Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
MONday
Abstract # Abstract #
#425 Poster Board Number.....................................106
APPROACH FOR DETECTING
FLUTAMIDE-INDUCED HEPATOTOXICITY
USING GLUTATHIONE DEPLETED RATS. ​
H. Horie, I. Miyawaki, I. Matsumoto, T. Kai, M.
Aoki, T. Yamada, J. Kimura, H. Funabashi and T.
Seki. Dainippon Sumitomo Pharmacology Co., Ltd.,
Osaka, Japan.
#426 Poster Board Number.....................................107
A 3-DIMENSIONAL LIVER MODEL FOR
THE SAFETY-EVALUATION OF DRUG
CANDIDATES. ​R. M. Kostadinova, F. Boess,
L. Suter-Dick, T. Weiser, T. Singer and A. Roth. F.
Hoffmann-La Roche Ltd., Basel, Switzerland.
#427 Poster Board Number.....................................108
A BENCHMARK DRUG LIST FOR THE
STUDY OF DRUG-INDUCED LIVER INJURY. ​
V. Vijay, M. Chen, Q. Shi and W. Tong. Systems
Biology, NCTR /U.S. FDA, Jefferson, AR.
#428 Poster Board Number.....................................109
MONOCYTE TO MACROPHAGE
DIFFERENTIATION-ASSOCIATED 2
(MMD2) IS A NEW CANDIDATE GENE
FOR HEPATOPROTECTIVE EFFECT OF
TAMOXIFEN AGAINST DRUG-INDUCED
LIVER INJURY. ​T. Yokoi 1 , Y. Yoshikawa 1 , Y.
Toyoda 1 , S. Higuchi 1 , T. Tsukui 2 , K. Tsuneyama 3 ,
T. Fukami 1 and M. Nakajima 1 . 1 Graduate School of
Medical Science, Kanazawa University, Kanazawa,
Ishikawa, Japan, 2 Research Center for Genomic
Medicine, Saitama Medical University, Hidaka,
Saitama, Japan and 3 Department of Diagnostic
Pathology, Toyama University, Toyama, Japan.
#429 Poster Board Number.....................................110
INVESTIGATING LIVER MITOCHONDRIAL
TOXICITY USING PRIMARY RAT
HEPATOCYTES AND A LIVER CELL LINE. ​
C. Summers, K. Abbott, J. I. Goodman and A. Foster.
Safety Assessment, Astrazeneca, Alderley Park,
Cheshire, United Kingdom. Sponsor: D. Brown.
#430 Poster Board Number.....................................111
IN VITRO METHOD DEVELOPMENT TO
ASSESS THE ROLE OF KUPFFER CELLS
IN DRUG-INDUCED HEPATOTOXICTY. ​
N. Shangari 1 , M. Dong 2 , A. Reising 1 , O. Weber 2 ,
E. Cruz 1 , S. Sampath 1 , P. Patel 1 , M. Gurnani 1 ,
C. Buono-Dalton 4 , V. Richard 4 , T. Wang 3 , M.
Uteng 2 , J. Scheumann 2 , S. Chibout 2 , F. Pognan 2
and A. Wolf 2 . 1 iTOX, Preclinical Safety, Novartis
Institutes of Biomedical Research, East Hanover,
NJ, 2 iTOX, Preclinical Safety, Novartis Institutes
of Biomedical Research, Basel, Switzerland,
3
Preclinical Safety, Novartis Institutes of Biomedical
Research, Emeryville, CA and 4 iTOX, Preclinical
Safety, Novartis Institutes of Biomedical Research,
Cambridge, MA.
#431 Poster Board Number.....................................112
AUTOMATED IMAGING,
QUANTIFICATION, AND CLASSIFICATION
OF NF-KAPPA B AND NRF2 RESPONSES TO
IDENTIFY ADVERSE DRUG REACTIONS
IN HEPG2 CELLS. ​B. Herpers, L. Fredriksson,
Z. Di and B. van de Water. Division of Toxicology -
LACDR, Leiden University, Leiden, Netherlands.
#432 Poster Board Number.....................................113
MECHANISTIC STUDIES ON THE
CYTOTOXICITY OF LEFLUNOMIDE
AND ITS MAJOR METABOLITES IN RAT
HEPATIC CELLS. ​Q. Shi, X. Yang and W. F.
Salminen. Division of Systems Biology, U.S. FDA,
NCTR, Jefferson, AR.
#433 Poster Board Number.....................................114
THE HEMOSTATIC SYSTEM AND
NEUTROPHILS IN AMIODARONE/
LIPOPOLYSACCHARIDE-INDUCED LIVER
INJURY IN RATS. ​J. Lu 1 , R. A. Roth 2 and P.
E. Ganey 2 . 1 Department of Biochemistry and
Molecular Biology, Michigan State University, East
Lansing, MI and 2 Department of Pharmacology and
Toxicology, Michigan State University, East Lansing,
MI.
#434 Poster Board Number.....................................115
STUDY OF LIVER LYMPHOCYTES
IN AMODIAQUINE-INDUCED
HEPATOTOXICITY IN BROWN NORWAY
RATS. ​F. Liu 1 , P. Cai 1 , J. Li 2 and J. Uetrecht 1 .
1
Faculty of Pharmacy, University of Toronto,
Toronto, ON, Canada and 2 Immunotoxicology,
Bristol-Myers Squibb Company, New Brunswick,
NJ.
#435 Poster Board Number.....................................116
SIGNIFICANT RELATIONSHIP EXISTS
BETWEEN ORAL DRUG EXPOSURE LEVEL
AND ITS POTENTIAL RISK FOR HUMAN
HEPATOTOXICITY. ​M. Chen, V. Vijay and W.
Tong. Division of Systems Biology, U.S. FDA’s
NCTR, Jefferson, AR.
#436 Poster Board Number.....................................117
EVALUATION OF PHOSPHOLIPIDOSIS-
INDUCING POTENTIAL OF DRUGS FROM
ORAL SINGLE-DOSE RAT LIVER GENE
EXPRESSION PROFILING. ​T. Kai 2 , H. T.
Yudate 1 , Y. Minowa 3 , M. Aoki 4 , T. Yamada 5 , T.
Kimura 4 , A. Ono 6 , H. Yamada 3 , Y. Ohno 7 and T.
Urushidani 3,8 . 1 Strategic Planning & Management,
Dainippon Sumitomo Pharmacology Co., Ltd.,
Osaka, Japan, 2 Genomic Science Laboratories,
Dainippon Sumitomo Pharmacology Co., Ltd.,
Osaka, Japan, 3 Toxicogenomics-Informatics Project,
National Institute of Biomedical Innovation,
Osaka, Japan, 4 Research Planning & Management,
Dainippon Sumitomo Pharmacology Co., Ltd.,
Osaka, Japan, 5 Safety Research Laboratories,
Dainippon Sumitomo Pharmacology Co., Ltd.,
Osaka, Japan, 6 Division of Risk Assessment,
National Institute of Health Sciences, Tokyo, Japan,
7
National Institute of Health Sciences, Tokyo, Japan
and 8 Department of Pathophysiology, Doshisha
Women’s College of Liberal Arts, Kyoto, Japan.
#437 Poster Board Number.....................................118
EVALUATION OF 3 BILE ACIDS AS
POTENTIAL BIOMARKERS OF DRUG-
INDUCED LIVER INJURY. ​L. Luo, C. A. Fritz
and J. L. Colangelo. Drug Safety R&D, Pfizer Inc.,
Groton, CT.
154
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