Effet chez le porcelet d'une exposition Ã un rÃ©gime co-contaminÃ© en ...

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(21 day) - RBC, hemoglobin ↗- AST ↗- LDH ↗ (P)FB-T2Chicken(19 d)FB-DASTurkey(21 d)FB-DONPig(28 d)FB-DONChicken(21 d)FB-DONPig(35 d)FB-FAChicken egg(21 d)T2-DASLaying hen(24 d)DON-T2Pig(35 d)DON-T2Chicken(21 d)DON-NIV300 – 5.0300 – 4.050 – 4.0300 – 156.0 – 3.01.0 – 1.0(µg/egg)5.0 – 5.0(µg/egg)25 – 25(µg/egg)50 – 50(µg/egg)2.0 – 2.0- RW-Pc ↗ (P) - BWG, feed intake ↘- mortality ↗- RW-G ↗- inorganic phosphorus↘- RBC ↗ (P)- BWG ↘- AST, CHL, ALP ↗ (P)- lymphocytesstimulation ↘ (P)- mortality ↗- RW-Pv ↗ (P)- cholesterol ↗ (P)- AST ↗ (P)- LDH ↗- embryos mortality ↗- embryos mortality ↗- embryos mortality ↗- embryos mortality ↗- egg production (at endof the trial) ↘- feed intake↗↘- RW-L ↘ - feed intake ↘- RW-Lg ↗- cholesterol ↘- RW-L, K ↗- cholesterol ↗- calcium ↗- BWG, feed intake ↘ - RW-L, G ↗- RW-S,H ↘- AST, LDH ↗- RW-G ↗- BUN ↗- GGT ↗- severity, extent ofliver & lung lesions ↗- specific Ab IgG ↘- cytokines expression↘- oral lesions ↗- feed intake ↗- triglycerides ↘- uric acid ↗- oral lesions ↗- RW-S →- TP, albumin ↗- AST, LDH, GGT ↗- oral lesions ↗- RW-Pc →- cholesterol ↘Kubena et al.,1997aKubena et al.,1997b- creatinine ↗ - albumin ↘ - cholesterol ↗- GGT ↗ Harvey et al.,1996- BWG ↘- RW-L, K ↗- TP ↗- neutrophils ↘- severity, extent ofkidney lesions ↗- specific lymphocytesstimulation ↘2.5 – 0.4 - BWG, feed intake ↘2.5 – 0.8 - BWG, feed intake ↘2.5 – 1.6 - BWG, feed intake ↘2.5 – 3.2 - BWG, feed intake ↘- BW ↘- RW-G,BF ↗16 – 4.0- cholesterol ↘ - TP, albumin ↘- LDH ↘- oral lesions ↗0.071 bw –0.071 bw- uric acid ↗ - TP ↗- PROD ↗- RW-H → - RW-BF →- LDH ↗ - egg production (atintermediate time) ↘- GDH ↘- Ig A ↗- CDNB ↗- total CO2 ↘- EROD ↗- creatinine, albumin→- specific Ab IgA →Kubena et al.,1997aGrenier et al.(2011)Bacon et al.,1995Diaz et al.,1994Friend et al.,1992Kubena et al.,1989bGouze et al.,
Mouse(28 d) 2 0.071 bw –0.355 bwDON-ZEAMouse(56 d)DON-ZEAMouse(14-21 d)DON-MONTurkey(21 d)0.355 bw –0.071 bw0.355 bw –0.355 bw5.0 – 1025 – 1020 – 100- uric acid ↗ (P) - TP ↗- Ig A ↗- CDNB ↗- phosphorus ↗- total CO2 ↘- uric acid ↗- TP ↗- Ig A ↗- DCNB ↗- feed intake↘- globulin ↘- TP ↗- phosphorus ↗- total CO2 ↘- PROD ↗- DCNB ↗- Ig A ↗- CDNB ↗- total CO2 ↘- uric acid ↗- CDNB ↗- EROD ↗ - feed intake ↘ 2005- EROD, PROD ↗- RBC ↘ - BW ↘- RW-L →- Ig A ↗1) Ledoux et al. (2003) : for the highest dose of MON in the combination, feed intake and BWG not took into account due to high mortality2) Gouze et al. (2005) : administration thrice a week for 4 weeks- EROD, PROD ↗ - feed intake ↘- bacteria in spleen ↗ - DTH reaction ↘Forsell et al.,1986Pestka et al.,1987- RW-K ↗ - BWG ↘ - RW-H ↗- calcium → Morris et al.,1999
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
Page 6 and 7: J’ai une pensée particulière po
Page 8 and 9: Grenier, B., Loureiro-Bracarense, A
Page 10 and 11: TABLE DES MATIERES ................
