REFERENCES BIBLIOGRAPHIQUESETIENNE, M. & WACHE, Y. 2008. Biological and physiological effects of deoxyniva<strong>le</strong>nol (DON) in thepig. In: Oswald, I.P., Taranu, I. (Eds.), My<strong>co</strong>toxins in Farm Animals, Research Signpost, Kerala,113-130.FFARAG, R. S., RASHED, M. M., HUSSEIN, A. A. & ABO-HAGAR, A. 1995. Effect of Gamma Radiation onthe Infected Yellow Corn and Peanuts by Aspergillus flavus. Chemie MikrobiologieTechnologie der Leb<strong>en</strong>smittel, 17, 93-98.FERNANDEZ-SURUMAY, G., OSWEILER, G. D., YAEGER, M. J., HAUCK, C. C., HENDRICH, S. & MURPHY,P. A. 2004. Glu<strong>co</strong>se reaction with fumonisin B-1 partially reduces its toxicity in swine. Journalof Agricultural and Food Chemistry, 52, 7732-7739.FERNANDEZ-SURUMAY, G., OSWEILER, G. D., YAEGER, M. J., ROTTINGHAUS, G. E., HENDRICH, S.,BUCKLEY, L. K. & MURPHY, P. A. 2005. Fumonisin B-glu<strong>co</strong>se reaction products are <strong>le</strong>ss toxicwh<strong>en</strong> fed to swine. Journal of Agricultural and Food Chemistry, 53, 4264-4271.FIERS, W. 1991. Tumor-Necrosis-Factor - Characterization at the Mo<strong>le</strong>cular, Cellular and Invivo Level.Febs Letters, 285, 199-212.FINK-GREMMELS, J. 1999. My<strong>co</strong>toxins: Their implications for human and animal health. VeterinaryQuarterly, 21, 115-120.FLYNN, T. J., STACK, M. E., TROY, A. L. & CHIRTEL, S. J. 1997. Assessm<strong>en</strong>t of the embryotoxic pot<strong>en</strong>tialof the total hydrolysis product of fumonisin B-1 using cultured organog<strong>en</strong>esis-staged ratembryos. Food and Chemical Toxi<strong>co</strong>logy, 35, 1135-1141.FORSELL, J. H., WITT, M. F., TAI, J. H., JENSEN, R. & PESTKA, J. J. 1986. Effects of 8-Week Exposure ofthe B6c3f1 Mouse to Dietary Deoxyniva<strong>le</strong>nol (Vomitoxin) and Zeara<strong>le</strong>none. Food andChemical Toxi<strong>co</strong>logy, 24, 213-219.FREMY, J. M., GAUTIER, J. P., HERRY, M. P., TERRIER, C. & CALET, C. 1988. Effects of Ammoniation onthe Carry-over of Aflatoxins into Bovine-Milk. Food Additives and Contaminants, 5, 39-44.FRICKE, R. F. & JORGE, J. 1990. Assessm<strong>en</strong>t of Efficacy of Activated-Char<strong>co</strong>al for Treatm<strong>en</strong>t of AcuteT-2 Toxin Poisoning. Journal of Toxi<strong>co</strong>logy-Clinical Toxi<strong>co</strong>logy, 28, 421-431.FRIEND, D. W., THOMPSON, B. K., TRENHOLM, H. L., BOERMANS, H. J., HARTIN, K. E. & PANICH, P. L.1992. Toxicity of T-2 Toxin and Its Interaction with Deoxyniva<strong>le</strong>nol Wh<strong>en</strong> Fed to Yo<strong>un</strong>g-Pigs.Canadian Journal of Animal Sci<strong>en</strong>ce, 72, 703-711.FRIEND, D. W., TRENHOLM, H. L., YOUNG, J. C., THOMPSON, B. K. & HARTIN, K. E. 1984. Effect ofAdding Pot<strong>en</strong>tial Vomitoxin (Deoxyniva<strong>le</strong>nol) Detoxicants or a F-Graminearum InoculatedCorn Supp<strong>le</strong>m<strong>en</strong>t to Wheat Diets Fed to Pigs. Canadian Journal of Animal Sci<strong>en</strong>ce, 64, 733-741.FUCHS, E., BINDER, E. M., HEIDLER, D. & KRSKA, R. Charakterisier<strong>un</strong>g von metabolit<strong>en</strong> nach d<strong>en</strong>bakteriel<strong>le</strong>n abbau von A- <strong>un</strong>d B-Trichothec<strong>en</strong><strong>en</strong> durch BBSH 797. Proceeding of the 22ndMykotoxin-Workshop, 2000 Germany.FUCHS, E., BINDER, E. M., HEIDLER, D. & KRSKA, R. 2002. Structural characterization of metabolitesafter the microbial degradation of type A trichothec<strong>en</strong>es by the bacterial strain BBSH 797.Food Additives and Contaminants, 19, 379-386.FURUYA, H., OHKAWARA, S., NAGASHIMA, K., ASANUMA, N. & HINO, T. 2008. Dietary sphingomyelinal<strong>le</strong>viates experim<strong>en</strong>tal inflammatory bowel disease in mice. International Journal forVitamin and Nutrition Research, 78, 41-49.GGABAL, M. A. & AZZAM, A. H. 1998. Interaction of aflatoxin in the feed and imm<strong>un</strong>ization againstse<strong>le</strong>cted infectious diseases in poultry. II. Effect on one-day-old layer chicks simultaneously197
