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Table 3.4.15 continued<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Youngstrom et al<br />

2004<br />

[93]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Research setting,<br />

child psychiatric clinic,<br />

outpatients<br />

Population<br />

Participants from<br />

pharmacotherapy studies<br />

Index test<br />

YMRS<br />

Reference test<br />

K-SADS<br />

Number of patients<br />

n=642<br />

Drop-out rate<br />

36%<br />

Rater, index text<br />

Self rating<br />

Rater training, index test<br />

NA<br />

Rater<br />

Research assistants<br />

Rater training<br />

Highly trained<br />

ROC-AUC<br />

Children<br />

0.83<br />

Youth<br />

0.80<br />

Moderate<br />

Comments<br />

Sampling method<br />

Adequate<br />

Blinding<br />

Satisfactory<br />

Children: n=318<br />

Mean age: 8.3 years (SD 1.6)<br />

Interobserver reliability<br />

κ >0.85<br />

Youths: n=324<br />

Mean age: 14.1 years (SD 1.9)<br />

Inclusion criteria<br />

Age: 5–17 years<br />

Both the child and<br />

the primary caregiver<br />

presented for assessment<br />

Exclusion criteria<br />

Not speaking English,<br />

pervasive developmental<br />

disorder and/or autism<br />

or profound mental retardation<br />

Prevalence<br />

50% (160/318) age 5–10<br />

41% (132/324) age 11–17<br />

AC = Academic medical center; A-YMRS = Adolescent young mania rating scale; BPSD =<br />

Bipolar spectrum disorder; CI = Confidence interval; CMHC = Community mental health<br />

center; K-SADS = Kiddies-schedule for affective disorders and schizophrenia; NOS =<br />

Not otherwise specified; P-YMRS = Parent version young mania rating scale; ROC-AUC<br />

= Receiver operating characteristics – area under curve; SD = Standard deviation; NA =<br />

Not applicable; YMRS = Young mania rating scale<br />

192 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

193

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