23. Ulusal Biyokimya Kongresi Ãzel SayÄ±sÄ± - TÃ¼rk Biyokimya Dergisi

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XXIII. ULUSAL B‹YOK‹MYA KONGRES‹ 29 Kasım - 2 Aralık 2011 Hilton Hotel - Adana 23. Ulusal Biyokimya Kongresi, Adana [23 rd National Biochemistry Congress, Adana / TURKEY] İÇİNDEKİLER P. 075 / PREEKLAMPSİLİ VE SAĞLIKLI HAMİLE KADINLARDA AMNİOTİK SIVILARINDA İYOT VE MAGNEZYUM DÜZEYLERİNİN KARŞILAŞTIRILMASI Mine GÜLABOGLU 1 , Bünyamin BÖREKÇİ 2 , Muhammet USTA 2 1 Atatürk Üniversitesi, Eczacılık Temel Bilimleri-Biyokimya, Erzurum 2 Atatürk Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum, Erzurum P. 075 / COMPARISON OF AMNIOTIC FLUID IODINE AND MAGNESIUM LEVELS IN PREECLAMPTIC AND NORMAL PREGNANT WOMEN Mine GÜLABOGLU 1 , Bünyamin BÖREKÇİ 2 , Muhammet USTA 2 1 Biochemistry, Health Science, Ataturk University, Erzurum 2 Obstetrics and Gynecology, Health Science, Ataurk University, Erzurum CONTENTS Bu çalışmada Erzurum’da (Türkiye) yaşayan sağlıklı ve şiddetli preaklampsili hamile kadınların amniotik sıvılarında iyot ve magnezyum düzeyleri karşılaştırılmıştır. Amniotik sıvı örnekleri 20 sağlıklı hamile kadın ve 22 şiddetli preeklampsili hamile kadından elde edildi. Örneklerdeki iyot seviyeleri Sandell-Kolthoff reaksiyonu temeline dayanan Foss metoduyla tespit edildi. Şiddetli preeklampsili hamile kadınların amniotik sıvı iyot seviyeleri (8.95±6.15 μg/dL) sağlıklı hamile kadınlarınkinden (14.99±5.62 μg/dL) daha düşüktü (p 0.05). Sağlıklı hamile kadınların amniotik sıvılarındaki magnezyum ve iyot konsantrasyonu arasında pozitif bir korelasyon vardı (Pearson korelasyon katsayısı: r=0.69, p 0.05). Bizim bölgemizde (Kuzey-Doğu Anadolu) iyot eksikliği preeklampsinin artışında bir faktör olabilir. İyot takviyesi preeklampsinin tedavisi için aynı zamanda göz önüne alınabilir. In this study was compared iodine and magnesium concentrations in amniotic fluid of women with severe pre-eclampsia and of healthy pregnant women in Erzurum, Turkey. Amniotic fluid specimens were obtained from 22 women with severe preeclampsia and 20 healthy pregnant women. Iodine levels in samples were determined by the Foss method based on the Sandell-Kolthoff reaction. The amniotic fluid iodine level for women with severe preeclampsia was 8.95±6.15 μg/dL, lower than 14.99±5.62 μg/dL of amniotic fluid iodine for healthy pregnant women (p 0.05). There was a positive correlation between the iodine levels and magnesium concentrations in amniotic fluid for healthy pregnant women (Pearson correlation coefficient: r=0.69, p0.05) were observed there was also no difference in thyroid hormone levels (FT4, TSH, FT3) between women with severe preeclampsia and healthy pregnant women. The iodine deficiency in our region, North-East Anatolia, may be one of the factors increasing the pre-eclampsia. Iodine supplementation may also be considered for pre-eclamptic therapy. Turk J Biochem, 2011; 36 (S2) http://www.TurkJBiochem.com
XXIII. ULUSAL B‹YOK‹MYA KONGRES‹ 29 Kasım - 2 Aralık 2011 Hilton Hotel - Adana 23. Ulusal Biyokimya Kongresi, Adana [23 rd National Biochemistry Congress, Adana / TURKEY] İÇİNDEKİLER P. 076 / PRE-EKLAMPTİK HASTALARDA MATERNAL KARDİYAK RİSK Neslihan BUKAN 1 , Ömer KANDEMİR 2 , Tuncay NAS 3 , Özlem GÜLBAHAR 1 , Adem ÜNAL 1 , Banu ÇAYCI 1 1 Gazi Üniversitesi, Tıbbi Biyokimya, Ankara 2 Etlik Kadın-Doğum Hastanesi, Kadın Hastalıkları ve Doğum, Ankara 3 Gazi Üniversitesi, Kadın Hastalıkları ve Doğum, Ankara P. 076 / MATERNAL CARDIAC RISKS IN PRE-ECLAMPTIC PATIENTS Neslihan BUKAN 1 , Ömer KANDEMİR 2 , Tuncay NAS 3 , Özlem GÜLBAHAR 1 , Adem ÜNAL 1 , Banu ÇAYCI 1 1 Medical Biochemistry, Gazi University, Ankara 2 Obstetrics and Gynecology, Etlik Obstetrics and Gynecology Hospital, Ankara 3 Obstetrics and Gynecology, Gazi University, Ankara CONTENTS Bu çalışmanın amacı pre-eklampsi (PE) ve maternal kardiyak risk faktörleri arasındaki ilişkinin gösterilmesidir. Bu amaçla, toplam 41 gebe kadın çalışmaya dahil edilmiştir. Gruplar 25 pre-eklamptik 16 normal gebe olacak şekilde oluşturulmuştur. Hastaların serum total kolesterol, HDL-kolesterol (HDL-k), trigliserid (TG), homosistein, apoprotein AI, apoprotein B100, lipoprotein(a), high sensitive CRP (hsCRP) ve sistatin C düzeyleri kardiyak risk faktörleri olarak ölçülmüştür. LDL-kolesterol (LDL-k) ve VLDL-kolesterol (VLDL-k) düzeyleri ise Friedwald denklemi ile hesaplanmıştır. TG, LDL-k, homosistein, apoprotein B100 ve sistatin C düzeyleri PE grubunda kontrol grubuna göre yüksek bulunmuştur (p
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