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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #706 Poster Board Number.....................................708 DEVELOPMENT OF HUMAN GESTATION AND LACTATION PBPK MODELS FOR PERFLUOROOCTANOATE (PFOA) AND PERFLUOROOCTANESULFONATE (PFOS). A. E. Loccisano 1 , M. E. Andersen 1 , J. Butenhoff 2 and H. J. Clewell 1 . 1 The Hamner Institutes for Health Sciences, Research Triangle Park, NC and 2 3M Corporation, St. Paul, MN. #707 Poster Board Number.....................................709 LIFE-STAGE PBPK MODELS FOR MULTIPLE ROUTES OF ETHANOL EXPOSURE IN THE RAT. S. A. Martin 1,7 , J. L. Campbell 2 , K. Choi 2 , H. J. Clewell 2 , H. El-Masri 3,7 , W. R. LeFew 3,7 , T. E. Beasley 1,7 , W. M. Oshiro 1,7 , L. L. Degn 1,7 , P. A. Evansky 4,7 , A. Ledbetter 4,7 , J. Ford 5,7 , D. W. Herr 1,7 , W. K. Boyes 1,7 , P. J. Bushnell 1,7 and E. D. McLanahan 6,7 . 1 NB/TAD/NHEERL/ORD, Research Triangle Park, NC, 2 The Hamner Institutes for Health Sciences, Research Triangle Park, NC, 3 SBB/ISTD/NHEERL/ORD, Research Triangle Park, NC, 4 ITFB/EPHD/NHEERL/ORD, Research Triangle Park, NC, 5 ACRC/RCU/NHEERL/ORD, Research Triangle Park, NC, 6 NCEA/ORD, Research Triangle Park, NC and 7 U.S. EPA, Research Triangle Park, NC. #708 Poster Board Number.....................................710 ANALYSIS OF BISPHENOL A KINETICS AND METABOLISM IN NEONATAL AND ADULT MONKEYS AND RATS USING A PBPK MODEL. J. Fisher, N. C. Twaddle, M. Vanlandingham and D. R. Doerge. Biochemical Toxicology Division, U.S. FDA NCTR, Jefferson, AR. #709 Poster Board Number.....................................711 PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING (PBPK) AS A TOOL TO PREDICT 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) PHARMACOKINETICS (PK) DURING GESTATION AND LACTATION. C. Emond 1,2 , M. J. Devito 3 , M. Warner 4 , B. Eskenazi 4 , P. Mocarelli 5 and L. S. Birnbaum 6 . 1 BioSimulation Consulting Inc., Newark, DE, 2 University of Montréal, Montréal, QC, Canada, 3 NIEHS & NTP, Research Triangle Park, NC, 4 School of Public Health, University of California, Berkeley, CA, 5 Department of Laboratory Medicine, University of Milano-Bicocca, School of Medicine, Hospital of Desio, Desio, Desio-Milano, Italy and 6 NCI & NIEHS, Research Triangle Park, NC. #710 Poster Board Number.....................................712 DEVELOPMENT OF PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL TO PREDICT TULATHROMYCIN DISTRIBUTION IN GOATS. T. L. Leavens 1 , L. A. Tell 2 , K. A. Clothier 2 , R. W. Griffith 3 , R. E. Baynes 1 and J. E. Riviere 1 . 1 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, 2 Department of Medicine and Epidemiology, University of California Davis, CA and 3 Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA. #711 Poster Board Number.....................................713 APPLICATION OF A MULTIROUTE HUMAN PBPK MODEL FOR BROMODICHLOROMETHANE (BDCM). E. M. Kenyon 1 , T. L. Leavens 2 , C. Eklund 1 and R. A. Pegram 1 . 1 ORD/NHEERL/ISTD, U.S. EPA, Durham, NC and 2 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #712 Poster Board Number.....................................714 A PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) TOOL KIT TO EVALUATE EXPOSURES TO ENVIRONMENTAL POLLUTANTS. M. Mumtaz 1 , P. Ruiz 1 , M. Ray 2 , J. Fisher 3 and S. Hays 4 . 