Effet chez le porcelet d'une exposition Ã un rÃ©gime co-contaminÃ© en ...

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Figure 8ILEUM2.01.6TNF-αbbb2.52.0IL-1βbbb2.52.0IL-6b1.2a1.5a1.5aaaC y t o k i n e e x p r e s s i o n l e v e l s ( A . U.)0.80.40.01.61.41.21.00.80.60.40.20.01.61.41.21.00.80.60.40.20.01.00.50.0IL-12a2.0 IL-10aaa a1.6aa1.2a0.80.40.0IL-2MIP-1β2.0aaaaaa1.6a1.2 a0.80.41.00.50.02.0IL-8a a1.6aa1.20.80.40.02.5IFN-γa2.0a1.5aa1.00.50.00.0Cont DON FB DON+FB Cont DON FB DON+FB Cont DON FB DON+FBA n i m a l t r e a t m e n t s
Figure 9IMMUNOHISTOCHEMICAL ANALYSISWESTERN BLOT ANALYSISE-CadherinOccludinABβ-actinDON+FB1***E-cadherin**Band intensity (A.U.)1.21.00.80.60.40.20.01.41.21.00.80.60.40.20.0aa,bE-cadherinbbab b OccludinbControl DON FB DON+FBFB1DONControlDON+FB1FB1DON**0% 20% 40% 60% 80% 100%++++*********Strong andhomogeneous stainingWeak andheterogeneous stainingE-cadherinStrong andhomogeneous stainingWeak andheterogeneous stainingAnimal treatmentControl0% 20% 40% 60% 80% 100%
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
Page 102 and 103: INTRODUCTIONI. ADSORPTION OF MYCOTO
Page 104 and 105: Rats3000 ppb 0.5 %2500 ppb 0.5 %250
Page 106 and 107: INTRODUCTIONIn studies of the poten
Page 108 and 109: INTRODUCTIONSubstances investigated
Page 110 and 111: Table 9 : Outcome of yeast cell wal
Page 112 and 113: INTRODUCTIONFurthermore, cholestyra
Page 114 and 115: INTRODUCTIONwall peptidoglycans and
Page 116 and 117: INTRODUCTIONII. BIOLOGICAL DETOXIFI
Page 118 and 119: INTRODUCTIONdecrease in toxin-conce
Page 120 and 121: INTRODUCTIONCONCLUSIONPrevention an
Page 122 and 123: TRAVAILEXPERIMENTAL90
Page 124 and 125: TRAVAIL EXPERIMENTALtoxicité gén
Page 126 and 127: TRAVAIL EXPERIMENTALRESUME DES ETUD
Page 128 and 129: These are not the final page number
Page 140 and 141: TRAVAIL EXPERIMENTALChronic ingesti
Page 142 and 143: TRAVAIL EXPERIMENTALINTRODUCTIONMyc
Page 144 and 145: TRAVAIL EXPERIMENTALMATERIAL & METH
Page 146 and 147: TRAVAIL EXPERIMENTALthrough a grade
Page 148 and 149: Figure 5ABCDVilli height (µm)5432a
Page 150 and 151: TRAVAIL EXPERIMENTALRESULTS1) Histo
Page 154 and 155: TRAVAIL EXPERIMENTAL3) Intestinal i
Page 156 and 157: TRAVAIL EXPERIMENTALtreated group t
Page 158 and 159: TRAVAIL EXPERIMENTALThe potencial e
Page 160 and 161: TRAVAIL EXPERIMENTALQuantification
Page 162 and 163: Figure 10 :(a) Réaction de deesté
Page 164 and 165: TRAVAIL EXPERIMENTALrévélé de l
Page 166 and 167: TRAVAIL EXPERIMENTALABSTRACTFumonis
Page 168 and 169: TRAVAIL EXPERIMENTALintestinal leve
Page 170 and 171: TRAVAIL EXPERIMENTAL3) Experimental
Page 172 and 173: TRAVAIL EXPERIMENTALthe importance
Page 174 and 175: Figure 11 : Effects of FB1 and HFB1
Page 176 and 177: Table 15 : Effects of FB1 and HFB1
Page 178 and 179: Table 17 : Effects of FB1 and HFB1
Page 180 and 181: TRAVAIL EXPERIMENTALDISCUSSIONThe a
Page 182 and 183: TRAVAIL EXPERIMENTALassociated lymp
Page 184 and 185: TRAVAIL EXPERIMENTALHartinger et al
Page 186 and 187: Figure 13 :(a) Transformation par v
Page 188 and 189: Figure 14 :Illustrations de la proc
Page 190 and 191: Figure 15 :Plan expérimental de la
Page 192 and 193: TRAVAIL EXPERIMENTAL4) Analyses du
Page 194 and 195: TRAVAIL EXPERIMENTAL9) Analyses sta
Page 196 and 197: TRAVAIL EXPERIMENTALRESULTATS1) Eff
Page 198 and 199: TRAVAIL EXPERIMENTAL2) Effet des ag
Page 200 and 201: TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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DISCUSSION GENERALEet al., 2008b).
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DISCUSSION GENERALE• une réactio
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DISCUSSION GENERALE2. Les systèmes
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DISCUSSION GENERALEMycoplasma agala
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DISCUSSION GENERALEoptimale. Les au
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DISCUSSION GENERALEsphingomyéline
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DISCUSSION GENERALEsignalisation ce
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DISCUSSION GENERALEL’IMMUNITÉ IN
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DISCUSSION GENERALEplus spécifique
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DISCUSSION GENERALEsouligner que le
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DISCUSSION GENERALELA CARBOXYLESTER
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DISCUSSION GENERALEde HFB1. Toutefo
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CONCLUSIONS184
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CONCLUSIONSLes effets d’expositio
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CONCLUSIONSest utilisée lorsque la
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REFERENCES BIBLIOGRAPHIQUESAABDEL-W
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REFERENCES BIBLIOGRAPHIQUESBHANDARI
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REFERENCES BIBLIOGRAPHIQUESCASADO,
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REFERENCES BIBLIOGRAPHIQUESDEGIRMEN
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REFERENCES BIBLIOGRAPHIQUESETIENNE,
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REFERENCES BIBLIOGRAPHIQUESGRENIER,
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REFERENCES BIBLIOGRAPHIQUESHERZALLA
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REFERENCES BIBLIOGRAPHIQUESKERKADI,
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REFERENCES BIBLIOGRAPHIQUESKUMAR, M
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REFERENCES BIBLIOGRAPHIQUESMARZOCCO
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REFERENCES BIBLIOGRAPHIQUESODHAV, B
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REFERENCES BIBLIOGRAPHIQUESPFOHL-LE
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REFERENCES BIBLIOGRAPHIQUESREFAI, M
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REFERENCES BIBLIOGRAPHIQUESSCHWARTZ
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REFERENCES BIBLIOGRAPHIQUESSWANSON,
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REFERENCES BIBLIOGRAPHIQUESVEKIRU,
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REFERENCES BIBLIOGRAPHIQUESYAN, D.,
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