REFERENCES BIBLIOGRAPHIQUESPFOHL-LESZKOWICZ, A., MOLINIE, A., TOZLOVANU, M. & MANDERVILLE, R. A. 2008. Combined ToxicEffects of Ochratoxin A and Citrinin, In Vivo and In Vitro. In: SIANTAR, D. P., TRUCKSESS, M.W., SCOTT, P. M. & HERMAN, E. M. (eds.) Food Contaminants: My<strong>co</strong>toxins and FoodAl<strong>le</strong>rg<strong>en</strong>s. Washington: Amer Chemical Soc.PHILLIPS, T. D. 1999. Dietary clay in the chemoprev<strong>en</strong>tion of aflatoxin-induced disease. Toxi<strong>co</strong>logicalSci<strong>en</strong>ces, 52, 118-126.PHILLIPS, T. D., CLEMENT, B. A., KUBENA, L. F. & HARVEY, R. B. 1990. Detection and Detoxification ofAflatoxins - Prev<strong>en</strong>tion of Aflatoxi<strong>co</strong>sis and Aflatoxin Residues with Hydrated Sodium CalciumAluminosilicate. Veterinary and Human Toxi<strong>co</strong>logy, 32, 15-19.PHILLIPS, T. D., CLEMENT, B. A. & PARK, D. L. 1994. Approaches to reduction of aflatoxin in foods andfeeds. In: EATON, L. D. & GROOPMAN, J. D. (eds.) The Toxi<strong>co</strong>logy of Aflatoxins: HumanHealth, Veterinary Agricultural Significance. Academic Press, New York.PHILLIPS, T. D., KUBENA, L. F., HARVEY, R. B., TAYLOR, D. R. & HEIDELBAUGH, N. D. 1988. HydratedSodium Calcium Aluminosilicate - a High-Affinity Sorb<strong>en</strong>t for Aflatoxin. Poultry Sci<strong>en</strong>ce, 67,243-247.PHILLIPS, T. D., SARR, A. B., CLEMENT, B. A., KUBENA, L. F. & HARVEY, R. B. 1991. Prev<strong>en</strong>tion ofaflatoxi<strong>co</strong>sis in farm animals via se<strong>le</strong>ctive chemisorption of aflatoxin. In: BRAY, G. A. & RYAN,D. H. (eds.) My<strong>co</strong>toxins, Cancer and Health. Louisiana State University Press, Baton Rouge.PIER, A. C., BELDEN, E. L., ELLIS, J. A., NELSON, E. W. & MAKI, L. R. 1989. Effects of Cyclopiazonic Acidand Aflatoxin Singly and in Combination on Se<strong>le</strong>cted Clinical, Pathological and Imm<strong>un</strong>ologicalResponses of Guinea-Pigs. My<strong>co</strong>pathologia, 105, 135-142.PIERIDES, M., EL-NEZAMI, H., PELTONEN, K., SALMINEN, S. & AHOKAS, J. 2000. Ability of dairy strainsof lactic acid bacteria to bind aflatoxin M-1 in a food model. Journal of Food Protection, 63,645-650.PIETRI, A., BERTUZZI, T., PIVA, G., BINDER, E. M., SCHATZMAYR, G. & RODRIGUES, I. 2009. Aflatoxintransfer from naturally <strong>co</strong>ntaminated feed to milk of dairy <strong>co</strong>ws and the effici<strong>en</strong>cy of amy<strong>co</strong>toxin deactivating product. International Journal of Dairy Sci<strong>en</strong>ce, 4, 34-42.PINELLI, E., POUX, N., GARREN, L., PIPY, B., CASTEGNARO, M., MILLER, D. J. & PFOHL-LESZKOWICZ, A.1999. Activation of mitog<strong>en</strong>-activated protein kinase by fumonisin B-1 stimulates cPLA(2)phosphorylation, the arachidonic acid cascade and cAMP production. Carcinog<strong>en</strong>esis, 20,1683-1688.PINTON, P., ACCENSI, F., BEAUCHAMP, E., COSSALTER, A. M., CALLU, P., GROSJEAN, F. & OSWALD, I.P. 2008. Ingestion of deoxyniva<strong>le</strong>nol (DON) <strong>co</strong>ntaminated feed alters the pig vaccinalimm<strong>un</strong>e responses. Toxi<strong>co</strong>l