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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Wednesday Abstract # Abstract # #2251 Poster Board Number.....................................355 TELOMERE DYSFUNCTION AND TELOMERASE REACTIVATION IN HUMAN SKIN KERATINOCYTES: A POSSIBLE NEW MECHANISM OF PCB CARCINOGENESIS. P. Senthilkumar, A. Klingelhutz, L. Robertson and G. Ludewig. Human Toxicology, The University of Iowa, Iowa City, IA. #2252 Poster Board Number.....................................356 GLOBAL ASSESSMENT OF POLYBROMINATED DIPHENYL ETHERS IN SPERM WHALE (PHYSETER MACROCEPHALUS) SKIN. L. Savery 1,2,3 , S. Eagle 4 , H. M. Stapleton 4 , I. Kerr 5 , W. Thompson 2,3 and J. P. Wise, Sr. 1,2,3 . 1 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME, 2 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME, 3 Department of Applied Medical Sciences, University of Southern Maine, Portland, ME, 4 Nicholas School of the Environment, Duke University, Durham, NC and 5 Ocean Alliance, Lincoln, MA. #2253 Poster Board Number.....................................357 UNDERSTANDING THE TOXICITY OF BROMKAL 70-5DE, A PBDE FLAME RETARDANT MIXTURE, USING A YEAST MODEL. B. Gaytan, C. Monroy, A. Loguinov and C. Vulpe. University of California at Berkeley, Berkeley, CA. #2254 Poster Board Number.....................................358 THE GENDER DIFFERENCE IN SENSITIVITY TO ACUTE TOXICITY OF TCDD IS REVERSED IN MICE COMPARED WITH RATS. R. Pohjanvirta 1 , H. Miettinen 2 , S. Sankari 3 and J. Lindén 1,4 . 1 Department of Food Hygiene and Environmental Health, University of Helsinki, University of Helsinki, Finland, 2 Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland, 3 Central Laboratory of the Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland and 4 Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland. Sponsor: M. Viluksela. #2255 Poster Board Number.....................................359 REVERSE CAUSATION OF DIOXIN DOSE-RESPONSE TRENDS FOR RISK OF DIABETES MELLITUS TYPE 2 AMONG OPERATION RANCH HAND VIETNAM VETERANS. B. D. Kerger 1 , P. K. Scott 2 , M. Pavuk 3 , M. Gough 4 and D. J. Paustenbach 5 . 1 Health Science Resource Integration, Tallahassee, FL, 2 ChemRisk, Pittsburgh, PA, 3 Centers for Disease Control and Prevention, Atlanta, GA, 4 Private Consultant, Berkeley, CA and 5 ChemRisk, San Francisco, CA. #2256 Poster Board Number.....................................360 UNUSUALLY HIGH LEVELS OF BISPHENOL-A IN CASH RECEIPTS. R. C. Achuthan 1 , S. Babu 1 , S. N. Uppu 3 , K. Smith 1 , N. L. Parinandi 2 and R. M. Uppu 1 . 1 Environmental Toxicology, Southern University, Baton Rouge, LA, 2 DHLRI, The Ohio State University Medical Center, Columbus, OH and 3 Prairieville Middle, Prairieville, LA. Wednesday Afternoon, March 9 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Pharmacokinetics and Disposition Chairperson(s): Michele Bouchard, University de Montréal, Québec, Canada. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #2257 Poster Board Number.....................................401 PHARMACOKINETICS, TISSUE DISTRIBUTION, EXCRETION BALANCE, AND METABOLITE PROFILING FOLLOWING A SINGLE INTRAVENOUS OR ORAL DOSE OF [ 14 C]-FORODESINE IN RATS. D. Draganov 1 , D. Sved 1 , L. Harman 2 and B. S. Levine 3 . 1 Metabolism, WIL Research Laboratories, LLC, Ashland, OH, 2 BioCryst Pharmaceuticals, Inc., Durham, NC and 3 Levine & Associates, LLC, Chicago, IL. #2258 Poster Board Number.....................................402 PHARMACOKINETICS, EXCRETION BALANCE, AND METABOLITE PROFILING FOLLOWING A SINGLE INTRAVENOUS OR ORAL DOSE OF [ 14 C]-FORODESINE IN CYNOMOLGUS MONKEYS. B. S. Levine 1 , D. Sved 2 , L. Harman 3 and D. Draganov 2 . 