Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Continuing Education (Continued)
Sunday Afternoon, March 6
1:15 PM to 5:00 PM
First and Second Level (See signage at CE Booths for room
locations)
The Biology and Toxicology of the Peri- and Post-Natal
Development
PM15
CE Basic
Chairperson(s): Gregg D. Cappon, Pfizer Global Research and
Development, Groton, CT, and Gary J. Chellman, Charles River
Laboratories, Reno, NV.
Thank You
Speakers
CE
Sponsor:
Reproductive and Developmental Toxicology Specialty Section
The susceptibility to toxicity of organ systems during in utero and
post-natal development is a concern for both drugs and environmental
chemicals. While developmental toxicity can be manifested by death,
structural abnormalities, and altered growth, alterations in the functional
competence are of special concern during post-natal development. The
primary focus in the past has been on functional toxicity to the CNS and
reproduction, but the potential for developmental exposure to impact
function of other systems such as the cardiovascular, respiratory, immune,
endocrine, and digestive systems is now widely recognized. This basic
course will begin with a review of post-natal development of major organ
systems in humans and how those developmental processes might translate
to sensitive periods for toxicity. Focus will be placed on study designs
for evaluation of pharmaceuticals during the pre- and post-natal development
period and designs for juvenile animal toxicity studies to support
pediatric drug development. Next, designs will be presented for assessment
of post-natal and juvenile toxicity studies in non-human primates, a
rapidly expanding area given the increase in biopharmaceutical research.
The course will wrap up with a discussion of multigenerational studies
used to assess potential toxicity of environmental chemicals. Attendees
will leave this course with an appreciation of the complex biology of
pre- and post-natal development periods and an overview of current
approaches to evaluating safety during this period.
On behalf of the SOT Council and
the entire membership of the Society
of Toxicology (SOT), thank you to
all of the speakers who graciously
agreed to come to Washington, D.C.,
to participate in the 2011 Annual
Meeting. SOT’s Annual Meeting
is the largest international forum
to highlight novel discoveries and
emerging fields and how they apply to
toxicology. You played an important
role in helping SOT showcase this
year’s achievements in research and
education and your time, efforts, and
expertise are truly appreciated.
• Post-Natal Maturation of Major Organ Systems, Christopher J.
Bowman, Pfizer Inc., Groton, CT
• Post-Natal and Juvenile Toxicity Studies: Basic Study Designs and
Practical Approaches, Donald G. Stump, WIL Research Laboratories
LLC, Ashland, OH
• Post-Natal and Juvenile Toxicity Studies in Non-Human Primates,
Gary J. Chellman, Charles River Laboratories, Reno, NV
• One and Two-Generation Studies for Assessment of
Environmental Chemicals, Sue Marty, The Dow Chemical Company,
Midland, MI
96 SOT 50th Anniversary Annual Meeting