Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Afternoon, March 8 1:30 PM to 4:15 PM Room 145 Platform Session: Chemical and Biological Weapons—Sulfur Mustard Effects Chairperson(s): JeanClare Seagrave, Lovelace Respiratory Research Institute, Albuquerque, NM, and Gunda Reddy, U.S. Army-CHPPM, Aberdeen Proving Ground, MD. #1748 1:30 MOLECULAR EVALUATION OF RABBIT CORNEAL OCULAR SULFUR MUSTARD INJURY: TOWARDS MECHANISMS OF PERSISTENT INJURY. D. Milhorn 2 , P. McNutt 1 , T. Hamilton 1 and R. Lawrence 1 . 1 USAMRICD, Aberdeen Proving Ground- Edgewood Area, MD and 2 Medical Research and Materiel Command, Fort Detrick, MD. Sponsor: G. Rockwood. #1749 1:49 INDUCTION OF AUTOPHAGY IN A MOUSE KERATINOCYTE CONSTRUCT MODEL BY THE VESICANT 2-CHLOROETHYL ETHYL SULFIDE; REGULATION BY MAP KINASES AND CAVEOLAE. A. T. Black 1 , R. P. Casillas 2 , D. E. Heck 3 , D. R. Gerecke 1 , D. L. Laskin 1 and J. D. Laskin 4 . 1 Rutgers University, Piscataway, NJ, 2 Battelle Biomedical Research Center, Columbus, OH, 3 New York Medical College, Valhalla, NY and 4 UMDNJ-RWJ Medical School, Piscataway, NJ. #1750 2:08 ROLE OF CAVEOLAE IN REGULATING EXPRESSION OF HSP27 AND HSP70 FOLLOWING EXPOSURE OF HUMAN AND MOUSE SKIN MODELS TO THE VESICANT 2-CHLOROETHYL ETHYL SULFIDE. J. D. Laskin 1 , A. T. Black 2 , P. J. Hayden 3 , R. P. Casillas 4 , D. E. Heck 5 , D. R. Gerecke 2 and D. L. Laskin 2 . 1 UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, 2 Rutgers University, Piscataway, NJ, 3 MatTek Corporation, Ashland, MA, 4 Batelle Memorial Institute, Columbus, OH and 5 New York Medical College, Valhalla, NY. #1751 2:27 SULFUR MUSTARD VAPORS INDUCE DNA DAMAGE AND APOPTOSIS IN MOUSE SKIN. L. B. Joseph 1 , D. R. Gerecke 1 , A. T. Black 1 , R. P. Casillas 2 , N. D. Heindel 3 , P. J. Sinko 1 , D. E. Heck 4 , D. L. Laskin 1 and J. D. Laskin 5 . 1 Rutgers University, Piscataway, NJ, 2 Battelle, Columbus, OH, 3 Lehigh University, Bethlehem, PA, 4 New York Medical College, Valhalla, NY and 5 UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. #1752 2:45 MECHANISMS OF VESICANT-INDUCED CYTOTOXICITY IN LUNG EPITHELIAL CELLS. Y. Wang 1 , D. E. Heck 3 , D. L. Laskin 2 and J. D. Laskin 1 . 1 Environmental & Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, 2 Pharmacology & Toxicology, Rutgers University, Piscataway, NJ and 3 Environmental Health Sciences, New York Medical College, Valhalla, NY. #1753 3:03 HOUSEKEEPING GENE EXPRESSION IN NORMAL HUMAN EPIDERMAL KERATINOCYTES IS ALTERED BY SULFUR MUSTARD EXPOSURE. S. L. Beach, J. F. Dillman and A. L. Ruff. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD. #1754 3:21 DEVELOPMENT OF A SULFUR MUSTARD NON-HUMAN PRIMATE INHALATION EXPOSURE MODEL. W. M. Weber, J. D. McDonald, L. F. Blair, M. R. Lehman, D. A. Kracko, C. Cox, M. Duncan, J. Baldwin, J. Seagrave, T. March and G. R. Grotendorst. Lovelace Respiratory Research Institute, Albuquerque, NM. #1755 3:39 A TOXICOLOGICAL, BIOCHEMICAL, AND PHYSIOLOGICAL ASSESSMENT OF LUNG AND SYSTEMIC INJURY IN RATS EXPOSED TO INHALED SULFUR MUSTARD ACROSS DOSE AND TIME. D. S. Olivera 1 , K. A. Whitten 2 , R. K. Kan 3 , J. L. Collins 1 , J. B. Simons 1 , A. M. Rodriguez 1 , C. M. Bowens 1 , A. M. Witriol 1 and A. M. Sciuto 1 . 1 Analytical Toxicology, USAMRICD, Gunpowder, MD, 2 Research Support, USAMRICD, Gunpowder, MD and 3 Research, USAMRICD, Gunpowder, MD. #1756 3:57 THERAPEUTIC EFFICACY OF CATALYTIC ANTIOXIDANT AEOL 10150 IN ATTENUATING SULFUR MUSTARD ANALOG 2-CHLOROETHYL ETHYL SULFIDE-INDUCED SKIN INJURY. N. Tewari-Singh 1 , A. K. Jain 1 , S. Inturi 1 , M. Gu 1 , C. Agarwal 1 , B. J. Day 2 , C. W. White 3 and R. Agarwal 1 . 