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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # #1585 Poster Board Number.....................................703 DESCRIPTIVE ’OMICS OF ACETAMINOPHEN IN HUMANS. M. Jetten 1 , S. Gaj 1 , A. Ruiz-Aracama 2 , T. de Kok 1 , J. van Delft 1 , S. Claessen 1 , A. Lommen 2 , A. Peijnenburg 2 , L. Pellis 3 , E. van Someren 3 , R. Stierum 3 and J. Kleinjans 1 . 1 Health Risk Analysis & Toxicology, Maastricht University, Maastricht, Netherlands, 2 Institute of Food Safety, RIKILT, Wageningen, Netherlands and 3 Quality of Life, TNO, Zeist, Netherlands. Sponsor: H. van Loveren. #1586 Poster Board Number.....................................704 CISPLATIN-INDUCED GENOTOXIC STRESS IN PRIMARY MOUSE HEPATOCYTES, MOUSE EMBRYONIC STEM CELLS, AND HEPG2 CELLS. L. Rieswijk 1,2 , D. Lizárraga 1,2 , K. Brauers 1 , B. van de Water 2,3 , H. Vrieling 2,3 , J. van Delft 1,2 and J. Kleinjans 1,2 . 1 Health Risk Analysis and Toxicology, Maastricht University, Maastricht, Netherlands, 2 Netherlands Toxicogenomics Centre, Maastricht, Netherlands and 3 Toxicogenetics, LUMC, Leiden, Netherlands. Sponsor: H. van Loveren. #1587 Poster Board Number.....................................705 USING A TRANSCRIPTIONAL GENE SIGNATURE TO PREDICT NEPHROTOXICITY in vitro. D. DeSilver 1 , V. Bonato 2 , M. Kuhn 2 and M. T. Pletcher 1 . 1 Compound Safety Prediction, Pfizer, Inc., Groton, CT and 2 Biostatistics, Pfizer, Inc., Groton, CT. #1588 Poster Board Number.....................................706 TOXICOGENOMIC COMPARISON OF THE TOXIC EFFECTS OF DIETARY TCDD IN RAINBOW TROUT AND ZEBRAFISH. Q. Liu 1,2 , M. L. Rise 3 , C. A. Struble 4 , J. M. Spitsbergen 5 , G. Goetz 1 , R. J. Hutz 2 and M. J. Carvan 6,1 . 1 Great Lakes WATER Institute, Milwaukee, WI, 2 Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI, 3 Ocean Sciences Centre, Memorial University of Newfoundland, St. John’s, NF, Canada, 4 Department of Math, Statistics, and Computer Science, Marquette University, Milwaukee, WI, 5 Microbiology, Oregon State University, Corvallis, OR and 6 School of Freshwater Sciences, University of Wisconsin Milwaukee, Milwaukee, WI. #1589 Poster Board Number.....................................707 IDENTIFICATION OF MECHANISTIC BIOMARKERS OF CARDIAC AND SKELETAL MUSCLE TOXICITY TO AID THE DEVELOPMENT OF TISSUE-SPECIFIC IN VITRO MODELS. W. Dott 1 , P. Mistry 2 , J. Wright 2 and K. Herbert 1 . 1 Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom and 2 Syngenta, Bracknell, United Kingdom. Sponsor: R. Peffer. #1590 Poster Board Number.....................................708 RETROSPECTIVE GENE EXPRESSION ANALYSIS USING FORMALIN-FIXED TISSUE BLOCKS FROM TOXICOLOGICAL STUDIES. F. v. Landenberg, P. Hewitt, S. O. Mueller and C. S. Schmitt. Merck Serono, Darmstadt, Germany. #1591 Poster Board Number.....................................709 TRANSCRIPTIONAL DOSE RESPONSE ANALYSIS IN FEMALE MOUSE AND RAT LUNGS FOLLOWING REPEATED INHALATION EXPOSURE TO 2-CHLORO-1, 3-BUTADIENE. M. W. Himmelstein 1 and R. S. Thomas 2 . 