS. #698 Poster Board Number.....................................648 IMMUNOMODULATORY ROLES OF THE PROKARYOTIC METALLOTHIONEIN. K. Pietrosimone 1 , S. Davis 1 , D. Laukens 2 , D. A. Lawrence 3 and M. Lynes 1 . 1 University of Connecticut, Storrs, CT, 2 University of Ghent, Ghent, Belgium and 3 Wadsworth Laboratory, Albany, NY. Monday Afternoon, March 7 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Biological Modeling: Computational Approaches, Mixtures, Multiroute and Lifestage Applications Chairperson(s): Andy Nong, Health Canada, Ottawa, Ontario, Canada, and John Wambaugh, U.S. EPA, Research Triangle Park, NC. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #699 Poster Board Number.....................................701 PROGRESS IN DEVELOPMENT OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS FOR PAHS. S. R. Crowell 1 , J. Soelberg 1 , S. G. Amin 2 , K. A. Anderson 3 , D. E. Williams 3 and R. A. Corley 1 . 1 Pacific Northwest National Laboratory, Richland, WA, 2 Penn State College of Medicine, Hershey, PA and 3 Oregon State University, Corvallis, OR. Abstract # #700 Poster Board Number.....................................702 DOSIMETRY ASSESSMENT OF SILOXANES IN COSMETIC PRODUCTS USING PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING. A. Nong, R. Wang and J. Zhu. Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. #701 Poster Board Number.....................................703 PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF MANGANESE EXPOSURE IN HUMANS DURING FETAL AND NEONATAL DEVELOPMENT. M. Yoon 1 , J. D. Schroeter 1 , A. Nong 1 , M. Taylor 2 , D. C. Dorman 1,3 , M. E. Andersen 1 and H. J. Clewell 1 . 1 The Hamner Institutes for Health Sciences, Durham, NC, 2 Afton Chemical, Richmond, VA and 3 North Carolina State University, Raleigh, NC. #702 Poster Board Number.....................................704 A BBDR-HPT AXIS MODEL FOR THE LACTATING RAT AND NURSING PUP: EVALUATION OF IODIDE DEFICIENCY. S. Li 1 , M. E. Gilbert 2 , R. T. Zoeller 3 , K. M. Crofton 2 , E. D. McLanahan 4 , D. R. Mattie 5 , B. C. Blount 6 , L. Valentin-Blasini 6 , K. Kurunthachalam 7 , T. Kunisue 7 and J. W. Fisher 1 . 1 College of Public Health, University of Georgia, Athens, GA, 2 NHEERL, U.S. EPA, Research Triangle Park, NC, 3 Biology Department, University of Massachusetts, Amherst, MA, 4 NCEA, U.S. EPA, Research Triangle Park, NC, 5 711 HPW/RHPBA, Wright-Patterson AFB, OH, 6 CCEHIP/NCEH, CDC, Atlanta, GA and 7 Wadsworth Center, New York State Department of Health, Albany, NY. #703 Poster Board Number.....................................705 AGE-DEPENDENT METABOLISM OF CHLOPYRIFOS AND CHLORPYRIFOS- OXON IN HUMAN PLASMA AND HEPATIC MICROSOMES. T. S. Poet 1 , C. Timchalk 1 , M. J. Bartels 2 and J. N. Smith 1 . 1 Biological Monitoring & Modeling, Battelle, Pacific Northwest Division, Richland, WA and 2 The Dow Chemical Company, Midland, MI. #704 Poster Board Number.....................................706 DEVELOPMENT OF A LIFESTAGE PHYSIOLOGICALLY BASED PHARMACOKINETIC AND PHARMACODYNAMIC (PBPK/PD) MODEL FOR CHLORPYRIFOS IN RATS AND HUMANS. J. N. Smith 1 , P. M. Hinderliter 1 , C. Timchalk 1 , M. J. Bartels 2 and T. S. Poet 1 . 1 Biological Monitoring & Modeling, Battelle, Pacific Northwest Division, Richland, WA and 2 The Dow Chemical Company, Midland, MI. #705 Poster Board Number.....................................707 EFFECT OF PARAMETER VARIABILITY AND UNCERTAINTY IN A LIFESTAGE PBPK MODEL FOR CHLORPYRIFOS. P. M. Hinderliter 1 , J. N. Smith 1 , M. J. Bartels 2 , P. S. Price 2 and T. S. Poet 1 . 1 Biological Monitoring & Modeling, Battelle, Pacific Northwest Division, Richland, WA and 2 The Dow Chemical Company, Midland, MI. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 175
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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