Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Wednesday Abstract # Abstract # #1891 Poster Board Number.....................................311 BINDING OF THE THERAPEUTIC ANTIBODY CP-751871 TO IGF-1R INDUCES PARTIAL AGONIST SIGNALING IN HUMAN AND MONKEY IMMUNE CELLS. D. U. Lee and B. Jessen. Drug Safety, Pfizer R&D, La Jolla, CA. #1892 Poster Board Number.....................................312 A 5-DAY ORAL REPEAT-DOSE TOXICITY STUDY IN SPRAGUE-DAWLEY RATS TO EVALUATE THE TOLERABILITY OF AN S1P AGONIST. C. Hurst, T. Sullivan and J. Clarke. Biogen Idec, Cambridge, MA. #1893 Poster Board Number.....................................313 THERAPEUTIC EFFICACY AND SAFETY EVALUATION OF UC-II ALONE OR IN COMBINATION WITH GLUCOSAMINE AND CHONDROITIN IN ARTHRITIC DOGS USING PIEZOELECTRIC SENSOR-BASED GROUND FORCE PLATE. R. C. Gupta 1 , T. D. Canerdy 1 , J. Lindley 1 , B. A. Carroll 1 , M. Konemann 1 , C. Hendricks 1 , M. Bagchi 2 , D. Bagchi 2 and J. T. Goad 1 . 1 Toxicology, Murray State University, Hopkinsville, KY and 2 InterHealth Research Center, Benicia, CA. Wednesday Morning, March 9 9:00 AM to 12:30 PM Exhibit Hall Novel Approaches to Preclinical Safety Assessment: Bridging the Gap between Discovery and the Clinic through Translational Toxicology Poster Session: Pharmaceutical Safety Assessment: Novel Methods Chairperson(s): Clement Yedjou, Jackson State University, Jackson, MS. Displayed: 9:00 AM–12:30 PM Author Attended: 9:00 AM–11:00 AM #1894 Poster Board Number.....................................322 AUTOMATIC SINGLE CELL CALCIUM TRANSIENT ANALYSIS FOR CARDIOTOXICITY SCREENING AND PHARMACOLOGICAL TESTING. F. Cerignoli 1,2 , D. Charlot 3,4 , R. Ingermanson 2 , K. Wei 1 , A. Savtchenko 2 , J. H. Price 2,3 , P. M. McDonough 2 and M. Mercola 1 . 1 Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, 2 Vala Sciences Inc., San Diego, CA, 3 Quantitative Microscopy Laboratory, Sanford-Burnham Medical Research Institute, La Jolla, CA and 4 Bioengineering, University of California, San Diego, CA. #1895 Poster Board Number.....................................323 A STRATEGY COMBINING HIGH- CONTENT SCREENING AND ZEBRAFISH LARVAE TO PREDICT HUMAN DRUG- INDUCED HEPATOTOXICITY. N. Mesens, M. Steemans, F. Van Goethem and J. Van Gompel. Global Preclinical Development, Janssen Pharmaceutical Companies of Johnson&Johnson, Beerse, Belgium. #1896 Poster Board Number.....................................324 MULTIPLEX DETECTION OF OXIDATIVE PHOSPHORYLATION AS A MECHANISTIC INDICATOR FOR DRUG-INDUCED MITOCHONDRIAL TOXICITY. W. Zheng 1 , L. Goretzki 1 , G. Korzus 1 , J. Wang 1 , J. Murray 2 and R. Capaldi 2 . 1 R&D, EMD Millipore, San Diego, CA and 2 R&D, MitoSciences, Eugene, OR. Sponsor: R. Wiese. #1897 Poster Board Number.....................................325 IMPORTANCE OF RAT AND HUMAN SCREENS FOR ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATION/CYP1A INDUCTION. H. J. Garside, S. Atwal, M. R. Brown, J. Bowes, M. Graham and J. Valentin. Global Safety Assessment, AstraZeneca, Macclesfield, United Kingdom. #1898 Poster Board Number.....................................326 NOVEL IN VITRO APPROACH FOR ASSESSING CARDIAC CONTRACTILE LIABILITIES USING MICROPATTERNED MUSCULAR THIN FILMS. A. Grosberg 1,2 , M. D. Brigham 1 , J. A. Goss 1 , P. W. Alford 1 and K. K. Parker 1,2 . 