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Table 6 : Interaction between Ochratoxin A (OTA) and other mycotoxins; interaction between T-2 toxin (T2) and cyclopiazonic acid (CPA) isalso includedMycotoxinsSpecies(exposure)OTA-CITRabbit(60 d)OTA-CITChicken(21 d)Doses0.75 – 153.0 – 300OTA-CITRat(20 d) 1 1.0 – 30OTA-CITRat(21 d)0.026 – 0.1OTA-CITRat(1 d) 2 1.0 – 25OTA-T2Chicken(21 d)OTA-T2Pig(30 d)OTA-T2Chicken(21 d)OTA-T2Chicken0.567 –0.9272.5 – 8.02.0 – 4.02.0 – 3.0SYNERGISTIC INTERACTIONANTAGONISTIC INTERACTIONLESS THANADDITIVEADDITIVEType 1 Type 2 Type 3 INTERACTIONType 1 Type 2INTERACTION- maternal mortality ↗- resorptions ↗- live fetuses ↘- % malformed ↗- DNA adducts in kidney↗ (P)- renal Na + -K + -ATPaseactivity ↘- % repairing tissue inliver ↗- NADPHdehydrogenase, NADPHcytochrome creductase ↘- cytochromeP-450 content↘- RW-L ↗- potassium ↘- GGT ↘ - BWG, feed intake ↘- hemoglobin ↘- lymphocytesstimulation ↘- RW-G ↗- BUN ↘- triglycerides ↗- AST ↘ (P)- lymphocytesstimulation ↘- RW-K ↗- glucose ↗- calcium ↘- lesion score in kidney↗- renal Mg 2+ -ATPaseactivity ↘- BWG, feed intake ↘ - TP, albumin, globulin↘- % tumid, necrotic cellsin liver ↗- calcium → - BWG ↘- hemoglobin ↘- TP ↘- CK ↘- LDH ↘- RW-G ↗- hemoglobin ↘- cholesterol ↘- creatinine ↗- ALP ↘- phagocytosis activity↘- oral lesions ↗- RW-L,K,Pv ↗- creatinine ↗- cholesterol, albumin ↘- BW, feed intake ↘- mortality ↗- Ab SRBC ↘- feed intake, BW ↘- water consumption ↗- triglycerides ↗- phosphorus ↘- aniline oxidation ↘- TP, albumin,globulin ↘- cholesterol →- uric acid ↗REFKumar etal., 2008Manning etal., 1985Mayura etal., 1984- BWG → Pfohl-Leszkowiczet al., 2008- RW-L ↗ - uric acid →- RW-K ↗- % necrotic tubularcells in kidney ↗- inorganic phosphorus - TP →↘- phosphorus ↘ - RW-Pc ↗- magnesium ↘- uric acid ↗- GGT →- ALP ↘- RW-L ↗- TP, BUN →Siraj et al.,1981Garcia etal., 2003Harvey etal., 1994Kubena etal., 1989aRaju andDevegowda,
(35 d) - RW-K,A ↗- GGT ↗ ALT ↘OTA-T2- RW-T ↘ - RW-BF →Chicken 2.0 – 3.0- Ab ND,IBD ↘(35 d)OTA-DASChicken(19 d)OTA-DONChicken(21 d)2.0 – 6.02.0 – 165.10 -6 bw/d– 2.10 -4bw/dOTA-FB5.10Rat-6 bw/d(15 d) 3 – 0.05 bw/dOTA-FBTurkey(21 d)0.05 bw/d –0.05 bw/d3.0 – 300OTA-FBRabbit 2.0 – 10(45 d)OTA-PAChicken1.0 bw – 60(28d) 4 bwOTA-PAMouse10 – 40(21 d)OTA-CPAChicken(21 d)2.5 – 34- MDA, PC in liver ↗- CAT in kidney ↘- MDA, PC in liver ↗- MDA in kidney ↗- CAT in kidney ↘- PC in liver ↗- PC in kidney ↗- CAT in kidney ↘- BWG, feed intake ↘- RW-H ↘- cholesterol ↘ (P)- creatinine ↗- AST ↗ (P)- ALT ↗- mortality ↘ - RW-G ↗ - BW ↘- oral lesions ↗- RW-K ↗- TP, albumin ↘- CK ↘- RW-G ↗- RBC ↗- BWG ↘- RW-L,K,Pv ↗- glucose, TP, albumin↘- RW-Pv ↗- uric acid →- cholesterol ↘- PC in kidney ↗ - MDA in kidney ↗- PC in kidney ↗- MDA in liver ↗- MDA in kidney ↗- uric acid ↗ - BUN ↗ - RW-K ↗ - RW-L,Pc,G ↗- RW-S ↘- RBC ↗- TP ↘ - albumin, globulin ↘- ALP ↗- mortality ↗ - BW ↘- RW-S ↘ (P)- mortality ↗- RW-Pc ↗- RW-L,K ↗ (P)- TP, cholesterol ↘ (P)- albumin ↘- creatinine ↗- ALT, AST, LDH ↗- RW-K ↘- BW ↘- BW ↘ - uric acid, triglycerides↗- cholesterol ↘- coagulation time ↗- RW-L ↗- triglycerides ↗- BUN → - uric acid ↗- creatinine →- triglycerides ↗- cholesterol ↘- inorganic phosphorus→- hemoglobin ↗ - triglycerides →- LDH ↗- glucose ↘- RW-Pv ↗2000Raju andDevegowda,2002Kubena etal., 1994aKubena etal., 1988Domijan etal., 2007Kubena etal., 1997bSivakumaret al., 2009Kubena etal., 1984Shepherd etal., 1981Gentles etal., 1999
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
Page 14 and 15: FIGURES ET TABLEAUXFigure 1 : Mycot
Page 16 and 17: INTRODUCTION8
Page 18 and 19: INTRODUCTIONCONTEXTE DE L’ETUDELe
Page 20 and 21: INTRODUCTIONElle se présentait sou
Page 22 and 23: INTRODUCTIONl’utilisation de ce m
Page 24 and 25: INTRODUCTION1. Les mycotoxines : g
Page 26 and 27: INTRODUCTIONc) La zéaralénone (vo
Page 28 and 29: INTRODUCTIONleucoencéphalomalacies
Page 30 and 31: INTRODUCTIONMycotoxins co-contamina
Page 32 and 33: INTRODUCTIONINTRODUCTIONFood safety
Page 34 and 35: INTRODUCTIONCHARACTERIZATION OF THE
Page 36 and 37: Quail(140 d)AF-FBRabbit(21 d)AF-FBR
Page 38 and 39: INTRODUCTIONdue to the ingestion of
Page 40 and 41: Table 2 : Interaction between Aflat
Page 42 and 43: (49 d) - RW-L ↗- Ab SRBC ↘- RW-
Page 44 and 45: INTRODUCTIONb) effects AF and OTA o
Page 46 and 47: INTRODUCTIONThe depletion of lympho
Page 48 and 49: AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
Page 50 and 51: INTRODUCTIONonly seen in birds give
Page 52 and 53: (30 d) 2AF-RUBGuinea pig 0.02 bw -(
