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50 th Anniversary Annual Meeting and ToxExpo Abstract Key Word Index (Continued) The numerals following each key word refer to the relevant abstract number(s). Key Word Index Arsenite.... 232, 1279, 1973, 1994, 1995, 1996, 2366, 2565 Artemia franciscana........................ 2236 Arthritis................................. 1511, 1893 Artificial Turf.................................. 1568 Aryl hydrocarbon receptor...... 103, 218, 349, 351, 353, 356, 360, 364, 368, 372, 405, 1121, 1122, 1127, 1134, 1139, 1158, 1631, 1642, 1897, 2369 aryl hydrocarbon receptor (AHR)... 347, 1129, 1157, 1704, 2666 aryl hydrocarbon receptor interacting protein........................... 1366 Aryl hydrocarbon receptor nuclear translocator................ 372, 1365 Aryl hydrocarbon receptor repressor........................................... 353 AS3MT polymorphism................... 1980 AS3MT/M287T polymorphism...... 1981 Asbestos..... 24, 601, 602, 683, 687, 689, 693, 1247, 1509, 1511, 1935, 1936 asphalt fumes.................................... 237 assessments....................................... 619 asthma...................... 599, 606, 681, 886, 1372, 2335 Asthma model................................... 904 asthmatic inflammation.................... 253 astrocyte.......................................... 1350 astrocytes............ 163, 2129, 2620, 2664 Astroglial cells.................................. 344 ATCA.............................................. 1689 atherosclerosis..... 190, 209, 1202, 1712, 1970, 1971, 2086, 2113, 2180 Athersclerosis................................... 183 atmosphere.............................. 594, 2493 Atopic Dermatitis........................... 2207 ATP................................................. 1520 ATP depletion................................. 1671 ATP Synathase.................................. 373 ATP-binding cassette transporters.... 535 ATP-competitive............................... 401 Atrazine... 665, 1031, 1032, 1042, 1071, 1357, 1747, 2090, 2093 Atresia............................................. 1033 attention.......................................... 1618 attrition................................. 2675, 2680 Aurora............................................... 792 Australasia...................................... 1878 autism.......... 610, 620, 992, 1769, 1770, 1771, 1772, 1773, 2611 Autism Spectrum Disorder............. 2594 Autohpagy...................................... 2446 autoimmune................ 1515, 2683, 2686 autoimmune disease..... 949, 1514, 1628, 2196, 2687 Autoimmunity.... 287, 1508, 1509, 1510, 2682, 2683, 2684 Automated........................................ 153 automated micronuclei scoring......... 339 autophagy........ 1278, 1655, 1749, 1988, 2031, 2347, 2444, 2445, 2447, 2448 avian............................. 205, 1018, 1620 Azo dye........................................... 1418 azo dyes.......................................... 2409 AZT.................................................. 116 B cell activation.............................. 1125 B cells............................................. 1513 B lymphocytes................................ 1666 B(a)P................................................. 217 B[a]P metabolome.......................... 1681 B[a]P-7, 8-dione............................. 1831 bacteria........................... 548, 844, 2441 bacterial metabolism....................... 1827 BAG1................................................ 166 baicalin........................................... 1825 Balb 3T3 NRU test......................... 1012 BaP................................ 814, 1599, 2203 Barium............................................ 1228 base excision repair.......................... 112 Basic Red 51................................... 2408 Bax.................................................. 2588 bayesian............................................ 478 Bayesian Network............................ 716 BBB & BCB................................... 1478 BBDR-HPT axis model.................. 2668 b-catenin........................................... 985 B-cells............................................. 1121 Bcl-xL............................................... 200 BCOP.................................... 2550, 2569 BCRP.............................................. 1047 Beauvericin..................................... 2423 Behavior.... 588, 872, 1329, 1337, 1338, 1340, 1490, 2143, 2150 Behavioral....................................... 1724 behavioral development.................. 2628 behavioral effects.............................. 871 Behavioral toxicity............... 1886, 2609 Behaviour....................................... 2614 Belief Theory.................................... 729 Benazepril....................................... 2285 benchmark dose analysis................ 2692 benzene.......... 337, 731, 732, 824, 1210, 1255, 1263, 1373, 1941, 2282 Benzo(a)pyrene.... 699, 942, 1065, 1670, 1695, 2546, 2607, 2648 Berberine.............................. 