1 Harvard School of Engineering and Applied Sciences, Boston, MA and 2 Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA. Sponsor: A. Bahinski. #1899 Poster Board Number.....................................327 A NOVEL IN VITRO APPROACH TO IDENTIFY MECHANISMS OF HEPATOTOXICITY. C. Hu, D. Pietrzak, K. French and K. Frazier. Safety Assessment, GlaxoSmithKline, King of Prussia, PA. #1900 Poster Board Number.....................................328 GENERATION OF PRECISION CUT LIVER SLICES FROM PINCH BIOPSY SECTIONS. K. Kowalkowski, A. Lisowski, W. R. Buck, E. Blomme and Y. Yang. Abbott Laboratories, Abbott Park, IL. #1901 Poster Board Number.....................................329 A HUMAN BREATHING LUNG-ON-A- CHIP FOR DRUG SCREENING AND NANOTOXICOLOGY APPLICATIONS. D. Huh 1,2 , B. D. Matthews 2 , A. Mammoto 2 , M. Montoya 1 , H. Hsin 2 and D. E. Ingber 1,2,3 . 1 Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 2 Children’s Hospital Boston and Harvard Medical School, Boston, MA and 3 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA. Sponsor: A. Bahinski. #1902 Poster Board Number.....................................330 IN VITRO PREDICTION OF INJECTION SITE REACTIONS USING L6 RAT SKELETAL MUSCLE CELLS. J. A. Willy 1 , N. Schulte 2 , E. Kreklau 1 , J. Walgren 1 , A. Stauber 1 , J. L. Stevens 1 and T. K. Baker 1 . 1 Toxicology, Eli Lilly and Co., Indianapolis, IN and 2 Preformulation, Eli Lilly and Co., Indianapolis, IN. 284 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1903 Poster Board Number.....................................331 HEPARG CELL MODEL IN HIGH-CONTENT SCREENING ASSAYS GIVES MECHANISTIC INSIGHT INTO METABOLISM-MEDIATED HEPATOTOXICITY. J. Mein 1,3 , P. Walker 3 , M. Jacewicz 1,3 , R. Annand 1,3 , D. Steen 2 , C. Chesne 2 , H. Gill 2 and K. Tsaioun 1,3 . 1 Apredica, Watertown, MA, 2 Biopredic, Rennes, France and 3 Cyprotex, Macclesfield, United Kingdom. #1904 Poster Board Number.....................................332 A NOVEL RESAZURIN/RESORUFIN CELLULAR ASSAY TO DETECT AND CHARACTERIZE REACTIVE ACYL GLUCURONIDES. M. McMillian, J. Sasaki, M. Singer, F. Xu and H. Lim. Johnson & Johnson, Raritan, NJ. #1905 Poster Board Number.....................................333 HEPATOTOXIC DRUGS THAT DISTURB MITOCHONDRIAL FUNCTIONS ARE DETECTED IN THE SPERMATOZOA MOTILITY ASSAY. I. Edebert 1 , L. Löfstedt 1 , I. Rafter 1 , I. Cotgreave 1 , P. Rigler 2 , A. Serov 2 and R. Rigler 2 . 1 Safety Assessment, Molecular Toxiclogy, AstraZeneca R&D Södertälje, Södertälje, Sweden and 2 Biophos SA, PSE-A EPFL, CH-1015, Lausanne, Switzerland. Sponsor: P. Moldeus. #1906 Poster Board Number.....................................334 IDENTIFYING KEY KINASES ASSOCIATED WITH BONE MARROW TOXICITY. L. Marroquin, W. Hu and B. Jessen. Pfizer, San Diego, CA. #1907 Poster Board Number.....................................335 A RAT HEART SLICE MODEL TO EVALUATE THE IMPACT OF DRUG- INDUCED INJURY ON CARDIAC HEALTH. J. Herrmann and A. Vickers. Allergan, Inc., Irvine, CA. #1908 Poster Board Number.....................................336 DETECTION OF DRUG-INDUCED STRUCTURAL CARDIOTOXICITY IN THE RAT H9C2 CELL LINE: SUB- LETHAL ENDPOINTS OFFER GREATER SENSITIVITY THAN CYTOTOXICITY. A. Pointon, S. Dawson, N. Gerges and J. E. Sidaway. Global Safety Assessment, AstraZeneca, Macclesfield, United Kingdom. Sponsor: D. Brown. #1909 Poster Board Number.....................................337 EX VIVO CYTOCHROME P450 INDUCTION ANALYSIS AS A TOOL TO CLARIFY MECHANISM OF LIVER DYSFUNCTION IN RODENT TOXICITY STUDIES. M. Graham 2 , C. Garner 1 , P. P. Lainee 1 , H. Garside 1 , A. Scally 2 , H. Marshall 2 and J. Valentin 1 . 