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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #476 Poster Board Number.....................................219 THE HUMAN-RELEVANT-POTENCY- THRESHOLD: UNCERTAINTY ANALYSIS AND HUMAN CALIBRATION FOR CUMULATIVE RISK ASSESSMENTS. E. Sargent 2 , R. Golden 4 , D. Dietrich 3 , G. Casella 5 and C. Borgert 1 . 1 Applied Pharmacology & Toxicology, Inc., Gainesville, FL, 2 EV Sargent LLC, Clearwater, FL, 3 Faculty of Biology, University of Konstanz, Konstanz, Germany, 4 ToxLogic, Potomac, MD and 5 Department of Statistics, University of Florida, Gainesville, FL. #477 Poster Board Number.....................................220 THRESHOLD ANALYSES FOR ACRYLONITRILE AND BRAIN TUMORS IN RATS. D. E. Strother 1 and C. R. Kirman 2 . 1 ToxSolve LLC, Manassas, VA and 2 Summit Toxicology LLP, Orange, OH. #478 Poster Board Number.....................................221 EFFICIENT DESIGN OF BIOLOGICAL EXPERIMENTS FOR DOSE-RESPONSE MODELING IN TOXICOLOGY STUDIES. F. Yang 1 and D. Porter 2 . 1 West Virginia University, Morgantown, WV and 2 NIOSH, Morgantown, WV. #479 Poster Board Number.....................................222 PHARMACOKINETIC AND TOXICOLOGICAL PROFILING OF NATURAL PRODUCTS AND DRUGS. C. Hasselgren 1 , H. Chen 2 , Y. Yang 2 , S. Boyer 1 , T. I. Oprea 3 and S. Muresan 2 . 1 Global Safety Assessment, AstraZeneca, Mölndal, Sweden, 2 DECS, AstraZeneca, Mölndal, Sweden and 3 Division of Biocomputing, University of New Mexico, Albuquerque, NM. #480 Poster Board Number.....................................223 A FLEXIBLE METHOD FOR BUILDING AND USING PREDICTIVE MODELS APPLIED TO SAFETY ENDPOINTS. O. Spjuth 2 , L. Carlsson 1 , M. Eklund 2 , E. Ahlberg Helgee 1 and S. Boyer 1 . 1 Computational Toxicology, AstraZeneca, Mölndal, Sweden and 2 Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. #481 Poster Board Number.....................................224 ASSESSING DOSE-RESPONSE OF ENVIRONMENTAL CHEMICALS INTERACTION WITH DNA USING A SYSTEM BIOLOGY MODELING APPROACH. J. M. Gavina, Y. Feng and A. Nong. Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. #482 Poster Board Number.....................................225 USING A MULTIPLE STAGE DECISION TREE TO MAKE ACTIVITY CALLS IN QUANTITATIVE HIGH-THROUGHPUT SCREENING (QHTS) DATA. K. R. Shockley 1 , G. E. Kissling 1 , R. Huang 2 , M. Xia 2 , C. P. Austin 2 and R. R. Tice 1 . 1 National Toxicology Program/ National Inistitute of Environmental Health Sciences, Research Triangle Park, NC and 2 NIH Chemical Genomic Center, Bethesda, MD. #483 Poster Board Number.....................................226 TESTING MULTIPLE AVAILABLE QSARS FOR REPRODUCTIVE TOXICITY AND CARCINOGENICITY TO DRINKING WATER CONTAMINANTS. M. Heringa 1 , A. Roncaglioni 2 , R. Benigni 3 and A. Worth 4 . 1 KWR Watercycle Research Institute, Nieuwegein, Netherlands, 2 Istituto di Ricerche Farmacologiche “Mario Negri”(IRFMN), Milan, Italy, 3 Istituto Superiore di Sanita (ISS), Rome, Italy and 4 European Commission - Joint Research Centre (JRC), Ispra, Italy. #484 Poster Board Number.....................................227 CONSENSUS MULTIPLE-POTENCY QSAR MODELING FOR PREDICTION OF RODENT CARCINOGENICITY. E. J. Matthews 2 and K. P. Cross 1 . 1 Leadscope, Inc., Columbus, OH and 2 U.S. FDA/CFSAN/OFAS, College Park, MD. Sponsor: R. Tice. #485 Poster Board Number.....................................228 DECISION ANALYSIS APPROACH TO MODE-OF-ACTION MODELS: EXPLICIT EXPRESSION OF DATA QUALITY AND RELIABILITY TO EVALUATE CAUSALITY. A. M. Jarabek 1,2 and D. Crawford-Brown 2 . 