REFERENCES BIBLIOGRAPHIQUESBHANDARI, N., BROWN, C. C. & SHARMA, R. P. 2002. Fumonisin B-1-induced localized activation ofcytokine network in mouse liver. Food and Chemical Toxi<strong>co</strong>logy, 40, 1483-1491.BHAT, R. V., SHETTY, P. H., RAO, P. A. & RAO, V. S. 1997. A foodborne disease outbreak due to the<strong>co</strong>nsumption of moldy sorghum and maize <strong>co</strong>ntaining fumonisin my<strong>co</strong>toxins. Journal ofToxi<strong>co</strong>logy-Clinical Toxi<strong>co</strong>logy, 35, 249-255.BIMCZOK, D., DOLL, S., RAU, H., GOYARTS, T., WUNDRACK, N., NAUMANN, M., DANICKE, S. &ROTHKOTTER, H. J. 2007. The Fusarium toxin deoxyniva<strong>le</strong>nol disrupts ph<strong>en</strong>otype andf<strong>un</strong>ction of monocyte-derived d<strong>en</strong>dritic cells in vivo and in vitro. Imm<strong>un</strong>obiology, 212, 655-66.BINDER, E. M. 2007. Managing the risk of my<strong>co</strong>toxins in modern feed production. 133, 149-166.BINDER, E. M., HEIDLER, D., SCHATZMAYR, G., THIMM, N., FUCHS, E., SCHUH, M., KRSKA, R. &BINDER, J. Microbial detoxification of my<strong>co</strong>toxins in animal feed. Proceedings of the 10thInternational IUPAC Symposium on the My<strong>co</strong>toxins and Phy<strong>co</strong>toxins, 2000 Brazil.BINDER, E. M., HEIDLER, D., SCHATZMAYR, G., THIMM, N., FUCHS, E., SCHUH, M., KRSKA, R. &BINDER, J. Microbial detoxification of my<strong>co</strong>toxins. Proceedings of the World My<strong>co</strong>toxinForum, 2001 Netherlands.BINDER, E. M., TAN, L. M., CHIN, L. J., HANDL, J. & RICHARD, J. 2007. Worldwide occurr<strong>en</strong>ce ofmy<strong>co</strong>toxins in <strong>co</strong>mmodities, feeds and feed ingredi<strong>en</strong>ts. Animal Feed Sci<strong>en</strong>ce andTechnology, 137, 265-282.BLACKWELL, B. A., GILLIAM, J. T., SAVARD, M. E., MILLER, J. D. & DUVICK, J. P. 1999. Oxidativedeamination of hydrolyzed fumonisin B-1 (AP(1)) by cultures of Exophiala spinifera. NaturalToxins, 7, 31-38.BOEIRA, L. S., BRYCE, J. H., STEWART, G. G. & FLANNIGAN, B. 2000. The effect of <strong>co</strong>mbinations ofFusarium my<strong>co</strong>toxins (deoxyniva<strong>le</strong>nol, zeara<strong>le</strong>none and fumonisin B1) on growth of brewingyeasts. J Appl Microbiol, 88, 388-403.BÖHM, J., GRAJEWSKI, J., ASPERGER, H., CECON, B., RABUS, B. & RAZZAZI, E. 2000. Study onbiodegradation of some A- and B-trichothec<strong>en</strong>es and ochratoxin A by use of probioticmicroorganisms. My<strong>co</strong>toxin Research, 16, 70-74.BONNA, R. J., AULERICH, R. J., BURSIAN, S. J., POPPENGA, R. H., BRASELTON, W. E. & WATSON, G. L.1991. Efficacy of Hydrated Sodium Calcium Aluminosilicate and Activated-Char<strong>co</strong>al inReducing the Toxicity of Dietary Aflatoxin to Mink. Archives of Environm<strong>en</strong>tal Contaminationand Toxi<strong>co</strong>logy, 20, 441-447.BOTHAST, R. J. & HESSELTINE, C. W. 1975. Bright Gre<strong>en</strong>ish-Yellow Fluoresc<strong>en</strong>ce and Aflatoxin inAgricultural Commodities. Applied Microbiology, 30, 337-338.BOUHET, S., HOURCADE, E., LOISEAU, N., FIKRY, A., MARTINEZ, S., ROSELLI, M., GALTIER, P.,MENGHERI, E. & OSWALD, I. P. 2004. The my<strong>co</strong>toxin fumonisin B-1 alters the proliferationand the barrier f<strong>un</strong>ction of porcine intestinal epithelial cells. Toxi<strong>co</strong>logical Sci<strong>en</strong>ces, 77, 165-171.BOUHET, S., LE DORZE, E., PERES, S., FAIRBROTHER, J. M. & OSWALD, I. P. 2006. My<strong>co</strong>toxin fumonisinB-1 se<strong>le</strong>ctively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitrostudies. Food and Chemical Toxi<strong>co</strong>logy, 44, 1768-1773.BOUHET, S. & OSWALD, I. P. 2005. The effects of my<strong>co</strong>toxins, f<strong>un</strong>gal food <strong>co</strong>ntaminants, on theintestinal epithelial cell-derived innate imm<strong>un</strong>e response. Veterinary Imm<strong>un</strong>ology andImm<strong>un</strong>opathology, 108, 199-209.BOUHET, S. & OSWALD, I. P. 2007. The intestine as a possib<strong>le</strong> target for fumonisin toxicity. Mol NutrFood Res, 51, 925-31.BRATICH, P. M., BUCK, W. B. & HASCHEK, W. M. 1990. Prev<strong>en</strong>tion of T-2 Toxin-Induced MorphologicEffects in the Rat by Highly Activated-Char<strong>co</strong>al. Archives of Toxi<strong>co</strong>logy, 64, 251-253.191