1117, 1850 beryllium............................... 1529, 2487 beta cell........................................... 2653 beta-amyloid................................... 2138 beverage,......................................... 2443 BFRs............................................... 2200 Bibliometry..................................... 1484 Bile acid........................ 437, 1104, 1643 bile acids................................. 548, 1080 Biliary Excretion............................ 2557 Bilirubin............................................ 386 bilobalide.......................................... 377 bioaccessibility... 298, 1942, 2566, 2572 bioactivation............................. 73, 2220 bioanalysis...................................... 1230 bioanalytical................................... 1926 Bioassay.......................................... 1419 Bioavailability........... 1178, 1265, 1938, 2009, 2263, 2566 biocompatability........ 1312, 1313, 1314, 1550 Biodegradable....................................... 1 biodegradation.............................. 25, 54 biodiesel...................... 1413, 1462, 2489 Biodiesel exhaust.............................. 606 biodistribution............. 1460, 2065, 2084 BioEpisteme..................................... 137 Biofuel.................................... 707, 1547 bioinformatics.......... 128, 130, 133, 151, 859, 1336 Bioinformatics tools............................. 4 biokinetic model............................. 1316 biokinetics....................................... 2170 biological barrier............................ 1763 Biological Descriptors...................... 488 biological modeling......... 481, 703, 704, 705, 735, 940, 1735, 2287 Biological models............................. 702 biological monitoring......................... 50 Biological Pathway Networks........ 1598 biological pathways.................. 143, 532 biological toxins................... 2043, 2044 biological warfare........................... 2042 Biologically Based Dose Response........................................... 702 Biologically effective dose............... 865 biologically-based models.............. 2688 Biologics........................................... 809 Biomarker............................................... 164, 185, 202, 436, 438, 440, 744, 745, 880, 934, 1066, 1101, 1185, 1237, 1238, 1288, 1426, 1427, 1438, 1440, 1442, 1443, 1444, 1446, 1448, 1451, 1492, 1494, 1506, 1680, 1682, 1685, 1693, 1695, 2241, 2317, 2669, 2696 Biomarker and Biomonitoring........ 1239 Biomarker discovery.... 135, 1281, 1433 Biomarker Genes............................ 1677 biomarkers.............................................. 51, 281, 310, 453, 521, 737, 833, 838, 888, 947, 1110, 1204, 1240, 1241, 1258, 1264, 1283, 1284, 1330, 1425, 1428, 1432, 1434, 1435, 1676, 1678, 1683, 1684, 1692, 1785, 2043, 2044, 2111, 2117, 2148, 2232, 2260, 2278, 2672 biomass........................................... 1535 Biometrics......................................... 635 Biomonitoring............ 1424, 1449, 1942, 1943, 1974 Biomonitoring Equivalent.............. 1940 biopesticides................................... 1731 Biopharmaceuticals..... 809, 1150, 1151, 1922 bioremediation................................ 2238 biosafety......................................... 1517 Biosensor........................................ 1260 Biosignature.................................... 1442 Biosimilars........................................ 806 Biosolids Microconstituents........... 1264 Biospectrum...................................... 156 biotechnology................................. 1525 bioterrorism............... 2414 , 2432, 2433 biotherapeutics........................ 881, 2673 Biotransformation...... 1418, 1818, 1819, 1825, 1826, 1827, 1833, 2102 birds.......................................... 295, 296 birth defects...................................... 810 bi-specific......................................... 776 Bisphenol A..................... 100, 102, 708, 720, 959, 1025, 1033, 1064, 1078, 1252, 1315, 1612, 1720, 1943, 2186, 2246, 2256, 2352, 2363, 2365, 2626, 2667 Bisphenol AF.................................. 1660 Bisphenol-A.......................... 1063, 2270 Bizzy................................................. 131 black cohosh................................... 2374 Bladder................................. 1677, 2645 bladder cancer................................. 1997 bleomycin......................................... 540 Blood.............................................. 2318 blood brain barrier.......................... 2627 Blood Cadmium................................ 767 blood lead............................... 628, 1538 Blood mercury................................ 1256 Blood pressure........ 202, 557, 568, 1930 blood-brain barrier.................. 993, 2266 blood-brain barrier (BBB).............. 1495 Blood-brain-barrier......................... 1464 blue-green algae.................... 2435, 2436 BMAA...................................... 165, 166 Body Temperature.......................... 