Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #142 Poster Board Number.....................................231 EFFECTS OF GENETIC VARIATION IN ENZYME CYTOCHROME P450 2D6 ON XENOBIOTIC METABOLISM THROUGH IN SILICO MOLECULAR DOCKING MODELS. C. B. Tolson 1,2 , Y. Tie 1 and E. Demchuk 1 . 1 Division Toxicology & Environmental Medicine, ATSDR/ CDC, Atlanta, GA and 2 Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA. Sponsor: B. Fowler. #143 Poster Board Number.....................................232 INCORPORATION OF TOXCAST IN VITRO ASSAY DATA AND RELEVANT TOXICITY PATHWAY INFORMATION IMPROVES THE EXTERNAL PREDICTION ACCURACY OF QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) MODELS OF CHEMICAL HEPATOTOXICITY. H. Zhu, L. Zhang, J. Staab, A. Sedykh, H. Tang, S. Gomez, I. Rusyn and A. Tropsha. University of North Carolina at Chapel Hill, Chapel Hill, NC. #144 Poster Board Number.....................................233 COMPUTATIONAL DOCKING OF THE ISOMERS OF NONYLPHENOL TO THE LIGAND BINDING DOMAIN OF THE ESTROGEN RECEPTOR. J. Rabinowitz and S. Little. NCCT/ORD /U.S. EPA, Research Triangle Park, NC. #145 Poster Board Number.....................................234 ANALYSIS OF RELATIVE ROSIGLITAZONE, PIOGLITAZONE, AND EPIRUBICIN CARDIOTOXICITY IN RATS USING HISTORICAL MICROARRAY DATA. H. Zhou and T. J. Colatsky. CDER/OPS/OTR/DAPR, U.S. FDA, Silver Spring, MD. #146 Poster Board Number.....................................235 COMPUTATIONAL MODELING FOR QT PROLONGATION: A DRUG CARDIOVASCULAR SAFETY ENDPOINT OF PARAMOUNT IMPORTANCE. L. G. Valerio 1 , J. Prous Blancafort 2 , A. Valencia 2 and X. Mensa 2 . 1 CDER/OPS, U.S. FDA, Silver Spring, MD and 2 Prous Institute for Biomedical Research, Barcelona, Spain. Sponsor: N. Sadrieh. #147 Poster Board Number.....................................236 TRANSLATABILITY OF DRUG-INDUCED CARDIOTOXICITY MOLECULAR MECHANISMS FROM IN VIVO TO IN VITRO. A. Enayetallah 1 , D. Puppala 1 , D. Ziemek 2 , N. Greene 1 , Y. Will 1 and M. Pletcher 1 . 1 Compound Safety Prediction-PGRD, Pfizer Inc., Groton, CT and 2 Computational Sciences CoE, Pfizer Inc., Cambridge, MA. #148 Poster Board Number.....................................237 ASSOCIATION NETWORKS AND VISUALIZATION TOOLS TO CORRELATE PRECLINICAL SIGNALS TO DRUG- INDUCED NAUSEA IN MAN. J. Glab 1 , M. Clark 2 , J. Valentin 1 and L. Ewart 1 . 1 Safety Pharmacology, AstraZeneca, Alderley Park, United Kingdom and 2 Discovery Information, AstraZeneca, Wilmington, DE. #149 Poster Board Number.....................................238 DDT AND TCDD INTERACT WITH PROTEINS INVOLVED IN THE INSULIN RECEPTOR SIGNALING. M. Cabarcas- Montalvo, D. Montes-Grajales and J. Olivero-Verbel. Environmental and Computational Chemistry Group, University of Cartagena, Cartagena, Colombia. #150 Poster Board Number.....................................239 COMPUTATIONAL BASED APPROACHES FOR IDENTIFYING AND UNDERSTANDING KINASES ASSOCIATED WITH CARDIOTOXICITY. D. Puppala 1 , V. Bonato 2 , K. Leach 1 , S. Louise-May 1 , K. J. McConnell 3 , M. Gosink 4 and M. T. Pletcher 1 . 1 Compound Safety Prediction, Pfizer Inc., Groton, CT, 2 Biostatistics Group, Pfizer Inc., Groton, CT, 3 Computational Science CoE, Pfizer Inc., Groton, CT and 4 DSRD, Pfizer Inc., Groton, CT. #151 Poster Board Number.....................................240 DISCOVERY OF NOVEL MICRO-RNAS FROM RAT LYMPHOCYTES DURING GLUCOCORTICOID INDUCED APOPTOSIS. R. Shah 1 , S. Vasa 1 , L. Smith 2 and J. Cidlowski 2 . 