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Table 3.5.30 Which diagnoses are associated to false positive screen<br />

by Mood Disorder Questionnaire (MDQ)<br />

Author<br />

Year<br />

Reference nb<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Zimmerman et al<br />

2010<br />

[129]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Community-based outpatient<br />

practice affiliated with academic<br />

center; The Rhode Island MIDAS<br />

project<br />

Population<br />

Participants in the MIDAS Project<br />

n=534 patients filled MDQ,<br />

90% (480) had complete data<br />

Mean age: 39.5 years<br />

(SD 13.7)<br />

(61% females)<br />

Index test<br />

MDQ<br />

Standard criteria:<br />

Cut off 7 + at least<br />

moderate impairment<br />

Reference test<br />

SCID-I<br />

SIDP-IV interview<br />

Number of patients<br />

480–52 (bipolar) = 428<br />

Drop-out rate<br />

10% (54/534)<br />

Rater of index test<br />

PhD Level psychologist<br />

and research assistents<br />

Rater training<br />

Highly trained, monitored<br />

throughout project<br />

Interobserver reliability<br />

Reliability diagnosing BP<br />

κ 0.85<br />

Reliability diagnosing<br />

dimensional BPD scores<br />

ICC=0.96<br />

OR BP for MDQ+ vs MDQ<br />

6.4 (95% CI, 2.9; 13.9)<br />

High<br />

Comments<br />

Sampling method<br />

Adequate<br />

Blinding<br />

Yes<br />

Handling of missing data<br />

Reported with drop-out<br />

analysis<br />

Other comments<br />

Patients with bipolar<br />

disorder excluded in<br />

this analysis<br />

Inclusion criteria<br />

All patients referred<br />

Exclusion criteria<br />

Bipolar patients<br />

Prevalence<br />

Lifetime BP: 10.8% (52/480)<br />

BP = Bipolar disorder; CI = Confidence interval; ICC = Interclass correlation; MDQ =<br />

Mood disorder questionnaire; OR = Odds ratio; SCID-I = Structured clinical interview<br />

for DSM-IV axis I disorders; SD = Standard deviation; SIDP-IV = Structured interview of<br />

DSM-IV personality<br />

410 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

411

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