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Table 3.5.20 continued<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

De Souza et al<br />

2010<br />

[38]<br />

United Kingdom<br />

Design<br />

Cross sectional<br />

Setting<br />

Neuropsychiatric clinic<br />

in Birmingham<br />

Population<br />

Outpatients with<br />

Huntington’s disease<br />

Inclusion criteria<br />

>18 years<br />

Exclusion criteria<br />

Not able to give informed<br />

consent, not fluent in English<br />

Index test<br />

BDI-II<br />

Reference test<br />

SCAN<br />

Number of patients<br />

n=50<br />

Mean age: 51.2 years<br />

(SD 10.35)<br />

Drop-out rate<br />

Not reported<br />

Rater of index test<br />

NA<br />

Training of index rater<br />

NA<br />

Rater of reference test<br />

One researcher and<br />

one psychologist<br />

Training of reference test<br />

Yes, but not specified<br />

Interobserver reliability<br />

Not reported<br />

Major depressive<br />

disorder<br />

Sensitivity: 83%<br />

Specificity: 71%<br />

Moderate<br />

Comments<br />

Sampling method<br />

Adequate<br />

Blinding<br />

Unclear<br />

Handling of missing data<br />

Not reported<br />

Prevalence<br />

MDD: 24% (12/50)<br />

Dutton et al<br />

2004<br />

[39]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Waiting rooms of two primary<br />

care clinics in southeastern USA<br />

Population<br />

n=223 African-American patients<br />

fulfilled criteria and consented<br />

Inclusion criteria<br />

>18 years<br />

Index test<br />

BDI-II<br />

Reference test<br />

PRIME-MD<br />

Number of patients<br />

n=220<br />

Mean age: 49.3 years<br />

(SD 10.91)<br />

Drop-out rate<br />

1%<br />

Rater of index test<br />

NA<br />

Training of index rater<br />

NA<br />

Rater of reference test<br />

Six research assistants who<br />

all were doctoral students<br />

in clinical psychology<br />

Training of reference test<br />

Yes but not specified<br />

Major depressive<br />

disorder<br />

Sensitivity:<br />

88% (95% CI, 77; 94)<br />

Specificity:<br />

84% (95% CI, 77; 89)<br />

Moderate<br />

Comments<br />

Sampling method<br />

Adequate<br />

Blinding<br />

Yes<br />

Handling of missing data<br />

Not reported<br />

Exclusion criteria<br />

Failing to demonstrate at least<br />

a 5th grade oral comprehension level<br />

Interobserver reliability<br />

Not reported<br />

Prevalence<br />

MDD: 29.5% (65/220)<br />

The table continues on the next page<br />

314 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

315

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