REFERENCES BIBLIOGRAPHIQUESvaccinated against Newcast<strong>le</strong> disease, infectious bronchitis and infectious bursal disease.Avian Pathology, 27, 290-295.GALEY, F. D., LAMBERT, R. J., BUSSE, M. & BUCK, W. B. 1987. Therapeutic Efficacy of SuperactiveChar<strong>co</strong>al in Rats Exposed to Oral Lethal Doses of T-2 Toxin. Toxi<strong>co</strong>n, 25, 493-499.GALVANO, F., RITIENI, A., PIVA, G. & PIETRI, A. 2005. My<strong>co</strong>toxins in the human food chain. In: DIAZ,D. E. (ed.) My<strong>co</strong>toxin Bluebook. Nottingham UK: Nottingham University Press.GAOU, I., DUBOIS, M., PFOHL-LESZKOWICZ, A., COSTE, C., DE JOUFFREY, S. & PARENT-MASSIN, D.2005. Safety of Oxygre<strong>en</strong> (R), an ozone treatm<strong>en</strong>t on wheat grains. Part 1. A four-weektoxicity study in rats by dietary administration of treated wheat. Food Additives andContaminants, 22, 1113-1119.GARCIA, A. R., AVILA, E., ROSILES, R. & PETRONE, V. M. 2003. Evaluation of two my<strong>co</strong>toxin binders toreduce toxicity of broi<strong>le</strong>r diets <strong>co</strong>ntaining ochratoxin A and T-2 toxin <strong>co</strong>ntaminated grain.Avian Diseases, 47, 691-699.GAUMY, J. L., BAILLY, J. D., BURGAT, V. & GUERRE, P. 2001. Zéaralénone : propriétés et toxicitéexpérim<strong>en</strong>ta<strong>le</strong>. Revue Médecine Vétérinaire, 152, 219-234.GELDERBLOM, W. C. A., MARASAS, W. F. O., LEBEPE-MAZUR, S., SWANEVELDER, S., VESSEY, C. J. &HALL, P. D. 2002. Interaction of fumonisin B-1 and aflatoxin B-1 in a short-termcarcinog<strong>en</strong>esis model in rat liver. Toxi<strong>co</strong>logy, 171, 161-173.GENTLES, A., SMITH, E. E., KUBENA, L. F., DUFFUS, E., JOHNSON, P., THOMPSON, J., HARVEY, R. B. &EDRINGTON, T. S. 1999. Toxi<strong>co</strong>logical evaluations of cyclopiazonic acid and ochratoxin a inbroi<strong>le</strong>rs. Poultry Sci<strong>en</strong>ce, 78, 1380-1384.GIRISH, C. K. & DEVEGOWDA, C. 2006. Efficacy of glu<strong>co</strong>mannan-<strong>co</strong>ntaining yeast product (My<strong>co</strong>sorb(R)) and hydrated sodium calcium aluminosilicate in prev<strong>en</strong>ting the individual and <strong>co</strong>mbinedtoxicity of aflatoxin and T-2 toxin in <strong>co</strong>mmercial broi<strong>le</strong>rs. Asian-Australasian Journal ofAnimal Sci<strong>en</strong>ces, 19, 877-883.GLAHN, R. P., WIDEMAN, R. F., EVANGELISTI, J. W. & HUFF, W. E. 1988. Effects of Ochratoxin-a Aloneand in Combination with Citrinin on Kidney-F<strong>un</strong>ction of Sing<strong>le</strong> Comb White Leghorn Pul<strong>le</strong>ts.Poultry Sci<strong>en</strong>ce, 67, 1034-1042.GOPEE, N. V., HE, Q. R. & SHARMA, R. P. 2003. Fumonisin B-1-induced apoptosis is associated withdelayed inhibition of protein kinase C, nuc<strong>le</strong>ar factor-kappa B and tumor necrosis factoralpha in LLC-PK1 cells. Chemi<strong>co</strong>-Biological Interactions, 146, 131-145.GOUZE, M. E., LAFFITTE, J., DEDIEU, G., GALINIER, A., THOUVENOT, J. P., OSWALD, I. P. & GALTIER, P.2005. Individual and <strong>co</strong>mbined effects of low oral doses of deoxyniva<strong>le</strong>nol and niva<strong>le</strong>nol inmice. Cellular and Mo<strong>le</strong>cular Biology, 51, OL809-OL817.GOWDA, N. K. S., LEDOUX, D. R., ROTTINGHAUS, G. E., BERMUDEZ, A. J. & CHEN, Y. C. 2008. Efficacyof turmeric (Curcuma longa), <strong>co</strong>ntaining a known <strong>le</strong>vel of curcumin, and a hydrated sodiumcalcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broi<strong>le</strong>r chicks.Poultry Sci<strong>en</strong>ce, 87, 1125-1130.GOYARTS, T., DANICKE, S., ROTHKOTTER, H. J., SPILKE, J., TIEMANN, U. & SCHOLLENBERGER, M. 2005.On the effects of a chronic deoxyniva<strong>le</strong>nol intoxication on performance, haematological andserum parameters of pigs wh<strong>en</strong> diets are offered either for ad libitum <strong>co</strong>nsumption or fedrestrictively. J Vet Med A Physiol Pathol Clin Med, 52, 305-14.GRANT, P. G. & PHILLIPS, T. D. 1998. Isothermal adsorption of aflatoxin B-1 on HSCAS clay. Journal ofAgricultural and Food Chemistry, 46, 599-605.GRATZ, S. 2007. Aflatoxin binding by probiotics experim<strong>en</strong>tal studies on intestinal aflatoxin transport,metabolism and toxicity. Doctoral dissertation, Kuopio University.GRATZ, S., TAUBEL, M., JUVONEN, R. O., VILUKSELA, M., TURNER, P. C., MYKKANEN, H. & EL-NEZAMI,H. 2006. Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion,and toxicity of aflatoxin B-1 in rats. Applied and Environm<strong>en</strong>tal Microbiology, 72, 7398-7400.198
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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