1 SRA International, Durham, NC and 2 National Institute of Environmental Health Science, Research Triangle Park, NC. #152 Poster Board Number.....................................241 AUTOMATIC IN SILICO ASSESSMENT OF GENOTOXIC POTENTIAL IMPURITIES. A. Brigo, G. Gerebtzoff, M. Kansy, T. Weiser and T. Singer. Nonclinical Safety, F. Hoffmann-La Roche Ltd., Basel, Switzerland. #153 Poster Board Number.....................................242 AUTOMATED IDENTIFICATION OF STRUCTURE-TOXICITY RELATIONSHIPS USING ATOM SIGNATURES. L. Carlsson, E. Ahlberg Helgee and S. Boyer. Computational Toxicology, AstraZeneca, Mölndal, Sweden. #154 Poster Board Number.....................................243 COMPUTATIONAL ASSESSMENT OF REACTIVE METABOLITE RISK IN DRUG DISCOVERY USING MECHANISTIC ENSEMBLE MODELLING. S. Boyer 1 , C. Hasselgren 1 , L. Peterlin-Masic 2 , O. Spjuth 3 and L. Carlsson 1 . 1 Computational Toxicology, AstraZeneca, Mölndal, Sweden, 2 Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia and 3 Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. #155 Poster Board Number.....................................244 DESIGN AND DEVELOPMENT OF AN INSTITUTIONAL KNOWLEDGE-BASE AT FDA’S CENTER FOR FOOD SAFETY AND APPLIED NUTRITION. K. Arvidson, A. McCarthy, C. Yang and D. Hristozov. CFSAN, U.S. FDA, College Park, MD. #156 Poster Board Number.....................................245 PHARMACOLOGICAL PROFILE SIMILARITY – A RELEVANT METHOD FOR ANTICIPATION OF IN VIVO SAFETY? D. Muthas 1 , M. Rolf 2 , S. Matis-Mitchell 3 and S. Boyer 1 . 1 Global Safety Assessment, AstraZeneca R&D, Mölndal, Sweden, 2 Global Safety Assessment, AstraZeneca R&D, Alderly Park, United Kingdom and 3 Discovery Information, AstraZeneca R&D, Wilmington, DE. 128 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #157 Poster Board Number.....................................246 DEVELOPMENT OF QSAR MODEL FOR HIGH-SPEED IN SILICO IDENTIFICATION OF POTENTIALLY PHOTOTOXIC ORGANIC COMPOUNDS. W. Plonka 1 and J. M. Ciloy 2 . 1 Life Science, FQS Poland, Cracow, Poland and 2 Life Science, Fujitsu Kyushu Systems Ltd., Fukuoka, Japan. Sponsor: K. Hayamizu. #158 Poster Board Number.....................................247 THE POWER OF AN ONTOLOGY-DRIVEN DEVELOPMENTAL TOXICITY DATABASE FOR DATA MINING AND COMPUTATIONAL MODELING. A. Richard 1 , E. Julien 2 , E. Busta 3 , M. Wolf 4 and C. Yang 3 . 1 NCCT (D343-03), U.S. EPA, Research Triangle Park, NC, 2 LifeSci Research Service, Rockville, MD, 3 HFS-2775, U.S. FDA CFSA, College Park, Maryland, MD and 4 Lockheed- Martin, U.S. EPA, Research Triangle Park, NC. #159 Poster Board Number.....................................248 USE OF C. ELEGANS GROWTH ASSAY DATA IN NOVEL TWO-STEP HIERARCHICAL QSAR MODELING WORKFLOW ENHANCES IN VIVO TOXICITY PREDICTION FOR TOXCAST PHASE I CHEMICALS. A. Golbraikh 1,2 , R. Shah 1,4 , W. Boyd 3 , M. Smith 4 , A. Tropsha 1,2 and J. Freedman 3 . 1 SciOme LLC, Research Triangle Park, NC, 2 University of North Carolina at Chapel Hill, Chapel Hill, NC, 3 National Institute of Environmental Health Science, Research Triangle Park, NC and 4 SRA International, Durham, NC. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall Poster Session: Neurodegenerative Diseases Chairperson(s): Richard Nass, Indiana University School of Medicine, Indianapolis, IN. Displayed: 9:30 AM–12:30 PM Author Attended: 9:30 AM–11:00 AM #160 Poster Board Number.....................................301 EVALUATION OF JP-8 JET FUEL INDUCED HEARING LOSS IN RATS. L. D. Fechter 1 , J. W. Fisher 2 , G. D. Chapman 3 , V. P. Mokashi 3 , J. E. Reboulet 3 , J. E. Stubbs 4 , A. M. Lear 3 , S. L. Prues 3 , C. A. Gearhart 1 , S. Fulton 1 and D. R. Mattie 5 . 