1925 body weight...................................... 518 bone.............................. 291, 1302, 2274 bone formation................................ 2343 bone lead......................................... 1686 Bone marrow.......................... 101, 1168 bone marrow toxicity.... 785, 1153, 1906 Bone marrow, Spleen, thymus, blood............................................... 1138 Boolean Networks............................ 937 Botanical dietary supplements.......... 227 botanical extracts.............................. 995 bottlenose dolphin............................ 657 Botulinum........................................... 77 botulinum toxin type A..................... 787 Bovine Corneal Opacity and Permeability Assay......................... 1551 bowhead whale................................. 279 BP oil spill...................................... 2342 BPA....................................... 2311, 2359 BPDE.............................................. 2235 B-Raf................................................ 244 brain........................................ 174, 2495 brain metastases................................ 260 BrdU................. 1154, 1518, 2536, 2595 breast cancer...... 21, 111, 229, 248, 351, 953, 957, 1983, 2661 breast cancer risk............................ 1203 Breast carcinogenesis....................... 230 Breast milk........................................ 386 Brevenal............................................ 808 bromate................................... 774, 2281 Brominated flame retardants.......... 1268 bromodichloromethane............. 685, 711 bromopropane........................... 176, 177 bronchial epithelial cells................. 2655 Bronchoalveolar lavage.......... 573, 2477 Brown Norway rats......................... 2685 BSEP............................................... 2543 BTEX.............................................. 1261 butadiene......................................... 1843 butylparaben................................... 2276 Butyrylcholinesterase..................... 1335 C(60) fullerene................................ 1177 C. elegans........ 274, 389, 984, 986, 994, 1073, 1356, 1744, 1872, 2123, 2517 C/EBPb........................................... 1117 C2C12............................................. 1295 Caco-2 cells.......................... 1015, 1021 cadmium.......... 265, 266, 267, 268, 269, 270, 271, 272, 274, 275, 276, 277, 313, 389, 412, 764, 769, 770, 771, 772, 1155, 1973, 1992, 1994, 1995, 1996 Cadmium oxide nanoparticles....... 1067, 2057 Cadmium transport........................... 241 cADPR.............................................. 408 Caenorhabditis elegans.................... 297 Caffeine.......................................... 1659 Calcium............. 1477, 1890, 2376, 2623 Calcium Channel.................. 1342, 1344 Calcium channels............................ 1395 calcium homeostasis....................... 1485 Calcium-independent phospholipase A2............................ 1300 California.......................................... 910 Caloric Restriction.......................... 1862 Calpain............................................ 1341 Calpain 10......................................... 749 cAMP................................................ 402 Campylobacter................................ 2417 Canary Islands................................ 1228 cancer............... 115, 318, 354, 358, 477, 760, 764, 782, 783, 804, 896, 900, 1069, 1712, 1714, 1740, 1743, 1790, 1964, 1967, 1973, 1994, 1995, 2251 Cancer biomarker............................. 877 Cancer mode of action..... 224, 914, 952, 1934, 2632 Cancer Potency............................... 1956 cancer potency estimate.................... 498 Cancer Prevention.......................... 2411 cancer progression............................ 228 cancer risk assessment...................... 486 Cancer Stem Cells............................ 231 candidate loci.................................... 822 Canine Hepatocytes........................ 1853 cannabidiol....................................... 802 Cannabinoid.................... 674, 964, 1325 Cannabinoid Receptor...................... 344 Cannabinoids................... 226, 675, 676, 678, 1666 canned dog food............................. 2410 Capsaicin.............................. 2210, 2333 capsule administration...................... 514 Captan............................................. 2278 captopril.......................................... 2010 CAR................................................ 2657 Carbaryl................................ 1338, 1339 Carbon disulfide............................. 1220 carbon monoxide.................... 614, 1075 carbon nanomaterials...................... 1174 carbon nanoparticles....................... 1190 Carbon Nanotube........1182, 1184, 1186, 1803 388 SOT 50th Anniversary Annual Meeting