Page 54 and 55: INTRODUCTIONbetween AF and CPA on t
Page 56 and 57: (21 day) - RBC, hemoglobin ↗- AST
Page 58 and 59: INTRODUCTIONII. INTERACTIONS BETWEE
Page 60 and 61: INTRODUCTIONwhereas in the experime
Page 62 and 63: INTRODUCTION2.2) TCT type A and BTw
Page 66 and 67: T2-CPAChicken(28 d)T2-CPAChicken(21
Page 68 and 69: INTRODUCTIONexposed group (Brown et
Page 70 and 71: INTRODUCTION2.3) Interaction betwee
Page 72 and 73: INTRODUCTIONeffects in comparison t
Page 74 and 75: INTRODUCTION3. Procédés de décon
Page 76 and 77: INTRODUCTIONPhysical and chemical m
Page 78 and 79: INTRODUCTIONINTRODUCTIONConsumption
Page 80 and 81: INTRODUCTIONmm screen shows that fr
Page 82 and 83: INTRODUCTIONseparate the grain into
Page 84 and 85: Table 7 : toxicological evaluation
Page 86 and 87: INTRODUCTIONextrusion parameters ra
Page 88 and 89: INTRODUCTION- an important loss of
Page 90 and 91: INTRODUCTIONal., 2005). The fate of
Page 92 and 93: INTRODUCTIONby a steeping period. S
Page 94 and 95: INTRODUCTIONon cell tissue cultures
Page 96 and 97: INTRODUCTIONCONCLUSIONDetoxificatio
Page 98 and 99: INTRODUCTIONMycotoxin Reduction in
Page 100 and 101: INTRODUCTIONINTRODUCTIONMycotoxin-p
Page 102 and 103: INTRODUCTIONI. ADSORPTION OF MYCOTO
Page 104 and 105: Rats3000 ppb 0.5 %2500 ppb 0.5 %250
Page 106 and 107: INTRODUCTIONIn studies of the poten
Page 108 and 109: INTRODUCTIONSubstances investigated
Page 110 and 111: Table 9 : Outcome of yeast cell wal
Page 112 and 113: INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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These are not the final page number
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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DISCUSSION GENERALEet al., 2008b).
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DISCUSSION GENERALE• une réactio
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DISCUSSION GENERALE2. Les systèmes
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DISCUSSION GENERALEMycoplasma agala
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DISCUSSION GENERALEoptimale. Les au
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DISCUSSION GENERALEsphingomyéline
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DISCUSSION GENERALEsignalisation ce
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DISCUSSION GENERALEL’IMMUNITÉ IN
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DISCUSSION GENERALEplus spécifique
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DISCUSSION GENERALEsouligner que le
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DISCUSSION GENERALELA CARBOXYLESTER
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DISCUSSION GENERALEde HFB1. Toutefo
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CONCLUSIONS184
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CONCLUSIONSLes effets d’expositio
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CONCLUSIONSest utilisée lorsque la
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REFERENCES BIBLIOGRAPHIQUESAABDEL-W
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REFERENCES BIBLIOGRAPHIQUESBHANDARI
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REFERENCES BIBLIOGRAPHIQUESCASADO,
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REFERENCES BIBLIOGRAPHIQUESDEGIRMEN
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REFERENCES BIBLIOGRAPHIQUESETIENNE,
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REFERENCES BIBLIOGRAPHIQUESGRENIER,
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REFERENCES BIBLIOGRAPHIQUESHERZALLA
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REFERENCES BIBLIOGRAPHIQUESKERKADI,
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REFERENCES BIBLIOGRAPHIQUESKUMAR, M
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REFERENCES BIBLIOGRAPHIQUESMARZOCCO
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REFERENCES BIBLIOGRAPHIQUESODHAV, B
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REFERENCES BIBLIOGRAPHIQUESPFOHL-LE
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REFERENCES BIBLIOGRAPHIQUESREFAI, M
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REFERENCES BIBLIOGRAPHIQUESSCHWARTZ
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REFERENCES BIBLIOGRAPHIQUESSWANSON,
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REFERENCES BIBLIOGRAPHIQUESVEKIRU,
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REFERENCES BIBLIOGRAPHIQUESYAN, D.,
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