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Table 3.5.28 continued<br />

Author<br />

Year<br />

Reference<br />

Country<br />

Study design<br />

Setting<br />

Population<br />

Inclusion & exclusion criteria<br />

Prevalence<br />

Index test<br />

Reference test<br />

Number of patients<br />

Drop-out rate<br />

Rater<br />

Rater training<br />

Interobserver reliability<br />

Sensitivity<br />

Specificity<br />

Study quality<br />

Comments<br />

Graves et al<br />

2007<br />

[119]<br />

USA<br />

Design<br />

Cross sectional<br />

Setting<br />

Waiting room for<br />

3 primary care clinics<br />

Population<br />

n=1 441 patients were invited<br />

to participate in screening<br />

with MDQ and CAPS<br />

Index test<br />

MDQ<br />

Standard criteria<br />

Reference test<br />

SCID-I interview<br />

Number of patients<br />

n=228 (66% females)<br />

Mean age: 41.8 years<br />

(SD 13.5, range 18–78)<br />

Rater of reference test<br />

Experienced research staff<br />

Rater training<br />

Exensively trained until<br />

minimum κ of 0.75<br />

Interobserver reliability<br />

Final SCID-I diagnoses determined<br />

in consensus meeting<br />

with one certified psychiatrist<br />

BP<br />

Sensitivity: 61.9%<br />

Specificity: 69%<br />

Moderate<br />

Comments<br />

Sampling method<br />

Adequate<br />

Blinding<br />

Yes<br />

Handing of missing data<br />

Unclear<br />

n=579 accepted<br />

n=356 had experienced at<br />

least one significant trauma<br />

Drop-out rate<br />

Not reported<br />

Other comments<br />

Number of assessors not<br />

given, but highly trained<br />

Inclusion criteria<br />

Informed consent and at least<br />

one significant trauma<br />

Prevalence<br />

BP: 9% (21/228)<br />

Hardoy et al<br />

2005<br />

[118]<br />

Italy<br />

Design<br />

Cross sectional<br />

Setting<br />

Outpatient psychiatric<br />

clinic in Italy<br />

Population<br />

n=154 consecutive patients<br />

seeking psychiatric care, coming<br />

for psychiatric evaluation from<br />

general hospital, or applying for<br />

certification of mental capacities<br />

(gun, driving license)<br />

Prevalence (SCID-I)<br />

BP: 33.1% (51/154)<br />

Index test<br />

MDQ<br />

Cut off ≥7 symptoms +<br />

unclear if other standard<br />

criteria<br />

Reference test<br />

SCID-I interview<br />

Number of patients<br />

n=154 (60% females)<br />

Mean age: 37.2±12.4 years<br />

Drop-out rate<br />

Not reported<br />

Rater of reference test<br />

Physicians working at least<br />

three years in psychiatry<br />

Rater training<br />

Specific training, but not how<br />

Interobserver reliability<br />

Not reported<br />

BP<br />

Sensitivity: 67%<br />

Specificity: 86%<br />

Moderate<br />

Comments<br />

Sampling<br />

Adequate<br />

Blinding<br />

Unclear, but probable<br />

Handling of missing data<br />

Unclear<br />

Other comments<br />

Not clear if standard<br />

criteria for diagnosis<br />

of BP with MDQ<br />

The table continues on the next page<br />

396 diagnostik och uppföljning av förstämningssyndrom<br />

KAPITEL 3 • Systematisk litteraturgenomgång<br />

397

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