Society of Toxicology 2011 Abstract Key Word Index (Continued) The numerals following each key word refer to the relevant abstract number(s). carbon nanotubes.................................... 54, 55, 61, 848, 1178, 1181, 1187, 1188, 1195, 1196, 1797, 1800, 2178 carbon tetrachloride.......................... 247 carbonyl stress................................ 1296 carbonylation.................................. 1297 Carboxyhemoglobin....................... 1217 carboxylesterases........ 1857, 2086, 2098 carcinogenesis.......... 106, 219, 233, 242, 508, 525, 876, 926, 1188, 1404, 1780, 1782, 2645, 2647, 2698 Carcinogenesis screening................... 12 carcinogenicity.... 484, 777, 1403, 1528, 1816, 1946, 2654 carcinoma......................................... 244 Cardiac.................................... 188, 1371 Cardiac cell death............................. 210 Cardiac channels..................... 215, 1166 cardiac gene expression.................... 604 cardiac hypertrophy........................ 1437 cardiac injury.................................. 1907 cardiac ischemia............................... 193 cardiac lesions................................ 2015 cardiac myoblasts............................. 973 Cardiac Neuronal Agent................... 812 cardiac output................................... 598 Cardiac Safety.................................. 215 Cardiac toxicity............ 204, 1589, 1915 Cardiac troponin I............................. 211 cardiolipin....................................... 1285 Cardiomyocytes.................... 1163, 1164 cardiorespiratory................... 1290, 2494 Cardiotoxicity...... 150, 205, 1161, 1164, 1432, 1888, 1898, 1908, 2472 Cardiotoxicity Mechanisms.............. 147 Cardiotrophin-1................................ 196 cardiovascular.................. 189, 218, 558, 561, 583, 1241, 1696, 2188, 2189, 2468, 2469, 2471, 2473, 2667 cardiovascular complications......... 2593 cardiovascular disease..... 185, 187, 554, 1492, 2199, 2203 Cardiovascular diseases.................. 1459 cardiovascular drug safety.... 2672, 2674 Cardiovascular Function................... 184 cardiovascular safety....... 145, 146, 147, 2670 cardiovascular system..................... 1637 Cardiovascular Toxicity.............. 3, 2470 Cardiovascular Toxicology...... 183, 201, 208, 211 career.............................................. 2482 Career Development....................... 2508 Career planning.............................. 2485 Carotid intima-media thickness...... 1972 Cash receipts................................... 2256 catalase........................................... 2147 Catalytic bioscavenger.................... 2024 catecholamines............................... 2015 categorical regression....................... 473 cattle............................................... 2273 Causal reasoning............................... 147 caveolae.......................................... 1750 caveolin........................................... 1749 CB1 receptor................................... 1881 CB2................................................... 344 CCNG2............................................. 371 CCO.................................................. 207 CD-1 Mice........................................ 507 CD24 Neg....................................... 1406 CD25................................................. 288 CD4................................................. 2687 CD4+ T lymphocyte......................... 547 CD40L............................................ 1137 CD90............................................... 1082 C-DIM.............................................. 225 cdr-1.................................................. 274 CEES.............................................. 2040 Celiac.............................................. 1515 cell based imaging.............................. 29 cell culture...................................... 1870 Cell cycle................................ 390, 1154 cell cycle status................................. 339 cell death............. 450, 1656, 2313, 2533 cell differentiation............................. 837 cell proliferation......... 1004, 1851, 1852 Cell signaling........................ 1990, 2377 cell toxicity........................... 2512, 2515 cell uptake................... 1175, 1758, 2053 cell viability............................ 985, 2529 Cell-based Toxicity Assay.............. 2651 cellular aging.................................. 1654 Cellular microarray............... 2525, 2526 Cement plants................................. 1246 Centella Asiatica..................... 527, 1842 central nervous system........... 835, 2345 centrosome amplification................. 278 CeO2 Nanoparticles........................ 1473 cerebrospinal fluid................ 1924, 2138 ceria...................................... 1460, 2065 cerium oxide........................... 605, 1489 cerium oxide nanoparticle.............. 2081 CFD-PBPK..................................... 2288 c-FLIP............................................. 1657 CFU-GM......................................... 1172 Chamomile..................................... 1559 Characterization.............................. 