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Table 3.4.15 continued<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Youngstrom et al<br />

2003<br />

[107]<br />

USA<br />

Gracious et al<br />

2002<br />

[106]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Outpatient research<br />

clinic specializing in<br />

mood disorders<br />

Population<br />

117 children and adolescent<br />

and their parents participating<br />

in research<br />

Inclusion criteria<br />

Age: 5–17 years<br />

Exclusion criteria<br />

Pervasive developmental<br />

disorder, a psychiatric<br />

disorder due to a medical<br />

condition, mental retardation<br />

Index test<br />

YMRS<br />

P-YMRS<br />

Reference test<br />

K-SADS<br />

Number of patients<br />

n=117 (45.4% girls)<br />

Mean age:<br />

12.4±3.1 years<br />

Drop-out rate<br />

Not reported<br />

Rater, index text<br />

Parents or self rating<br />

Rater training, index test<br />

NA<br />

Rater, reference test<br />

Research assistants with<br />

either bachelor’s (n=4)<br />

or master’s level degrees (n=3)<br />

Rater training<br />

Trained to reach<br />

an overall κ >0.85<br />

Interobserver reliability<br />

κ >0.85<br />

P-YMRS cut off 17<br />

Sensitivity: 79%<br />

Specificity: 78%<br />

P-YMRS ROC-AUC<br />

0.85<br />

High<br />

Comments<br />

Sampling method<br />

Unclear<br />

Blinding<br />

Satisfactory<br />

Handling of missing data<br />

Unclear<br />

Prevalence BPSD<br />

50% (58/117)<br />

The table continues on the next page<br />

188 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

189

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