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Table 3.4.12 Child Behavior Checklist screening instrument for bipolar<br />

syndromes with semistructured or structured interviews as reference standard.<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Kahana et al<br />

2003<br />

[36]<br />

USA<br />

Design<br />

Cohort<br />

Setting<br />

Clinic for child psychiatry<br />

Population<br />

Referred from two pediatric<br />

psychopharmacology research units<br />

Outpatients, mean age: 10.9 years<br />

SD: 3.3 years (35% girls)<br />

Inclusion criteria<br />

Exclusion criteria<br />

Psychiatric disorder due to<br />

a general medical condition,<br />

pervasive developmental<br />

disorder, mental retardation<br />

Prevalence<br />

23% (100/439) BPSD I,<br />

15% (66/439) BPSD II,<br />

cyclothymia, BPSD NOS<br />

Index test<br />

CBCL, aggressive<br />

subscale<br />

Reference test<br />

K-SADS<br />

Number of patients<br />

n=439<br />

Four comparison<br />

groups:<br />

BPSD=166<br />

DBD=115<br />

MDD=90<br />

Any individual without<br />

BPSD=250<br />

Drop-out rate<br />

Not reported<br />

Rater, index test<br />

Self rating<br />

Rater training, index test<br />

NA<br />

Rater, reference test<br />

Three child and adolescent<br />

psychiatrists<br />

11 highly trained research<br />

assistants<br />

Rater training<br />

Five K-SADS interviews<br />

along with an experienced<br />

rater. Joint rating sessions<br />

every 10th interview<br />

Interobserver reliability<br />

κ >0.85<br />

ROC-AUC<br />

0.81<br />

High<br />

Comments<br />

Sampling method<br />

Probably consecutively<br />

included patients<br />

Blinding<br />

Satisfactory<br />

Handling of missing data<br />

Completed rate of<br />

CBCL are reported:<br />

157/166 BPSD group<br />

82/90 MDD group<br />

109/115 DBD group<br />

The table continues on the next page<br />

172 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

173

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