1 DuPont Haskell Global Centers, Newark, DE and 2 The Hamner Institutes for Health Sciences, Research Triangle Park, NC. #1592 Poster Board Number.....................................710 GENE EXPRESSION PROFILING OF LXR- MEDIATED HEPATIC STEATOSIS IN RATS. J. M. Maher, W. R. Buck, M. J. Liguori, J. Lai- Zhang, T. Sharapova, S. J. Morgan, E. A. Blomme and Y. Yang. Investigative Toxicology and Pathology, Abbott Laboratories, Abbott Park, IL. #1593 Poster Board Number.....................................711 CHARACTERIZATION OF THE HEPATIC TRANSCRIPTOME RESPONSE TO A MIXTURE OF LOW MOLECULAR WEIGHT POLYBROMINATED DIPHENYL ETHERS: DISEASE, SIGNATURE, NETWORK AND PATHWAY ANALYSIS. S. S. Auerbach 1 , K. R. Shockley 1 , R. Thomas 2 , N. J. Machesky 4 , M. K. Vallant 1 , C. D. Hebert 3 , H. C. Cunny 1 and J. K. Dunnick 1 . 1 National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 2 Environmental Health Sciences, University of California, Berkeley, CA, 3 Southern Research Institute, Birmingham, AL and 4 Battelle Columbus Operations, Columbus, OH. #1594 Poster Board Number.....................................712 AGE AND SEX DIFFERENCES IN RENAL GENE EXPRESSION DURING THE RAT LIFE CYCLE. J. C. Kwekel, V. G. Desai, T. Han, W. S. Branham, C. L. Moland and J. C. Fuscoe. Systems Toxicology/Center for Functional Genomics, U.S. FDA/National Center for Toxicological Research, Jefferson, AR. #1595 Poster Board Number.....................................713 GENE EXPRESSION PROFILE OF RAT PRIMARY HEPATOCYTES EXPOSED TO DI(2-ETHYLHEXYL) PHTHALATE OR DIISONONYL PHTHALATE, THE PATH TO GENERATE TOXIGENOMICS DATA AS SUPPORT FOR STRUCTURE ACTIVITY RELATIONSHIPS ASSESSMENTS. J. M. Naciff, G. J. Overmann, R. Adams, G. J. Carr, J. P. Tiesman and G. P. Daston. Procter & Gamble, Cincinnati, OH. #1596 Poster Board Number.....................................714 PERCELLOME TOXICOGENOMICS PROJECT AND ITS APPLICATION TO STUDIES ON ANTICANCER AGENTS. J. Kanno, K. Aisaki, K. Igarashi and S. Kitajima. Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo, Japan. Sponsor: N. Ryoichi. #1597 Poster Board Number.....................................715 COMPARISON OF BASAL AND CRVI- MEDIATED SOLUTE CARRIER GENE EXPRESSION IN RODENT DUODENAL EPITHELIUM. S. Kim 1 , C. M. Thompson 2 , A. K. Kopec 1 , M. A. Harris 2 and T. R. Zacharewski 1 . 1 Biochemistry & Molecular Biology and Center for Integrative Toxicology, East Lansing, MI and 2 ToxStrategies, Inc., Katy, TX. 254 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1598 Poster Board Number.....................................716 NOVEL SHORT TERM PREDICTION SYSTEM FOR CARCINOGENICITY OF CHEMICALS BY HEPATIC TRANSCRIPT PROFILING IN A 28-DAY REPEAT-DOSE TOXICITY STUDY. F. Saito 1 , H. Matsumoto 1 , M. Takeyoshi 1 , Y. Yakabe 1 and T. Shirai 2 . 1 Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI), Japan, Saitama, Japan and 2 Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. #1599 Poster Board Number.....................................717 TIME AND CONCENTRATION DEPENDENT REGULATION OF THE TRANSCRIPTOME AND THE PHENOTYPE OF A MOUSE LIVER CELL LINE EXPOSED TO BAP. D. Jannuzzi Madureira 1,2 , J. Michaelson 3 , A. Beyer 3 , S. Trump 4 , I. Lehmann 4 and K. Schirmer 1,2 . 1 Eawag, Swiss Federal Institute of Aquatic Science and Technology, Duebendorf, Switzerland, 2 Swiss Federal Institute of Technology Zürich, Switzerland, Zuerich, Switzerland, 3 Biotechnology Center TU Dresden, Dresden, Germany and 4 Helmholtz Centre for Environmental Research, Leipzig, Germany. Sponsor: M. R. Embry. #1600 Poster Board Number.....................................718 TRANSCRIPTOMICS ANALYSIS OF NANOPARTICLE-CONTAINING HAIR DYES. D. A. Sarigiannis, G. Cimino Reale, E. Marafante, B. Casati, R. Brustio and A. Collotta. Institute for Health and Consumer Protection, European Commission - Joint Research Centre, Ispra, Varese, Italy. Sponsor: L. Birnbaum. #1601 Poster Board Number.....................................719 A TOXICOGENOMIC COMPARISON OF PRIMARY VERSUS PHOTOCHEMICALLY ALTERED AIR POLLUTANTS IN HUMAN LUNG CELLS. J. E. Rager 1 , K. G. Sexton 1 , L. Smeester 1 , I. Jaspers 2 and R. C. Fry 1 . 