1997 Swinburne Higher Education Handbook

SE230 Cardiovascular Biophysics
10 credit points 4 hours per week Hawthorn
Prerequisites: Nil Corequisites: Nil
A second year subject in the Bachelor of Applied Science
(Medical Biophysics and Instrumentation)
Objedive
This subject deals in the detail the biophysics and
physiology of excitable cells which leads into a detailed
coverage of the structure and function of synapses, skeletal
and smooth muscle tissue and the automatic nervous system.
During practical sessions, students will exposed to various
underlying scientific principals as sell as a range of clinical
monitoring techniques.
Content
The heart: cardiac cycle, mechanical and electrical events,
Starling's law, mechanical properties of cardiac muscle.
Pulsatile pressure and flow in arteries, wave propagation in
arteries, blood Rheology, atherosclerosis, Starling's
hypothesis of the capillary system, mass transport, flow in
collapsible tubes, blood flow in particular organs, Guyton's
model.
Cardiac monitoring and pathologies.
The ECG: genesis of myocardial field; changes in disease;
arrhythmias and conduction defects
Pressure and flow monitoring: invasive and non-invasive
methods, Swan Ganz catheters, cardiac output methods,
oximetry, nuclear methods. Diagnosis by sonic and
ultrasonic methods.
Intensive care instrumentation. Cardiopulmonary bypass
SE240 Cellular Biophysics
10 credit points 4 hours per week Hawthorn
Prerequisites: SE112, SE122 Assessment: practical work,
assignments and examination
A second year subject in the degree of Bachelor of Applied
Science(Medica1 Biophysics and Instrumentation)
Content
Membrane Phenomena: Structure and function of
membranes and membrane channels; modes of transport of
ions and non-electrolytes; Diffusive processes; Nernst and
Donnan equilibria.
Measurement of intracellular potentials: electrode processes;
~ver~otentials; diffusion Experimental -
techniaues: noise rejection; high impedance and differential
Experimental techniques: voltage clamping and patch
clamping (lhr); Hodgkin-Huxley model: elements. Synapses.
Pre-and post-synaptic processes: inhibitors and agonists;
statistical analysis of mepps; Receptors and
neurotransmitters: types and mode of operation; Inhibitory
and excitatory neurons: integrative functions of soma.
Muscles: Ultrastructure: Excitation-contraction coupling:
cross-bridges and sliding filament theory;
Correlation between cellular and macroscopic properties:
Length-tension relation ships in skeletal, smooth and cardiac
muscles ; Force velocity relationships: cellular correlates of
Hill equation ; Energy supply and metabolic measurements;
Electrical activitv: MUAPs and the EMG: Cellular basis of
muscle fatigue and muscle disease.
Recommended Reading
Guyton A.C. and Hall, Textbook of Medical Physiology, 9th Edn,
Saunders
Plonsey R.L. and Barr R., Bioelectric Phenomena, Plenum, 1988
Weiss, T.F. Cellular Biophysics Vol. 2, MIT Press 1996
SE250 Biomedical Instrumentation
10 credit points 3 hours per week Hawthorn
Prerequisites: Nil Corequisites: Nil
A second year subject in the Bachelor of Applied Science
(IvIedical Biophysics and Instrumentation)
0 b jedives
examine specific aspects of particular types of
biomedical instrumentation
primary emphasis on transducers and electronics
secondary emphasis on physiology and applications
Content
This subject deals with techniques and instrumentation
relevant to clinical, hospital and biomedical areas.
Biophysical and technical aspects are covered in detail as
well as their practical application in hospitals and clinical
circumstances. Material is treated in both lectures, and
where possible, in practical exercises. Fundamental
considerations are developed so that complete systems are
thoroughly covered. Most topics range from the detection,
recording, processing and therapeutic uses of a range of
biological signals.
SE260 Respiratory and Renal Biophysics
10 credit points 4 hours per week Hawthorn
Prerequisites: Nil Corequisites: Nil
A second year subject in the Bachelor of Applied Science
(Medical Biophysics and Instrumentation)
0 biedives
To provide a thorough coverage of the structure, function
and clinical considerations of the respiratory system. along
with the basic biochemical, biophysical and physiological
principles, details of the symptoms and measurement of
clinically relevant respiratory disorders are covered in
lecture material as well as in various practical exercises.
Content
Respiratory system, structure and function, lung volumes
and dead space, diffusion, blood flow, ventilation perfusion
inequality, gas transport, Bohr and Haldane effects, acid/
base balance, respiratory mechanics, control of respiration,
Lung function testing and lung diseases, obstruction,
restriction, flow/volume curves, diffusion capacity,
compliance, body plethysmography,
Exercise Biophysics: respiratory changes associated with