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Table 3.3.3 continued
Author
Year
Reference
Country
Study design
Setting
Population
Inclusion & exclusion criteria
Prevalence
Index test
Reference test
Number of patients
Drop-out rate
Rater
Rater training
Interobserver reliability
Sensitivity
Specificity
Study quality
Comments
Taiminen et al
2001
[4]
Finland
Design
Cross sectional
Setting
Turku University Central
Hospital and Turku City
Mental Health Centre, Finland
Population
All patients admitted
during study period
n=116
53% females,
84% inpatients
Mean age: 34.5 years
(SD 11.4, range 16–62)
Inclusion criteria
1. Schizophrenia spectrum
disorder, bipolar disorder,
severe major depression
2. First-ever psychiatric treatment
in the public sector for
the disorder
3. Age 16–64 years
4. Residence in the catchment area
Index test
Clinical discharge diagnoses
according to DSM-IV and
ICD-10, retrospectively
obtained by a researcher
Reference test
LEAD
Interview with structured
anamnestic information,
SCAN-interview and assessment
of the severity
of psychiatric symptoms
Consensus meetings, with
three psychiatrists among
one had performed the
interview, decided Bestestimate
diagnoses according
to DSM-IV using all data
Number of patients
n=116
Drop-out rate
Not reported
Rater of index test
Psychiatrists
Training of index rater
NA
Rater of reference test
Five research psychiatrists
Training of reference test
Not reported
Interobserver reliability
Not reported
Depressive disorders
Sensitivity: 88%
Specificity: 82%
Bipolar disorder
Sensitivity: 46%
Specificity: 98%
Moderate
Comments
Sampling method
Yes, but inclusion criteria
might imply some bias
Blinding
Yes
Handling of missing data
NA
Other comments
Training and interrater
reliability not reported
but careful Best estimate
process with consensus
diagnoses. Period between
clinical evaluation
and LEAD unclear
Exclusion criteria
Not reported
Prevalence
BP: 11% (13/116)
MDD: 51% (59/116)
BP = Bipolar disorder; DSM-IV = Diagnostic and statistical manual of mental disorder,
fourth edition; LEAD = Longitudinal, Experts, All Data procedure; MDD = Major
depressive disorder; NA = Not applicable; SCAN = Schedules for Clinical Assessment
in Neuropsychiatry; SCID-I = Structured Clinical Interview for DSM-IV Axis I disorders;
SD = Standard deviation
108 diagnostik och uppföljning av förstämningssyndrom
KAPITEL 3 • Systematisk litteraturgenomgång
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