Effet chez le porcelet d'une exposition à un régime co-contaminé en ...

INTRODUCTIONdiets containing ZEA and zeolite than in piglets fed diets with ZEA and without the zeolite (Guerre,2000; Coenen and Boyens, 2001).This observation supported the hypothesis that an anion-exchange zeolite, which together withzearalenone is anionic at intestinal pH, treated zearalenone toxicosis by reducing absorption of thetoxin and increasing excretion of zearalenone in feces (Ramos, 1996a).d) Other claysTo some extent other clays such as diatomaceous earth have also been studied for their ability tobind mycotoxins in vitro and in vivo.Some commercial products have been reported to have positive effects against aflatoxins inbroilers (Denli et al., 2009) and ochratoxin A in hens leading to an increase in egg albumen height,redness color of egg yolk and serum calcium concentration (Denli et al., 2008).e) Nutrient interactions in animalsThe adsorbents’ activity has raised many questions regarding their influence on the utilization ofnutrients such as carbohydrates, proteins, vitamins and minerals and controversy results have beenreported.No nutrient interactions have been reported with HSCAS at the 0.5% level in the diet (Phillips,1999); it did not impair phytate or inorganic phosphorous utilization. In other studies, the addition ofHSCAS to basal diets at concentrations of 0.5% or 1% did not impair the utilization of riboflavin,vitamin A or manganese; however there was a slight but significant reduction in zinc utilization in thepresence of 1% clay (Chung et al., 1990). According to Schell et al. (1993a) significant interactions formany minerals indicated that the effects on mineral metabolism were more pronounced whenaflatoxin-contaminated corn was fed. Feeding bentonite with aflatoxin-contaminated corn resultedin partial restoration of performance and liver function without greatly influencing mineralmetabolism (Schell et al., 1993a). Nonetheless, zeolites seemed to have a significantly negative effecton vitamin and mineral uptake and on their distribution in the body of sows (Papaioannou et al.,2002). Thus, one of the most important criteria to take into account when evaluating a potentialbinder is the absence of affinity for vitamins, minerals or other nutrients (Huwig et al., 2001).2) Use of organic adsorbents77