1 Safety Assessment, AstraZeneca, Alderley Park, United Kingdom and 2 Safety Assessment, AstraZeneca, Charnwood, United Kingdom. #1910 Poster Board Number.....................................338 A FLOW CYTOMETRIC MULTIPLEX HIGH- THROUGHPUT APOPTOSIS ASSAY USING THE HTFC SYSTEM. C. Black 1 , B. Stout 1 , K. Luu 1 , T. Duensing 1 , P. Rana 2 and Y. Will 2 . 1 IntelliCyt Corporation, Albuquerque, NM and 2 Compound Safety Prediction, Pfizer Inc., Groton, CT. Abstract # #1911 Poster Board Number.....................................339 POLYSORBATE 80 14.7% IS A SUITABLE VEHICLE IN LONG-TERM RAT TOXICOLOGY STUDIES. E. Lesage 1 , M. Awori 1 , F. Vlasseros 1 , S. Y. Smith 1 , T. Ahn 2 and K. Veverka 2 . 1 Toxicology, Charles River Preclinical Services, Montréal, QC, Canada and 2 GTx Inc., Memphis, TN. Sponsor: M. Vézina. #1912 Poster Board Number.....................................340 FUNCTIONAL ASSESSMENTS IN REPEAT- DOSE TOXICITY STUDIES IN RODENTS AND NON-RODENTS: OVERCOMING PREJUDICES. W. S. Redfern, L. Ewart, P. Lainée, S. Robinson and J. Valentin. Safety Assessment UK, AstraZeneca R&D Alderley Park, Macclesfield, Cheshire, United Kingdom. #1913 Poster Board Number.....................................341 AN IMPROVED SYSTEM FOR SURGICALLY IMPLANTED IN-DWELLING CATHETERIZATION FOR LONG TERM INTRAVENOUS INFUSION IN CYNOMOLGUS MONKEYS, USING 2% TAUROLIDINE-CITRATE (TC) TO MAINTAIN CATHETER PATENCY. R. Tavcar and K. Draper. Laboratory Research, Laval, QC, Canada. #1914 Poster Board Number.....................................342 VALIDATION OF RESPIRATORY INDUCTANCE PLETHYSMOGRAPHY IN CONSCIOUS CYNOMOLGUS MONKEYS. K. R. Kearney, M. R. Metea and P. R. Atterson. WIL Research Laboratories, LLC, Ashland, OH. #1915 Poster Board Number.....................................343 DRUG DISPOSITION AND CARDIAC TOXICITY: A LITERATURE-BASED REVIEW. T. G. Hammond 1 , J. Bowes 1 , S. Boyer 3 , M. P. Burnham 1 , D. Cook 1 , C. Gavaghan 3 , M. Hance 4 , M. M. Haywood 1 , S. Matis 4 , S. Roberts 1 , B. Springthorpe 2 and J. Valentin 1 . 1 Safety Assessment, AstraZeneca, Alderley Park, United Kingdom, 2 Safety Assessment, Astrazeneca, Charnwood, United Kingdom, 3 Safety Assessment, Astrazeneca, Molndal, Sweden and 4 Safety Assessment, Astrazeneca, Wilmington, DE. #1916 Poster Board Number.....................................344 POLYSORBATE 80 14.7% IS A SUITABLE VEHICLE IN LONG-TERM NON-HUMAN PRIMATE TOXICOLOGY STUDIES. M. Awori 1 , E. Lesage 1 , F. Vlasseros 1 , S. Y. Smith 1 , T. Ahn 2 and K. Veverka 2 . 1 Toxicology, Charles River Preclinical Services, Montréal, QC, Canada and 2 GTx, Inc., Memphis, TN. Sponsor: M. Vézina. #1917 Poster Board Number.....................................345 BACKGROUND DATA AND COMPARISON OF TWO LONG-TERM CONTINUOUS INTRAVENOUS INFUSION MODELS IN THE MOUSE USED FOR SAFETY ASSESSMENT STUDIES. H. Van Wijk and A. Fraser. Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: S. Kirk. Wednesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 285
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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