23. Ulusal Biyokimya Kongresi Ãzel SayÄ±sÄ± - TÃ¼rk Biyokimya Dergisi

More documents

Recommendations

Info

XXIII. ULUSAL B‹YOK‹MYA KONGRES‹ 29 Kasım - 2 Aralık 2011 Hilton Hotel - Adana 23. Ulusal Biyokimya Kongresi, Adana [23 rd National Biochemistry Congress, Adana / TURKEY] İÇİNDEKİLER been recently shown to result in inhibition of the triggering of glycoxidative stress. Thus RAGEs inhibitors are promising agents for longer health span. Moreover, AGER receptors are also important to avoid the AGEs-induced injury and aging. In addition to contributing to AGE removal, AGER1 opposes AGE-mediated RAGE, MAPK and Nf-kB-dependent inflammatory responses. Recently, we synthesized antioxidant pyridoindole derivatives, which inhibit the production of AGEs. CONTENTS DAVETLİ KONUŞMACI ÖZETLERİ ABSTRACTS OF INVITED LECTURES Turk J Biochem, 2011; 36 (S2) http://www.TurkJBiochem.com
XXIII. ULUSAL B‹YOK‹MYA KONGRES‹ 29 Kasım - 2 Aralık 2011 Hilton Hotel - Adana 23. Ulusal Biyokimya Kongresi, Adana [23 rd National Biochemistry Congress, Adana / TURKEY] İÇİNDEKİLER DAVETLİ KONUŞMACI ÖZETLERİ OZONUN ANTİOKSİDAN MEKANİZMALARI VE TEDAVİDE KULLANILMASI Mine İNAL Osmangazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Eskişekir Ozon reaksiyondaki karşılaştığı biyomoleküllere bağlı olarak farklı mekanizmalar verir. Organik reaksiyon katılımcılarının varlığında ozon belirgin biçimde seçici bir reaksiyon dizisi gösterir. Genellikle serbest radikal ve iyonik mekanizmaları ile birlikte gider. Fizyolojik koşullarda tam kanda reaksiyon mekanizmaları, esansiyel yağ asitlerinin karbon-karbon çift bağına ek olarak 1,3-dipolar şeklindedir. Kanın hücresel elemanlarından alyuvarların membran bileşenlerini alan doymamış yağ asitleri ozonun tercih edilen reaksiyon parametreleridir. Ozonun sistemik uygulamasında, tıbbi ozonun etkisiyle oluşan peroksitler ozonun etki mekanizmasında önemli yer tutar. Özellikle alyuvarlarda yarattığı oksidatif etkiye antioksidatif enzimleri aktive ederek cevap verir. Enfekte ülserlerin lokal tedavisinde, ozon veya ozon peroksitlerinin ozon konsantrasyonuna bağlı olan etkisi hemen ortaya çıkar. Ozonitler ve ozon peroksitleri, ozonize yağlarda O3 reaksiyon ürünleri biçiminde korunur ve yara iyileşmesinde etkili olur. Tedavi dozlarında organizmadaki peroksidasyon reaksiyonlarına karşı katılan enzimler aktive olur. Peroksit ve oksijen radikalleri üzerindeki dejeneratif sonuçlara karşı koruyucu bir fonksiyon üstlenirler. Süperoksit dismutaz, fazla süpeoksit radikallerinin, katalaz hidrojen peroksit ve glutatyon peroksidaz ozon peroksitler veya organik peroksitlerin parçalanmasından sorumludur. Redükte glutatyon gibi ozon peroksitleri hem radikal yakalayıcı hem de iyonlarla raksiyona girerler. Antioksidatif enzimlerden başka alyuvar hücrelerindeki diğer enzimler örneğin glukoz-6-fosfat dehidrogenaz gibi enzimler ve heksoz monofosfat yolu gibi metabolik yollar da aktive olur. Anahtar Kelimeler: ozon, oksidatif stres OZONE THERAPY: CLINICAL AND BASIC EVIDENCE OF ITS THERAPEUTIC POTENTIAL Mine İNAL Department of Medical Biochemistry, Faculty of Medicine, Osmangazi University, Eskişekir Ozone has recently been subjected to criticism and emphasis in relation to clinical efficacy and toxicity, respectively. Without a doubt, ozone, in common with oxygen itself, is one of the major pollutants in urban areas. Nevertheless, inereasingly widwspread use lately has highlighted the potential benefits as a therapeutic agent when used according to well-defined and safe protocols. In recent years, emphasis and attention has been focused on the use of medical ozone. Despite ample clarification (1), confusion persists concerning its potential toxicity as an oxidant agent us the reported clinical efficacy. This confusion is a major factor preventing a more widespred acceptance. Furthermore, the use in specialties so diverse as neurology, orthopedics, internal medicine, sports medicine, endocrinology and others makes is difficult to categorize ozone as a therapeutic agent. This may cause conflicts between the different fields of application and the various medical areas. Ozone, at nontoxic deses, can induce a rearrangement of the biochemical pathways with the activation of a second Messenger in a cascade with a multiple system action. Ischemic preconditioning represents the best similarity in this. Diabetes produces a large number of chenges in vessles that affect the reactivity of smooth muscle and endothelium. Vascular endothelium appears to be a vulnerable target for hyperglycemia-induced metabolic changes. Ozone has been used as a therapeutic agent and beneficial effects have been observed. However, so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. Given that diabetes is a disorder associated with oxidative stres, it was postulated that ozone treatment might protect antioxidant systems and maintain at a physiological level other markers of a endothelial cell damage associated with diabetic complications. Ozone antioxidant properties preserved beta-cell functions and reduced hyperglycemia. Together, these results suggest that this approach may represent a potential complement in the treatment of diabetes its complications. Many studies indicate that, after reoxygenation of the liver, oxygen free-radical formation may initiate the cascade of hepatocellular injury, necrosis/apoptosis and subsequent infiltration of inflammatory cells. Superoxide is one of the most relevant radical in biological regulation. Many regulatory effects are nediated by hydrogen peroxide and other ROS that are chemically derived from superoxide. CONTENTS ABSTRACTS OF INVITED LECTURES Turk J Biochem, 2011; 36 (S2) http://www.TurkJBiochem.com
Page 1 and 2:
XXIII. ULUSAL B‹YOK‹MYA KONGRES
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20: XXIII. ULUSAL B‹YOK‹MYA KONGRES
Page 69: XXIII. ULUSAL B‹YOK‹MYA KONGRES
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321 and 322:
Page 323 and 324:
Page 325 and 326:
Page 327 and 328:
Page 329 and 330:
Page 331 and 332:
Page 333 and 334:
Page 335 and 336:
Page 337 and 338:
Page 339 and 340:
Page 341 and 342:
Page 343 and 344:
Page 345 and 346:
Page 347:
show all

23. Ulusal Biyokimya Kongresi Ãzel SayÄ±sÄ± - TÃ¼rk Biyokimya Dergisi

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?

23. Ulusal Biyokimya Kongresi Ãzel SayÄ±sÄ± - TÃ¼rk Biyokimya Dergisi