Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
Tuesday Morning, March 8
8:00 AM to 9:00 AM
Grand Ballroom
Keynote Plenary Lecture: Increasing the
Prestige of Regulatory Sciences
Lecturer: Margaret Hamburg, U.S. FDA, Washington,
D.C.
Described as “an inspiring public health leader with
broad experience in infectious disease, bioterrorism,
and health policy” by HHS Secretary Kathleen Sebelius we are delighted
to have Dr. Margaret A. Hamburg, the 21st U.S. FDA Commissioner
present a keynote plenary lecture at the Society’s 50th Anniversary
Annual Meeting. Dr. Hamburg is exceptionally qualified by her training
and experience as a medical doctor, scientist, and public health executive.
Dr. Hamburg graduated from Harvard Medical School, and completed
her residency in internal medicine at what is now New York Presbyterian
Hospital-Weill Cornell Medical Center, one of the top-ten hospitals in the
nation. She conducted research on neuroscience at Rockefeller University
in New York, studied neuropharmacology at the National Institute of
Mental Health on the National Institutes of Health campus in Bethesda,
Maryland, and later focused on AIDS research as Assistant Director of
the National Institute of Allergy and Infectious Diseases.
During her career she has been widely praised for her initiatives, decisive
leadership, and significant public health measures. As a public health
official she is credited with improving services for women and children,
a needle-exchange program to reduce the spread of HIV (the AIDS
virus), and the initiation the first public health bio-terrorism defense
program in the nation. Her most celebrated achievement, however, was
curbing the spread of tuberculosis in the 1990s.
In 1994, Dr. Hamburg was elected to the membership in the Institute of
Medicine, one of the youngest persons to be so honored. Three years
later, at the request of President Clinton, she accepted the position of
Assistant Secretary for Policy and Evaluation in the U.S. Department of
Health and Human Services (HHS).
Tuesday Morning, March 8
9:00 AM to 11:45 AM
Room 206
Global Air Quality and Human Health
Symposium Session: Metabolic Basis of Respiratory Tract
Chemical Toxicity
Chairperson(s): Laura Van Winkle, University of California Davis, Davis,
CA, and Xinxin Ding, New York State Department of Health, Albany, NY.
Sponsor:
Inhalation and Respiratory Specialty Section
Endorsed by:
Mechanisms Specialty Section
Molecular Biology Specialty Section
The respiratory tract, including both the lung and the nasal tissue, has
substantial metabolic activity, which can influence the distribution and
action of drugs and xenobiotics, either inhaled or ingested. The metabolic
enzymes that are active in the respiratory tract include cytochrome P450
monooxygenases, esterases, oxidoreductases, and dehydrogenases. Their
distribution and activity can vary greatly with anatomic location, by species,
sex and history of prior exposure. Respiratory tract metabolic activity can
either enhance, or inhibit, local and systemic chemical toxicity. While
this basic principle has been understood and investigated for many years,
recent new approaches have allowed more in-Department investigation of
Abstract #
the mechanisms of toxicity in the respiratory tract following exposure to
bioactivated toxicants. Significant advances have been made, with the use
of novel animal models, new detection methods, application of site-specific
approaches to colocalize toxicity and metabolism, recombinant human
enzymes, and modeling, which enhance our understanding of the contributions
of xenobiotic metabolism in the respiratory tract to toxicity in humans.
Several examples highlighting recent progress in this area will be presented.
#884 9:00 METABOLIC BASIS OF RESPIRATORY
TRACT CHEMICAL TOXICITY. ​L. S. Van
Winkle 1 and X. Ding 2 . 1 Center for Health and the
Environment/Veterinary Medicine, Anatomy,
Physiology, and Cell Physiology, University of
California Davis, Davis, CA and 2 Division of
Environmental Health Sciences, Laboratory of
Molecular Toxicology, Wadsworth Center, New York
State Department of Health, Albany, NY.
9:00 INTRODUCTION. ​Laura Van Winkle
#885 9:05 ROLE OF CYP2A AND CYP2F ENZYMES
IN RESPIRATORY TRACT CHEMICAL
TOXICITY – INSIGHTS FROM P450
KNOCKOUT AND HUMANIZED MOUSE
MODELS. ​X. Ding 1,2 . 1 Laboratory of Molecular
Toxicology, Wadsworth Center, New York State
Department of Health, Albany, NY and 2 School
of Public Health, State University of New York at
Albany, Albany, NY.
#886 9:36 METABOLISM OF INHALED
GLUCOCORTICOIDS IN LUNG:
SELECTIVE INACTIVATION OF CYP3A5. ​
G. S. Yost. Deptartment of Pharmacology and
Toxicology, University of Utah, Salt Lake City, UT.
#887 10:07 SEX DIFFERENCES IN METABOLISM AND
TOXICITY IN THE LUNG. ​L. S. Van Winkle, K.
Sutherland, D. Morin, P. Edwards and A. Buckpitt.
University of California Davis, Davis, CA.
#888 10:38 DEVELOPMENT OF ADDUCTED PEPTIDE
BIOMARKERS TO ADDRESS THE
CONSEQUENCES OF HUMAN EXPOSURE
TO RODENT PULMONARY TOXICANTS. ​A.
Buckpitt, N. Pham, D. Krawiec, D. Morin, W. Jewell
and L. Van Winkle. University of California Davis,
Davis, CA.
#889 11:09 RESPIRATORY TRACT METABOLISM AND
INHALATION DOSIMETRY OF VAPORS. ​
J. B. Morris. Toxicology Program, University of
Connecticut, Storrs, CT.
11:40 SUMMARY.
Tuesday
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