Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#406 Poster Board Number.....................................827
E7 VIRAL ONCOPROTEIN NEGATIVELY
INFLUENCES THE TRANSCRIPTIONAL
ACTIVITY OF THE L1MD
RETROTRANSPOSON PROMOTER UNDER
CONDITIONS OF CELLULAR STRESS. ​
D. E. Montoya-Durango 1,2 and K. S. Ramos 1,2 .
1
Biochemistry and Molecular Biology, University of
Louisville, Louisville, KY and 2 Center for Genetics
and Molecular Medicine, University of Louisville,
Louisville, KY.
#407 Poster Board Number.....................................828
NEOPLASTIC LUNG CELL
PROLIFERATION, STIMULATED BY
ALVEOLAR MACROPHAGE-DERIVED
IGF-1, CAN BE ABROGATED BY THE
COMBINED INHIBITION OF MEK AND
PI3K. ​J. M. Fritz, L. D. Dwyer-Nield and A. M.
Malkinson. Department of Pharmaceutical Sciences,
University of Colorado Denver, Aurora, CO.
#408 Poster Board Number.....................................829
MASS SPECTROMETRY TECHNIQUES TO
STUDY PROTEIN-LIGAND INTERACTIONS
AND MOLECULAR TOXICOLOGY
PATHWAYS. ​K. E. Yamada 1,2 , C. M. Ryan 3 , J.
P. Whitelegge 3 and C. D. Eckhert 1,2 . 1 Molecular
Toxicology IDP, University of California Los
Angeles, Los Angeles, CA, 2 Environmental Health
Sciences, University of California Los Angeles, Los
Angeles, CA and 3 The Pasarow Mass Spectrometry
Laboratory, The NPI-Semel Institute, David Geffen
School of Medicine, University of California Los
Angeles, Los Angeles, CA.
#409 Poster Board Number.....................................830
DICLOFENAC INHIBITS TNF-INDUCED
NF-B NUCLEAR SHUTTLING CAUSING
SYNERGISTIC HEPATOCYTE APOPTOSIS
VIA CASPASE-8. ​L. Fredriksson, B. Herpers, Z.
Di and B. van de Water. Toxicology, LACDR, Leiden
University, Leiden, Netherlands.
#410 Poster Board Number.....................................831
NRF2B: A NOVEL NRF2 PARALOG IN
ZEBRAFISH. ​A. R. Timme-Laragy 1 , S. I.
Karchner 1 , D. G. Franks 1 , M. J. Jenny 2 and M.
E. Hahn 1 . 1 Biology, Woods Hole Oceanographic
Institution, Woods Hole, MA and 2 University of
Alabama, Tuscaloosa, AL.
#411 Poster Board Number.....................................832
CRITICAL CYSTEINE RESIDUES OF
KEAP1 IN SUPPRESSION OF NRF2 BASAL
ACTIVITY AND ARSENIC-SENSING BY
REGULATING THE UBIQUITINATION-
PROTEASOMAL DEGRADATION OF NRF2
PROTEIN. ​X. He 1 and Q. Ma 1,2 . 1 Receptor Biology
Lab. /TMBB/HELD, NIOSH, Morgantown, WV and
2
Biochemistry, West Virginia University, School of
Medicine, Morgantown, WV.
Abstract #
#412 Poster Board Number.....................................833
THE KEAP1-NRF2 SYSTEM REGULATES
METALLOTHIONEIN EXPRESSION AND
PROTECTS VASCULAR ENDOTHELIAL
CELLS FROM CADMIUM CYTOTOXICITY. ​
Y. Shinkai 1 , Y. Kumagai 1 , T. Kimura 2 , C. Yamamoto 3 ,
M. Yamamoto 4 , H. Jinno 5 , T. Tanaka-Kagawa 5 and T.
Kaji 6 . 1 Graduate School of Comprehensive Human
Sciences, University of Tsukuba, Tsukuba, Japan,
2
Faculty of Pharmaceutical Sciences, Setsunan
University, Osaka, Japan, 3 Faculty of Pharmaceutical
Sciences, Hokuriku University, Kanazawa, Japan,
4
Graduate School of Medicine, Tohoku University,
Sendai, Japan, 5 Division of Environmental
Chemistry, National Institute of Health Sciences,
Tokyo, Japan and 6 Faculty of Pharmaceutical
Sciences, Tokyo University of Science, Noda, Japan.
Sponsor: A. Naganuma.
#413 Poster Board Number.....................................834
MECHANISTIC INVOLVEMENT OF THE
NRF2/KEAP1 ANTI-OXIDANT RESPONSE
IN THE REGULATION OF HUMAN ABCC3. ​
M. D. Merrell 1 , M. J. Canet 1 , F. Zhao 1 , T. Wu 1 , J.
M. Maher 2 and N. J. Cherrington 1 . 1 Pharmacology
and Toxicology, University of Arizona, Tucson, AZ
and 2 Department of Medical Biochemistry, Tohoku
University, Sendai, Japan.
#414 Poster Board Number.....................................835
ATTENUATION OF THE NRF2 SIGNALING
PATHWAY IN HEPATOCYTES LACKING
SIRTUIN 1 (SIRT1). ​W. Wei 1 , J. Xu 1 , S. Kulkarni 1 ,
X. Li 2 and A. Slitt 1 . 1 BPS, University of Rhode
Island, Kingston, RI and 2 National Institute of
Environmental Health Sciences, Research Triangle
Park, NC.
#415 Poster Board Number.....................................836
RESPONSE OF NRF2-MODULATED GENES
TO CIGARETTE SMOKE. ​B. Kosmider, E.
Messier, H. Chu and R. J. Mason. National Jewish
Health, Denver, CO.
#416 Poster Board Number.....................................837
INDIRUBIN-3’-(2, 3 DIHYDROXYPROPYL)-
OXIMETHER (E804) IS A POTENT
AHR-AGONIST AND MODULATOR OF
INFLAMMATION PROFILES IN LPS-
TREATED RAW264.7 MACROPHAGES. ​A.
S. Babcock and C. D. Rice. Biological Sciences,
Clemson University, Clemson, SC.
Monday Morning, March 7
10:30 AM to 11:30 AM
Room 156
Exhibitor Hosted Session: First in Human Monoclonal
Antibody Development Strategies for the Treatment of
Cancer Patients
Presented by: Huntingdon Life Sciences
Monoclonal antibodies have demonstrated to provide huge healthcare
benefits in treatment of cancer. Designing and performing the optimal IND
enabling nonclinical safety package is very important. Some non-standard
approaches are discussed which highlight the need for focus upon the pathophysiology
of disease, the biology of the drug target and the risks that need
to be considered with drug intervention.
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