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Table 3.5.29 continued<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Zimmerman et al<br />

2009<br />

[115]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Community-based outpatient<br />

practice affiliated with academic<br />

center; The Rhode Island MIDAS<br />

project<br />

Population<br />

n=534 outpatients<br />

Prevalence<br />

Lifetime BP: 10.8% (52/480)<br />

BPI: n=18<br />

BPII: n=21<br />

BPNOS: n=8<br />

Cyclothymia: n=5<br />

Index test:<br />

MDQ, standard criteria<br />

and modified Geneva<br />

algorithm<br />

Reference test<br />

SCID-I interview<br />

Number of patients<br />

n=480 (61% females<br />

Mean age: 39.5 years<br />

(SD 13.7)<br />

Drop-out rate<br />

10% (54 /534)<br />

Rater of reference test<br />

PhD level psychologists<br />

and research assistants<br />

Rater training<br />

Highly trained, monitored<br />

throughout project<br />

Interobserver reliability<br />

Reliability diagnosing BP<br />

κ 0.85<br />

BP vs non-BP<br />

Standard criteria<br />

Sensitivity: 63.5%<br />

Specificity: 84.8%<br />

Modified criteria<br />

Sensitivity: 73.1%<br />

Specificity: 81.5%<br />

BPI vs non-BP<br />

Standard criteria<br />

Sensitivity: 61.1%<br />

Modified criteria<br />

Sensitivity: 72.2%<br />

BPII vs non-BP<br />

Standard criteria<br />

Sensitivity: 57%<br />

High<br />

Comments<br />

Sampling method<br />

Adequate<br />

Blinding<br />

Yes<br />

Handling of missing data<br />

Excluded from analysis,<br />

drop-out analysis<br />

reported<br />

Modified criteria<br />

Sensitivity: 66.7%<br />

BP = Bipolar disorder; BPI/II = Bipolar type I/II; BPNOS = Bipolar not otherwise specified;<br />

MDQ = Mood disorder questionnaire; SCID-I = Structured clinical interview for<br />

DSM-IV axis I disorders; UP = Unipolar<br />

408 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

409

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