1 Levine & Associates, LLC, Chicago, IL, 2 Metabolism, WIL Research Laboratories, LLC, Ashland, OH and 3 BioCryst Pharmaceuticals, Inc., Durham, NC. #2259 Poster Board Number.....................................403 INHALATION KINETICS OF 1, 1-DIFLUOROETHANE IN HUMANS. L. Ernstgård 1 , W. Dekant 2 , S. Juran 1 , B. Lind 1 , B. Sjögren 1 and G. Johanson 1 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and 2 University of Wuerzburg, Wuerzburg, Germany. #2260 Poster Board Number.....................................404 TOXICOKINETICS OF FOLPET BIOMARKERS IN ORALLY AND DERMALLY EXPOSED VOLUNTEERS. A. Berthet 1,2 , M. Bouchard 1 and B. Danuser 2 . 1 Department Environmental & Occupational Health, University of Montréal, Montréal, QC, Canada and 2 Institute for Work and Health, Lausanne, Switzerland. #2261 Poster Board Number.....................................405 TISSUE DISTRIBUTION AND EXCRETION OF SR13668 IN RATS. J. M. Gow 1 , K. O’Loughlin 1 , A. Ta 1 , L. Jong 1 , I. M. Kapetanovic 2 and C. E. Green 1 . 1 Biosciences Division, SRI International, Menlo Park, CA and 2 National Cancer Institute, Bethesda, MD. #2262 Poster Board Number.....................................406 PHARMACOKINETICS OF A PYRETHROID INSECTICIDE MIXTURE IN THE RAT. D. G. Ross 1 , J. M. Starr 2 , E. J. Scollon 3 , K. M. Crofton 1 , M. J. Wolansky 4 , M. F. Hughes 1 and M. J. DeVito 5 . 1 ORD/NHEERL, U.S. EPA, Research Triangle Park, NC, 2 ORD/NERL, U.S. EPA, Research Triangle Park, NC, 3 OCSPP/HED, U.S. EPA, Alexandria, VA, 4 University of Buenos Aires, Buenos Aires, Argentina and 5 NTP, NIEHS, Research Triangle Park, NC. 316 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #2263 Poster Board Number.....................................407 EVALUATING PHARMACOKINETICS AND BIOAVAILABILITY OF LEVOFLOXACIN IN RATS. A. Banerjee 1 , K. Kabirov 1 , T. Martín- Jiménez 2 and A. Lyubimov 1 . 1 Toxicology Research Laboratory, University of Illinois at Chicago, Chicago, IL and 2 College of Veterinary Medicine, University of Tennessee, Knoxville, TN. #2264 Poster Board Number.....................................408 ROLE OF INTESTINAL P450 AND P-GLYCOPROTEIN IN MODULATING THE BIOAVAILABILITY OF ORAL LOVASTATIN. Y. Zhu. Environmental Health Sciences, Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, NY. Sponsor: X. Ding. #2265 Poster Board Number.....................................409 PARAQUAT DISPOSITION: A POTENTIAL ROLE FOR P-GLYCOPROTEIN TRANSPORT. S. Lacher, F. Cardozo-Pelaez and E. L. Woodahl. University of Montana, Missoula, MT. #2266 Poster Board Number.....................................410 THE IMPORTANCE OF EFFLUX TRANSPORTERS IN CNS EXPOSURE TO AVERMECTIN INSECTICIDES. A. M. Dalzell 1 , F. M. Williams 2 , P. Mistry 3 , J. Wright 3 and C. D. Brown 1 . 1 Cell & Molecular Biosciences, University of Newcastle, Newcastle-Upon-Tyne, United Kingdom, 2 Medical Toxicology Centre, University of Newcastle, Newcastle-Upon-Tyne, United Kingdom and 3 Syngenta, Bracknell, United Kingdom. Sponsor: R. Peffer. #2267 Poster Board Number.....................................411 SENSITIVE AND SPECIFIC FLUORESCENT PROBES FOR FUNCTIONAL ANALYSIS OF ALL THREE MAJOR TYPES OF MAMMALIAN ABC TRANSPORTERS. W. F. Patton, I. V. Lebedeva, P. Pande, D. Shen and D. Gatica. R&D, Enzo Life Sciences, Farmingdale, NY. Sponsor: J. Davis. #2268 Poster Board Number.....................................412 OAT2 REPRESENTS AN INITIAL STEP IN THE RENAL TUBULAR SECRETION OF GUANINE-CONTAINING ANTIVIRAL DRUGS. Y. Cheng and R. Pelis. DMPK-DDI, Novartis Institutes for BioMedical Research, East Hanover, NJ. #2269 Poster Board Number.....................................413 COMPARISON OF TRANSPORTER EXPRESSION IN BRAIN, EYE, TESTIS, AND PLACENTA. F. Selwyn, J. Liu and C. Klaassen. Pharmacology and Toxicology, University of Kansas Medical Center, Kansas City, KS. #2270 Poster Board Number.....................................414 DIFFERENTIAL HEPATIC AND INTESTINAL PHASE-II BIOTRANSFORMATION ENZYME/TRANSPORTER EXPRESSION AND SERUM BISPHENOL A (BPA) LEVELS IN MOUSE MODELS OF OBESITY AND DIABETES. O. DiPrete 1 , V. R. More 1 , J. Xu 1 , D. Doerge 2 and A. Slitt 1 . 