1 Department of Toxicology and Environmental Medicine, ATSDR, Atlanta, GA, 2 University of South Carolina, Columbia, SC, 3 U.S. FDA, National Center for Toxicological Research, Jefferson, AR and 4 Summit Toxicology Inc., Lyons, CO. #713 Poster Board Number.....................................715 DERIVATION OF CHEMICAL-SPECIFIC ADJUSTMENT FACTORS FOR HUMAN VARIABILITY IN TOXICOKINETICS OF ACETONE. G. Johanson and A. Mörk. Work Environment Toxicology, Karolinska Institute, Stockholm, Sweden. #714 Poster Board Number.....................................716 PRIORITIZING TOXCAST CHEMICALS ACROSS MULTIPLE SECTORS OF TOXICITY USING TOXPI. D. Reif, M. Martin, M. Holly, S. Gangwal, A. Wang, R. Judson, P. Volarath, R. Kavlock and D. Dix. National Center for Computational Toxicology, U.S. EPA, Durham, NC. #715 Poster Board Number.....................................717 INTEGRATION OF HIGH-THROUGHPUT SCREENING DATA WITH DOSIMETRY AND HUMAN EXPOSURE IN THE TOXICITY ASSESSMENT OF ENVIRONMENTAL CHEMICALS. B. A. Wetmore 1 , J. F. Wambaugh 2 , D. M. Rotroff 2,3 , H. J. Clewell 1 , M. E. Andersen 1 , S. Ferguson 4 , D. J. Dix 2 and R. S. Thomas 1 . 1 The Hamner Institutes for Health Sciences, Research Triangle Park, NC, 2 National Center for Computational Toxicology, U.S. EPA, Research Triangle Park, NC, 3 Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC and 4 Life Technologies, Inc., Durham, NC. #716 Poster Board Number.....................................718 A BIOLOGICALLY INFORMED FRAMEWORK FOR THE ANALYSIS OF THE PPAR SIGNALING PATHWAY USING A BAYESIAN NETWORK. A. Beam 1,2 , W. John 1 , R. Setzer 1 , K. Houck 1 , S. Imran 1 , D. Dix 1 and R. Judson 1 . 1 U.S. EPA/ORD/NCCT, Research Triangle Park, NC and 2 Statistics, North Carolina State University, Raleigh, NC. #717 Poster Board Number.....................................719 MODELING REPRODUCTIVE TOXICITY FOR CHEMICAL PRIORITIZATION INTO AN INTEGRATED TESTING STRATEGY. M. T. Martin, T. Knudsen, K. Houck, R. Judson, R. Kavlock and D. Dix. NCCT, U.S. EPA, Research Triangle Park, NC. 176 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #718 Poster Board Number.....................................720 BIOLOGICALLY-BASED LUMPING METHODOLOGY (BBLM) TO INVESTIGATE TOXICOLOGICAL INTERACTIONS OF COMPLEX CHEMICAL MIXTURES. W. LeFew and H. El-Masri. U.S. EPA, Durham, NC. #719 Poster Board Number.....................................721 A PBPK MODEL OF MICRO AND NANO SIZED FLUORESCENT POLYSTYRENE SPHERES IN RATS. X. Chang 1 , K. Sarlo 2 , N. Walker 1 , K. Blackburn 2 , E. Clark 2 , J. Grothaus 2 and C. Portier 1 . 1 NIEHS, Reseach Triangle Park, NC and 2 Miami Valley Laboratories, Procter & Gamble, Cincinnati, OH. #720 Poster Board Number.....................................722 PHARMACOKINETICS-ENABLED REVERSE DOSIMETRY APPROACH IMPROVES THE ACCURACY OF BISPHENOL A (BPA) EXPOSURE ASSESSMENT. R. Gunawan and J. Teeguarden. Biological Monitoring/Modeling, Pacific Northwest National Laboratory, Richland, WA. #721 Poster Board Number.....................................723 A SHOW OF HANDS FOR MODERN RISK ASSESSMENT: SPECIES-TO-SPECIES EXTRAPOLATIONS OF STEREOISOMERIC MIXTURES WITH PROVISIONAL PBPK MODELS. R. Goldsmith 1 , J. Kenneke 2 , C. Mazur 2 , D. Chang 1 , Y. Tan 1 , R. Tornero-Velez 1 , C. Dary 3 and E. Ulrich 1 . 1 U.S. EPA, Durham, NC, 2 U.S. EPA, Athens, GA and 3 U.S. EPA, Las Vegas, NV. #722 Poster Board Number.....................................724 MARKOV CHAIN MONTE CARLO ANALYSIS OF RAT TISSUE:AIR PARTITION COEFFICIENTS. T. Peyret and K. Krishnan. Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montréal, QC, Canada. #723 Poster Board Number.....................................725 INTEGRATED KNOWLEDGE-DRIVEN IN SILICO WORKFLOW IN SUPPORT OF PBPK/PD MODEL DEVELOPMENT: ESTABLISHING PRIORS FOR PYRETHROID CLASS INSECTICIDES. X. Zhang 1 , D. Chang 2 , R. Goldsmith 2 , J. B. Knaak 3 , C. Tan 2 , R. Tornero-Velez 2 , J. Johnson 4 and C. C. Dary 4 . 1 General Dynamics Information Technology, Henderson, NV, 2 NERL, U.S. EPA, Research Triangle Park, NC, 3 Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY and 4 NERL, U.S. EPA, Las Vegas, NV. #724 Poster Board Number.....................................726 GROUPING OF CHEMICALS IN THE 21 ST CENTURY: A BIOLOGY BASED APPROACH USING METABOLOMICS. B. van Ravenzwaay 2 , M. Herold 1 , H. Kamp 2 , M. Kapp 2 , E. Fabian 2 , R. Looser 1 , G. Krennrich 2 , W. Mellert 2 , A. Prokoudine 1 , V. Strauss 2 , T. Walk 1 and J. Wiemer 1 . 1 Metanomics GmbH, Berlin, Germany and 2 Experimental Toxicology, BASF SE, Ludwigshafen, Germany. Sponsor: R. David. Abstract # #725 Poster Board Number.....................................727 STATISTICAL APPROACHES TO ANALYZING A LARGE, MULTI- TREATMENT, TIME COURSE STUDY OF METAL PELLETS IMPLANTED INTO MOUSE MUSCLE: CLINICAL MEASUREMENTS AND PREDICTIVE MODELING. W. Bao 2 , C. Tsu-Ming 2 , R. D. Wolfinger 2 , E. J. Perkins 3 and D. I. Bannon 1 . 1 Directorate of Toxicology, U.S. Army Public Health Command, APG, Aberdeen, MD, 2 SAS Institute, Inc., Cary, NC and 3 Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS. #726 Poster Board Number.....................................728 UPDATED ALUMINUM PHARMACOKINETICS IN INFANTS FOLLOWING EXPOSURES THROUGH DIET AND VACCINATION. R. J. Mitkus, M. O. Walderhaug and M. Hess. U.S. FDA/CBER, Rockville, MD. #727 Poster Board Number.....................................729 ASSESSING THE ROBUSTNESS OF CHEMICAL PRIORITIZATIONS BASED ON TOXCAST CHEMICAL PROFILING. A. Wilson, S. Gangwal, M. Martin, R. Judson, D. Dix and D. Reif. National Center for Computational Toxicology, Office of Research and Development, U.S. EPA, Research Triangle Park, NC. #728 Poster Board Number.....................................730 TOXPLORER: A COMPREHENSIVE KNOWLEDGEBASE OF TOXICITY PATHWAYS USING ONTOLOGY-DRIVEN INFORMATION EXTRACTION. I. Shah 1 , A. Singh 2 , C. Haugh 1 , J. Jack 1 , R. Judson 1 , T. Knudsen 1 , M. Martin 1 and J. Wambaugh 1 . 1 NCCT, U.S. EPA, Research Triangle Park, NC and 2 Lockheed Martin, Research Triangle Park, NC. #729 Poster Board Number.....................................731 BELIEF THEORY IN MECHANISTIC PHARMACOVIGILANCE: USING THE BIOMEDICAL LITERATURE TO CONFIRM ADVERSE DRUG EVENT REPORTS FROM ELECTRONIC HEALTH RECORDS. E. Ahlberg Helgee and S. Boyer. Computational Toxicology, AstraZeneca and EU-ADR Consortium, Mölndal, Sweden. #730 Poster Board Number.....................................732 PREDICTING ADAPTIVE RESPONSE TO FADROZOLE EXPOSURE: COMPUTATIONAL MODEL OF THE FATHEAD MINNOWS HYPOTHALAMIC- PITUITARY-GONADAL AXIS. M. Breen 1,2 , D. Villeneuve 1 , G. Ankley 1 , K. Watanabe 3 , M. Breen 1 , A. Lloyd 2 and R. Conolly 1 . 1 U.S. EPA, Research Triangle Park, NC, 2 North Carolina State University, Raleigh, NC and 3 Oregon Health and Science University, Beaverton, OR. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 177
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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