1 U.S. EPA, Research Triangle Park, NC and 2 DESE University North Carolina, Chapel Hill, NC. #486 Poster Board Number.....................................229 CASE STUDIES ON THE ROLE OF DNA ADDUCT DATA IN CANCER RISK ASSESSMENT: CONTEXT IS KEY. J. Skare 1 , L. H. Pottenger 2 , L. Andrews 2 , A. Bachman 3 , P. J. Boogaard 4 , J. Cadet 5 , P. Farmer 6 , M. Himmelstein 7 , A. Jarabek 8 , J. Kim 9 , E. Martin 10 , R. Mauthe 11 , R. Persaud 12 , J. Preston 8 , R. Schoeny 8 , J. Swenberg 13 , G. Williams 14 , F. Zhang 2 and E. Zeiger 15 . 1 Procter & Gamble, Cincinnati, OH, 2 The Dow Chemical Company, Midland, MI, 3 EMBSI, Annandale, NJ, 4 Shell International, The Hague, Netherlands, 5 CEA/ Grenoble, Grenoble, France, 6 U. Leicester, Leicester, United Kingdom, 7 DuPont, Newark, DE, 8 U.S. EPA, Research Triangle Park, NC, 9 HESI, Washington, D.C., 10 AstraZeneca, Macclesfield, United Kingdom, 11 Pfizer, Groton, CT, 12 L’Oreal, Clark, NJ, 13 University of North Carolina, Chapel Hill, NC, 14 NY Medical College, Valhalla, NY and 15 E. Zeiger Consulting, Chapel Hill, NC. #487 Poster Board Number.....................................230 QSAR PREDICTION OF CARCINOGENIC POTENCY (TD50) AND THE RISK SPECIFIC DOSE(RSD) ADJUSTED THRESHOLD OF TOXICOLOGICAL CONCERN (TTC) FOR GENOTOXIC CHEMICALS AND PHARMACEUTICAL IMPURITIES. J. F. Contrera. Computational Toxicology Services LLC, Rockville, MD. #488 Poster Board Number.....................................231 VIRTUAL CHEMICAL-PROTEIN RECEPTOR INTERACTIONS CAN DIFFERENTIATE TUMOR SITE SELECTIVE CARCINOGENS. N. Malik, S. Qamar, C. Carrasquer and A. R. Cunningham. James Graham Brown Cancer Center, University of Louisville, Louisville, KY. 158 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #489 Poster Board Number.....................................232 USE OF 'OMICS DATA TO IMPROVE PAH MIXTURES CANCER RISK ASSESSMENT. P. McClure 1 , H. Carlson-Lynch 1 , J. Stickney 1 , K. Salinas 1 , I. Cote 2 and L. Flower 2 . 1 Chemical, Biological, and Environmental Center, SRC, Inc., North Syracuse, NY and 2 Office of Research and Development, U.S. EPA, Washington, D.C. #490 Poster Board Number.....................................233 SOME TRICKS FOR STATISTICAL ANALYSIS OF NEOPLASTIC LESIONS USING PROC MULTTEST IN SAS. A. K. Thakur and H. Chen. Nonclinical Safety Assessment, Covance Laboratories, Vienna, VA. #491 Poster Board Number.....................................234 A GROUP APPROACH FOR HUMAN HEALTH SAFETY ASSESSMENT OF FRAGRANCE INGREDIENTS. A. Api, S. Bhatia, C. Letizia, D. McGinty, J. Scognamiglio and L. W. Smith. Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ. #492 Poster Board Number.....................................235 IMPLEMENTING COMPUTATIONAL METHODS IN AN INSTITUTIONAL KNOWLEDGE-BASE AT FDA’S CENTER FOR FOOD SAFETY AND APPLIED NUTRITION: A MODE-OF-ACTION-BASED APPROACH TO BUILDING QSAR MODELS. L. Ye, R. Brown, E. Busta, K. Arvidson and C. Yang. CFSAN, U.S. FDA, College Park, MD. #493 Poster Board Number.....................................236 ASSESSMENT OF MITOCHONDRIAL TOXICITY OF ENVIRONMENTAL CHEMICALS USING A QUANTITATIVE HIGH-THROUGHPUT SCREENING APPROACH. M. S. Attene-Ramos 1 , R. Huang 1 , S. Sakamuru 1 , S. Shahane 1 , L. Shou 1 , K. L. Witt 2 , R. R. Tice 2 , C. P. Austin 1 and M. Xia 1 . 1 National Institutes of Health Chemical Genomics Center (NCGC), Rockville, MD and 2 National Toxicology Program (NTP). National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC. #494 Poster Board Number.....................................237 QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) MODELING OF ESTROGEN RECEPTOR (ER) BINDING AFFINITY AND VIRTUAL SCREENING FOR POTENTIAL ENDOCRINE DISRUPTING COMPOUNDS (EDCS). L. Zhang 1 , H. Zhu 1 , A. Afantitis 2 , G. Melagraki 2 , H. Sarimveis 2 , I. Rusyn 3 and A. Tropsha 1 . 