Oral and Poster Abstracts

2 AFSSA, Laboratoire d’Etudes Caprines, Niort, France
Objective of study: Oxyclozanide is known as efficacious against the
rumen fluke in cattle. However there are very little data about its
efficacy in goats. The aim of this study was to check the efficacy of
oxyclozanide in experimentally infected goats by Calicophoron
daubneyi, both at its immature stage and adult stage.
Material and methods: Animals included were 25 free of helminth
dairy goats Metacercariae were obtained after artificial infection of
Galba truncatula by miracidiums of C. daubneyi. Each goat was
infected by 250 metacercariae on day 0. Goats were allocated in 4
groups:-group 1: untreated control group- group 2: oxyclozanide
(Douvistome, CEVA) at the dose of 22.5 mg/kg BW on day 10 post
infection (PI) (immature stage: worms in small intestine) - group 3:
oxyclozanide at 15 mg/kg BW on day 131 PI (adult stage)- group 4:
oxyclozanide at 22.5 mg/kg BW on day 131 PI Animals were
checked for adverse reactions following treatment. They were
necropsied at day 138 PI. Paramphistomes were removed from the
rumen and counted. Efficacy of the treatment was determined using
the formula (C-T)/C x 100 (C = arithmetic mean of adult worm
counts of the untreated control group, T = arithmetic mean of adult
worm counts of oxyclozanide treated group).
Results: The treatment at immature stage (group 2) with oxyclozanide
at 22.5 mg/kg BW induced a transient diarrhea on all treated goats
lasting less than 48 hours. No diarrhea was observed with any dosage
applied at adult stage. The absence of diarrhea when oxyclozanide was
applied on adult stage let us think that it might be the destruction of
immature stages in bowel mucosae which might induce
diarrhea.Individual establishment rates of metacercariae in the control
group were very variable, ranging from 0 to 34% (mean = 12%).Worm
reduction was 82% in group 2, 96% in group 3 and 96% in group 4
compared to untreated control group. The number of worms was
significantly lower in the 2 groups treated at adult stage than in the
untreated control group (p