1578 chemical.................................. 930, 2464 Chemical and Biological Weapons... 927 chemical burns.................................. 893 chemical carcinogenesis......... 957, 2661 Chemical composition...................... 672 chemical dispersants..... 828, 1577, 2342 Chemical Genetics............................ 231 chemical mixture............................ 1810 Chemical mixtures..... 8, 417, 633, 1581, 2309, 2314 Chemical Prioritization..................... 714 chemical reactivity.......................... 2312 Chemical respiratory allergy.... 902, 906 chemical safety................................. 497 Chemical Sensitizers.......................... 92 chemical toxicity.............................. 981 chemical versus non-chemical stressors.......................................... 1796 Chemical warfare.................. 2029, 2041 chemical warfare materiel................ 928 Chemical warfare nerve agents...... 2024 chemical weapons............................. 931 chemical-induced immunotoxicity... 652 chemokine......................................... 674 chemokines..................................... 1781 chemopreventative.......................... 2371 Chemoprevention.... 227, 405, 782, 783, 1404, 1702, 1708, 1885, 2638 Chemoprevention/ Chemotherapy................................. 2261 Chemopreventive............................ 2231 Chemotherapeutics............................. 62 chemotherapy................................... 900 Chemotypes.................................... 1559 Chemweapons................................... 932 CHHSL........................................... 1533 chicory root extract......................... 2438 children.......... 610, 612, 625, 629, 1243, 1538, 1569, 1941 children’s health risk......................... 498 Chimeric mouse................................ 532 China............................................... 1224 ChIP-Seq........................................... 358 chip-x enrichment analysis............. 1738 chirality................................... 721, 1820 Chlamydia pneumoniae.................... 666 chlorination..................................... 2409 Chlorine.......................................... 2038 Chlorine hypersensitivity................ 2335 Chlorine Vapor.................................. 543 chlorophyllin................................... 2658 chloroprene..................................... 1591 chloropropanols.............................. 1967 chlorotriazine herbicides................ 2549 chlorpromazine............................... 1015 Chlorpyrifos............. 342, 862, 866, 993, 1324, 1325, 1326, 1327, 1331, 2089, 2096, 2103, 2105, 2106, 2279, 2520 Chlorpyrifos oxon........................... 1327 CHO, TK6 Cells............................... 320 CHO-K1 cells................................. 2423 cholesterol....................................... 1116 cholesterol synthesis......................... 374 choline............................................ 2277 Cholinesterase....................... 2106, 2279 cholinesterase inhibition....... 1324, 2048 Chorioallantoic Membrane Vascular Assay (CAMVA).............. 1551 Choroid Plexus.................... 1377, 2122, 2136, 2137 chromate........................................... 757 chromatin.......................................... 109 Chromatin Immunoprecipitation...... 615 chromium......... 121, 273, 279, 280, 303, 754, 814, 2405 Chromosome aberrations.................. 334 Chromosome damage..................... 2164 chromosome instability.................... 278 Chronic obstructive pulmonary disease..................................... 960, 2330 chronic organophosphate toxicity............................................ 1207 Chronic toxicity.............................. 1182 chronic toxicology............................ 519 chronotherapeutics.......................... 1707 chronotoxicity......................... 393, 1705 chrysotile.......................................... 600 Cigarette......................................... 1026 cigarette smoke........ 415, 513, 574, 666, 960, 998, 1069, 1072, 1190, 1254, 1288, 2288, 2324, 2327, 2492 Cigarette Smoke Condensate............ 985 Cigarette Smoke Exposure............. 2194 Cigarette Smoke Extract................. 2488 Cigarettes.............................. 1219, 1224 cilostazol........................................... 533 cinacalcet.......................................... 779 Cinnabar............................... 2004, 2005 circadian................................... 271, 396 circadian clock.................................. 393 Circadian oscillators....................... 1703 Circadian Rhythm........ 446, 1104, 1436, 1702, 1705 cis-2-butene-1, 4-dial...................... 1417 Cisplatin........... 62, 104, 740, 741, 1586, 1668, 1991 Clara cell........................................... 887 cleanup............................................ 1533 Clearance........................................ 1763 cleft palate.............................. 810, 1632 climate change................................ 