Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Morning, March 8 11:45 AM to 12:45 PM Room 156 Exhibitor Hosted Session: A Systems Toxicology Approach to Understanding Drug Toxicity and Compound Prioritization Presented by: Ingenuity Systems, Inc. This session will demonstrate using an industry relevant case study, how IPA’s rich molecular toxicity content and functionality, such as toxicity pathways, pathology endpoints, clinical chemistry, and hematology assay data associations can add to the understanding and evaluation of drug mechanisms and compound prioritization. Presented by: Kevin T. Morgan, Ph.D., Independent Consultant. Tuesday Morning, March 8 11:45 AM to 12:45 PM Room 140B Exhibitor Hosted Session: New Applications of Latest Telemetry Technology in Toxicology and Safety Pharmacology Presented by: Data Sciences International Advances in wireless technology have enabled new non-invasive and plantable telemetric physiological monitoring to provide additional new parameters. Leading researchers will present their latest validation data from recent work with new innovative combined applications in toxicology and safety pharmacology. Data from rodent, canine, and NHP model studies will be presented. Tuesday Afternoon, March 8 12:00 NOON to 1:30 PM Room 141 Tuesday Afternoon Special Interest Group Luncheon: ASIO Lunch and Learn Program Tuesday Afternoon, March 8 12:00 NOON to 1:30 PM Room 149 Specialty Section Meeting/Luncheon: Comparative and Veterinary Tuesday Afternoon, March 8 12:00 NOON to 1:15 PM Salon I New Investigator Lunch Sponsor: Research Funding Committee Chairperson(s): Joel G. Pounds, Pacific Northwest National Laboratory, Richland, WA, and Nancy Kerkvliet, Oregon State University, Corvallis, OR. This event is focused on new investigators such as new assistant professors on tenure track. Participants will be able to speak informally with federal funding agency program officers and more senior investigators, including members of the Research Funding Committee. After a brief grantsmanship talk by Sally J. Rockey, Ph.D., NIH Deputy Director for Extramural Research, discussion will continue with the program officers at each table. Ask your questions and benefit from conversation resulting from the questions of others. You can also arrange at this time to meet these representatives later in the Research Funding Resource Room for an individual discussions. A limited number of box lunches and seats will be available. Tuesday Afternoon, March 8 12:00 NOON to 1:15 PM Salon G (Ticket Required) Postdoctoral Assembly Luncheon Chairperson(s): Sarah Campion, Brown University, Providence, RI. Sponsor: Postdoctoral Assembly Amidst scrambling to attend all of the events at the meeting, this will be time for postdocs to kick back and relax! All postdoctoral scholars are invited to a casual luncheon organized by the Postdoctoral Assembly (PDA). We will announce the recipients of the Best Postdoctoral Publication Awards and acknowledge the postdocs who received awards this year from Regional Chapters, Special Interest Groups, and Specialty Sections. The PDA Board members will present an overview of accomplishments and future directions for the PDA, and will introduce the new board members for 2011–2012. There will be a drawing for prizes. Postdocs can reserve a ticket for $5 when they register for the Annual Meeting. Tuesday Afternoon, March 8 12:00 NOON to 1:20 PM Room 143 Toxicity Testing: State of Science and Strategies to Improve Public Health Roundtable Session: Integrating Alternative Test Methods into the Federal Regulatory Framework Chairperson(s): Suzanne Fitzpatrick, U.S. FDA, Rockville, MD, and Leonard Schechtman, Innovative Toxicology Testing, Lake Worth, FL. Sponsor: In Vitro and Alternative Methods Specialty Section Endorsed by: Regulatory and Safety Evaluation Specialty Section Current regulatory testing paradigms require certain sets of data needed for regulatory evaluation and risk assessment. Many of the methodologies used 230 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # today in the traditional approach to toxicity testing originated over a half century ago and are both time and animal intensive. In 2007, the National Academy of Sciences report described a new vision and strategy for toxicity testing in the 21st century that would be based on human biology rather than animal biology and would be less expensive and less time consuming. This strategy would also involve a strong commitment to the 3Rs—replacement, reduction, and refinement of animal use in research, testing, and education. Being responsive to this progressive scientific perspective would necessitate moving forward in developing, validating, and incorporating alternative toxicological test methods into the federal regulatory framework. This transformational toxicological approach would also entail an active dialogue and collaboration between stakeholders, NGOs, academics, and federal scientists. Our panel of experts will offer the opportunity for such a discourse between U.S. FDA and U.S. EPA and their stakeholders about the type of data needed from alternative methods to demonstrate that they are scientifically valid and address the fundamental questions of human safety and efficacy. #1309 12:00 INTEGRATING ALTERNATIVE TEST METHODS INTO THE FEDERAL REGULATORY FRAMEWORK. S. C. Fitzpatrick 1 and L. Schechtman 2 . 