Page 12 and 13: LISTE DES ABREVIATIONSAFAflatoxineD
Page 14 and 15: FIGURES ET TABLEAUXFigure 1 : Mycot
Page 16 and 17: INTRODUCTION8
Page 18 and 19: INTRODUCTIONCONTEXTE DE L’ETUDELe
Page 20 and 21: INTRODUCTIONElle se présentait sou
Page 22 and 23: INTRODUCTIONl’utilisation de ce m
Page 24 and 25: INTRODUCTION1. Les mycotoxines : g
Page 26 and 27: INTRODUCTIONc) La zéaralénone (vo
Page 28 and 29: INTRODUCTIONleucoencéphalomalacies
Page 30 and 31: INTRODUCTIONMycotoxins co-contamina
Page 32 and 33: INTRODUCTIONINTRODUCTIONFood safety
Page 34 and 35: INTRODUCTIONCHARACTERIZATION OF THE
Page 36 and 37: Quail(140 d)AF-FBRabbit(21 d)AF-FBR
Page 38 and 39: INTRODUCTIONdue to the ingestion of
Page 40 and 41: Table 2 : Interaction between Aflat
Page 42 and 43: (49 d) - RW-L ↗- Ab SRBC ↘- RW-
Page 44 and 45: INTRODUCTIONb) effects AF and OTA o
Page 46 and 47: INTRODUCTIONThe depletion of lympho
Page 48 and 49: AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
Page 50 and 51: INTRODUCTIONonly seen in birds give
Page 52 and 53: (30 d) 2AF-RUBGuinea pig 0.02 bw -(
Page 54 and 55: INTRODUCTIONbetween AF and CPA on t
Page 58 and 59: INTRODUCTIONII. INTERACTIONS BETWEE
Page 60 and 61: INTRODUCTIONwhereas in the experime
Page 62 and 63: INTRODUCTION2.2) TCT type A and BTw
Page 64 and 65: Table 6 : Interaction between Ochra
Page 66 and 67: T2-CPAChicken(28 d)T2-CPAChicken(21
Page 68 and 69: INTRODUCTIONexposed group (Brown et
Page 70 and 71: INTRODUCTION2.3) Interaction betwee
Page 72 and 73: INTRODUCTIONeffects in comparison t
Page 74 and 75: INTRODUCTION3. Procédés de décon
Page 76 and 77: INTRODUCTIONPhysical and chemical m
Page 78 and 79: INTRODUCTIONINTRODUCTIONConsumption
Page 80 and 81: INTRODUCTIONmm screen shows that fr
Page 82 and 83: INTRODUCTIONseparate the grain into
Page 84 and 85: Table 7 : toxicological evaluation
Page 86 and 87: INTRODUCTIONextrusion parameters ra
Page 88 and 89: INTRODUCTION- an important loss of
Page 90 and 91: INTRODUCTIONal., 2005). The fate of
Page 92 and 93: INTRODUCTIONby a steeping period. S
Page 94 and 95: INTRODUCTIONon cell tissue cultures
Page 96 and 97: INTRODUCTIONCONCLUSIONDetoxificatio
Page 98 and 99: INTRODUCTIONMycotoxin Reduction in
Page 100 and 101: INTRODUCTIONINTRODUCTIONMycotoxin-p
Page 102 and 103: INTRODUCTIONI. ADSORPTION OF MYCOTO
Page 104 and 105: Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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These are not the final page number
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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DISCUSSION GENERALEet al., 2008b).
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DISCUSSION GENERALE• une réactio
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DISCUSSION GENERALE2. Les systèmes
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DISCUSSION GENERALEMycoplasma agala
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DISCUSSION GENERALEoptimale. Les au
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DISCUSSION GENERALEsphingomyéline
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DISCUSSION GENERALEsignalisation ce
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DISCUSSION GENERALEL’IMMUNITÉ IN
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DISCUSSION GENERALEplus spécifique
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DISCUSSION GENERALEsouligner que le
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DISCUSSION GENERALELA CARBOXYLESTER
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DISCUSSION GENERALEde HFB1. Toutefo
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CONCLUSIONS184
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CONCLUSIONSLes effets d’expositio
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CONCLUSIONSest utilisée lorsque la
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REFERENCES BIBLIOGRAPHIQUESAABDEL-W
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REFERENCES BIBLIOGRAPHIQUESBHANDARI
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REFERENCES BIBLIOGRAPHIQUESCASADO,
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REFERENCES BIBLIOGRAPHIQUESDEGIRMEN
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REFERENCES BIBLIOGRAPHIQUESETIENNE,
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REFERENCES BIBLIOGRAPHIQUESGRENIER,
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REFERENCES BIBLIOGRAPHIQUESHERZALLA
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REFERENCES BIBLIOGRAPHIQUESKERKADI,
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REFERENCES BIBLIOGRAPHIQUESKUMAR, M
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REFERENCES BIBLIOGRAPHIQUESMARZOCCO
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REFERENCES BIBLIOGRAPHIQUESODHAV, B
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REFERENCES BIBLIOGRAPHIQUESPFOHL-LE
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REFERENCES BIBLIOGRAPHIQUESREFAI, M
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REFERENCES BIBLIOGRAPHIQUESSCHWARTZ
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REFERENCES BIBLIOGRAPHIQUESSWANSON,
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REFERENCES BIBLIOGRAPHIQUESVEKIRU,
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REFERENCES BIBLIOGRAPHIQUESYAN, D.,
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