Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
Wednesday
Abstract # Abstract #
12:00 MICHAEL BOLGER. ​Introduction
12:05 IMPROVING OUR UNDERSTANDING
OF MYCOTOXINS: EMERGING ISSUES
RELEVANT TO FOOD SAFETY AND PUBLIC
HEALTH. ​Kenneth A. Voss
12:20 MYCOTOXINS: U.S. AND EUROPEAN
REGULATORY STRATEGIES. ​Sara H. Henry
12:35 AFLATOXIN LIMITS: A CASE STUDY OF
RISK MANAGEMENT APPROACHES IN
THE COMMERCIAL ENVIRONMENT. ​Julie
G. Adams
12:50 RISKS IN LESS DEVELOPED COUNTRIES:
FOCUS ON PUBLIC HEALTH
INTERVENTIONS, NOT REGULATIONS. ​
Felicia Wu
1:05 PANEL DISCUSSION/Q&A.
Wednesday Afternoon, March 9
12:15 PM to 1:05 PM
Room 151
Translational Impact Award Lecture:
Integration of Bioinformatics into Regulatory
Decision Making
Lecturer: Weida Tong, U.S. FDA, Jefferson, AR.
Advanced high throughput and high content technologies
such as genomics offer new opportunities
for investigating disease and toxicity at the molecular level, and for
discovery of corresponding biomarkers. Data from the new experimental
platforms are both huge in number and noisy in content. Extraction of
useful knowledge requires bioinformatics for data management, analysis
and interpretation. The NCTR Center for Bioinformatics provides
an array of informatics infrastructures and data analysis capability to
address the U.S. FDA regulatory needs. The presentation highlights
a diversity of projects developed in the center to address key bioinformatics
issues associated with the omics research and predictive
toxicology in FDA. Specifically, the following projects will be discussed
with focused on lessons learned: (1) The U.S. FDA bioinformatics tool,
Array-Track; (2) The FDA-led community wide effort, MicroArray
Quality Control (MAQC) project; (3) Liver Toxicity Knowledge Base
(LTKB); and (4) Endocrine Disruptor Knowledge Base (EDKB).
Wednesday Afternoon, March 9
1:00 PM to 4:30 PM
Exhibit Hall
Poster Session: Nanotoxicology: In Vitro or Ex Vivo Studies
Chairperson(s): Nan Mei, U.S. FDA, Jefferson, AR.
Displayed: 1:00 PM–4:30 PM
Author Attended: 1:00 PM–2:45 PM
#2154 Poster Board Number.....................................118
TERPENE EFFECTS ON PENETRATION
OF NANOPARTICLES IN HUMAN SKIN. ​N.
A. Monteiro-Riviere 1 , A. O. Inman 1 , D. Erdmann 2 ,
X. Xia 1 and J. E. Riviere 1 . 1 Center for Chemical
Toxicology Research and Pharmacokinetics, North
Carolina State University, Raleigh, NC and 2 Duke
University Medical Center, Duke University,
Durham, NC.
#2155 Poster Board Number.....................................119
SKIN PH EFFECTS THE PENETRATION
OF QUANTUM DOT NANOPARTICLES IN
PORCINE SKIN. ​A. O. Inman, N. A. Monteiro-
Riviere and J. E. Riviere. Center for Chemical
Toxicology Research and Pharmacokinetics, North
Carolina State University, Raleigh, NC.
#2156 Poster Board Number.....................................120
INFORMING SELECTION OF
NANOMATERIAL CONCENTRATIONS FOR
TOXCAST IN VITRO TESTING USING THE
MULTIPLE-PATH PARTICLE DOSIMETRY
MODEL. ​S. Gangwal 1 , J. S. Brown 2 , A. Wang 1 ,
K. A. Houck 1 , D. J. Dix 1 , R. J. Kavlock 1 and E. A.
Cohen Hubal 1 . 1 National Center for Computational
Toxicology (NCCT), U.S. EPA, Research Triangle
Park, NC and 2 National Center for Environmental
Assessment (NCEA), U.S. EPA, Research Triangle
Park, NC.
#2157 Poster Board Number.....................................121
NANOTOXICOLOGY – QUO VADIS? ​H. F.
Krug. Materials Meet Life, EMPA - Materials &
Technology, St. Gallen, Switzerland. Sponsor: B.
Fadeel.
#2158 Poster Board Number.....................................122
A NOVEL COMPREHENSIVE EVALUATION
PLATFORM TO ASSESS NANOPARTICLE
TOXICITY IN VITRO. ​C. Hirsch 1 , F. Wessling 1 ,
K. Fischer 1 , M. Roesslein 1 , P. Wick 1 , H. Hofmann 2
and H. F. Krug 1 . 1 Materials-Biology Interactions,
Empa, Swiss Federal Laboratories for Materials
Science and Technology, St. Gallen, Switzerland and
2
Powder Technology Laboratory, EPFL, Lausanne,
Switzerland. Sponsor: B. Fadeel.
#2159 Poster Board Number.....................................123
PROTEOME PROFILING OF BEAS-2B
CELLS TREATED WITH TITANIUM
DIOXIDE REVEALS POTENTIAL TOXICITY
OF AND DETOXIFICATION PATHWAYS
FOR NANOMATERIALS. ​M. E. Bruno, W.
Winnik, K. Wallace, R. Prasad and Y. Ge. U.S. EPA,
Research Triangle Park, NC. Sponsor: E. Kenyon.
#2160 Poster Board Number.....................................124
SWCNT EXPOSURE OF ALVEOLAR
EPITHELIAL CELLS AND MACROPHAGES
INDUCED OPN AND TGF-β1 RESPONSE. ​
M. J. Waltz 1,2 , A. R. Murray 1,2 , E. Kisin 2 and A. A.
Shvedova 1,2 . 1 West Virginia University, Morgantown,
WV and 2 NIOSH, Morgantown, WV.
#2161 Poster Board Number.....................................125
MEMBRANE-MEDIATED MODES
OF ENTRY OF C 60
INTO CULTURED
IMMORTALIZED MACROPHAGES. ​K. A.
Russ 1 , I. C. Speirs 1 , P. Elvati 2 , J. A. Fernandez 1 , A.
Violi 2 and M. A. Philbert 1 . 1 Department of EHS,
Toxicology, University of Michigan, Ann Arbor,
MI and 2 Department of Mechanical Engineering,
University of Michigan, Ann Arbor, MI.
#2162 Poster Board Number.....................................126
IN VITRO TESTING STRATEGIES FOR
ASSESSING PARTICLE-INDUCED GENETIC
DAMAGE USING ALVEOLAR CELL LINES. ​
K. P. Glover, A. Myhre, M. Laskowski, K. L. Reed,
E. Donner and D. B. Warheit. DuPont Haskell Global
Centers for Health and Environmental Sciences,
Newark, DE.
308
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