1 Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2 NovaMechanics Ltd., Nicosia, Cyprus and 3 Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC. #495 Poster Board Number.....................................238 A COLLABORATIVE PROJECT FOR DATA SHARING AND HARMONIZATION OF DEVELOPMENTAL TOXICITY DATABASES. E. Busta 1 , S. Espada 2 , M. Martin 3 , D. Hristozov 1 , K. Arvidson 1 , D. Mattison 4 and C. Yang 1 . 1 U.S. FDA, College Park, MD, 2 Pennsylvania State University, College Station, PA, 3 U.S. EPA, Research Triangle Park, NC and 4 NICHD, Bethesda, MD. Abstract # #496 Poster Board Number.....................................239 DEHP: COMPARISON OF IN SILICO PREDICTIONS WITH IN VITRO AND IN VIVO TOXICITY. M. M. Dingemans 1 , E. Rorije 2 , A. Efremenko 3 , H. Clewell 3 and B. Blaauboer 1 . 1 Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands, 2 National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands and 3 The Hamner Institutes, Research Triangle Park, NC. #497 Poster Board Number.....................................240 CHEMICALS IN CONTEXT: EPA DESIGN FOR THE ENVIRONMENT GREEN CHEMISTRY EVALUATIONS FOR SAFER CONSUMER PRODUCTS. C. Baier-Anderson 1 , C. Davies 1 , D. DiFiore 1 , K. Grant 1 , D. Johnson 2 , E. Lavoie 1 , L. Morlacci 2 , E. Sommer 1 and M. Vrabel 1 . 1 Design for the Environment Branch, U.S. EPA, Washington, D.C. and 2 SRC, Inc., Arlington, VA. #498 Poster Board Number.....................................241 APPLICATION OF AGE-SPECIFIC ADJUSTMENTS TO CANCER POTENCY FOR CHILDREN AT CALIFORNIA SCHOOL SITES. S. A. Knadle 1 , H. Bolstad 2 , M. S. Sandy 1 , M. A. Marty 1 and J. Carlisle 1 . 1 Cal /U.S. EPA, OEHHA, Sacramento, CA and 2 Environmental Toxicology, University of California at Davis, Davis, CA. #499 Poster Board Number.....................................242 DERMAL DNEL SETTING: USING QSAR PREDICTIONS FOR DERMAL ABSORPTION FOR A REFINED ROUTE-TO-ROUTE EXTRAPOLATION. V. Mostert and A. Goergens. Toxicology/Human Exposure, Knoell Consult GmbH, Leverkusen, Germany. #500 Poster Board Number.....................................243 AN ASSESSMENT OF THE IMPACT OF EXPOSURE DURATION AND INTENSITY ON THE HUMAN KINETIC ADJUSTMENT FACTOR (HKAF). K. Krishnan 1 and M. Valcke 1,2 . 1 Santé environnementale et Santé au travail, Université de Montréal, Montréal, QC, Canada and 2 Direction de la Santé environnementale et de la Toxicologie, Institut national de santé publique du Québec, Montréal, QC, Canada. #501 Poster Board Number.....................................244 EVALUATION OF THE IMPACT OF DEMOGRAPHY ON THE ADEQUACY OF THE HUMAN KINETIC ADJUSTMENT FACTOR (HKAF). M. Valcke 1,2 and K. Krishnan 1 . 1 Santé environnementale et Santé au travail, Université de Montréal, Montréal, QC, Canada and 2 Direction de la Santé environnementale et de la Toxicologie, Institut national de santé publique du Québec, Montréal, QC, Canada. #502 Poster Board Number.....................................245 DEVELOPMENT OF SURROGATE REFERENCE CONCENTRATIONS FOR VOLATILE ORGANIC COMPOUNDS COMMONLY ENCOUNTERED AT HAZARDOUS WASTE SITES. K. Fehling 1 , T. Copeland 3 , J. Otani 4 and B. Kerger 2 . 1 The Fehling Group, LLC, Novato, CA, 2 Health Science Resource Integration, Inc., Tallahassee, FL, 3 Consultant, Agoura Hills, CA and 4 Consultant, Menlo Park, CA. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 159
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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