2589 Clinical................................. 1288, 1725 Clinical Pharmacology................... 2473 cluster analysis................................ 1526 CMML............................................ 1210 Cnestis ferruginea........................... 2230 CNS........................................ 775, 1924 CNV................................................ 1770 coagulation..................................... 1119 coal miners...................................... 1212 Coarse particles................................ 579 cobalt................................................ 305 co-culture model............................. 2163 co-cultures...................................... 2066 CODP exacerbation........................ 1289 cognition......................................... 1205 cognitive ability................................ 628 cognitive decline............................. 2609 cognitive function............................. 835 collaboration..................................... 418 collagen-sandwich culture.............. 2537 colon............................. 302, 1670, 2648 Colon Cancer.......................... 359, 1171 Colon tumors.................................... 245 colorectal cancer............................. 2650 combination of non-animal skin sensitization data............................ 2570 combination therapy......................... 785 Combustion Particles.............. 188, 1627 Comet............................................... 315 Comet assay............................. 320, 321, 322, 323, 329, 336, 341, 343, 972, 1003, 1548, 2077, 2162 communication....................... 933, 2484 Communities..................................... 932 community based participatory research........................................... 1249 community health................... 931, 1696 comparative toxicity....................... 1744 Complement..................................... 800 complex disease................................ 821 complex I........................................ 1297 complex mixtures..................... 119, 327 compound conservation.................... 577 compound optimization.................... 855 compound safety screening............ 1902 compound selectivity...................... 1815 Computational Assessment............... 152 computational fluid dynamics........ 2290 Computational modeling...... 9, 836, 840 Computational models........................ 33 computational toxicology.......... 60, 143, 146, 152, 484, 489, 492, 712, 714, 715, 730, 908, 912, 913, 1619, 1809, 1814, 1816 COMT............................................. 1831 Concanavalin A............................... 1093 concentrated ambient particles...... 2491, 2612 Condor............................................ 2397 Confounding variables, fasting effects................................................ 523 Connexin........................................... 771 connexin channels.......................... 1656 Constitutive Androstane Receptor........... 224, 365, 375, 377, 378, 952, 1090 Consumer Product.......................... 1545 contact allergen................................... 87 Contact allergy.................................... 84 Contact Hypersensitivity.................... 87 contact sensitization........ 98, 1011, 2571 contaminated soils.......................... 2009 contaminated surfaces...................... 863 Contamination........................ 807, 1932 Continuing education...................... 1878 Continuous infusion........................ 1917 Continuous intravenous infusion.... 1566 Contraception................................. 1765 control contamination..................... 1932 controlled substance....................... 1727 Convulsion...................................... 1805 convulsions....... 1804, 1806, 1807, 1808 COPD................................... 1287, 2324 COPD - mechanism.......................... 541 Copepode........................................ 1571 copper.... 1103, 1376, 1377, 1378, 1453, 2122 Copper Nanoparticles.................... 1464, 1474, 1486 Copper Pyrithione........................... 2389 copper-doped titanium dioxide....... 2051 Copy Number Variation.................. 1368 coral.................................................. 828 Cord blood BDNF.......................... 1391 Corexit................................................ 74 COREXIT 9500.............................. 2338 Coronary........................................... 194 Cortical Neuronal Function........... 2588, 2607 Cosmetic Directive - REACH.......... 645 Cosmetics....................................... 1527 Countermeasures............................ 2050 Key Word Index up-to-date information at www.toxicology.org 389
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Celebration Event Floor Plan Ba
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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Society of Toxicology 2011 Washingt
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 Recognit
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