Lett, 177, 215-22.PINTON, P., BRAICU, C., NOUGAYREDE, J. P., LAFFITTE, J., TARANU, I. & OSWALD, I. P. 2010.Deoxyniva<strong>le</strong>nol impairs porcine intestinal barrier f<strong>un</strong>ction and decreases the proteinexpression of claudin-4 through a Mitog<strong>en</strong> Activated Protein Kinase dep<strong>en</strong>d<strong>en</strong>t mechanism.Journal of Nutrition, In Press.PINTON, P., NOUGAYREDE, J. P., DEL RIO, J. C., MORENO, C., MARIN, D. E., FERRIER, L., BRACARENSE,A. P., KOLF-CLAUW, M. & OSWALD, I. P. 2009. The food <strong>co</strong>ntaminant deoxyniva<strong>le</strong>nol,decreases intestinal barrier permeability and reduces claudin expression. Toxi<strong>co</strong>logy andApplied Pharma<strong>co</strong>logy, 237, 41-48.PIVA, A., CASADEI, G., PAGLIUCA, G., CABASSI, E., GALVANO, F., SOLFRIZZO, M., RILEY, R. T. & DIAZ, D.E. 2005. Activated carbon does not prev<strong>en</strong>t the toxicity of culture material <strong>co</strong>ntainingfumonisin B-1 wh<strong>en</strong> fed to weanling pig<strong>le</strong>ts. Journal of Animal Sci<strong>en</strong>ce, 83, 1939-1947.PIVA, G., GALVANO, F., PIETRI, A. & PIVA, A. 1995. Detoxification Methods of Aflatoxins - a Review.Nutrition Research, 15, 767-776.PLACINTA, C. M., D'MELLO, J. P. F. & MACDONALD, A. M. C. 1999. A review of worldwide<strong>co</strong>ntamination of cereal grains and animal feed with Fusarium my<strong>co</strong>toxins. Animal FeedSci<strong>en</strong>ce and Technology, 78, 21-37.211
REFERENCES BIBLIOGRAPHIQUESPLANK, G., BAUER, J., GRÜNKERNEIER, A., FISCHER, S., GEDEK, B. & BERNER, H. 1990.Untersucg<strong>un</strong>g<strong>en</strong> zur protektiv<strong>en</strong> wirk<strong>un</strong>g von adsorb<strong>en</strong>ti<strong>en</strong> geg<strong>en</strong>über ochratoxin A beimschwein. Tieräztl. Prax., 18, 483-489.PLANK, G., SCHUH, M. & BINDER, E. M. 2009. Untersuch<strong>un</strong>g<strong>en</strong> über die detoxifizier<strong>en</strong>de wirk<strong>un</strong>g derFuttermittelzusätze Biomin BBSH 797 <strong>un</strong>d My<strong>co</strong>fix Plus 3.E in bezug auf DON imFerkelaufzuchtfutter. Wi<strong>en</strong>er Tierärztliche Monatszeitschrift - VeterinärmedizinischeUniversität, 96, 55-71.POLITIS, I., FEGEROS, K., NITSCH, S., SCHATZMAYR, G. & KANTAS, D. 2005. Use of Trichosporonmy<strong>co</strong>toxinivorans to suppress the effects of ochratoxi<strong>co</strong>sis on the imm<strong>un</strong>e system of broi<strong>le</strong>rchicks. British Poultry Sci<strong>en</strong>ce, 46, 58-65.POZZI, C. R., CORREA, B., XAVIER, J. G., DIREITO, G. M., ORSI, R. B. & MATARAZZO, S. V. 2001. Effectsof prolonged oral administration of fumonisin B-1 and aflatoxin B-1 in rats. My<strong>co</strong>pathologia,151, 21-27.PRICE, R. L. & JORGENSEN, K. V. 1985. Effects of Processing on Aflatoxin Levels and on Mutag<strong>en</strong>icPot<strong>en</strong>tial of Tortillas Made from Naturally Contaminated Corn. Journal of Food Sci<strong>en</strong>ce, 50,347-&.PRUDENTE JR, A. D. & KING, J. M. 2002. Efficacy and safety evaluation of ozonation to degradeaflatoxin in <strong>co</strong>rn. Journal of Food Sci<strong>en</strong>ce, 67, 2866-2872.PUJOL, R., TORRES, M., SANCHIS, V. & CANELA, R. 1999. Fate of fumonisin B-1 in <strong>co</strong>rn kernel steepingwater <strong>co</strong>ntaining SO2. Journal of Agricultural and Food Chemistry, 47, 276-278.QQURESHI, M. A. & HAGLER, W. M. 1992. Effect of Fumonisin-B1 Exposure on Chick<strong>en</strong> MacrophageF<strong>un</strong>ctions Invitro. Poultry Sci<strong>en</strong>ce, 71, 104-112.RRAJMON, R., SEDMIKOVA, M., JILEK, F., KOUBKOVA, M., HARTLOVA, H., BARTA, I. & SMERAK, P. 2001.Combined effects of repeated low doses of aflatoxin B-1 and T-2 toxin on the Chinesehamster. Veterinarni Medicina, 46, 301-307.RAJU, M. & DEVEGOWDA, G. 2000. Influ<strong>en</strong>ce of esterified-glu<strong>co</strong>mannan on performance and organmorphology, serum biochemistry and haematology in broi<strong>le</strong>rs exposed to individual and<strong>co</strong>mbined my<strong>co</strong>toxi<strong>co</strong>sis (aflatoxin, ochratoxin and T-2 toxin). British Poultry Sci<strong>en</strong>ce, 41, 640-650.RAJU, M. & DEVEGOWDA, G. 2002. Esterified-glu<strong>co</strong>mannan in broi<strong>le</strong>r chick<strong>en</strong> diets-<strong>co</strong>ntaminatedwith aflatoxin, ochratoxin and T-2 toxin: Evaluation of its binding ability (in vitro) and efficacyas imm<strong>un</strong>omodulator. Asian-Australasian Journal of Animal Sci<strong>en</strong>ces, 15, 1051-1056.RAMIRO-PUIG, E., PEREZ-CANO, F. J., CASTELLOTE, C., FRANCH, A. & CASTELL, M. 2008. The bowel: Akey <strong>co</strong>mpon<strong>en</strong>t of the imm<strong>un</strong>e system. Revista Espanola De Enfermedades Digestivas, 100,29-34.RAMOS, A. J. 1994. Prev<strong>en</strong>cion de los efectos cancerig<strong>en</strong>os de las aflatoxinas y la zeara<strong>le</strong>nonamediante el emp<strong>le</strong>o de <strong>co</strong>mpuestos adsorb<strong>en</strong>tes no nutritivos. Estudios in vitro. PhD Thesis.Polytechnic Univeristy of Va<strong>le</strong>ncia, Spain.RAMOS, A. J., FINKGREMMELS, J. & HERNANDEZ, E. 1996. Prev<strong>en</strong>tion of toxic effects of my<strong>co</strong>toxinsby means of nonnutritive adsorb<strong>en</strong>t <strong>co</strong>mpo<strong>un</strong>ds. Journal of Food Protection, 59, 631-641.RAMOS, A. J. & HERNANDEZ, E. 1996. In vitro aflatoxin adsorption by means of a montmorillonitesilicate. A study of adsorption isotherms. Animal Feed Sci<strong>en</strong>ce and Technology, 62, 263-269.REDDY, N. B., DEVEGOWDA, G. & GIRISH, C. K. 2003. Modified glu<strong>co</strong>mannan: a promising solution tobind T-2 toxin in broi<strong>le</strong>rs. Feed Technology, 8, 23-24.212
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AUTEUR : Bertrand GRENIERTITRE : Ef
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REMERCIEMENTSLe travail ici présen
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J’ai une pensée particulière po
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Grenier, B., Loureiro-Bracarense, A
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TABLE DES MATIERES ................
