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Annexes 208IST15 (median=28, IQR=24-33), 1,600 subjects completed the BVRT (median=11, IQR=10-13) and 1,596 completed the DSST (median=28, IQR=20-37).Longitudinal Multivariate modelImpact of gender on cognition:Estimates of the multivariate model are displayed in table 2. Firstly, while gender was notglobally associated with the latent common cognition when not taking into account thevascular factors (neither associated with the mean latent cognitive level (β=0.0005, p=0.40)nor with the cognitive evolution (β=0.0019, p=0.18)), it was associated with the cognitiveevolution when adjusting on the vascular factors and especially the smoking status. Indeed, itwas still not associated with the basic latent cognitive level (β=-0.0056, p=0.23) but wasassociated with the cognitive evolution (β=0.0061, p=0.002), women having a slightly worstcognitive decline with age than men in oldest age as seen in figure 1(a). In the following, thecommented results come from the model adjusted for vascular factors.After adjusting on the latent cognitive level, gender effect was significantly different over thefour tests both on the mean level of the tests (p