1 Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, 2 Medicine, National Jewish Health, Denver, CO and 3 Pediatrics, National Jewish Health, Denver, CO. Tuesday Afternoon, March 8 1:30 PM to 4:15 PM Room 202A Platform Session: Nanotoxicology—Nanosilver Particulates Chairperson(s): David Barber, University of Florida, Gainesville, FL, and William Waissmann, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. #1757 1:30 NANOSILVER MOVEMENT THROUGH BIOLOGICAL BARRIERS RELATES TO PHYSICOCHEMICAL PROPERTIES. B. Veronesi 1 , N. Nazo 1 , A. Tennant 1 , S. Simmons 1 , B. Baruwati 2 and R. Varma 2 . 1 NHEERL-ISTD, U.S. EPA, Research Triangle Park, NC and 2 NRMRL- STD, U.S. EPA, Cincinnati, OH. #1758 1:51 TOXICITY, CELLULAR UPTAKE, AND DIFFERENTIATION OF HUMAN ADULT STEM CELLS EXPOSED TO SILVER NANOPARTICLES. M. E. Samberg 1,2 , E. G. Loboa 2 and N. A. Monteiro-Riviere 1,2 . 1 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina and 2 Joint Department of Biomedical Engineering at North Carolina State University and University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC. #1759 2:12 PULMONARY TOXICITY FOLLOWING INTRATRACHEAL INSTILLATION OF DISPERSED SILVER NANOPARTICLES IN RATS. J. R. Roberts 1 , R. S. Chapman 1 , S. Young 1 , A. Kenyon 1 , D. Schwegler-Berry 1 , A. B. Stefaniak 2 , B. T. Chen 1 and J. M. Antonini 1 . 1 HELD, NIOSH, Morgantown, WV and 2 DRDS, NIOSH, Morgantown, WV. 268 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1760 2:33 OPTIMIZATION OF HIGH-THROUGHPUT NANOMATERIAL DEVELOPMENTAL TOXICITY TESTING IN ZEBRAFISH EMBRYOS. A. Wang 1 , C. Matson 2 , S. Frady 1 , M. Arnold 2 , S. Padilla 3 , R. T. Di Giulio 2 and K. Houck 1 . 1 National Center for Computational Toxicology, U.S. EPA, Research Triangle Park, NC, 2 Center for the Environmental Implications of NanoTechnology, Duke University, Durham, NC and 3 ISTD, NHEERL, U.S. EPA, Research Triangle Park, NC. #1761 2:54 TOXICITY OF INTRANASALLY- ADMINISTERED SILVER NANOPARTICLES. M. Genter 1 , N. C. Newman 1 , H. G. Shertzer 1 , S. F. Ali 2 , S. M. Hussain 3 and B. Bolon 4 . 1 Environmental Health, University of Cincinnati, Cincinnati, OH, 2 Neurochemistry Laboratory, Division of Neurotoxicology, NCTR/U.S. FDA, Jefferson, AR, 3 Applied Biotechnology Branch, AFRL, Wright-Patterson AFB, Dayton, OH and 4 GEMpath, Longmont, CO. #1762 3:15 RECOVERY FROM SILVER NANOPARTICLE EXPOSURE-INDUCED LUNG FUNCTION CHANGES IN SPRAGUE- DAWLEY RATS. I. Yu 1 , J. Sung 2 , J. Ji 3 , K. Song 2 , J. Lee 1 , J. Lee 4 , J. Park 5 , H. Park 6 , C. Kang 1 and K. Ahn 7 . 1 Hoseo University, Asan, Republic of Korea, 2 Korea Conformity Laboratories, Incheon, Republic of Korea, 3 Samung Electronics, Ltd., Suwon, Republic of Korea, 4 Occupational Lung Diseases Institute, COMWEL, Ansan, Republic of Korea, 5 Chung-Ang University, Seoul, Republic of Korea, 6 Korea Research Institute of Standards and Science, Daejeon, Republic of Korea and 7 Hanyang University, Seoul, Republic of Korea. #1763 3:35 CLEARANCE OF ACCUMULATED SILVER AFTER CESSATION OF SILVER NANOPARTICLE (AGNP) EXPOSURE IN TISSUES OF SPRAGUE-DAWLEY RATS. J. Lee 1 , I. Yu 1 , Y. Kim 2 , K. Song 3 , H. Ryu 3 , J. Sung 3 , M. Kwon 1 , J. Park 4 , J. Lee 5 , H. Park 6 , C. Kang 1 and D. Marshak 7 . 