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LISTE DES ABREVIATIONSAFAflatoxineD
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FIGURES ET TABLEAUXFigure 1 : Mycot
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INTRODUCTION8
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INTRODUCTIONCONTEXTE DE L’ETUDELe
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INTRODUCTIONElle se présentait sou
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INTRODUCTIONl’utilisation de ce m
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INTRODUCTION1. Les mycotoxines : g
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INTRODUCTIONc) La zéaralénone (vo
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INTRODUCTIONleucoencéphalomalacies
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INTRODUCTIONMycotoxins co-contamina
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INTRODUCTIONINTRODUCTIONFood safety
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INTRODUCTIONCHARACTERIZATION OF THE
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Quail(140 d)AF-FBRabbit(21 d)AF-FBR
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INTRODUCTIONdue to the ingestion of
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Table 2 : Interaction between Aflat
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(49 d) - RW-L ↗- Ab SRBC ↘- RW-
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INTRODUCTIONb) effects AF and OTA o
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INTRODUCTIONThe depletion of lympho
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AF-T2Chicken 0.3 - 3.0(35 d)AF-T2Ra
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INTRODUCTIONonly seen in birds give
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(30 d) 2AF-RUBGuinea pig 0.02 bw -(
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INTRODUCTIONbetween AF and CPA on t
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(21 day) - RBC, hemoglobin ↗- AST
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INTRODUCTIONII. INTERACTIONS BETWEE
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INTRODUCTIONwhereas in the experime
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INTRODUCTION2.2) TCT type A and BTw
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Table 6 : Interaction between Ochra
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T2-CPAChicken(28 d)T2-CPAChicken(21
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INTRODUCTIONexposed group (Brown et
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INTRODUCTION2.3) Interaction betwee
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INTRODUCTIONeffects in comparison t
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INTRODUCTION3. Procédés de décon
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INTRODUCTIONPhysical and chemical m
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INTRODUCTIONINTRODUCTIONConsumption
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INTRODUCTIONmm screen shows that fr
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INTRODUCTIONseparate the grain into
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Table 7 : toxicological evaluation
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INTRODUCTIONextrusion parameters ra
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INTRODUCTION- an important loss of
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INTRODUCTIONal., 2005). The fate of
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INTRODUCTIONby a steeping period. S
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INTRODUCTIONon cell tissue cultures
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INTRODUCTIONCONCLUSIONDetoxificatio
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INTRODUCTIONMycotoxin Reduction in
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INTRODUCTIONINTRODUCTIONMycotoxin-p
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INTRODUCTIONI. ADSORPTION OF MYCOTO
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Rats3000 ppb 0.5 %2500 ppb 0.5 %250
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INTRODUCTIONIn studies of the poten
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INTRODUCTIONSubstances investigated
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Table 9 : Outcome of yeast cell wal
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INTRODUCTIONFurthermore, cholestyra
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INTRODUCTIONwall peptidoglycans and
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INTRODUCTIONII. BIOLOGICAL DETOXIFI
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INTRODUCTIONdecrease in toxin-conce
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INTRODUCTIONCONCLUSIONPrevention an
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TRAVAILEXPERIMENTAL90
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TRAVAIL EXPERIMENTALtoxicité gén
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TRAVAIL EXPERIMENTALRESUME DES ETUD
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TRAVAIL EXPERIMENTALChronic ingesti
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TRAVAIL EXPERIMENTALINTRODUCTIONMyc
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TRAVAIL EXPERIMENTALMATERIAL & METH
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TRAVAIL EXPERIMENTALthrough a grade
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Figure 5ABCDVilli height (µm)5432a
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TRAVAIL EXPERIMENTALRESULTS1) Histo
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Figure 8ILEUM2.01.6TNF-αbbb2.52.0I
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TRAVAIL EXPERIMENTAL3) Intestinal i
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TRAVAIL EXPERIMENTALtreated group t
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TRAVAIL EXPERIMENTALThe potencial e
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TRAVAIL EXPERIMENTALQuantification
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Figure 10 :(a) Réaction de deesté
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TRAVAIL EXPERIMENTALrévélé de l
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TRAVAIL EXPERIMENTALABSTRACTFumonis
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TRAVAIL EXPERIMENTALintestinal leve
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TRAVAIL EXPERIMENTAL3) Experimental
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TRAVAIL EXPERIMENTALthe importance
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Figure 11 : Effects of FB1 and HFB1
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Table 15 : Effects of FB1 and HFB1
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Table 17 : Effects of FB1 and HFB1
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TRAVAIL EXPERIMENTALDISCUSSIONThe a
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TRAVAIL EXPERIMENTALassociated lymp
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TRAVAIL EXPERIMENTALHartinger et al
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Figure 13 :(a) Transformation par v
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Figure 14 :Illustrations de la proc
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Figure 15 :Plan expérimental de la
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TRAVAIL EXPERIMENTAL4) Analyses du
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TRAVAIL EXPERIMENTAL9) Analyses sta
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TRAVAIL EXPERIMENTALRESULTATS1) Eff
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TRAVAIL EXPERIMENTAL2) Effet des ag
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TRAVAIL EXPERIMENTALb,cca,ba,b,da,d
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TRAVAIL EXPERIMENTALL’exposition
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Figure 21 : Effet de l’exposition
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1,41,21,00,80,60,40,20,0IL‐8a,cc
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TRAVAIL EXPERIMENTALDISCUSSIONLes o
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TRAVAIL EXPERIMENTALœdèmes pulmon
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DISCUSSIONGENERALE160
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DISCUSSION GENERALEDans ce travail
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DISCUSSION GENERALEdes vaches laiti
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Tableau 24 : Analyse de denrées ag
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DISCUSSION GENERALEet al., 2008b).
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