REFERENCES BIBLIOGRAPHIQUESBREINHOLT, V., HENDRICKS, J., PEREIRA, C., ARBOGAST, D. & BAILEY, G. 1995. Dietary Chlorophyllin Isa Pot<strong>en</strong>t Inhibitor of Aflatoxin B1 Hepatocarcinog<strong>en</strong>esis in Rainbow Trout. Cancer Research,55, 57-62.BROOMHEAD, J. N., LEDOUX, D. R., BERMUDEZ, A. J. & ROTTINGHAUS, G. E. 2002. Chronic effects offumonisin B-1 in broi<strong>le</strong>rs and turkeys fed dietary treatm<strong>en</strong>ts to market age. Poultry Sci<strong>en</strong>ce,81, 56-61.BROWN, T. P., MANNING, R. O., FLETCHER, O. J. & WYATT, R. D. 1986. The Individual and CombinedEffects of Citrinin-a and Ochratoxin-a on R<strong>en</strong>al Ultrastructure in Layer Chicks. Avian Diseases,30, 191-198.BROWN, T. P., ROTTINGHAUS, G. E. & WILLIAMS, M. E. 1992. Fumonisin My<strong>co</strong>toxi<strong>co</strong>sis in Broi<strong>le</strong>rs -Performance and Pathology. Avian Diseases, 36, 450-454.BRUININK, A., RASONYI, T. & SIDLER, C. 1998. Differ<strong>en</strong>ces in neurotoxic effects of ochratoxin A,ochracin and ochratoxin-αin vitro. Natural Toxins, 6, 173-177.BRYDEN, W. L. 2009. My<strong>co</strong>toxins and My<strong>co</strong>toxi<strong>co</strong>ses: Significance, Occurr<strong>en</strong>ce and Mitigation in theFood Chain, John Wi<strong>le</strong>y & Sons, Ltd.BULLERMAN, L. B. & BIANCHINI, A. 2007. Stability of my<strong>co</strong>toxins during food processing.International Journal of Food Microbiology, 119, 140-146.BULLERMAN, L. B., RYU, D. & BIANCHINI, A. 2007. Biological Evaluation of Reduction of Fumonisin B1Toxicity in Corn Grits by Extrusion Processing. Final Report to The Andersons Research GrantProgram of NC 213. Managem<strong>en</strong>t of Grain Quality and Security in World Markets.BURNS, T. D., SNOOK, M. E., RILEY, R. T. & VOSS, K. A. 2008. Fumonisin <strong>co</strong>nc<strong>en</strong>trations and in vivotoxicity of nixtamalized Fusarium verticillioides culture material: Evid<strong>en</strong>ce for fumonisinmatrixinteractions. Food and Chemical Toxi<strong>co</strong>logy, 46, 2841-2848.BURSIAN, S. J., AULERICH, R. J., CAMERON, J. K., AMES, N. K. & STEFICEK, B. A. 1992. Efficacy ofHydrated Sodium Calcium Aluminosilicate in Reducing the Toxicity of Dietary Zeara<strong>le</strong>none toMink. Journal of Applied Toxi<strong>co</strong>logy, 12, 85-90.BURSIAN, S. J., MITCHELL, R. R., YAMINI, B., FITZGERALD, S. D., MURPHY, P. A., FERNADEZ, G.,ROTTINGHAUS, G. E., MORAN, L., LEEFERS, K. & CHOI, I. 2004. Efficacy of a <strong>co</strong>mmercialmy<strong>co</strong>toxin binder in al<strong>le</strong>viating effects of ochratoxin A, fumonisin B-1, moniliformin andzeara<strong>le</strong>none in adult mink. Veterinary and Human Toxi<strong>co</strong>logy, 46, 122-129.CCALONI, F., SPOTTI, M., POMPA, G., ZUCCO, F., STAMMATI, A. & DE ANGELIS, I. 2002. Evaluation ofFumonisin B-1 and its metabolites absorption and toxicity on intestinal cells line Ca<strong>co</strong>-2.Toxi<strong>co</strong>n, 40, 1181-1188.CAMILO, S. B., ONO, C. J., UENO, Y. & HIROOKA, E. Y. 2000. Anti-Fusarium moniliforme activity andfumonisin biodegradation by <strong>co</strong>rn and silage microflora. Brazilian Archives of Biology andTechnology, 43, 159-164.CANELA, R., PUJOL, R., SALA, N. & SANCHIS, V. 1996. Fate of fumonisins B-1 and B-2 in steeped <strong>co</strong>rnkernels. Food Additives and Contaminants, 13, 511-517.CAPALDO, C. T. & NUSRAT, A. 2009. Cytokine regulation of tight j<strong>un</strong>ctions. Biochimica Et BiophysicaActa-Biomembranes, 1788, 864-871.CARLSON, D. B., WILLIAMS, D. E., SPITSBERGEN, J. M., ROSS, P. F., BACON, C. W., MEREDITH, F. I. &RILEY, R. T. 2001. Fumonisin B-1 promotes aflatoxin B-1 and N-methyl-N '-nitronitrosoguanidine-initiatedliver tumors in rainbow trout. Toxi<strong>co</strong>logy and AppliedPharma<strong>co</strong>logy, 172, 29-36.CARSON, M. S. & SMITH, T. K. 1983. Ro<strong>le</strong> of B<strong>en</strong>tonite in Prev<strong>en</strong>tion of T-2 Toxi<strong>co</strong>sis in Rats. Journalof Animal Sci<strong>en</strong>ce, 57, 1498-1506.192
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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