1 Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC and 2 Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. #1602 Poster Board Number.....................................720 UNCOVERING TRANSCRIPTIONAL REGULATORS OF KIDNEY INJURY MOLECULE-1 IN CISPLATIN-INDUCED KIDNEY TOXICITY. M. P. Wagoner, J. Milano, D. Brott, D. Thurman, Y. Dragan, L. B. Kinter and B. Jeffy. Safety Assessment U.S., AstraZeneca, Wilmington, DE. #1603 Poster Board Number.....................................721 CORRELATION BETWEEN TOXICOGENOMIC PROFILING AND TRADITIONAL SAFETY BIOMARKERS. T. Wang 1 , M. Papoutsi 2 , M. Decristofaro 3 , M. Keselica 3 , E. Skuba 3 , R. Spaet 3 , P. Moulin 2 , F. Pognan 2 , A. Wolf 2 and W. Kluwe 1 . 1 Translational Sciences, Novartis Institute of Biomedical Research-USA, Emeryville, CA, 2 Translational Sciences, Novartis Institute of Biomedical Research-Switzerland, Basel, Switzerland and 3 Novartis Institute of Biomedical Research-USA, Easter Hanover, NJ. Abstract # #1604 Poster Board Number.....................................722 MUSCLE IMPLANTED PELLETS OF TUNGSTEN/NICKEL/COBALT, NICKEL, OR TANTALUM: A 12 MONTH STUDY OF METAL MOBILIZATION AND MICROARRAY EXPRESSION. D. I. Bannon 1 , A. B. Rosencrance 2 , W. E. Dennis 2 , W. Bao 3 , C. Tsu-Ming 3 , R. D. Wolfinger 3 and E. J. Perkins 4 . 1 Directorate of Toxicology, U.S. Army Public Health Command, APG, Aberdeen, MD, 2 Department of Chemistry, U.S. Army Center for Environmental Health Research, Fort Detrick, MD, 3 SAS Institute, Inc., Cary, NC and 4 Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS. #1605 Poster Board Number.....................................723 EXPOSURE TO HEAVY METALS CAUSES DISTINCT CHANGES IN THE GENE EXPRESSION PATTERN OF A RAT LIVER- DERIVED CELL LINE. M. Permenter 2 , J. A. Lewis 1 and D. A. Jackson 1 . 1 U.S. Army Center for Environmental Health Research, Fort Detrick, MD and 2 Excet, Inc., Fort Detrick, MD. #1606 Poster Board Number.....................................724 TRANSCRIPTIONAL SIGNATURES FOR CHEMICALLY INDUCED HEPATOXICITY: IN VIVO PREDICTIVE POWER OF 3D LIVER CO-CULTURE OVER 2D HEPATOTOXICITY. B. A. Naughton 1 , R. S. Thomas 3 , L. New 1 , C. I. Pearson 1 , A. H. Roter 2 and D. R. Applegate 1 . 1 RegeneMed Inc., San Diego, CA, 2 Entelos, Inc., Foster City, CA and 3 Genomics, The Hamer Institutes for Health Sciences, Research Triangle Park, NC. Tuesday Afternoon, March 8 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Developmental Toxicology Chairperson(s): Jyotshna Kanungo, U.S. FDA, Jefferson, AR. Displayed: 1:00 PM–4:30 PM Author Attended: 2:45 PM–4:30 PM #1607 Poster Board Number.....................................801 COMPARISON OF BDE-47 AND ITS HYDROXYLATED ANALOGUES ON THE DEVELOPMENT OF EMBRYONIC ZEBRAFISH. C. Y. Usenko 1,2 and E. D. Bruce 1,3 . 1 Biology, Baylor University, Waco, TX, 2 Biomedical Studies, Baylor University, Waco, TX and 3 Department of Environmental Science, Baylor University, Waco, TX. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 255
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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