1 Jerry Pettis Memorial VA Medical Center, Loma Linda, CA, 2 U.S. FDA NCTR, Jefferson, AR, 3 NHRC/ EHEL, Wright-Patterson AFB, OH, 4 AFIT/ENV, Wright-Patterson AFB, OH and 5 711 HPW/RHPBA, Wright-Patterson AFB, OH. #161 Poster Board Number.....................................302 1, 3-DICARBONYL ENOLATES: A NEW CLASS OF NEUROPROTECTANTS. R. M. LoPachin 1 , T. Gavin 2 , D. Casper 3 and D. S. Barber 4 . 1 Department of Anesthesia Research, Montefiore Medical Center, Bronx, NY, 2 Chemistry, Iona College, New Rochelle, NY, 3 Neurosurgery, Montefiore Medical Center, Bronx, NY and 4 CEHT, University of Florida, Gainesville, FL. Abstract # #162 Poster Board Number.....................................303 MOLECULAR MODELING OF 1, 3-DINITROBENZENE (1, 3-DNB) INTERACTIONS WITH ADENOSINE DEAMINASE (ADA). R. J. Richardson 1 , S. J. Wijeyesakere 2 , Y. Wang 1 and M. A. Philbert 1 . 1 Department of Environmental Health Sciences, Toxicology Program, University of Michigan, Ann Arbor, MI and 2 Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI. #163 Poster Board Number.....................................304 1, 3-DINITROBENZENE (1, 3-DNB) INHIBITS ADENOSINE DEAMINASE (ADA) LEADING TO INCREASED ADENOSINE LEVELS IN IMMORTALIZED DI TNC-1 ASTROCYTES. Y. Wang 1 , X. Liu 2 , B. Schneider 1 , E. A. Zverina 4 , K. A. Russ 1 , C. A. Fierke 3 , R. J. Richardson 1 and M. A. Philbert 1 . 1 Department of EHS, Toxicology, University of Michigan, Ann Arbor, MI, 2 Department of Chemistry, University of Michigan, Ann Arbor, MI, 3 Department of Biological Chemistry, University of Michigan, Ann Arbor, MI and 4 Chemical Biology Program, University of Michigan, Ann Arbor, MI. #164 Poster Board Number.....................................305 TRANSLOCATOR PROTEIN (18 KDA) (TSPO): A Preclinical BIOMARKER OF NEURODEGENERATION IN SANDHOFF DISEASE MICE. J. Choi 1 , H. Wang 2 , C. J. Endres 2 , J. J. Fox 2 , G. Green 2 , M. G. Pomper 2 and T. R. Guilarte 1 . 1 Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY and 2 Radiology, Johns Hopkins Hospital, Baltimore, MD. #165 Poster Board Number.....................................306 THE CYANOBACTERIAL NEUROTOXIN β-N-METHYLAMINO-L-ALANINE (BMAA) INDUCES UNFOLDED PROTEIN RESPONSE (UPR) AND CHANGES OF SOD ACTIVITY LEVELS IN HUMAN NEURONAL CELLS. O. Okle 1 , M. Helmer 1 , K. Stemmer 1,2 and D. R. Dietrich 1 . 1 Human & Environmental Toxicology, University of Konstanz, Konstanz, Germany and 2 Obesity Research Centre at the Metabolic Disease Institute, University of Cincinnati, Cincinnati, OH. #166 Poster Board Number.....................................307 CYTOTOXICITY OF β-N-METHYLAMINO- L-ALANINE (L-BMAA) AND METHYLAZOXYMETHANOLACETATE (MAMAC) AND ASSOCIATED DIFFERENTIAL MRNA EXPRESSION IN HUMAN NEURONAL CELLS. M. Helmer 1 , O. Okle 1 , K. Stemmer 1,2 and D. R. Dietrich 1 . 1 Human & Environmental Toxicology, University of Konstanz, Konstanz, Germany and 2 Obesity Research Centre at the Metabolic Disease Institute, University of Cincinnati, Cincinnati, OH. #167 Poster Board Number.....................................308 PERTURBATION OF REGIONAL BRAIN METABOLISM IN F344 RATS AFTER LOW LEVEL EXPOSURE TO DIISOPROPYLFLUOROPHOSPHATE (DFP). D. Mahle 1 and N. V. Reo 2 . 1 AFRL/RHPB, Wright- Patterson AFB, OH and 2 Wright State University, Fairborn, OH. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 129
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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SOT Presidents 1961-2011 1966 1967
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Toxicological Sciences The Official
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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