Effet chez le porcelet d'une exposition Ã un rÃ©gime co-contaminÃ© en ...

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Table 2 : Interaction between Aflatoxins (AF) and Ochratoxin A (OTA)MycotoxinsSpecies(exposure)Doses0.025 –AF-OTA 1.15Chicken egg (µg/egg)(10 d) 1 0.05 – 2.3(µg/egg)AF-OTA 0.025 – 1.0(µg/egg)Chicken egg(15 d) 1 0.05 – 2.0(µg/egg)AF-OTAPig(28 d)AF-OTAChicken(21 d)AF-OTAChicken(42 d)AF-OTAChicken(42 d)AF-OTAChicken(21 d)AF-OTAChicken(42 d)AF-OTACalve(87 d)2.0 – 2.02.5 – 2.02.5 – 2.02.5 – 2.03.5 – 2.00.2 – 0.20.013 –0.450SYNERGISTIC INTERACTIONANTAGONISTIC INTERACTIONLESS THANADDITIVEADDITIVEType 1 Type 2 Type 3 INTERACTIONType 1 Type 2INTERACTION- embryos mortality ↗ - abnormalities ↗- abnormalities ↗ - embryos mortality ↗- abnormalities ↗ - embryos mortality ↗- abnormalities ↗ - embryos mortality ↗- triglycerides ↗ (P) - TP ↗- RW-L ↗- BW ↘- mortality ↗- RW-L,K,G,S,Pv,Pc ↗- BW ↘- prothrombin times ↗- live, dressed,eviscerated weight ↘- carcasse yield, breast,drum, thigh, wing, backweights ↘- plasma carotenoids ↘- BW ↘- ALP ↗- inorganic phosphorus↘- incidence andseverity of breastbruises ↗- BW ↘- RW-L,K,H,Pv ↗- RW-S ↘- DTH reaction ↘- BUN, cholesterol,glucose ↘- calcium →- sodium ↘- incidence and severityof right thigh bruises ↗- albumin →- hemoglobin →- RW-K →- liver lipid levels →- breast yield ↘ - liver lipid levels ↗- hemoglobin ↘- albumin, cholesterol,triglycerides ↘- creatinine, uric acid ↗- ALP ↗- RW-L ↗- RW- BF,T ↘- albumin, TP,cholesterol ↘- Ab ND ↘- WBC ↘- uric acid ↗- AST ↘REFEdringtonet al., 1995Edringtonet al., 1995Harvey etal., 1989aHuff andDoerr, 1981Huff et al.,1983Huff et al.,1984Huff et al.,1992Kalorey etal., 2005Patterson etal., 1981
AF-OTAChicken(35 d)AF-OTAChicken(35 d)AF-OTAGuinea pig(28 d)AF-OTAChicken(42 d)AF-OTAPig(42 d)AF-OTALaying hen(50 d)AF-OTALaying hen(50-75 d)AF-OTAChicken0.3 – 2.00.3 – 2.00.01 mg/d –0.45 mg/d0.2 – 0.20.375 – 1.00.5 – 1.01.0 – 2.02.0 – 4.00.5 – 1.01.0 – 2.02.0 – 4.0- feed consumed forproduction of 1 dozeneggs ↗- metabolizable energy,protein retention ↘- maintenance energyrequirement ↗- maintenance energyrequirement ↗- RW-G,A ↗- GGT ↗- hemoglobin ↘- BW ↘- cholesterol ↘- RW-S,T ↘- Ab ND, DTHreaction ↘- BW, feed intake ↘- ALT ↘- TP, globulin ↘- complement titer ↘- triglyceride ↘- creatinine, uric acid ↗- mortality ↗- RW-L, K ↗- TP, cholesterol, BUN↘-coagulation time →- RW-BF,T ↘- Ab ND, IBD ↘- hemoglobin ↘- RW-L ↗, RW-BF ↘- WBC →Raju andDevegowda, 2000Raju andDevegowda, 2002Richard etal., 1975Sakhare etal., 2007- BWG ↘ - creatinine ↗ - BUN → Tapia andSeawright,1985- egg production ↘ - egg shape index ↘ - feed intake ↘- egg shell thickness →- egg production ↘- feed consumed forproduction of 1 dozeneggs ↗- egg shape index ↘- egg production ↘- feed consumed forproduction of 1 dozeneggs ↗- egg energydeposition ↘- metabolizableenergy, proteinretention, egg energydeposition ↘- metabolizableenergy, proteinretention ↘- feed intake ↘- egg shape index ↘- egg energy deposition↘- maintenance energyrequirement ↗- feed intake ↘ - egg shell thickness↘- egg shell thickness →- BWG ↘- RW-L ↗- Ab SRBC ↘0.5 – 1.0- feed intake ↘- DTH reaction ↘1.0 – 2.0 - feed intake ↘ - BWG ↘ - RW-BF ↘ - RW-K ↗Verma etal., 2003Verma etal., 2007Verma etal., 2004
Page 2 and 3: AUTEUR : Bertrand GRENIERTITRE : Ef
Page 4 and 5: REMERCIEMENTSLe travail ici présen
Page 6 and 7: J’ai une pensée particulière po
Page 8 and 9: Grenier, B., Loureiro-Bracarense, A
Page 10 and 11: TABLE DES MATIERES ................
