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Table 3.4.16b continued Sensitivity and specificity for CBQ as screening<br />

instrument for bipolar syndromes with structured or semistructured interviews<br />

as reference standard.<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Papolos et al<br />

2006<br />

[99]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Online research program<br />

about juvenile bipolar disorder<br />

Population<br />

5 120 children and adolescents<br />

aged 5–17 years participating<br />

in an online investigation<br />

Inclusion criteria<br />

BPSD, ADHD or<br />

no psychiatric disorder<br />

Exclusion criteria<br />

Not reported<br />

Index test<br />

CBQ<br />

Scoring algorithm<br />

for DSM-IV BPSD<br />

Reference test<br />

K-SADS<br />

Number of patients<br />

n=135 self selected,<br />

no information about<br />

age or gender<br />

Drop-out rate<br />

Not reported<br />

Rater, index test<br />

Self rating<br />

Rater training, index test<br />

NA<br />

Rater, reference test<br />

Four graduate level<br />

interviewers<br />

Rater training, reference test<br />

Trained by the project director<br />

Interobserver reliability<br />

Not reported<br />

Cut off according to scoring<br />

algorithm for DSM-IV BP<br />

Sensitivity: 76%<br />

Specificity: 97%<br />

Low<br />

Comments<br />

Sampling method<br />

Not adequate<br />

Blinding<br />

Unclear<br />

Handling of missing data<br />

Unclear<br />

Other comments<br />

The time between<br />

index and reference<br />

test is unclear<br />

Prevalence BPSD<br />

56%<br />

ADHD = Attentions deficit/hyperactivity disorder; BP = Bipolar disoder; BPSD = Bipolar<br />

spectrum disorder; CBQ = Child bipolar questionnaire; DSM-IV = Diagnostic and statistical<br />

manual of mental disorder, fourth edition; K-SADS = Kiddie-schedule for affective<br />

disorders and schizophrenia for school-age children; NA = Not applicable<br />

196 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

197

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