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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Afternoon, March 8 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Mutagenecity Chairperson(s): Leslie Recio, ILSIntegrated Laboratory Systems Inc., Research Triangle Park, NC. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #1403 Poster Board Number.....................................301 GENOTOXICITY AND PRE- NEOPLASTIC LESIONS INDUCED BY 2, 4-DIAMINOTOLUENE IN THE LIVER OF F344 GPT DELTA TRANSGENIC RATS. T. Nohmi 1 , N. Toyoda-Hokaiwado 1 , T. Inoue 2 , K. Masumura 1 , H. Hayashi 3 , Y. Kawamura 3 , Y. Kurata 3 , M. Takamune 1 , M. Yamada 1 , H. Sanada 4 , T. Umemura 2 and A. Nishikawa 2 . 1 Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagata, Tokyo, Japan, 2 Division of Pathology, National Institute of Health Sciences, Setagata, Tokyo, Japan, 3 Meiji Seika Kaisha, Ltd., Yokohama, Kanagawa, Japan and 4 Safety Research Department, Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Fujieda, Shizuoka, Japan. #1404 Poster Board Number.....................................302 CHEMOPREVENTIVE EFFECTS OF SILYMARIN ON 1, 2-DIMETHYLHYDRAZINE-INDUCED MUTAGENESIS AND CARCINOGENESIS IN THE COLON OF GPT DELTA TRANSGENIC RATS. K. Masumura 1 , N. Toyoda-Hokaiwado 1 , Y. Yasui 2 , M. Muramatsu 1,3 , M. Takamune 1 , M. Yamada 1 , T. Tanaka 4 and T. Nohmi 1 . 1 Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan, 2 School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, 3 Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan and 4 Tohkai Cytopathology Institute, Gifu, Japan. Sponsor: A. Nishikawa. #1405 Poster Board Number.....................................303 EXAMINING THE MUTAGENICITY OF ETHYL METHANESULFONATE IN MICE USING THE PIG-A, HPRT, AND GPT DELTA ASSAYS. X. Cao, J. G. Shaddock, R. A. Mittelstaedt, V. N. Dobrovolsky, S. D. Shelton, M. Manjanatha and R. H. Heflich. DGMT, NCTR /U.S. FDA, Jefferson, AR. Sponsor: T. Chen. #1406 Poster Board Number.....................................304 MANIFESTATION AND PERSISTENCE OF PIG-A MUTANT FREQUENCY IN C57BL/6 MICE TREATED WITH DIFFERENT DOSES OF ENU. J. A. Bhalli, M. G. Pearce, V. N. Dobrovolsky and R. H. Heflich. NCTR, U.S. FDA, Jefferson, AR. Sponsor: B. Parsons. #1407 Poster Board Number.....................................305 NITROXIDES TEMPO AND TEMPOL INDUCE TK MUTATIONS IN MOUSE LYMPHOMA CELLS. X. Guo 1 , L. Guo 2 , M. M. Moore 1 and N. Mei 1 . 1 Division of Genetic and Molecular Toxicology, NCTR /U.S. FDA, Jefferson, AR and 2 Division of Biochemical Toxicology, NCTR /U.S. FDA, Jefferson, AR. #1408 Poster Board Number.....................................306 GENOTOXICITY OF 3, 5-DIMETHYLANILINE AND ITS METABOLITES. M. Chao, L. J. Trudel and G. N. Wogan. Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA. #1409 Poster Board Number.....................................307 COMPARISON OF THE BACTERIAL MUTAGENICITY OF MAINSTREAM WHOLE SMOKE FROM CIGARETTES WITH DIFFERENT LEVELS OF MENTHOL. R. Leverette. Lorillard, Greensboro, NC. #1410 Poster Board Number.....................................308 A NOVEL IN VITRO SYSTEM FOR THE TOXICOLOGICAL EVALUATION OF GENOTOXIC COMPOUNDS. S. O. Mueller, K. Boehme, Y. Dietz and P. G. Hewitt. Toxicology, Merck KGaA, Darmstadt, Germany. #1411 Poster Board Number.....................................309 COMPARATIVE MUTAGENICITY OF CYCLOPHOSPHAMIDE IN F344 MALE RATS USING THE PIG-A AND HPRT ASSAYS. V. N. Dobrovolsky, J. G. Shaddock, M. Pearce and R. H. Heflich. NCTR, Jefferson, AR. Sponsor: B. Parsons. #1412 Poster Board Number.....................................310 INTERNATIONAL, INTERLABORATORY PIG-A MUTATION ASSAY TRIAL: EVALUATION OF TRANSFERABILITY. S. Dertinger 1 , S. Phonethepswath 1 , P. Weller 1 , L. Stankowski 2 , D. Roberts 2 , J. Shi 3 , L. Krsmanovic 3 , H. Vohr 4 , L. Custer 5 , C. Gleason 5 , A. Henwood 5 , K. Sweder 5 , A. Giddings 6 , A. Lynch 6 , W. Gunther 7 , C. Thiffeault 7 , T. Shutsky 7 , R. Fiedler 7 , J. Bhalli 8 , R. Heflich 8 , J. Nicolette 9 , P. Sonders 9 , J. Murray 9 , T. Kimoto 10 and J. MacGregor 11 . 