1 Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI and 2 Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR. Abstract # #2271 Poster Board Number.....................................415 TOXICOKINETICS OF PERFLUOROOCTANOIC ACID (PFOA) AND PERFLUOROOCTANE SULFONATE (PFOS) AFTER A SINGLE INTRAVENOUS OR GAVAGE ADMINISTRATION TO HARLAN SPRAGUE-DAWLEY RATS. S. Hong 1 , V. Robinson 2 , S. Gibbs 1 , S. W. Graves 1 , B. Burback 1 , M. Eifrid 1 and C. Smith 2 . 1 Battelle Memorial, Columbus, OH and 2 NIEHS, NIH, Research Triangle Park, NC. #2272 Poster Board Number.....................................416 TOXICOKINETICS OF PERFLUOROHEXANOIC ACID (PFHXA) AND PERFLUOROHEXANE-1-SULPHONIC ACID POTASSIUM SALT (PFHSKSLT) AFTER A SINGLE INTRAVENOUS OR GAVAGE ADMINISTRATION TO HARLAN SPRAGUE-DAWLEY RATS. S. Gibbs 1 , V. Robinson 2 , S. Hong 1 , S. W. Graves 1 , B. Burback 1 , C. Granville 1 , M. Eifrid 1 and C. Smith 2 . 1 Battelle Memorial, Columbus, OH and 2 NIEHS, NIH, Research Triangle Park, NC. #2273 Poster Board Number.....................................417 ABSORPTION AND EXCRETION OF 14 C- PERFLUOROOCTANOIC ACID (PFOA) IN BEEF CATTLE. J. Huwe 1 , S. Lupton 1 , D. J. Smith 1 , K. Dearfield 2 and J. J. Johnston 3 . 1 USDA, ARS, Biosciences Research Laboratory, Fargo, ND, 2 USDA, FSIS, Office of Public Health Science, Washington, D.C. and 3 USDA, FSIS, Office of Public Health Science, Fort Collins, CO. #2274 Poster Board Number.....................................418 SPECIES-SPECIFIC FACTORS WHEN PREDICTING SYSTEMIC CLEARANCE OF ENB-0040 IN RABBITS VIA AN ALLOMETIC SCALING APPROACH. C. Jomphe 1 , I. Lemire 2 , P. Leonard 2 , M. Reimer 1 and M. Beliveau 1 . 1 RAS, Pharsight Corporation, Montréal, QC, Canada and 2 Enobia Pharmacology Montréal, QC, Canada. #2275 Poster Board Number.....................................419 METABOLISM AND DISPOSITION OF 2-METHOXY-4-NITROANILINE IN MALE AND FEMALE SPRAGUE-DAWLEY RATS AND B6C3F1 MICE. S. Waidyanatha 1 , Q. Zhan 2 , I. Surh 1 , S. Warren 2 , P. Patel 2 , S. Black 2 , J. Burgess 2 and J. Mathews 2 . 1 National Institute of Environmental Health Sciences, Research Triangle Park, NC and 2 RTI International, Research Triangle Park, NC. #2276 Poster Board Number.....................................420 METABOLISM AND DISPOSITION OF N-BUTYLPARABEN FOLLOWING ORAL AND DERMAL ADMINISTRATION. J. Mathews 1 , S. Black 1 , C. Blystone 2 , S. Brown 1 , P. Patel 1 , A. Etheridge 1 and S. Waidyanatha 2 . 1 RTI International, Research Triangle Park, NC and 2 National Institute of Environmental Health Sciences, Research Triangle Park, NC. #2277 Poster Board Number.....................................421 DIMETHYLETHANOLAMINE INCREASED SERUM CHOLINE, BUT DID NOT ALTER [14C]-CHOLINE TISSUE DISTRIBUTION IN WISTAR HAN RATS. J. M. Sanders 2 , C. J. Wegerski 1 , M. Doyle-Eisele 1 and J. D. McDonald 1 . 1 LRRI, Albuquerque, NM and 2 NTP/NIEHS, Reserach Triangle Park, NC. Wednesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 317
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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Society of Toxicology 2011 ToxExpo
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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