1 Hoseo University, Asan, Republic of Korea, 2 KT&G, Daejeon, Republic of Korea, 3 Korea Conformity Laboratories, Incheon, Republic of Korea, 4 Chung-Ang University, Seoul, Republic of Korea, 5 Occupational Lung Diseases Institute, COMWEL, Ansan, Republic of Korea, 6 Korea Research Institute of Standards and Science, Daejeon, Republic of Korea and 7 PerkinElmer, Boston, MA. #1764 3:55 PREMATURE CELLULAR SENESCENCE- INDUCED BY NANOPARTICLE EXPOSURE: A NOVEL APPROACH TO NANOTOXICITY TESTING. D. Ellis and S. Hussain. Air Force Research Laboratory 711 HPW/RHPBA, Wright- Patterson AFB, OH. Tuesday Afternoon, March 8 2:15 PM to 3:15 PM Room 140B Exhibitor Hosted Session: Automated GLP Infusion Studies: Improved Process Quality and Labor Utilization Presented by: Instech Solomon GLP infusion studies, rife with high labor content and opportunities for quality improvement, present a classic automation opportunity. This session describes the costs (investment) and benefits (reduced labor and improved process data quality) of moving from manual to Part 11 compatible automated processes. Abstract # Tuesday Afternoon, March 8 2:15 PM to 3:15 PM Room 140A Exhibitor Hosted Session: Machine Learning and Exposure to Modeling in the Prediction of In Vivo Toxicity from High Content Screening (HCS) Data Presented by: Cyprotex Discovery High content screening (HCS) is a powerful tool for generating insight into changes arising from exposure of cells to potentially toxic xenobiotics. Linking these changes to in vivo toxic responses enables the creation of predictive models for in vivo drug-mediated toxicity. In this presentation, novel developments in modeling of drug-induced hepatotoxicity from HCS data will be described. Tuesday Afternoon, March 8 2:15 PM to 3:15 PM Room 156 Exhibitor Hosted Session: Predictive Analysis of Cell Viability, Apoptosis and ADME/Tox Properties Using Multiparametric In Vitro Assays and Human Induced Pluripotent Stem (iPS) Cell-Derived Cardiomyocytes and Hepatocytes Presented by: Promega Corporation This seminar will highlight the use of multiplexed bioluminescent and fluorescent cell-based assays with human iPS cell-derived cardiomyocytes and hepatocytes that offer a powerful new approach to predictive analysis of cell viability, apoptosis and ADME/Tox properties while enabling streamlined data collection, high data quality and robust interpretation with biologically relevant human cell model systems. Tuesday Afternoon, March 8 3:00 PM to 4:15 PM CC Room 103 Undergraduate Faculty Meeting Chairperson(s): Aaron Barchawsky, University of Pittsburgh, Pittsburgh, PA. Sponsor: Education Committee The Education Committee and the Undergraduate Education Subcommittee are hosting the Undergraduate Toxicology Faculty Meeting for all faculty involved in the teaching of toxicology to undergraduates, or for those interested in including toxicology at the undergraduate level. Hear an update on initiatives for undergraduate faculty, provide your input, and network. Tuesday Afternoon, March 8 3:30 PM to 4:30 PM Room 140B Exhibitor Hosted Session: Cryopreserved HepaRG: An Alternative In Vitro Screening Tool for Human Hepatic Drug Metabolism, and Safety Applications Presented by: Life Technologies The use of primary human hepatoxytes in screening applications is limited by tissue availability, donor variability, cost and a relative short lifespan in culture. The use of HepaRG cells solves these limitations without sacrificing many of the critical hepatocyte traits such as drug metabolizing enzyme expression, functional transport proteins, and expression of key nuclear receptor pathways. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 269
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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