Effet chez le porcelet d'une exposition à un régime co-contaminé en ...

INTRODUCTIONmitogenic stimulation, the reduced activity of phagocytosis in the combined treatment was similar tothe individual OTA treatment (Harvey et al., 1994), and an antagonistic effect was reported for thelevel of specific antibodies (Raju and Devegowda, 2002) (Table 6).One experiment investigated the interaction between OTA and DAS in chicken (Table 6), andobserved in general less than additive or antagonistic effect (Kubena et al., 1994a). Surprisingly, nomortality was recorded in comparison to the individual treatments. A less than additive effect wasobserved for the oral lesions, induced by DAS. Like T-2 toxin, in association with OTA, DAS seems tospare the OTA-induced renal dysfunction, as shown with the antagonistic effect on uric acidconcentration.2.1.2) with TCT type BOne study focused on the interaction between OTA and DON in chicken (Kubena et al., 1988). Formany parameters, such as BWG, relative weight of organs and biochemistry, the interaction was lessthan additive or antagonistic in nature (Table 6). Similarly, lesions in liver and kidney were only dueto the OTA presence in the contaminated diet.2.2) Interaction between OTA and FBThree experiments were conducted in rats, turkey poults and rabbits to analyze the interactionbetween these two toxins (Table 6); however the authors used very different doses of mycotoxins(Domijan et al., 2007; Kubena et al., 1997b; Sivakumar et al., 2009). Using very high concentrations ofFB, Kubena et al. (1997b) showed synergistic effects in association with OTA compared to mycotoxinsalone (performance, some biochemical parameters and enzyme levels). Using lower doses of toxins,Sivakumar et al. (2009) observed less than additive or additive effects on biochemistry and enzymelevels. Interestingly, in both studies, the concentrations of serum enzymes were increased comparedto the interaction between OTA and T-2 toxin (Table 6).Using doses of toxins reflecting the European-type diet, Domijan et al. (2007) analyzed theinteraction between these two toxins on the oxidative stress, in liver and kidneys of rats (Table 6).They observed that although the lowest doses of OTA and FB given separately did not increase theconcentration of malondialdehyde (MDA) and protein carbonyls (PCs) in the liver, their combinationproduced a synergistic effect. Similarly, in the kidney, the combination further increased the PCsconcentration, ranging from synergistic to additive or to less than additive effect, depending on thedoses used. The catalase activity in rat kidney decreased in a synergistic manner after exposure toboth OTA and FB, while this parameter was not affected by separate OTA or FB treatments.43