Page 12 and 13: LISTE DES ABREVIATIONSAFAflatoxineD
Page 14 and 15: FIGURES ET TABLEAUXFigure 1 : Mycot
Page 16 and 17: INTRODUCTION8
Page 18 and 19: INTRODUCTIONCONTEXTE DE L’ETUDELe
Page 20 and 21: INTRODUCTIONElle se présentait sou
Page 22 and 23: INTRODUCTIONl’utilisation de ce m
Page 24 and 25: INTRODUCTION1. Les mycotoxines : g
Page 26 and 27: INTRODUCTIONc) La zéaralénone (vo
Page 28 and 29: INTRODUCTIONleucoencéphalomalacies
Page 30 and 31: INTRODUCTIONMycotoxins co-contamina
Page 32 and 33: INTRODUCTIONINTRODUCTIONFood safety
Page 34 and 35: INTRODUCTIONCHARACTERIZATION OF THE
Page 36 and 37: Quail(140 d)AF-FBRabbit(21 d)AF-FBR
Page 38 and 39: INTRODUCTIONdue to the ingestion of
Page 42 and 43: (49 d) - RW-L ↗- Ab SRBC ↘- RW-
Page 44 and 45: INTRODUCTIONb) effects AF and OTA o
Page 46 and 47: INTRODUCTIONThe depletion of lympho
Page 48 and 49: AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
Page 50 and 51: INTRODUCTIONonly seen in birds give
Page 52 and 53: (30 d) 2AF-RUBGuinea pig 0.02 bw -(
Page 54 and 55: INTRODUCTIONbetween AF and CPA on t
Page 56 and 57: (21 day) - RBC, hemoglobin ↗- AST
Page 58 and 59: INTRODUCTIONII. INTERACTIONS BETWEE
Page 60 and 61: INTRODUCTIONwhereas in the experime
Page 62 and 63: INTRODUCTION2.2) TCT type A and BTw
Page 64 and 65: Table 6 : Interaction between Ochra
Page 66 and 67: T2-CPAChicken(28 d)T2-CPAChicken(21
Page 68 and 69: INTRODUCTIONexposed group (Brown et
Page 70 and 71: INTRODUCTION2.3) Interaction betwee
Page 72 and 73: INTRODUCTIONeffects in comparison t
Page 74 and 75: INTRODUCTION3. Procédés de décon
Page 76 and 77: INTRODUCTIONPhysical and chemical m
Page 78 and 79: INTRODUCTIONINTRODUCTIONConsumption
Page 80 and 81: INTRODUCTIONmm screen shows that fr
Page 82 and 83: INTRODUCTIONseparate the grain into
Page 84 and 85: Table 7 : toxicological evaluation
Page 86 and 87: INTRODUCTIONextrusion parameters ra
Page 88 and 89: INTRODUCTION- an important loss of
Page 90 and 91:
INTRODUCTIONal., 2005). The fate of
Page 92 and 93:
INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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These are not the final page number
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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DISCUSSION GENERALEet al., 2008b).
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DISCUSSION GENERALE• une réactio
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DISCUSSION GENERALE2. Les systèmes
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DISCUSSION GENERALEMycoplasma agala
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DISCUSSION GENERALEoptimale. Les au
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DISCUSSION GENERALEsphingomyéline
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DISCUSSION GENERALEsignalisation ce
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DISCUSSION GENERALEL’IMMUNITÉ IN
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DISCUSSION GENERALEplus spécifique
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DISCUSSION GENERALEsouligner que le
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DISCUSSION GENERALELA CARBOXYLESTER
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DISCUSSION GENERALEde HFB1. Toutefo
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CONCLUSIONS184
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CONCLUSIONSLes effets d’expositio
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CONCLUSIONSest utilisée lorsque la
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REFERENCES BIBLIOGRAPHIQUESAABDEL-W
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REFERENCES BIBLIOGRAPHIQUESBHANDARI
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REFERENCES BIBLIOGRAPHIQUESCASADO,
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REFERENCES BIBLIOGRAPHIQUESDEGIRMEN
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REFERENCES BIBLIOGRAPHIQUESETIENNE,
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REFERENCES BIBLIOGRAPHIQUESGRENIER,
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REFERENCES BIBLIOGRAPHIQUESHERZALLA
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REFERENCES BIBLIOGRAPHIQUESKERKADI,
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REFERENCES BIBLIOGRAPHIQUESKUMAR, M
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REFERENCES BIBLIOGRAPHIQUESMARZOCCO
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REFERENCES BIBLIOGRAPHIQUESODHAV, B
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REFERENCES BIBLIOGRAPHIQUESPFOHL-LE
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REFERENCES BIBLIOGRAPHIQUESREFAI, M
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REFERENCES BIBLIOGRAPHIQUESSCHWARTZ
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REFERENCES BIBLIOGRAPHIQUESSWANSON,
Page 280 and 281:
REFERENCES BIBLIOGRAPHIQUESVEKIRU,
Page 282 and 283:
REFERENCES BIBLIOGRAPHIQUESYAN, D.,
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