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Table 3.4.15 continued
Author
Year
Reference
Country
Study design
Setting
Population
Inclusion & exclusion criteria
Prevalence
Index test
Reference test
Number of patients
Drop-out rate
Rater
Rater training
Interobserver reliability
Sensitivity
Specificity
Study quality
Comments
Frazier et al
2007
[108]
USA
Design
Cross sectional
Two different cohort studies
Setting
Research clinic
Population
1 014 children, either child
psychiatric patients from
treatment studies or children
with bipolar parents or children
recruited by fliers and word
of mouth
Mean age total sample:
11.11 years (3.51),
62% males, 38% females
Index test
YMRS
Reference test
K-SADS
Number of patients
n=1 014
Drop-out rate
Not reported
Rater, index text
Self rating
Rater training, index test
NA
Rater
From bachelor’s degrees
to doctoral level
Rater training
Trained to criterion
by completing ratings
independently of an
experienced rater
over the course
of three to five
interviews
YMRS ROC-AUC
0.97
Moderate
Comments
Sampling method
Adequate
Blinding
NA
Handling of missing data
NA
Inclusion criteria
Age 4 to 17 years, and
both caregivers present
for assessment
Exclusion criteria
Oral difficulties, pervasive
development disorder, autism,
mental retardation or if the
child had a current or past
medical or neurological history
New raters led 3 to 5
K-SADS interviews with
an experienced rater
Interobserver reliability
Interrater
κ ≥0.95
Prevalence
53% (476/1 014) bipolar diagnosis
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190 diagnostik och uppföljning av förstämningssyndrom
KAPITEL 3 • Systematisk litteraturgenomgång
191