1 Litron Laboratories, Rochester, NY, 2 Covance Laboratories, Vienna, VA, 3 BioReliance, Rockville, MD, 4 Bayer Schering Pharmacology AG, Wuppertal, Germany, 5 Bristol- Myers Squibb, Syracuse, NY, 6 GlaxoSmithKline, Ware, United Kingdom, 7 Pfizer Global R&D, Groton, CT, 8 U.S. FDA NCTR, Jefferson, AR, 9 Abbott Laboratories, Abbott Park, IL, 10 Teijin Pharmacology Tokyo, Japan and 11 Toxicology Consulting Services, Arnold, MD. #1413 Poster Board Number.....................................311 TOXICOLOGICAL CHARACTERIZATION OF DIESEL ENGINE EMISSIONS USING BIODIESEL AND A CLOSED SOOT FILTER. I. M. Kooter, M. A. van Vugt, A. D. Jedynska, R. P. Verbeek and C. A. Krul. TNO, Utrecht, Netherlands. Sponsor: R. Woutersen. #1414 Poster Board Number.....................................312 IN VITRO PREDICTIONS OF IN VIVO GENOTOXICITY ARE BETTER THAN PREDICTIONS OF CARCINOGENICITY. R. Walmsley 1,2 . 1 Life Sciences, University of Manchester, Manchester, United Kingdom and 2 Gentronix Ltd., Manchester, United Kingdom. 240 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1415 Poster Board Number.....................................313 CYTOTOXICITY AND GENE EXPRESSION ALTERATIONS FOLLOWING TREATMENT OF TK6 CELLS WITH ETOPOSIDE AND SODIUM CHLORIDE. Y. Chen 1 , M. M. Moore 1 and J. C. Fuscoe 2 . 1 Division of Genetic and Molecular Toxicology, U.S. FDA NCTR, Jefferson, AR and 2 Division of Systems Biology, U.S. FDA NCTR, Jefferson, AR. #1416 Poster Board Number.....................................314 PIG-A MUTATION AND MICRONUCLEATED RETICULOCYTE ASSAYS DISCRIMINATE THE MUTAGENIC/ NON-MUTAGENIC PAIR: BENZO[A] PYRENE/PYRENE. D. Torous 1 , J. MacGregor 2 , S. Phonethepswath 1 , P. Weller 1 , J. Bemis 1 and S. Dertinger 1 . 1 Litron Laboratories, Rochester, NY and 2 Toxicology Consulting Services, Arnold, MD. #1417 Poster Board Number.....................................315 THE MUTAGENIC POTENTIAL OF CIS-2- BUTENE-1, 4-DIAL. A. Terrell 1 , M. Huynh 2 and L. A. Peterson 1,3 . 1 Environmental Health Sciences, University of Minnesota, Minneapolis, MN, 2 Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN and 3 Masonic Cancer Center, University of Minnesota, Minneapolis, MN. #1418 Poster Board Number.....................................316 THE METABOLITES OF THE AZO DYE DISPERSE RED 1 CAN REPRESENT HUMAN RISKS CONSIDERING THE INGESTION OF CONTAMINATED WATER AND FOOD. F. D. Chequer 1 , T. M. Lizier 2 , M. B. Zanoni 2 , R. Marcos 3 and D. P. Oliveira 1 . 1 Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil, 2 (2) Universidade Paulista Júlio de Mesquita Filho, Araraquara, São Paulo, Brazil and 3 (3) Universitat Autònoma de Barcelona, Barcelona, Spain. #1419 Poster Board Number.....................................317 MUTATION SPECTRUM IN HPRT-/ GPT+ V79 CELLS TREATED WITH TEAK WOOD EXTRACT AND 2-METHYLANTHRAQUINONE, AN ABUNDANT BIQUINONE IN TEAK WOOD. M. J. Wilson 1 , C. Miller 1,2 , G. Sabbioni 1,2 and R. Rando 1 . 1 Environmental Health Sciences, Tulane University, New Orleans, LA and 2 Tulane Cancer Center, Tulane University, New Orleans, LA. #1420 Poster Board Number.....................................318 GENOTOXICITY ASSESSMENT OF ETHYLENEDIAMINE DINITRATE (EDDN) AND DIETHYLENETRIAMINE TRINITRATE (DETN). G. Reddy 1 , J. Song 2 , P. Kirby 2 and M. S. Johnson 1 . 