1 Office of the Commissioner, U.S. FDA, Silver Spring, MD and 2 Innovative Consulting, LLC, Lake Worth, FL. 12:00 THE 3 R’S: MORE IMPORTANT NOW THAN EVER. Andrew N. Rowan 12:05 INTEGRATED TESTING AND EMPLOYING ADVANCED METHODS FOR BIOLOGICAL PROFILING IN THE MODERNIZED TSCA. Richard A. Becker 12:20 REGULATORY ACCEPTANCE OF ALTERNATIVE METHODS— PHARMACEUTICALS IN THE U.S. Abigail Jacobs 12:35 CURRENT APPROACHES TO ANIMAL TESTING IN REGULATION OF BIOLOGICS AND VACCINES BY U.S. FDA/CBER. Richard D. McFarland 12:50 CONSIDERATIONS FOR ACCEPTANCE OF ALTERNATIVES FOR PESTICIDES AND CHEMICALS. John R. Fowle 1:05 PANEL DISCUSSION/Q&A. Tuesday Afternoon, March 8 12:00 NOON to 1:20 PM Room 144 Global Air Quality and Human Health Informational Session: Coordinating Global Chemical Safety: The Big Four Chairperson(s): Philip Wexler, National Library of Medicine, Bethesda, MD, and Harihara Mehendale, University of Louisiana Monroe, Monroe, LA. Sponsor: Global Strategy Task Force Endorsed by: Ethical, Legal & Social Issues Specialty Section Risk Assessment Specialty Section As the toxicology community is well aware, chemicals are both a global benefit and concern. They routinely cross national borders in the marketplace and in planned or accidental pollution streams. With increasing production comes increasing opportunity for exposure. Novel chemical entities, such as those derived from nanotechnology, simply up the ante Abstract # with still undetermined effects. It has been nearly 40 years since the United Nations (Stockholm) Conference on the Human Environment stated in its declaration that ‘The protection and improvement of the human environment is a major issue which affects the well-being of peoples and economic development throughout the world; it is the urgent desire of the peoples of the whole world and the duty of all Governments.’ Principle 6 of this declaration also indirectly advocated control of chemicals by calling for a halt to the discharge of toxic substances which exceed the capacity of the environment to render them harmless. The strengthened global will to manage chemicals responsibly has been facilitated by advances in information and communications technologies, chief among them being the Internet. Many multilateral efforts, both legally binding vehicles and policy frameworks, can at least, in some respect, trace their lineage back to the Stockholm Conference. These three major international legal instruments dealing with chemicals including the transboundary movement of hazardous wastes and their disposal, prior informed consent, and persistent organic pollutants will be our focus. We will highlight the Strategic Approach to International Chemicals Management (SAICM), today’s major international policy framework. Finally, our panel of experts will offer a summary relative to the provisions of these multilateral environmental agreements (MEAs), highlight major successes and challenges, discuss future outlooks, and indicate the relevance of global chemical policy to toxicologists, and how they, in turn, can influence such policy. #1310 12:00 COORDINATING GLOBAL CHEMICAL SAFETY: THE BIG FOUR. P. Wexler 1 , P. Whiting 2 , D. Downie 3 , H. Selin 4 and L. Onyon 5 . 1 National Library of Medicine, Bethesda, MD, 2 U.S. EPA, Washington, D.C., 3 Fairfield University, Fairfield, CT, 4 Boston University, Boston, MA and 5 UNEP, Geneva, Switzerland. 12:00 Introduction. Philip Wexler 12:05 BASEL CONVENTION. Patricia Whiting 12:22 ROTTERDAM CONVENTION. David Downie 12:39 STOCKHOLM CONVENTION. Henrik Selin 12:56 STRATEGIC APPROACH TO INTERNATIONAL CHEMICALS MANAGEMENT. Lesley Onyon 1:13 PANEL DISCUSSION/Q&A. Tuesday Afternoon, March 8 12:00 NOON to 1:20 PM Room 147 Novel Approaches to Preclinical Safety Assessment: Bridging the Gap between Discovery and the Clinic through Translational Toxicology Informational Session: Livers on a Plate: Next Generation Hepatocyte Models for High-Throughput Screening and Mode-of-Action Prediction Chairperson(s): Chris Corton, U.S. EPA, Research Triangle Park, NC, and Susan Hester, U.S. EPA, Research Triangle Park, NC. Sponsor: Molecular Biology Specialty Section Endorsed by: In Vitro and Alternative Methods Specialty Section Mechanisms Specialty Section The liver is a common target for chemicals and drugs, due in part to the role of the liver in xenobiotic metabolism. Because the liver is frequently the most sensitive target in two-year bioassays, chemical regulation is often based on adverse liver effects. Drugs withdrawn from the market are more often due to unforeseen hepatotoxicity. Given the number of chemicals that need to be assessed for hepatotoxicity by the pharmaceutical and chemical Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 231
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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