1 Directorate of Toxicology, U.S. Army Public Health Command, Aberdeen Proving Ground, MD and 2 SITEK Research Laboratories, Rockville, MD. #1421 Poster Board Number.....................................319 DOSE-RESPONSE OF NAPHTHALENE– INDUCED GENOTOXICITY AND GLUTATHIONE DETOXIFICATION IN HUMAN TK6 LYMPHOBLASTS. L. Recio 1 , K. Shepard 1 , C. Swartz 1 and G. Kedderis 2 . 1 ILS, Research Triangle Park, NC and 2 Consultant, Chapel Hill, NC. Abstract # #1422 Poster Board Number.....................................320 DIMETHYLSULFOXIDE (DMSO) INHIBITION OF NAPHTHALENE-INDUCED CYTOTOXICITY AND GENOTOXICITY IN HUMAN TK6 CELLS. K. Shepard 1 , G. Kedderis 2 , C. Swartz 1 and L. Recio 1 . 1 ILS, Research Triangle Park, NC and 2 Consultant, Chapel Hill, NC. Tuesday Afternoon, March 8 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Methods in Biomarker Discovery and Validation Chairperson(s): Michael Dunn, Roche, Nutley, NJ. Displayed: 1:00 PM–4:30 PM Author Attended: 2:45 PM–4:30 PM #1423 Poster Board Number.....................................331 IN VIVO MRI OF RAT THYROID GLANDS AND CORRELATION WITH HISTOPATHOLOGY. M. Stephan-Gueldner, B. Kuenekke, B. Lenz, A. Braendli-Baiocco, J. Funk, M. vonKienlin and T. Pfister. F. Hoffmann-La Roche AG, Basel, Switzerland. #1424 Poster Board Number.....................................332 INTERPRETATION OF NHANES VOC BLOOD DATA USING HEALTH-BASED SCREENING VALUES. L. L. Aylward 1 , B. Blount 2 , D. Pyatt 3 , C. Kirman 4 and S. Hays 5 . 1 Summit Toxicology, LLP, Falls Church, VA, 2 Centers for Disease Control and Prevention, Atlanta, GA, 3 Summit Toxicology, LLP, Superior, Co., 4 Summit Toxicology, LLP, Orange Village, OH and 5 Summit Toxicology, LLP, Lyons, CO. #1425 Poster Board Number.....................................333 THE UTILITY OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AND KIDNEY INJURY MOLECULE-1 FOR DETECTION AND SCREENING OF NEPHROTOXIC AGENTS IN PRECLINICAL DRUG DEVELOPMENT. D. Kitchel, D. Ackley, A. McGuinty, T. Magee, W. J. Raegan and J. Aubrecht. Drug Safety Research and Development, Pfizer Inc., Groton, CT. #1426 Poster Board Number.....................................334 SERUM LEVELS OF THE PHOSPHOLIPID BIS(MONOACYLGLYCEROL) PHOSPHATE AS AN INDICATOR OF PHOSPHOLIPIDOSIS INDUCED IN THE RAT BY CORALGIL. K. Thompson 1 , K. Haskins 1 , N. Hartman 2 , B. Rosenzweig 1 , S. Stewart 1 , D. Peters 1 , D. Mans 3 and T. Colatsky 1 . 1 DAPR, CDER, U.S. FDA, Silver Spring, MD, 2 LCP, CDER, U.S. FDA, Silver Spring, MD and 3 DPA, CDER, U.S. FDA, St. Louis, MO. #1427 Poster Board Number.....................................335 INVESTIGATION OF PREDICTIVE GASTROINTESTINAL TOXICITY BIOMARKERS FOR ONCOLOGY DRUG DEVELOPMENT IN RATS. W. Huang 1 , W. Scott 1 , M. Twamley 1 , E. Kindt 2 , A. Wu 2 , A. Sacaan 1 , A. Vitsky 1 and A. John-Baptiste 1 . 1 Drug Safety, Pfizer Global Research and Development, San Diego, CA and 2 PDM, Pfizer Global Research and Development, San Diego, CA. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 241
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Celebration Event Floor Plan Ba
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Program
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 Abstract
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Endowmen
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Society of Toxicology 2011 SOT Affi
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